Amino acid dipepetide frequency for Aeromonas phage vB_AhyS-A18P4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.268AlaAla: 18.268 ± 1.285
0.787AlaCys: 0.787 ± 0.237
8.189AlaAsp: 8.189 ± 0.856
6.562AlaGlu: 6.562 ± 0.559
3.202AlaPhe: 3.202 ± 0.459
7.402AlaGly: 7.402 ± 0.564
1.837AlaHis: 1.837 ± 0.372
5.669AlaIle: 5.669 ± 0.621
5.879AlaLys: 5.879 ± 0.829
10.446AlaLeu: 10.446 ± 1.062
4.147AlaMet: 4.147 ± 0.451
3.622AlaAsn: 3.622 ± 0.399
5.774AlaPro: 5.774 ± 0.759
4.199AlaGln: 4.199 ± 0.809
8.031AlaArg: 8.031 ± 0.713
5.722AlaSer: 5.722 ± 0.593
5.827AlaThr: 5.827 ± 0.677
8.399AlaVal: 8.399 ± 0.848
1.575AlaTrp: 1.575 ± 0.312
2.73AlaTyr: 2.73 ± 0.321
0.0AlaXaa: 0.0 ± 0.0
Cys
1.155CysAla: 1.155 ± 0.251
0.105CysCys: 0.105 ± 0.076
0.682CysAsp: 0.682 ± 0.201
0.577CysGlu: 0.577 ± 0.206
0.21CysPhe: 0.21 ± 0.091
1.155CysGly: 1.155 ± 0.23
0.315CysHis: 0.315 ± 0.129
0.105CysIle: 0.105 ± 0.058
0.157CysLys: 0.157 ± 0.084
0.892CysLeu: 0.892 ± 0.194
0.21CysMet: 0.21 ± 0.095
0.262CysAsn: 0.262 ± 0.116
0.997CysPro: 0.997 ± 0.267
0.367CysGln: 0.367 ± 0.167
1.102CysArg: 1.102 ± 0.231
0.682CysSer: 0.682 ± 0.244
0.577CysThr: 0.577 ± 0.18
0.367CysVal: 0.367 ± 0.112
0.472CysTrp: 0.472 ± 0.154
0.525CysTyr: 0.525 ± 0.187
0.0CysXaa: 0.0 ± 0.0
Asp
7.244AspAla: 7.244 ± 0.677
0.577AspCys: 0.577 ± 0.256
4.724AspAsp: 4.724 ± 0.636
4.672AspGlu: 4.672 ± 0.637
1.732AspPhe: 1.732 ± 0.263
5.354AspGly: 5.354 ± 0.492
1.575AspHis: 1.575 ± 0.34
2.782AspIle: 2.782 ± 0.297
2.52AspLys: 2.52 ± 0.409
6.877AspLeu: 6.877 ± 0.515
1.68AspMet: 1.68 ± 0.272
2.415AspAsn: 2.415 ± 0.306
3.78AspPro: 3.78 ± 0.388
2.362AspGln: 2.362 ± 0.341
4.147AspArg: 4.147 ± 0.459
2.205AspSer: 2.205 ± 0.29
3.307AspThr: 3.307 ± 0.334
4.567AspVal: 4.567 ± 0.505
1.312AspTrp: 1.312 ± 0.291
2.047AspTyr: 2.047 ± 0.296
0.0AspXaa: 0.0 ± 0.0
Glu
7.192GluAla: 7.192 ± 0.68
0.472GluCys: 0.472 ± 0.145
3.78GluAsp: 3.78 ± 0.573
2.992GluGlu: 2.992 ± 0.599
1.785GluPhe: 1.785 ± 0.295
3.57GluGly: 3.57 ± 0.485
0.63GluHis: 0.63 ± 0.272
3.255GluIle: 3.255 ± 0.306
2.362GluLys: 2.362 ± 0.322
4.934GluLeu: 4.934 ± 0.504
1.47GluMet: 1.47 ± 0.348
2.52GluAsn: 2.52 ± 0.356
2.31GluPro: 2.31 ± 0.441
2.782GluGln: 2.782 ± 0.423
4.147GluArg: 4.147 ± 0.594
2.992GluSer: 2.992 ± 0.361
3.727GluThr: 3.727 ± 0.359
4.409GluVal: 4.409 ± 0.523
1.522GluTrp: 1.522 ± 0.281
2.152GluTyr: 2.152 ± 0.345
0.0GluXaa: 0.0 ± 0.0
Phe
2.73PheAla: 2.73 ± 0.328
0.367PheCys: 0.367 ± 0.155
2.94PheAsp: 2.94 ± 0.446
2.152PheGlu: 2.152 ± 0.313
1.155PhePhe: 1.155 ± 0.268
2.1PheGly: 2.1 ± 0.3
0.63PheHis: 0.63 ± 0.169
1.47PheIle: 1.47 ± 0.292
1.89PheLys: 1.89 ± 0.307
1.522PheLeu: 1.522 ± 0.226
0.42PheMet: 0.42 ± 0.145
1.26PheAsn: 1.26 ± 0.236
1.155PhePro: 1.155 ± 0.312
1.207PheGln: 1.207 ± 0.345
1.785PheArg: 1.785 ± 0.224
1.575PheSer: 1.575 ± 0.272
1.995PheThr: 1.995 ± 0.296
1.785PheVal: 1.785 ± 0.263
0.525PheTrp: 0.525 ± 0.157
0.84PheTyr: 0.84 ± 0.24
0.0PheXaa: 0.0 ± 0.0
Gly
6.877GlyAla: 6.877 ± 0.583
0.997GlyCys: 0.997 ± 0.279
5.512GlyAsp: 5.512 ± 0.505
4.777GlyGlu: 4.777 ± 0.475
2.625GlyPhe: 2.625 ± 0.329
5.879GlyGly: 5.879 ± 0.562
1.627GlyHis: 1.627 ± 0.296
4.147GlyIle: 4.147 ± 0.471
3.78GlyLys: 3.78 ± 0.416
6.142GlyLeu: 6.142 ± 0.574
2.31GlyMet: 2.31 ± 0.373
2.257GlyAsn: 2.257 ± 0.351
3.517GlyPro: 3.517 ± 0.57
2.992GlyGln: 2.992 ± 0.338
5.617GlyArg: 5.617 ± 0.558
3.78GlySer: 3.78 ± 0.465
4.147GlyThr: 4.147 ± 0.46
4.987GlyVal: 4.987 ± 0.537
1.522GlyTrp: 1.522 ± 0.295
2.677GlyTyr: 2.677 ± 0.425
0.0GlyXaa: 0.0 ± 0.0
His
1.207HisAla: 1.207 ± 0.263
0.42HisCys: 0.42 ± 0.186
1.26HisAsp: 1.26 ± 0.275
0.84HisGlu: 0.84 ± 0.218
0.42HisPhe: 0.42 ± 0.15
1.837HisGly: 1.837 ± 0.311
0.63HisHis: 0.63 ± 0.201
0.945HisIle: 0.945 ± 0.213
0.682HisLys: 0.682 ± 0.164
2.047HisLeu: 2.047 ± 0.35
0.525HisMet: 0.525 ± 0.204
0.735HisAsn: 0.735 ± 0.21
1.05HisPro: 1.05 ± 0.213
0.945HisGln: 0.945 ± 0.237
1.102HisArg: 1.102 ± 0.264
0.892HisSer: 0.892 ± 0.221
0.84HisThr: 0.84 ± 0.214
1.207HisVal: 1.207 ± 0.314
0.42HisTrp: 0.42 ± 0.113
0.787HisTyr: 0.787 ± 0.191
0.0HisXaa: 0.0 ± 0.0
Ile
4.987IleAla: 4.987 ± 0.466
0.262IleCys: 0.262 ± 0.102
3.675IleAsp: 3.675 ± 0.493
3.045IleGlu: 3.045 ± 0.418
1.05IlePhe: 1.05 ± 0.195
3.307IleGly: 3.307 ± 0.327
0.945IleHis: 0.945 ± 0.196
1.837IleIle: 1.837 ± 0.261
2.782IleLys: 2.782 ± 0.332
3.412IleLeu: 3.412 ± 0.341
1.575IleMet: 1.575 ± 0.235
2.572IleAsn: 2.572 ± 0.314
2.467IlePro: 2.467 ± 0.295
1.837IleGln: 1.837 ± 0.269
3.465IleArg: 3.465 ± 0.434
3.36IleSer: 3.36 ± 0.408
3.78IleThr: 3.78 ± 0.438
2.677IleVal: 2.677 ± 0.303
0.682IleTrp: 0.682 ± 0.231
1.942IleTyr: 1.942 ± 0.296
0.0IleXaa: 0.0 ± 0.0
Lys
6.194LysAla: 6.194 ± 0.86
0.42LysCys: 0.42 ± 0.171
3.202LysAsp: 3.202 ± 0.459
2.415LysGlu: 2.415 ± 0.346
1.627LysPhe: 1.627 ± 0.259
3.255LysGly: 3.255 ± 0.364
0.735LysHis: 0.735 ± 0.216
2.31LysIle: 2.31 ± 0.417
2.782LysLys: 2.782 ± 0.459
4.304LysLeu: 4.304 ± 0.513
1.365LysMet: 1.365 ± 0.292
1.05LysAsn: 1.05 ± 0.242
2.782LysPro: 2.782 ± 0.434
1.732LysGln: 1.732 ± 0.41
2.94LysArg: 2.94 ± 0.469
2.467LysSer: 2.467 ± 0.35
2.467LysThr: 2.467 ± 0.285
3.255LysVal: 3.255 ± 0.424
0.735LysTrp: 0.735 ± 0.223
0.945LysTyr: 0.945 ± 0.2
0.0LysXaa: 0.0 ± 0.0
Leu
11.076LeuAla: 11.076 ± 0.916
1.102LeuCys: 1.102 ± 0.217
5.354LeuAsp: 5.354 ± 0.552
5.302LeuGlu: 5.302 ± 0.646
2.205LeuPhe: 2.205 ± 0.322
6.667LeuGly: 6.667 ± 0.566
2.1LeuHis: 2.1 ± 0.38
5.092LeuIle: 5.092 ± 0.478
3.517LeuLys: 3.517 ± 0.431
5.249LeuLeu: 5.249 ± 0.6
2.362LeuMet: 2.362 ± 0.398
2.782LeuAsn: 2.782 ± 0.334
4.304LeuPro: 4.304 ± 0.431
3.57LeuGln: 3.57 ± 0.528
4.567LeuArg: 4.567 ± 0.53
4.042LeuSer: 4.042 ± 0.425
4.829LeuThr: 4.829 ± 0.559
6.247LeuVal: 6.247 ± 0.68
0.892LeuTrp: 0.892 ± 0.195
2.152LeuTyr: 2.152 ± 0.307
0.0LeuXaa: 0.0 ± 0.0
Met
3.412MetAla: 3.412 ± 0.484
0.42MetCys: 0.42 ± 0.177
1.837MetAsp: 1.837 ± 0.338
1.312MetGlu: 1.312 ± 0.29
0.735MetPhe: 0.735 ± 0.196
1.995MetGly: 1.995 ± 0.324
0.682MetHis: 0.682 ± 0.142
2.047MetIle: 2.047 ± 0.371
0.945MetLys: 0.945 ± 0.21
1.837MetLeu: 1.837 ± 0.294
0.84MetMet: 0.84 ± 0.211
1.155MetAsn: 1.155 ± 0.25
1.207MetPro: 1.207 ± 0.235
0.84MetGln: 0.84 ± 0.23
1.732MetArg: 1.732 ± 0.343
1.995MetSer: 1.995 ± 0.259
1.942MetThr: 1.942 ± 0.265
1.732MetVal: 1.732 ± 0.266
0.315MetTrp: 0.315 ± 0.151
0.472MetTyr: 0.472 ± 0.138
0.0MetXaa: 0.0 ± 0.0
Asn
3.832AsnAla: 3.832 ± 0.425
0.262AsnCys: 0.262 ± 0.116
1.785AsnAsp: 1.785 ± 0.295
1.312AsnGlu: 1.312 ± 0.28
0.997AsnPhe: 0.997 ± 0.214
3.202AsnGly: 3.202 ± 0.462
0.472AsnHis: 0.472 ± 0.176
1.837AsnIle: 1.837 ± 0.275
2.31AsnLys: 2.31 ± 0.271
3.202AsnLeu: 3.202 ± 0.385
1.417AsnMet: 1.417 ± 0.257
1.05AsnAsn: 1.05 ± 0.274
2.257AsnPro: 2.257 ± 0.385
1.365AsnGln: 1.365 ± 0.332
2.362AsnArg: 2.362 ± 0.317
1.785AsnSer: 1.785 ± 0.292
1.68AsnThr: 1.68 ± 0.282
1.785AsnVal: 1.785 ± 0.233
0.735AsnTrp: 0.735 ± 0.211
1.102AsnTyr: 1.102 ± 0.193
0.0AsnXaa: 0.0 ± 0.0
Pro
6.247ProAla: 6.247 ± 0.546
0.525ProCys: 0.525 ± 0.165
3.885ProAsp: 3.885 ± 0.447
2.992ProGlu: 2.992 ± 0.442
1.47ProPhe: 1.47 ± 0.27
4.987ProGly: 4.987 ± 0.64
1.102ProHis: 1.102 ± 0.256
2.205ProIle: 2.205 ± 0.326
2.31ProLys: 2.31 ± 0.291
3.727ProLeu: 3.727 ± 0.511
1.102ProMet: 1.102 ± 0.211
1.732ProAsn: 1.732 ± 0.292
1.837ProPro: 1.837 ± 0.383
1.102ProGln: 1.102 ± 0.26
2.362ProArg: 2.362 ± 0.31
3.412ProSer: 3.412 ± 0.341
2.31ProThr: 2.31 ± 0.329
4.777ProVal: 4.777 ± 0.61
1.102ProTrp: 1.102 ± 0.213
1.417ProTyr: 1.417 ± 0.275
0.0ProXaa: 0.0 ± 0.0
Gln
5.669GlnAla: 5.669 ± 0.863
0.367GlnCys: 0.367 ± 0.152
2.047GlnAsp: 2.047 ± 0.285
2.572GlnGlu: 2.572 ± 0.539
1.102GlnPhe: 1.102 ± 0.198
2.887GlnGly: 2.887 ± 0.379
0.787GlnHis: 0.787 ± 0.241
1.837GlnIle: 1.837 ± 0.268
1.785GlnLys: 1.785 ± 0.446
2.73GlnLeu: 2.73 ± 0.427
1.155GlnMet: 1.155 ± 0.302
1.312GlnAsn: 1.312 ± 0.245
1.417GlnPro: 1.417 ± 0.298
1.47GlnGln: 1.47 ± 0.334
2.572GlnArg: 2.572 ± 0.399
1.575GlnSer: 1.575 ± 0.263
2.31GlnThr: 2.31 ± 0.4
3.622GlnVal: 3.622 ± 0.418
0.84GlnTrp: 0.84 ± 0.216
0.945GlnTyr: 0.945 ± 0.181
0.0GlnXaa: 0.0 ± 0.0
Arg
7.139ArgAla: 7.139 ± 0.612
0.997ArgCys: 0.997 ± 0.284
4.042ArgAsp: 4.042 ± 0.534
4.462ArgGlu: 4.462 ± 0.463
1.89ArgPhe: 1.89 ± 0.299
4.514ArgGly: 4.514 ± 0.539
1.05ArgHis: 1.05 ± 0.218
3.465ArgIle: 3.465 ± 0.443
3.255ArgLys: 3.255 ± 0.403
7.139ArgLeu: 7.139 ± 0.691
1.207ArgMet: 1.207 ± 0.27
1.522ArgAsn: 1.522 ± 0.285
2.94ArgPro: 2.94 ± 0.392
3.727ArgGln: 3.727 ± 0.55
4.252ArgArg: 4.252 ± 0.457
2.362ArgSer: 2.362 ± 0.313
3.675ArgThr: 3.675 ± 0.51
3.36ArgVal: 3.36 ± 0.506
1.575ArgTrp: 1.575 ± 0.298
2.257ArgTyr: 2.257 ± 0.31
0.0ArgXaa: 0.0 ± 0.0
Ser
5.249SerAla: 5.249 ± 0.482
0.63SerCys: 0.63 ± 0.216
2.205SerAsp: 2.205 ± 0.267
2.625SerGlu: 2.625 ± 0.267
1.575SerPhe: 1.575 ± 0.223
5.249SerGly: 5.249 ± 0.415
0.945SerHis: 0.945 ± 0.23
2.152SerIle: 2.152 ± 0.333
2.047SerLys: 2.047 ± 0.325
4.514SerLeu: 4.514 ± 0.404
1.207SerMet: 1.207 ± 0.259
1.995SerAsn: 1.995 ± 0.295
2.52SerPro: 2.52 ± 0.323
1.89SerGln: 1.89 ± 0.37
3.465SerArg: 3.465 ± 0.474
2.257SerSer: 2.257 ± 0.367
2.782SerThr: 2.782 ± 0.487
2.992SerVal: 2.992 ± 0.346
1.155SerTrp: 1.155 ± 0.253
2.152SerTyr: 2.152 ± 0.469
0.0SerXaa: 0.0 ± 0.0
Thr
5.617ThrAla: 5.617 ± 0.732
0.577ThrCys: 0.577 ± 0.186
3.202ThrAsp: 3.202 ± 0.435
2.94ThrGlu: 2.94 ± 0.422
1.627ThrPhe: 1.627 ± 0.296
5.249ThrGly: 5.249 ± 0.632
0.892ThrHis: 0.892 ± 0.225
2.467ThrIle: 2.467 ± 0.335
3.202ThrLys: 3.202 ± 0.581
5.092ThrLeu: 5.092 ± 0.462
1.47ThrMet: 1.47 ± 0.225
1.785ThrAsn: 1.785 ± 0.292
3.57ThrPro: 3.57 ± 0.625
2.152ThrGln: 2.152 ± 0.371
2.31ThrArg: 2.31 ± 0.316
3.412ThrSer: 3.412 ± 0.579
3.045ThrThr: 3.045 ± 0.47
4.672ThrVal: 4.672 ± 0.599
1.312ThrTrp: 1.312 ± 0.285
1.89ThrTyr: 1.89 ± 0.31
0.0ThrXaa: 0.0 ± 0.0
Val
9.344ValAla: 9.344 ± 0.758
0.63ValCys: 0.63 ± 0.196
4.619ValAsp: 4.619 ± 0.487
4.409ValGlu: 4.409 ± 0.419
2.467ValPhe: 2.467 ± 0.305
4.409ValGly: 4.409 ± 0.64
0.892ValHis: 0.892 ± 0.209
3.57ValIle: 3.57 ± 0.39
3.36ValLys: 3.36 ± 0.37
4.252ValLeu: 4.252 ± 0.368
1.89ValMet: 1.89 ± 0.307
3.202ValAsn: 3.202 ± 0.479
3.727ValPro: 3.727 ± 0.559
2.362ValGln: 2.362 ± 0.346
4.357ValArg: 4.357 ± 0.479
3.097ValSer: 3.097 ± 0.329
4.672ValThr: 4.672 ± 0.473
5.197ValVal: 5.197 ± 0.566
0.735ValTrp: 0.735 ± 0.16
2.205ValTyr: 2.205 ± 0.307
0.0ValXaa: 0.0 ± 0.0
Trp
1.942TrpAla: 1.942 ± 0.285
0.367TrpCys: 0.367 ± 0.136
1.47TrpAsp: 1.47 ± 0.328
1.785TrpGlu: 1.785 ± 0.22
0.63TrpPhe: 0.63 ± 0.179
1.207TrpGly: 1.207 ± 0.237
0.21TrpHis: 0.21 ± 0.103
0.892TrpIle: 0.892 ± 0.229
0.42TrpLys: 0.42 ± 0.123
1.995TrpLeu: 1.995 ± 0.412
0.367TrpMet: 0.367 ± 0.134
0.472TrpAsn: 0.472 ± 0.162
0.682TrpPro: 0.682 ± 0.172
0.892TrpGln: 0.892 ± 0.199
1.365TrpArg: 1.365 ± 0.331
0.63TrpSer: 0.63 ± 0.189
0.735TrpThr: 0.735 ± 0.208
1.522TrpVal: 1.522 ± 0.343
0.367TrpTrp: 0.367 ± 0.175
0.63TrpTyr: 0.63 ± 0.204
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.887TyrAla: 2.887 ± 0.331
0.63TyrCys: 0.63 ± 0.151
1.47TyrAsp: 1.47 ± 0.252
1.26TyrGlu: 1.26 ± 0.197
0.997TyrPhe: 0.997 ± 0.221
1.942TyrGly: 1.942 ± 0.326
0.735TyrHis: 0.735 ± 0.241
1.627TyrIle: 1.627 ± 0.275
0.997TyrLys: 0.997 ± 0.208
3.097TyrLeu: 3.097 ± 0.376
0.682TyrMet: 0.682 ± 0.187
1.05TyrAsn: 1.05 ± 0.213
2.31TyrPro: 2.31 ± 0.434
1.207TyrGln: 1.207 ± 0.259
3.15TyrArg: 3.15 ± 0.432
1.365TyrSer: 1.365 ± 0.231
1.837TyrThr: 1.837 ± 0.329
1.837TyrVal: 1.837 ± 0.369
0.787TyrTrp: 0.787 ± 0.185
0.84TyrTyr: 0.84 ± 0.247
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (19051 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski