Amino acid dipepetide frequency for Deinococcus cellulosilyticus NBRC 106333 = KACC 11606

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.434AlaAla: 8.434 ± 0.09
0.759AlaCys: 0.759 ± 0.02
3.99AlaAsp: 3.99 ± 0.047
5.305AlaGlu: 5.305 ± 0.071
3.854AlaPhe: 3.854 ± 0.053
7.265AlaGly: 7.265 ± 0.077
2.067AlaHis: 2.067 ± 0.039
3.953AlaIle: 3.953 ± 0.051
3.092AlaLys: 3.092 ± 0.05
11.548AlaLeu: 11.548 ± 0.103
1.857AlaMet: 1.857 ± 0.031
2.107AlaAsn: 2.107 ± 0.041
3.762AlaPro: 3.762 ± 0.062
4.301AlaGln: 4.301 ± 0.054
5.754AlaArg: 5.754 ± 0.072
5.101AlaSer: 5.101 ± 0.062
4.572AlaThr: 4.572 ± 0.06
6.227AlaVal: 6.227 ± 0.063
1.19AlaTrp: 1.19 ± 0.029
2.501AlaTyr: 2.501 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.629CysAla: 0.629 ± 0.021
0.107CysCys: 0.107 ± 0.008
0.362CysAsp: 0.362 ± 0.014
0.417CysGlu: 0.417 ± 0.018
0.282CysPhe: 0.282 ± 0.013
0.649CysGly: 0.649 ± 0.021
0.225CysHis: 0.225 ± 0.013
0.376CysIle: 0.376 ± 0.014
0.268CysLys: 0.268 ± 0.013
0.722CysLeu: 0.722 ± 0.021
0.18CysMet: 0.18 ± 0.009
0.247CysAsn: 0.247 ± 0.013
0.455CysPro: 0.455 ± 0.016
0.317CysGln: 0.317 ± 0.017
0.353CysArg: 0.353 ± 0.015
0.489CysSer: 0.489 ± 0.019
0.51CysThr: 0.51 ± 0.018
0.5CysVal: 0.5 ± 0.016
0.131CysTrp: 0.131 ± 0.011
0.189CysTyr: 0.189 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
4.692AspAla: 4.692 ± 0.061
0.327AspCys: 0.327 ± 0.015
2.023AspAsp: 2.023 ± 0.038
2.658AspGlu: 2.658 ± 0.039
2.388AspPhe: 2.388 ± 0.038
3.749AspGly: 3.749 ± 0.061
1.492AspHis: 1.492 ± 0.033
2.424AspIle: 2.424 ± 0.042
1.156AspLys: 1.156 ± 0.034
6.913AspLeu: 6.913 ± 0.075
1.02AspMet: 1.02 ± 0.024
1.235AspAsn: 1.235 ± 0.03
3.314AspPro: 3.314 ± 0.046
2.373AspGln: 2.373 ± 0.036
2.966AspArg: 2.966 ± 0.046
2.349AspSer: 2.349 ± 0.047
2.711AspThr: 2.711 ± 0.044
3.674AspVal: 3.674 ± 0.051
0.837AspTrp: 0.837 ± 0.024
1.363AspTyr: 1.363 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
6.289GluAla: 6.289 ± 0.078
0.349GluCys: 0.349 ± 0.015
3.271GluAsp: 3.271 ± 0.052
4.022GluGlu: 4.022 ± 0.059
2.156GluPhe: 2.156 ± 0.032
4.744GluGly: 4.744 ± 0.053
1.934GluHis: 1.934 ± 0.036
2.863GluIle: 2.863 ± 0.046
3.2GluLys: 3.2 ± 0.056
6.259GluLeu: 6.259 ± 0.072
1.48GluMet: 1.48 ± 0.032
2.152GluAsn: 2.152 ± 0.04
2.287GluPro: 2.287 ± 0.038
3.255GluGln: 3.255 ± 0.048
3.906GluArg: 3.906 ± 0.054
2.744GluSer: 2.744 ± 0.041
3.214GluThr: 3.214 ± 0.042
5.322GluVal: 5.322 ± 0.066
0.84GluTrp: 0.84 ± 0.022
1.518GluTyr: 1.518 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.162PheAla: 3.162 ± 0.044
0.306PheCys: 0.306 ± 0.013
2.253PheAsp: 2.253 ± 0.034
2.576PheGlu: 2.576 ± 0.043
1.557PhePhe: 1.557 ± 0.032
2.871PheGly: 2.871 ± 0.045
0.881PheHis: 0.881 ± 0.025
1.679PheIle: 1.679 ± 0.038
1.737PheLys: 1.737 ± 0.034
3.966PheLeu: 3.966 ± 0.054
0.947PheMet: 0.947 ± 0.022
1.392PheAsn: 1.392 ± 0.03
1.892PhePro: 1.892 ± 0.029
1.922PheGln: 1.922 ± 0.03
2.168PheArg: 2.168 ± 0.042
2.718PheSer: 2.718 ± 0.041
2.509PheThr: 2.509 ± 0.038
2.655PheVal: 2.655 ± 0.037
0.662PheTrp: 0.662 ± 0.02
1.211PheTyr: 1.211 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
5.971GlyAla: 5.971 ± 0.068
0.627GlyCys: 0.627 ± 0.02
3.42GlyAsp: 3.42 ± 0.049
4.347GlyGlu: 4.347 ± 0.054
3.472GlyPhe: 3.472 ± 0.048
5.694GlyGly: 5.694 ± 0.078
1.892GlyHis: 1.892 ± 0.037
4.346GlyIle: 4.346 ± 0.06
4.029GlyLys: 4.029 ± 0.051
8.354GlyLeu: 8.354 ± 0.069
2.121GlyMet: 2.121 ± 0.034
2.854GlyAsn: 2.854 ± 0.062
2.538GlyPro: 2.538 ± 0.044
3.643GlyGln: 3.643 ± 0.053
3.85GlyArg: 3.85 ± 0.053
4.471GlySer: 4.471 ± 0.056
4.965GlyThr: 4.965 ± 0.075
6.043GlyVal: 6.043 ± 0.057
1.379GlyTrp: 1.379 ± 0.027
2.477GlyTyr: 2.477 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.267HisAla: 2.267 ± 0.043
0.21HisCys: 0.21 ± 0.011
1.123HisAsp: 1.123 ± 0.023
1.296HisGlu: 1.296 ± 0.034
1.208HisPhe: 1.208 ± 0.03
1.762HisGly: 1.762 ± 0.035
1.049HisHis: 1.049 ± 0.028
1.146HisIle: 1.146 ± 0.029
0.717HisLys: 0.717 ± 0.02
3.734HisLeu: 3.734 ± 0.058
0.572HisMet: 0.572 ± 0.016
0.699HisAsn: 0.699 ± 0.022
1.982HisPro: 1.982 ± 0.04
1.485HisGln: 1.485 ± 0.033
1.424HisArg: 1.424 ± 0.025
1.235HisSer: 1.235 ± 0.021
1.483HisThr: 1.483 ± 0.031
1.581HisVal: 1.581 ± 0.03
0.476HisTrp: 0.476 ± 0.018
0.767HisTyr: 0.767 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
4.2IleAla: 4.2 ± 0.056
0.386IleCys: 0.386 ± 0.016
2.384IleAsp: 2.384 ± 0.04
3.139IleGlu: 3.139 ± 0.046
1.714IlePhe: 1.714 ± 0.031
3.466IleGly: 3.466 ± 0.054
1.307IleHis: 1.307 ± 0.027
1.939IleIle: 1.939 ± 0.037
1.935IleLys: 1.935 ± 0.042
5.004IleLeu: 5.004 ± 0.061
0.92IleMet: 0.92 ± 0.024
1.57IleAsn: 1.57 ± 0.033
2.811IlePro: 2.811 ± 0.047
2.515IleGln: 2.515 ± 0.036
2.957IleArg: 2.957 ± 0.042
3.02IleSer: 3.02 ± 0.043
3.283IleThr: 3.283 ± 0.047
2.818IleVal: 2.818 ± 0.046
0.591IleTrp: 0.591 ± 0.02
1.37IleTyr: 1.37 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.253LysAla: 4.253 ± 0.062
0.242LysCys: 0.242 ± 0.013
2.43LysAsp: 2.43 ± 0.045
2.435LysGlu: 2.435 ± 0.048
1.245LysPhe: 1.245 ± 0.027
3.063LysGly: 3.063 ± 0.05
1.126LysHis: 1.126 ± 0.028
1.995LysIle: 1.995 ± 0.038
2.17LysLys: 2.17 ± 0.044
4.26LysLeu: 4.26 ± 0.061
1.011LysMet: 1.011 ± 0.025
1.71LysAsn: 1.71 ± 0.038
2.281LysPro: 2.281 ± 0.038
1.845LysGln: 1.845 ± 0.041
2.354LysArg: 2.354 ± 0.037
2.179LysSer: 2.179 ± 0.035
2.871LysThr: 2.871 ± 0.049
3.481LysVal: 3.481 ± 0.044
0.549LysTrp: 0.549 ± 0.016
1.212LysTyr: 1.212 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
9.231LeuAla: 9.231 ± 0.093
0.851LeuCys: 0.851 ± 0.024
5.902LeuAsp: 5.902 ± 0.069
7.775LeuGlu: 7.775 ± 0.08
3.614LeuPhe: 3.614 ± 0.06
8.704LeuGly: 8.704 ± 0.076
2.752LeuHis: 2.752 ± 0.046
5.266LeuIle: 5.266 ± 0.063
6.296LeuLys: 6.296 ± 0.074
12.405LeuLeu: 12.405 ± 0.14
2.767LeuMet: 2.767 ± 0.041
3.982LeuAsn: 3.982 ± 0.051
6.107LeuPro: 6.107 ± 0.063
6.48LeuGln: 6.48 ± 0.087
6.12LeuArg: 6.12 ± 0.068
7.413LeuSer: 7.413 ± 0.064
6.773LeuThr: 6.773 ± 0.062
7.102LeuVal: 7.102 ± 0.074
1.505LeuTrp: 1.505 ± 0.034
2.816LeuTyr: 2.816 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
1.893MetAla: 1.893 ± 0.033
0.158MetCys: 0.158 ± 0.009
1.25MetAsp: 1.25 ± 0.027
1.295MetGlu: 1.295 ± 0.024
0.745MetPhe: 0.745 ± 0.019
1.854MetGly: 1.854 ± 0.031
0.59MetHis: 0.59 ± 0.022
1.04MetIle: 1.04 ± 0.026
1.298MetLys: 1.298 ± 0.03
2.749MetLeu: 2.749 ± 0.041
0.554MetMet: 0.554 ± 0.017
0.924MetAsn: 0.924 ± 0.025
1.193MetPro: 1.193 ± 0.026
1.369MetGln: 1.369 ± 0.032
1.243MetArg: 1.243 ± 0.028
1.248MetSer: 1.248 ± 0.026
1.498MetThr: 1.498 ± 0.032
1.816MetVal: 1.816 ± 0.032
0.279MetTrp: 0.279 ± 0.012
0.533MetTyr: 0.533 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.928AsnAla: 2.928 ± 0.049
0.238AsnCys: 0.238 ± 0.011
1.353AsnAsp: 1.353 ± 0.033
1.344AsnGlu: 1.344 ± 0.028
1.327AsnPhe: 1.327 ± 0.027
2.451AsnGly: 2.451 ± 0.051
0.874AsnHis: 0.874 ± 0.021
1.679AsnIle: 1.679 ± 0.034
1.059AsnLys: 1.059 ± 0.027
3.986AsnLeu: 3.986 ± 0.056
0.703AsnMet: 0.703 ± 0.019
1.18AsnAsn: 1.18 ± 0.039
2.562AsnPro: 2.562 ± 0.041
1.43AsnGln: 1.43 ± 0.033
1.838AsnArg: 1.838 ± 0.034
1.828AsnSer: 1.828 ± 0.043
2.212AsnThr: 2.212 ± 0.052
2.266AsnVal: 2.266 ± 0.042
0.567AsnTrp: 0.567 ± 0.019
0.991AsnTyr: 0.991 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
4.643ProAla: 4.643 ± 0.062
0.306ProCys: 0.306 ± 0.014
3.214ProAsp: 3.214 ± 0.046
5.196ProGlu: 5.196 ± 0.063
2.014ProPhe: 2.014 ± 0.034
3.553ProGly: 3.553 ± 0.047
1.281ProHis: 1.281 ± 0.03
2.189ProIle: 2.189 ± 0.039
1.62ProLys: 1.62 ± 0.034
4.979ProLeu: 4.979 ± 0.056
1.166ProMet: 1.166 ± 0.025
1.472ProAsn: 1.472 ± 0.031
2.025ProPro: 2.025 ± 0.042
2.249ProGln: 2.249 ± 0.04
2.5ProArg: 2.5 ± 0.038
3.016ProSer: 3.016 ± 0.042
2.822ProThr: 2.822 ± 0.043
3.924ProVal: 3.924 ± 0.049
0.681ProTrp: 0.681 ± 0.02
1.432ProTyr: 1.432 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.963GlnAla: 4.963 ± 0.061
0.236GlnCys: 0.236 ± 0.013
2.927GlnAsp: 2.927 ± 0.042
3.413GlnGlu: 3.413 ± 0.057
1.424GlnPhe: 1.424 ± 0.032
3.83GlnGly: 3.83 ± 0.053
1.582GlnHis: 1.582 ± 0.033
2.143GlnIle: 2.143 ± 0.033
2.716GlnLys: 2.716 ± 0.044
4.628GlnLeu: 4.628 ± 0.061
1.23GlnMet: 1.23 ± 0.025
2.014GlnAsn: 2.014 ± 0.037
2.052GlnPro: 2.052 ± 0.033
3.133GlnGln: 3.133 ± 0.053
2.344GlnArg: 2.344 ± 0.041
2.426GlnSer: 2.426 ± 0.039
2.764GlnThr: 2.764 ± 0.046
4.467GlnVal: 4.467 ± 0.059
0.649GlnTrp: 0.649 ± 0.017
1.214GlnTyr: 1.214 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
4.615ArgAla: 4.615 ± 0.055
0.363ArgCys: 0.363 ± 0.014
2.919ArgAsp: 2.919 ± 0.042
4.095ArgGlu: 4.095 ± 0.055
2.489ArgPhe: 2.489 ± 0.034
3.522ArgGly: 3.522 ± 0.054
1.44ArgHis: 1.44 ± 0.029
3.321ArgIle: 3.321 ± 0.041
2.841ArgLys: 2.841 ± 0.041
6.049ArgLeu: 6.049 ± 0.072
1.651ArgMet: 1.651 ± 0.035
2.009ArgAsn: 2.009 ± 0.034
2.518ArgPro: 2.518 ± 0.042
2.598ArgGln: 2.598 ± 0.044
2.958ArgArg: 2.958 ± 0.046
3.102ArgSer: 3.102 ± 0.045
3.36ArgThr: 3.36 ± 0.043
4.2ArgVal: 4.2 ± 0.05
0.906ArgTrp: 0.906 ± 0.024
1.81ArgTyr: 1.81 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
4.732SerAla: 4.732 ± 0.056
0.497SerCys: 0.497 ± 0.018
2.651SerAsp: 2.651 ± 0.043
3.308SerGlu: 3.308 ± 0.046
2.306SerPhe: 2.306 ± 0.037
5.737SerGly: 5.737 ± 0.093
1.302SerHis: 1.302 ± 0.027
2.89SerIle: 2.89 ± 0.041
2.331SerLys: 2.331 ± 0.044
6.081SerLeu: 6.081 ± 0.058
1.46SerMet: 1.46 ± 0.03
1.843SerAsn: 1.843 ± 0.039
2.786SerPro: 2.786 ± 0.036
2.383SerGln: 2.383 ± 0.036
3.492SerArg: 3.492 ± 0.04
3.864SerSer: 3.864 ± 0.068
3.623SerThr: 3.623 ± 0.071
4.0SerVal: 4.0 ± 0.048
0.926SerTrp: 0.926 ± 0.024
1.515SerTyr: 1.515 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.144ThrAla: 5.144 ± 0.07
0.485ThrCys: 0.485 ± 0.021
2.838ThrAsp: 2.838 ± 0.052
3.26ThrGlu: 3.26 ± 0.042
2.525ThrPhe: 2.525 ± 0.045
5.009ThrGly: 5.009 ± 0.069
1.511ThrHis: 1.511 ± 0.03
2.69ThrIle: 2.69 ± 0.041
1.38ThrLys: 1.38 ± 0.033
8.317ThrLeu: 8.317 ± 0.078
0.957ThrMet: 0.957 ± 0.025
1.379ThrAsn: 1.379 ± 0.037
4.108ThrPro: 4.108 ± 0.053
2.41ThrGln: 2.41 ± 0.035
3.571ThrArg: 3.571 ± 0.046
3.575ThrSer: 3.575 ± 0.073
3.49ThrThr: 3.49 ± 0.072
4.795ThrVal: 4.795 ± 0.068
0.796ThrTrp: 0.796 ± 0.027
1.766ThrTyr: 1.766 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
6.067ValAla: 6.067 ± 0.066
0.58ValCys: 0.58 ± 0.018
3.213ValAsp: 3.213 ± 0.047
3.765ValGlu: 3.765 ± 0.051
3.032ValPhe: 3.032 ± 0.043
5.09ValGly: 5.09 ± 0.059
1.749ValHis: 1.749 ± 0.032
3.607ValIle: 3.607 ± 0.042
3.315ValLys: 3.315 ± 0.054
9.148ValLeu: 9.148 ± 0.096
1.931ValMet: 1.931 ± 0.036
2.423ValAsn: 2.423 ± 0.046
3.676ValPro: 3.676 ± 0.049
3.962ValGln: 3.962 ± 0.051
4.171ValArg: 4.171 ± 0.048
4.402ValSer: 4.402 ± 0.053
4.489ValThr: 4.489 ± 0.063
5.956ValVal: 5.956 ± 0.065
1.077ValTrp: 1.077 ± 0.023
2.063ValTyr: 2.063 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.072TrpAla: 1.072 ± 0.025
0.121TrpCys: 0.121 ± 0.009
0.824TrpAsp: 0.824 ± 0.025
0.866TrpGlu: 0.866 ± 0.023
0.539TrpPhe: 0.539 ± 0.019
1.074TrpGly: 1.074 ± 0.032
0.38TrpHis: 0.38 ± 0.014
0.754TrpIle: 0.754 ± 0.021
0.727TrpLys: 0.727 ± 0.019
1.563TrpLeu: 1.563 ± 0.03
0.528TrpMet: 0.528 ± 0.018
0.655TrpAsn: 0.655 ± 0.023
0.47TrpPro: 0.47 ± 0.017
0.762TrpGln: 0.762 ± 0.021
0.711TrpArg: 0.711 ± 0.023
0.868TrpSer: 0.868 ± 0.023
0.945TrpThr: 0.945 ± 0.023
1.196TrpVal: 1.196 ± 0.026
0.293TrpTrp: 0.293 ± 0.012
0.41TrpTyr: 0.41 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.451TyrAla: 2.451 ± 0.039
0.261TyrCys: 0.261 ± 0.014
1.318TyrAsp: 1.318 ± 0.033
1.29TyrGlu: 1.29 ± 0.028
1.173TyrPhe: 1.173 ± 0.026
2.407TyrGly: 2.407 ± 0.042
0.783TyrHis: 0.783 ± 0.02
1.032TyrIle: 1.032 ± 0.027
0.825TyrLys: 0.825 ± 0.024
3.196TyrLeu: 3.196 ± 0.047
0.474TyrMet: 0.474 ± 0.014
0.971TyrAsn: 0.971 ± 0.029
1.461TyrPro: 1.461 ± 0.029
1.723TyrGln: 1.723 ± 0.034
2.086TyrArg: 2.086 ± 0.034
1.677TyrSer: 1.677 ± 0.033
1.912TyrThr: 1.912 ± 0.036
1.692TyrVal: 1.692 ± 0.031
0.424TyrTrp: 0.424 ± 0.019
0.898TyrTyr: 0.898 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5844 proteins (1774904 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski