Amino acid dipepetide frequency for Anaplasma marginale (strain Florida)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.777AlaAla: 9.777 ± 0.297
1.656AlaCys: 1.656 ± 0.075
4.353AlaAsp: 4.353 ± 0.149
5.241AlaGlu: 5.241 ± 0.167
3.123AlaPhe: 3.123 ± 0.105
6.836AlaGly: 6.836 ± 0.157
2.156AlaHis: 2.156 ± 0.102
5.454AlaIle: 5.454 ± 0.152
4.487AlaLys: 4.487 ± 0.143
9.164AlaLeu: 9.164 ± 0.217
2.559AlaMet: 2.559 ± 0.104
2.445AlaAsn: 2.445 ± 0.101
3.275AlaPro: 3.275 ± 0.143
3.117AlaGln: 3.117 ± 0.141
5.229AlaArg: 5.229 ± 0.137
6.666AlaSer: 6.666 ± 0.168
4.233AlaThr: 4.233 ± 0.121
7.805AlaVal: 7.805 ± 0.196
0.792AlaTrp: 0.792 ± 0.06
2.445AlaTyr: 2.445 ± 0.085
0.0AlaXaa: 0.0 ± 0.0
Cys
1.887CysAla: 1.887 ± 0.072
0.52CysCys: 0.52 ± 0.049
0.982CysAsp: 0.982 ± 0.064
0.944CysGlu: 0.944 ± 0.052
0.646CysPhe: 0.646 ± 0.048
1.84CysGly: 1.84 ± 0.091
0.409CysHis: 0.409 ± 0.033
1.113CysIle: 1.113 ± 0.063
0.856CysLys: 0.856 ± 0.051
1.373CysLeu: 1.373 ± 0.071
0.651CysMet: 0.651 ± 0.045
0.783CysAsn: 0.783 ± 0.047
0.567CysPro: 0.567 ± 0.042
0.321CysGln: 0.321 ± 0.03
1.034CysArg: 1.034 ± 0.057
1.575CysSer: 1.575 ± 0.074
1.06CysThr: 1.06 ± 0.055
1.785CysVal: 1.785 ± 0.085
0.202CysTrp: 0.202 ± 0.029
0.599CysTyr: 0.599 ± 0.046
0.0CysXaa: 0.0 ± 0.0
Asp
5.03AspAla: 5.03 ± 0.174
0.868AspCys: 0.868 ± 0.055
2.886AspAsp: 2.886 ± 0.112
3.061AspGlu: 3.061 ± 0.11
2.226AspPhe: 2.226 ± 0.094
4.084AspGly: 4.084 ± 0.116
0.891AspHis: 0.891 ± 0.05
3.473AspIle: 3.473 ± 0.1
2.638AspLys: 2.638 ± 0.099
4.393AspLeu: 4.393 ± 0.113
1.399AspMet: 1.399 ± 0.062
1.63AspAsn: 1.63 ± 0.065
1.992AspPro: 1.992 ± 0.101
1.183AspGln: 1.183 ± 0.066
2.536AspArg: 2.536 ± 0.086
3.751AspSer: 3.751 ± 0.109
2.501AspThr: 2.501 ± 0.099
4.943AspVal: 4.943 ± 0.129
0.456AspTrp: 0.456 ± 0.031
1.586AspTyr: 1.586 ± 0.105
0.0AspXaa: 0.0 ± 0.0
Glu
4.802GluAla: 4.802 ± 0.138
1.011GluCys: 1.011 ± 0.06
3.058GluAsp: 3.058 ± 0.116
4.177GluGlu: 4.177 ± 0.119
2.395GluPhe: 2.395 ± 0.085
4.098GluGly: 4.098 ± 0.122
1.718GluHis: 1.718 ± 0.079
3.713GluIle: 3.713 ± 0.113
3.146GluLys: 3.146 ± 0.108
5.638GluLeu: 5.638 ± 0.178
1.443GluMet: 1.443 ± 0.072
2.179GluAsn: 2.179 ± 0.086
1.501GluPro: 1.501 ± 0.072
2.173GluGln: 2.173 ± 0.102
3.625GluArg: 3.625 ± 0.114
4.244GluSer: 4.244 ± 0.116
2.281GluThr: 2.281 ± 0.09
5.363GluVal: 5.363 ± 0.141
0.552GluTrp: 0.552 ± 0.055
1.913GluTyr: 1.913 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
3.523PheAla: 3.523 ± 0.12
0.92PheCys: 0.92 ± 0.06
2.121PheAsp: 2.121 ± 0.096
1.823PheGlu: 1.823 ± 0.088
2.036PhePhe: 2.036 ± 0.094
3.213PheGly: 3.213 ± 0.12
0.675PheHis: 0.675 ± 0.051
2.019PheIle: 2.019 ± 0.089
1.396PheLys: 1.396 ± 0.059
4.113PheLeu: 4.113 ± 0.142
1.055PheMet: 1.055 ± 0.054
1.128PheAsn: 1.128 ± 0.066
1.624PhePro: 1.624 ± 0.069
0.774PheGln: 0.774 ± 0.044
2.001PheArg: 2.001 ± 0.079
3.479PheSer: 3.479 ± 0.129
1.852PheThr: 1.852 ± 0.074
3.47PheVal: 3.47 ± 0.113
0.397PheTrp: 0.397 ± 0.04
1.212PheTyr: 1.212 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
6.97GlyAla: 6.97 ± 0.173
1.607GlyCys: 1.607 ± 0.09
3.929GlyAsp: 3.929 ± 0.127
4.469GlyGlu: 4.469 ± 0.116
3.091GlyPhe: 3.091 ± 0.106
6.713GlyGly: 6.713 ± 0.169
1.735GlyHis: 1.735 ± 0.072
5.007GlyIle: 5.007 ± 0.139
4.615GlyLys: 4.615 ± 0.124
6.243GlyLeu: 6.243 ± 0.171
2.281GlyMet: 2.281 ± 0.089
2.74GlyAsn: 2.74 ± 0.094
2.019GlyPro: 2.019 ± 0.088
2.027GlyGln: 2.027 ± 0.079
4.303GlyArg: 4.303 ± 0.124
5.842GlySer: 5.842 ± 0.149
3.92GlyThr: 3.92 ± 0.134
7.469GlyVal: 7.469 ± 0.173
0.649GlyTrp: 0.649 ± 0.054
2.378GlyTyr: 2.378 ± 0.116
0.0GlyXaa: 0.0 ± 0.0
His
1.983HisAla: 1.983 ± 0.088
0.389HisCys: 0.389 ± 0.033
1.09HisAsp: 1.09 ± 0.059
1.268HisGlu: 1.268 ± 0.065
0.806HisPhe: 0.806 ± 0.061
2.094HisGly: 2.094 ± 0.079
0.543HisHis: 0.543 ± 0.036
1.455HisIle: 1.455 ± 0.06
1.361HisLys: 1.361 ± 0.074
1.934HisLeu: 1.934 ± 0.091
0.66HisMet: 0.66 ± 0.046
1.043HisAsn: 1.043 ± 0.059
1.095HisPro: 1.095 ± 0.065
0.537HisGln: 0.537 ± 0.042
1.297HisArg: 1.297 ± 0.06
1.832HisSer: 1.832 ± 0.076
1.247HisThr: 1.247 ± 0.077
1.761HisVal: 1.761 ± 0.07
0.178HisTrp: 0.178 ± 0.019
0.698HisTyr: 0.698 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.822IleAla: 5.822 ± 0.131
1.218IleCys: 1.218 ± 0.055
3.146IleAsp: 3.146 ± 0.11
3.359IleGlu: 3.359 ± 0.108
2.045IlePhe: 2.045 ± 0.086
4.464IleGly: 4.464 ± 0.119
1.06IleHis: 1.06 ± 0.058
3.199IleIle: 3.199 ± 0.112
2.991IleLys: 2.991 ± 0.09
5.191IleLeu: 5.191 ± 0.156
1.592IleMet: 1.592 ± 0.078
2.019IleAsn: 2.019 ± 0.087
2.515IlePro: 2.515 ± 0.074
1.306IleGln: 1.306 ± 0.067
3.096IleArg: 3.096 ± 0.096
5.255IleSer: 5.255 ± 0.126
3.19IleThr: 3.19 ± 0.098
4.808IleVal: 4.808 ± 0.147
0.368IleTrp: 0.368 ± 0.033
1.42IleTyr: 1.42 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
3.979LysAla: 3.979 ± 0.117
0.8LysCys: 0.8 ± 0.048
2.48LysAsp: 2.48 ± 0.111
3.172LysGlu: 3.172 ± 0.121
2.121LysPhe: 2.121 ± 0.08
3.184LysGly: 3.184 ± 0.115
1.312LysHis: 1.312 ± 0.063
3.593LysIle: 3.593 ± 0.096
3.164LysLys: 3.164 ± 0.124
5.133LysLeu: 5.133 ± 0.127
1.35LysMet: 1.35 ± 0.069
2.01LysAsn: 2.01 ± 0.081
1.697LysPro: 1.697 ± 0.109
1.598LysGln: 1.598 ± 0.068
2.883LysArg: 2.883 ± 0.103
3.923LysSer: 3.923 ± 0.108
2.404LysThr: 2.404 ± 0.087
4.437LysVal: 4.437 ± 0.13
0.394LysTrp: 0.394 ± 0.03
1.607LysTyr: 1.607 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
8.027LeuAla: 8.027 ± 0.158
2.144LeuCys: 2.144 ± 0.081
4.458LeuAsp: 4.458 ± 0.12
5.53LeuGlu: 5.53 ± 0.156
3.286LeuPhe: 3.286 ± 0.117
7.081LeuGly: 7.081 ± 0.184
2.477LeuHis: 2.477 ± 0.091
4.23LeuIle: 4.23 ± 0.13
4.577LeuLys: 4.577 ± 0.13
10.069LeuLeu: 10.069 ± 0.272
2.354LeuMet: 2.354 ± 0.088
2.842LeuAsn: 2.842 ± 0.101
4.189LeuPro: 4.189 ± 0.124
3.254LeuGln: 3.254 ± 0.102
5.822LeuArg: 5.822 ± 0.138
8.273LeuSer: 8.273 ± 0.178
3.836LeuThr: 3.836 ± 0.12
7.265LeuVal: 7.265 ± 0.168
0.815LeuTrp: 0.815 ± 0.049
2.617LeuTyr: 2.617 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
2.144MetAla: 2.144 ± 0.083
0.631MetCys: 0.631 ± 0.051
1.055MetAsp: 1.055 ± 0.059
1.315MetGlu: 1.315 ± 0.063
1.084MetPhe: 1.084 ± 0.056
2.13MetGly: 2.13 ± 0.066
0.812MetHis: 0.812 ± 0.055
1.16MetIle: 1.16 ± 0.06
1.154MetLys: 1.154 ± 0.06
3.272MetLeu: 3.272 ± 0.117
0.602MetMet: 0.602 ± 0.045
0.8MetAsn: 0.8 ± 0.047
1.13MetPro: 1.13 ± 0.056
1.028MetGln: 1.028 ± 0.059
1.826MetArg: 1.826 ± 0.067
2.287MetSer: 2.287 ± 0.083
1.128MetThr: 1.128 ± 0.062
2.252MetVal: 2.252 ± 0.087
0.216MetTrp: 0.216 ± 0.024
0.751MetTyr: 0.751 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
3.257AsnAla: 3.257 ± 0.127
0.584AsnCys: 0.584 ± 0.042
1.376AsnAsp: 1.376 ± 0.072
1.537AsnGlu: 1.537 ± 0.073
1.519AsnPhe: 1.519 ± 0.08
2.325AsnGly: 2.325 ± 0.09
0.625AsnHis: 0.625 ± 0.043
2.404AsnIle: 2.404 ± 0.087
1.756AsnLys: 1.756 ± 0.073
3.137AsnLeu: 3.137 ± 0.107
0.926AsnMet: 0.926 ± 0.051
1.247AsnAsn: 1.247 ± 0.08
1.63AsnPro: 1.63 ± 0.061
0.733AsnGln: 0.733 ± 0.049
1.861AsnArg: 1.861 ± 0.076
2.591AsnSer: 2.591 ± 0.079
1.983AsnThr: 1.983 ± 0.07
2.909AsnVal: 2.909 ± 0.086
0.24AsnTrp: 0.24 ± 0.028
1.043AsnTyr: 1.043 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
