Amino acid dipepetide frequency for Streptosporangiales bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.63AlaAla: 19.63 ± 0.179	1.128AlaCys: 1.128 ± 0.029	7.613AlaAsp: 7.613 ± 0.076	8.911AlaGlu: 8.911 ± 0.09	3.549AlaPhe: 3.549 ± 0.049	12.941AlaGly: 12.941 ± 0.123	2.445AlaHis: 2.445 ± 0.042	4.389AlaIle: 4.389 ± 0.053	2.328AlaLys: 2.328 ± 0.041	13.171AlaLeu: 13.171 ± 0.107	2.466AlaMet: 2.466 ± 0.038	1.958AlaAsn: 1.958 ± 0.033	5.703AlaPro: 5.703 ± 0.068	3.193AlaGln: 3.193 ± 0.044	10.514AlaArg: 10.514 ± 0.099	5.829AlaSer: 5.829 ± 0.062	6.286AlaThr: 6.286 ± 0.064	11.762AlaVal: 11.762 ± 0.102	1.798AlaTrp: 1.798 ± 0.039	2.68AlaTyr: 2.68 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.026CysAla: 1.026 ± 0.025	0.133CysCys: 0.133 ± 0.009	0.542CysAsp: 0.542 ± 0.02	0.439CysGlu: 0.439 ± 0.016	0.243CysPhe: 0.243 ± 0.013	1.137CysGly: 1.137 ± 0.027	0.219CysHis: 0.219 ± 0.013	0.21CysIle: 0.21 ± 0.01	0.098CysLys: 0.098 ± 0.009	0.774CysLeu: 0.774 ± 0.021	0.13CysMet: 0.13 ± 0.008	0.152CysAsn: 0.152 ± 0.009	0.592CysPro: 0.592 ± 0.02	0.201CysGln: 0.201 ± 0.011	0.808CysArg: 0.808 ± 0.022	0.451CysSer: 0.451 ± 0.016	0.452CysThr: 0.452 ± 0.018	0.713CysVal: 0.713 ± 0.021	0.142CysTrp: 0.142 ± 0.009	0.202CysTyr: 0.202 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.141AspAla: 7.141 ± 0.065	0.436AspCys: 0.436 ± 0.016	3.699AspAsp: 3.699 ± 0.053	4.302AspGlu: 4.302 ± 0.063	1.588AspPhe: 1.588 ± 0.03	5.868AspGly: 5.868 ± 0.064	1.346AspHis: 1.346 ± 0.027	1.943AspIle: 1.943 ± 0.036	0.939AspLys: 0.939 ± 0.026	6.425AspLeu: 6.425 ± 0.071	0.876AspMet: 0.876 ± 0.025	0.889AspAsn: 0.889 ± 0.027	4.603AspPro: 4.603 ± 0.056	1.559AspGln: 1.559 ± 0.032	5.344AspArg: 5.344 ± 0.068	2.159AspSer: 2.159 ± 0.034	2.583AspThr: 2.583 ± 0.039	5.28AspVal: 5.28 ± 0.06	0.867AspTrp: 0.867 ± 0.025	1.199AspTyr: 1.199 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.413GluAla: 7.413 ± 0.096	0.386GluCys: 0.386 ± 0.016	3.035GluAsp: 3.035 ± 0.042	4.124GluGlu: 4.124 ± 0.069	1.644GluPhe: 1.644 ± 0.039	4.553GluGly: 4.553 ± 0.063	1.67GluHis: 1.67 ± 0.033	2.689GluIle: 2.689 ± 0.038	1.223GluLys: 1.223 ± 0.03	7.008GluLeu: 7.008 ± 0.073	1.134GluMet: 1.134 ± 0.029	1.043GluAsn: 1.043 ± 0.026	3.59GluPro: 3.59 ± 0.05	2.178GluGln: 2.178 ± 0.038	6.424GluArg: 6.424 ± 0.07	2.5GluSer: 2.5 ± 0.041	2.901GluThr: 2.901 ± 0.044	5.295GluVal: 5.295 ± 0.068	0.849GluTrp: 0.849 ± 0.024	1.184GluTyr: 1.184 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.804PheAla: 3.804 ± 0.052	0.332PheCys: 0.332 ± 0.015	1.968PheAsp: 1.968 ± 0.034	1.533PheGlu: 1.533 ± 0.03	1.023PhePhe: 1.023 ± 0.028	3.29PheGly: 3.29 ± 0.045	0.588PheHis: 0.588 ± 0.018	0.831PheIle: 0.831 ± 0.022	0.388PheLys: 0.388 ± 0.017	2.869PheLeu: 2.869 ± 0.059	0.424PheMet: 0.424 ± 0.018	0.54PheAsn: 0.54 ± 0.019	1.57PhePro: 1.57 ± 0.028	0.713PheGln: 0.713 ± 0.022	2.093PheArg: 2.093 ± 0.04	1.43PheSer: 1.43 ± 0.032	1.807PheThr: 1.807 ± 0.037	2.781PheVal: 2.781 ± 0.044	0.418PheTrp: 0.418 ± 0.017	0.638PheTyr: 0.638 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.31GlyAla: 10.31 ± 0.085	0.971GlyCys: 0.971 ± 0.026	5.071GlyAsp: 5.071 ± 0.056	5.698GlyGlu: 5.698 ± 0.063	3.012GlyPhe: 3.012 ± 0.051	9.118GlyGly: 9.118 ± 0.091	2.12GlyHis: 2.12 ± 0.033	3.768GlyIle: 3.768 ± 0.051	2.001GlyLys: 2.001 ± 0.038	9.719GlyLeu: 9.719 ± 0.091	2.168GlyMet: 2.168 ± 0.034	1.624GlyAsn: 1.624 ± 0.03	5.062GlyPro: 5.062 ± 0.063	2.663GlyGln: 2.663 ± 0.044	8.685GlyArg: 8.685 ± 0.071	5.185GlySer: 5.185 ± 0.063	5.189GlyThr: 5.189 ± 0.062	8.068GlyVal: 8.068 ± 0.08	1.778GlyTrp: 1.778 ± 0.033	2.611GlyTyr: 2.611 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.476HisAla: 2.476 ± 0.043	0.215HisCys: 0.215 ± 0.012	1.269HisAsp: 1.269 ± 0.025	1.245HisGlu: 1.245 ± 0.027	0.581HisPhe: 0.581 ± 0.017	2.291HisGly: 2.291 ± 0.039	0.649HisHis: 0.649 ± 0.024	0.677HisIle: 0.677 ± 0.021	0.287HisLys: 0.287 ± 0.013	2.259HisLeu: 2.259 ± 0.034	0.347HisMet: 0.347 ± 0.014	0.402HisAsn: 0.402 ± 0.017	1.787HisPro: 1.787 ± 0.032	0.595HisGln: 0.595 ± 0.017	2.088HisArg: 2.088 ± 0.039	0.862HisSer: 0.862 ± 0.025	1.078HisThr: 1.078 ± 0.025	1.876HisVal: 1.876 ± 0.035	0.321HisTrp: 0.321 ± 0.013	0.472HisTyr: 0.472 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.934IleAla: 4.934 ± 0.064	0.351IleCys: 0.351 ± 0.015	2.462IleAsp: 2.462 ± 0.042	2.513IleGlu: 2.513 ± 0.04	1.016IlePhe: 1.016 ± 0.026	3.65IleGly: 3.65 ± 0.054	0.722IleHis: 0.722 ± 0.021	1.21IleIle: 1.21 ± 0.033	0.704IleLys: 0.704 ± 0.023	2.97IleLeu: 2.97 ± 0.044	0.509IleMet: 0.509 ± 0.016	0.814IleAsn: 0.814 ± 0.023	2.059IlePro: 2.059 ± 0.04	0.827IleGln: 0.827 ± 0.024	2.695IleArg: 2.695 ± 0.04	1.752IleSer: 1.752 ± 0.034	2.138IleThr: 2.138 ± 0.043	3.347IleVal: 3.347 ± 0.043	0.435IleTrp: 0.435 ± 0.015	0.713IleTyr: 0.713 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.082LysAla: 2.082 ± 0.044	0.104LysCys: 0.104 ± 0.008	0.883LysAsp: 0.883 ± 0.024	1.042LysGlu: 1.042 ± 0.027	0.392LysPhe: 0.392 ± 0.016	1.407LysGly: 1.407 ± 0.034	0.365LysHis: 0.365 ± 0.015	0.891LysIle: 0.891 ± 0.027	0.487LysLys: 0.487 ± 0.02	1.68LysLeu: 1.68 ± 0.031	0.336LysMet: 0.336 ± 0.016	0.366LysAsn: 0.366 ± 0.017	1.105LysPro: 1.105 ± 0.022	0.557LysGln: 0.557 ± 0.018	1.403LysArg: 1.403 ± 0.031	0.858LysSer: 0.858 ± 0.022	1.067LysThr: 1.067 ± 0.026	1.589LysVal: 1.589 ± 0.03	0.218LysTrp: 0.218 ± 0.011	0.404LysTyr: 0.404 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.454LeuAla: 15.454 ± 0.126	0.873LeuCys: 0.873 ± 0.023	6.707LeuAsp: 6.707 ± 0.07	5.174LeuGlu: 5.174 ± 0.056	2.764LeuPhe: 2.764 ± 0.048	9.821LeuGly: 9.821 ± 0.099	2.137LeuHis: 2.137 ± 0.037	3.395LeuIle: 3.395 ± 0.053	1.334LeuLys: 1.334 ± 0.032	11.028LeuLeu: 11.028 ± 0.126	1.577LeuMet: 1.577 ± 0.029	1.631LeuAsn: 1.631 ± 0.031	6.17LeuPro: 6.17 ± 0.061	2.314LeuGln: 2.314 ± 0.041	9.386LeuArg: 9.386 ± 0.09	4.978LeuSer: 4.978 ± 0.061	5.818LeuThr: 5.818 ± 0.062	9.723LeuVal: 9.723 ± 0.091	1.308LeuTrp: 1.308 ± 0.034	1.98LeuTyr: 1.98 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.333MetAla: 2.333 ± 0.038	0.138MetCys: 0.138 ± 0.008	0.884MetAsp: 0.884 ± 0.024	0.82MetGlu: 0.82 ± 0.024	0.537MetPhe: 0.537 ± 0.019	1.478MetGly: 1.478 ± 0.031	0.336MetHis: 0.336 ± 0.012	0.703MetIle: 0.703 ± 0.02	0.382MetLys: 0.382 ± 0.016	1.936MetLeu: 1.936 ± 0.034	0.315MetMet: 0.315 ± 0.013	0.384MetAsn: 0.384 ± 0.016	1.165MetPro: 1.165 ± 0.026	0.443MetGln: 0.443 ± 0.017	1.745MetArg: 1.745 ± 0.031	1.286MetSer: 1.286 ± 0.028	1.425MetThr: 1.425 ± 0.029	1.531MetVal: 1.531 ± 0.03	0.217MetTrp: 0.217 ± 0.011	0.354MetTyr: 0.354 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.064AsnAla: 2.064 ± 0.038	0.176AsnCys: 0.176 ± 0.011	0.901AsnAsp: 0.901 ± 0.023	0.928AsnGlu: 0.928 ± 0.023	0.517AsnPhe: 0.517 ± 0.019	1.641AsnGly: 1.641 ± 0.031	0.355AsnHis: 0.355 ± 0.016	0.656AsnIle: 0.656 ± 0.02	0.323AsnLys: 0.323 ± 0.013	1.874AsnLeu: 1.874 ± 0.036	0.291AsnMet: 0.291 ± 0.012	0.386AsnAsn: 0.386 ± 0.013	1.426AsnPro: 1.426 ± 0.033	0.489AsnGln: 0.489 ± 0.017	1.35AsnArg: 1.35 ± 0.028	0.805AsnSer: 0.805 ± 0.021	0.974AsnThr: 0.974 ± 0.024	1.563AsnVal: 1.563 ± 0.028	0.3AsnTrp: 0.3 ± 0.015	0.44AsnTyr: 0.44 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.372ProAla: 7.372 ± 0.078	0.41ProCys: 0.41 ± 0.017	4.554ProAsp: 4.554 ± 0.058	4.341ProGlu: 4.341 ± 0.057	1.636ProPhe: 1.636 ± 0.033	6.366ProGly: 6.366 ± 0.076	1.245ProHis: 1.245 ± 0.026	1.93ProIle: 1.93 ± 0.037	1.039ProLys: 1.039 ± 0.029	5.137ProLeu: 5.137 ± 0.06	1.124ProMet: 1.124 ± 0.026	1.097ProAsn: 1.097 ± 0.024	4.017ProPro: 4.017 ± 0.066	1.533ProGln: 1.533 ± 0.034	4.533ProArg: 4.533 ± 0.058	3.348ProSer: 3.348 ± 0.05	3.187ProThr: 3.187 ± 0.053	5.009ProVal: 5.009 ± 0.052	0.914ProTrp: 0.914 ± 0.024	1.456ProTyr: 1.456 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.439GlnAla: 3.439 ± 0.052	0.177GlnCys: 0.177 ± 0.011	1.114GlnAsp: 1.114 ± 0.024	1.43GlnGlu: 1.43 ± 0.031	0.718GlnPhe: 0.718 ± 0.023	2.097GlnGly: 2.097 ± 0.039	0.615GlnHis: 0.615 ± 0.019	1.167GlnIle: 1.167 ± 0.026	0.452GlnLys: 0.452 ± 0.018	2.976GlnLeu: 2.976 ± 0.049	0.548GlnMet: 0.548 ± 0.018	0.479GlnAsn: 0.479 ± 0.017	1.72GlnPro: 1.72 ± 0.033	1.082GlnGln: 1.082 ± 0.032	2.704GlnArg: 2.704 ± 0.041	1.025GlnSer: 1.025 ± 0.023	1.296GlnThr: 1.296 ± 0.029	2.639GlnVal: 2.639 ± 0.038	0.373GlnTrp: 0.373 ± 0.014	0.5GlnTyr: 0.5 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.216ArgAla: 10.216 ± 0.089	0.754ArgCys: 0.754 ± 0.022	4.983ArgAsp: 4.983 ± 0.058	5.384ArgGlu: 5.384 ± 0.068	2.666ArgPhe: 2.666 ± 0.038	6.871ArgGly: 6.871 ± 0.074	2.199ArgHis: 2.199 ± 0.04	3.452ArgIle: 3.452 ± 0.047	1.425ArgLys: 1.425 ± 0.028	9.878ArgLeu: 9.878 ± 0.096	2.023ArgMet: 2.023 ± 0.034	1.473ArgAsn: 1.473 ± 0.027	5.47ArgPro: 5.47 ± 0.069	2.428ArgGln: 2.428 ± 0.039	9.881ArgArg: 9.881 ± 0.1	4.391ArgSer: 4.391 ± 0.059	4.666ArgThr: 4.666 ± 0.054	6.92ArgVal: 6.92 ± 0.073	1.591ArgTrp: 1.591 ± 0.036	2.214ArgTyr: 2.214 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.859SerAla: 5.859 ± 0.065	0.429SerCys: 0.429 ± 0.017	2.549SerAsp: 2.549 ± 0.035	2.514SerGlu: 2.514 ± 0.046	1.571SerPhe: 1.571 ± 0.033	5.492SerGly: 5.492 ± 0.058	0.962SerHis: 0.962 ± 0.021	1.606SerIle: 1.606 ± 0.032	0.854SerLys: 0.854 ± 0.022	4.581SerLeu: 4.581 ± 0.047	1.114SerMet: 1.114 ± 0.025	0.805SerAsn: 0.805 ± 0.023	3.266SerPro: 3.266 ± 0.044	1.213SerGln: 1.213 ± 0.025	3.982SerArg: 3.982 ± 0.055	2.769SerSer: 2.769 ± 0.047	2.661SerThr: 2.661 ± 0.043	4.135SerVal: 4.135 ± 0.052	0.884SerTrp: 0.884 ± 0.025	1.316SerTyr: 1.316 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.759ThrAla: 6.759 ± 0.069	0.462ThrCys: 0.462 ± 0.018	2.988ThrAsp: 2.988 ± 0.043	3.037ThrGlu: 3.037 ± 0.035	1.671ThrPhe: 1.671 ± 0.035	5.536ThrGly: 5.536 ± 0.053	1.072ThrHis: 1.072 ± 0.024	1.95ThrIle: 1.95 ± 0.035	1.016ThrLys: 1.016 ± 0.024	5.356ThrLeu: 5.356 ± 0.064	1.07ThrMet: 1.07 ± 0.026	1.001ThrAsn: 1.001 ± 0.025	3.469ThrPro: 3.469 ± 0.051	1.294ThrGln: 1.294 ± 0.03	3.941ThrArg: 3.941 ± 0.047	2.805ThrSer: 2.805 ± 0.037	3.055ThrThr: 3.055 ± 0.048	5.162ThrVal: 5.162 ± 0.06	0.859ThrTrp: 0.859 ± 0.024	1.363ThrTyr: 1.363 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.781ValAla: 11.781 ± 0.095	0.809ValCys: 0.809 ± 0.024	5.62ValAsp: 5.62 ± 0.066	5.337ValGlu: 5.337 ± 0.061	2.655ValPhe: 2.655 ± 0.043	7.745ValGly: 7.745 ± 0.078	1.898ValHis: 1.898 ± 0.038	3.203ValIle: 3.203 ± 0.046	1.375ValLys: 1.375 ± 0.038	9.635ValLeu: 9.635 ± 0.092	1.372ValMet: 1.372 ± 0.026	1.683ValAsn: 1.683 ± 0.035	5.302ValPro: 5.302 ± 0.058	2.04ValGln: 2.04 ± 0.036	7.591ValArg: 7.591 ± 0.07	4.328ValSer: 4.328 ± 0.053	5.323ValThr: 5.323 ± 0.051	9.005ValVal: 9.005 ± 0.089	1.116ValTrp: 1.116 ± 0.028	1.701ValTyr: 1.701 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.596TrpAla: 1.596 ± 0.034	0.15TrpCys: 0.15 ± 0.009	0.759TrpAsp: 0.759 ± 0.025	0.747TrpGlu: 0.747 ± 0.024	0.513TrpPhe: 0.513 ± 0.018	1.108TrpGly: 1.108 ± 0.024	0.359TrpHis: 0.359 ± 0.014	0.572TrpIle: 0.572 ± 0.018	0.279TrpLys: 0.279 ± 0.014	1.829TrpLeu: 1.829 ± 0.038	0.316TrpMet: 0.316 ± 0.015	0.355TrpAsn: 0.355 ± 0.017	0.878TrpPro: 0.878 ± 0.024	0.528TrpGln: 0.528 ± 0.018	1.543TrpArg: 1.543 ± 0.029	0.868TrpSer: 0.868 ± 0.024	0.901TrpThr: 0.901 ± 0.026	1.09TrpVal: 1.09 ± 0.025	0.335TrpTrp: 0.335 ± 0.016	0.357TrpTyr: 0.357 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.605TyrAla: 2.605 ± 0.039	0.231TyrCys: 0.231 ± 0.012	1.444TyrAsp: 1.444 ± 0.03	1.324TyrGlu: 1.324 ± 0.028	0.744TyrPhe: 0.744 ± 0.02	2.412TyrGly: 2.412 ± 0.041	0.474TyrHis: 0.474 ± 0.018	0.579TyrIle: 0.579 ± 0.021	0.303TyrLys: 0.303 ± 0.014	2.466TyrLeu: 2.466 ± 0.041	0.274TyrMet: 0.274 ± 0.013	0.377TyrAsn: 0.377 ± 0.016	1.293TyrPro: 1.293 ± 0.028	0.699TyrGln: 0.699 ± 0.018	2.174TyrArg: 2.174 ± 0.037	0.932TyrSer: 0.932 ± 0.022	1.06TyrThr: 1.06 ± 0.025	2.033TyrVal: 2.033 ± 0.034	0.36TyrTrp: 0.36 ± 0.014	0.509TyrTyr: 0.509 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5548 proteins (1684724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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