3.429ProAla: 3.429 ± 0.176
0.532ProCys: 0.532 ± 0.041
2.296ProAsp: 2.296 ± 0.121
2.839ProGlu: 2.839 ± 0.09
1.361ProPhe: 1.361 ± 0.069
2.985ProGly: 2.985 ± 0.103
1.031ProHis: 1.031 ± 0.052
2.057ProIle: 2.057 ± 0.077
1.834ProLys: 1.834 ± 0.09
2.86ProLeu: 2.86 ± 0.096
0.967ProMet: 0.967 ± 0.058
1.166ProAsn: 1.166 ± 0.063
1.595ProPro: 1.595 ± 0.081
1.37ProGln: 1.37 ± 0.077
1.776ProArg: 1.776 ± 0.075
2.761ProSer: 2.761 ± 0.092
2.01ProThr: 2.01 ± 0.107
3.523ProVal: 3.523 ± 0.126
0.374ProTrp: 0.374 ± 0.036
1.233ProTyr: 1.233 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
2.407GlnAla: 2.407 ± 0.116
0.479GlnCys: 0.479 ± 0.032
1.662GlnAsp: 1.662 ± 0.085
2.17GlnGlu: 2.17 ± 0.099
0.999GlnPhe: 0.999 ± 0.049
2.08GlnGly: 2.08 ± 0.079
0.903GlnHis: 0.903 ± 0.05
1.554GlnIle: 1.554 ± 0.07
1.919GlnLys: 1.919 ± 0.088
2.524GlnLeu: 2.524 ± 0.093
0.704GlnMet: 0.704 ± 0.049
1.204GlnAsn: 1.204 ± 0.054
1.209GlnPro: 1.209 ± 0.082
1.604GlnGln: 1.604 ± 0.115
1.718GlnArg: 1.718 ± 0.091
2.211GlnSer: 2.211 ± 0.11
1.192GlnThr: 1.192 ± 0.065
2.094GlnVal: 2.094 ± 0.077
0.28GlnTrp: 0.28 ± 0.028
0.938GlnTyr: 0.938 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
4.709ArgAla: 4.709 ± 0.123
1.098ArgCys: 1.098 ± 0.061
3.14ArgAsp: 3.14 ± 0.104
3.909ArgGlu: 3.909 ± 0.114
2.398ArgPhe: 2.398 ± 0.086
4.388ArgGly: 4.388 ± 0.129
1.309ArgHis: 1.309 ± 0.063
3.45ArgIle: 3.45 ± 0.106
3.085ArgLys: 3.085 ± 0.11
4.87ArgLeu: 4.87 ± 0.134
1.575ArgMet: 1.575 ± 0.069
2.252ArgAsn: 2.252 ± 0.081
1.799ArgPro: 1.799 ± 0.088
1.598ArgGln: 1.598 ± 0.068
3.374ArgArg: 3.374 ± 0.115
4.186ArgSer: 4.186 ± 0.112
2.375ArgThr: 2.375 ± 0.095
4.738ArgVal: 4.738 ± 0.126
0.494ArgTrp: 0.494 ± 0.04
1.875ArgTyr: 1.875 ± 0.074
0.0ArgXaa: 0.0 ± 0.0
Ser
7.475SerAla: 7.475 ± 0.199
1.475SerCys: 1.475 ± 0.062
4.169SerAsp: 4.169 ± 0.126
4.431SerGlu: 4.431 ± 0.129
3.015SerPhe: 3.015 ± 0.105
7.236SerGly: 7.236 ± 0.176
1.671SerHis: 1.671 ± 0.071
4.493SerIle: 4.493 ± 0.135
3.795SerLys: 3.795 ± 0.113
6.748SerLeu: 6.748 ± 0.152
2.127SerMet: 2.127 ± 0.079
2.436SerAsn: 2.436 ± 0.085
2.883SerPro: 2.883 ± 0.101
2.144SerGln: 2.144 ± 0.097
4.32SerArg: 4.32 ± 0.128
6.961SerSer: 6.961 ± 0.197
4.055SerThr: 4.055 ± 0.138
6.987SerVal: 6.987 ± 0.155
0.686SerTrp: 0.686 ± 0.046
2.258SerTyr: 2.258 ± 0.08
0.0SerXaa: 0.0 ± 0.0
Thr
4.49ThrAla: 4.49 ± 0.172
0.797ThrCys: 0.797 ± 0.046
2.352ThrAsp: 2.352 ± 0.091
2.673ThrGlu: 2.673 ± 0.089
1.618ThrPhe: 1.618 ± 0.064
3.724ThrGly: 3.724 ± 0.102
1.107ThrHis: 1.107 ± 0.066
2.758ThrIle: 2.758 ± 0.088
2.357ThrLys: 2.357 ± 0.092
4.431ThrLeu: 4.431 ± 0.126
1.116ThrMet: 1.116 ± 0.059
1.504ThrAsn: 1.504 ± 0.069
2.474ThrPro: 2.474 ± 0.121
1.466ThrGln: 1.466 ± 0.073
2.46ThrArg: 2.46 ± 0.094
3.774ThrSer: 3.774 ± 0.119
2.565ThrThr: 2.565 ± 0.122
3.929ThrVal: 3.929 ± 0.106
0.429ThrTrp: 0.429 ± 0.044
1.259ThrTyr: 1.259 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
8.089ValAla: 8.089 ± 0.181
1.639ValCys: 1.639 ± 0.078
4.68ValAsp: 4.68 ± 0.131
5.027ValGlu: 5.027 ± 0.122
3.619ValPhe: 3.619 ± 0.141
6.532ValGly: 6.532 ± 0.149
1.896ValHis: 1.896 ± 0.071
4.767ValIle: 4.767 ± 0.121
4.163ValLys: 4.163 ± 0.142
8.734ValLeu: 8.734 ± 0.197
2.363ValMet: 2.363 ± 0.094
2.685ValAsn: 2.685 ± 0.101
3.377ValPro: 3.377 ± 0.108
2.547ValGln: 2.547 ± 0.09
5.048ValArg: 5.048 ± 0.128
6.841ValSer: 6.841 ± 0.153
3.757ValThr: 3.757 ± 0.125
8.603ValVal: 8.603 ± 0.219
0.611ValTrp: 0.611 ± 0.039
2.369ValTyr: 2.369 ± 0.09
0.0ValXaa: 0.0 ± 0.0
Trp
0.561TrpAla: 0.561 ± 0.041
0.219TrpCys: 0.219 ± 0.025
0.429TrpAsp: 0.429 ± 0.043
0.488TrpGlu: 0.488 ± 0.038
0.365TrpPhe: 0.365 ± 0.034
0.625TrpGly: 0.625 ± 0.04
0.272TrpHis: 0.272 ± 0.03
0.467TrpIle: 0.467 ± 0.044
0.409TrpLys: 0.409 ± 0.037
0.876TrpLeu: 0.876 ± 0.054
0.245TrpMet: 0.245 ± 0.024
0.327TrpAsn: 0.327 ± 0.034
0.351TrpPro: 0.351 ± 0.035
0.295TrpGln: 0.295 ± 0.029
0.634TrpArg: 0.634 ± 0.051
0.526TrpSer: 0.526 ± 0.042
0.292TrpThr: 0.292 ± 0.026
0.631TrpVal: 0.631 ± 0.043
0.158TrpTrp: 0.158 ± 0.024
0.368TrpTyr: 0.368 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.451TyrAla: 2.451 ± 0.081
0.558TyrCys: 0.558 ± 0.044
1.867TyrAsp: 1.867 ± 0.086
1.601TyrGlu: 1.601 ± 0.076
1.078TyrPhe: 1.078 ± 0.067
2.375TyrGly: 2.375 ± 0.092
0.672TyrHis: 0.672 ± 0.045
1.7TyrIle: 1.7 ± 0.063
1.537TyrLys: 1.537 ± 0.072
2.445TyrLeu: 2.445 ± 0.093
0.803TyrMet: 0.803 ± 0.049
1.244TyrAsn: 1.244 ± 0.054
1.075TyrPro: 1.075 ± 0.056
0.774TyrGln: 0.774 ± 0.055
1.779TyrArg: 1.779 ± 0.075
2.387TyrSer: 2.387 ± 0.089
1.405TyrThr: 1.405 ± 0.068
2.571TyrVal: 2.571 ± 0.085
0.248TyrTrp: 0.248 ± 0.028
0.885TyrTyr: 0.885 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 939 proteins (342329 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski