Amino acid dipepetide frequency for Archaeoglobus sulfaticallidus PM70-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.212AlaAla: 3.212 ± 0.113	0.794AlaCys: 0.794 ± 0.038	3.192AlaAsp: 3.192 ± 0.069	5.808AlaGlu: 5.808 ± 0.113	3.178AlaPhe: 3.178 ± 0.076	5.305AlaGly: 5.305 ± 0.105	0.895AlaHis: 0.895 ± 0.045	6.534AlaIle: 6.534 ± 0.104	5.093AlaLys: 5.093 ± 0.099	6.458AlaLeu: 6.458 ± 0.112	2.033AlaMet: 2.033 ± 0.059	2.083AlaAsn: 2.083 ± 0.071	1.623AlaPro: 1.623 ± 0.052	1.045AlaGln: 1.045 ± 0.046	3.442AlaArg: 3.442 ± 0.071	3.622AlaSer: 3.622 ± 0.1	2.858AlaThr: 2.858 ± 0.073	6.069AlaVal: 6.069 ± 0.114	0.516AlaTrp: 0.516 ± 0.034	2.508AlaTyr: 2.508 ± 0.078	0.0AlaXaa: 0.0 ± 0.0
Cys	0.648CysAla: 0.648 ± 0.035	0.162CysCys: 0.162 ± 0.018	0.62CysAsp: 0.62 ± 0.039	0.804CysGlu: 0.804 ± 0.039	0.418CysPhe: 0.418 ± 0.03	1.249CysGly: 1.249 ± 0.057	0.22CysHis: 0.22 ± 0.022	0.726CysIle: 0.726 ± 0.038	0.703CysLys: 0.703 ± 0.035	0.845CysLeu: 0.845 ± 0.035	0.26CysMet: 0.26 ± 0.022	0.4CysAsn: 0.4 ± 0.027	0.748CysPro: 0.748 ± 0.046	0.182CysGln: 0.182 ± 0.018	0.731CysArg: 0.731 ± 0.039	0.706CysSer: 0.706 ± 0.037	0.46CysThr: 0.46 ± 0.033	0.761CysVal: 0.761 ± 0.038	0.106CysTrp: 0.106 ± 0.013	0.437CysTyr: 0.437 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.312AspAla: 3.312 ± 0.084	0.625AspCys: 0.625 ± 0.035	2.539AspAsp: 2.539 ± 0.06	5.315AspGlu: 5.315 ± 0.104	3.199AspPhe: 3.199 ± 0.071	3.96AspGly: 3.96 ± 0.094	0.769AspHis: 0.769 ± 0.038	4.721AspIle: 4.721 ± 0.104	2.989AspLys: 2.989 ± 0.084	5.204AspLeu: 5.204 ± 0.095	1.33AspMet: 1.33 ± 0.043	1.514AspAsn: 1.514 ± 0.051	2.137AspPro: 2.137 ± 0.067	0.691AspGln: 0.691 ± 0.032	2.984AspArg: 2.984 ± 0.069	3.001AspSer: 3.001 ± 0.083	1.957AspThr: 1.957 ± 0.07	5.237AspVal: 5.237 ± 0.097	0.574AspTrp: 0.574 ± 0.04	2.309AspTyr: 2.309 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	4.607GluAla: 4.607 ± 0.084	0.693GluCys: 0.693 ± 0.034	4.276GluAsp: 4.276 ± 0.093	7.857GluGlu: 7.857 ± 0.155	3.905GluPhe: 3.905 ± 0.089	4.895GluGly: 4.895 ± 0.092	1.191GluHis: 1.191 ± 0.044	8.904GluIle: 8.904 ± 0.142	8.148GluLys: 8.148 ± 0.134	8.044GluLeu: 8.044 ± 0.146	2.468GluMet: 2.468 ± 0.079	3.713GluAsn: 3.713 ± 0.081	1.975GluPro: 1.975 ± 0.062	1.274GluGln: 1.274 ± 0.05	5.138GluArg: 5.138 ± 0.111	3.882GluSer: 3.882 ± 0.077	2.868GluThr: 2.868 ± 0.067	7.05GluVal: 7.05 ± 0.117	0.883GluTrp: 0.883 ± 0.039	2.974GluTyr: 2.974 ± 0.077	0.0GluXaa: 0.0 ± 0.0
Phe	3.113PheAla: 3.113 ± 0.091	0.552PheCys: 0.552 ± 0.032	2.83PheAsp: 2.83 ± 0.084	3.727PheGlu: 3.727 ± 0.081	2.094PhePhe: 2.094 ± 0.069	3.512PheGly: 3.512 ± 0.086	0.72PheHis: 0.72 ± 0.036	3.558PheIle: 3.558 ± 0.093	2.743PheLys: 2.743 ± 0.067	4.325PheLeu: 4.325 ± 0.103	1.08PheMet: 1.08 ± 0.046	1.669PheAsn: 1.669 ± 0.059	1.571PhePro: 1.571 ± 0.048	0.777PheGln: 0.777 ± 0.036	2.602PheArg: 2.602 ± 0.065	3.247PheSer: 3.247 ± 0.081	1.97PheThr: 1.97 ± 0.07	3.541PheVal: 3.541 ± 0.081	0.453PheTrp: 0.453 ± 0.027	1.743PheTyr: 1.743 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.091GlyAla: 4.091 ± 0.09	0.964GlyCys: 0.964 ± 0.045	3.618GlyAsp: 3.618 ± 0.086	5.242GlyGlu: 5.242 ± 0.097	3.603GlyPhe: 3.603 ± 0.091	4.64GlyGly: 4.64 ± 0.099	1.007GlyHis: 1.007 ± 0.045	6.567GlyIle: 6.567 ± 0.12	5.65GlyLys: 5.65 ± 0.1	6.054GlyLeu: 6.054 ± 0.118	2.212GlyMet: 2.212 ± 0.064	2.395GlyAsn: 2.395 ± 0.073	1.338GlyPro: 1.338 ± 0.047	0.888GlyGln: 0.888 ± 0.039	3.608GlyArg: 3.608 ± 0.08	3.867GlySer: 3.867 ± 0.088	2.926GlyThr: 2.926 ± 0.088	5.801GlyVal: 5.801 ± 0.107	0.916GlyTrp: 0.916 ± 0.042	3.143GlyTyr: 3.143 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.05HisAla: 1.05 ± 0.041	0.23HisCys: 0.23 ± 0.021	0.751HisAsp: 0.751 ± 0.039	1.072HisGlu: 1.072 ± 0.039	0.723HisPhe: 0.723 ± 0.034	1.171HisGly: 1.171 ± 0.04	0.324HisHis: 0.324 ± 0.025	1.27HisIle: 1.27 ± 0.041	0.809HisLys: 0.809 ± 0.041	1.439HisLeu: 1.439 ± 0.053	0.361HisMet: 0.361 ± 0.027	0.549HisAsn: 0.549 ± 0.031	0.989HisPro: 0.989 ± 0.038	0.331HisGln: 0.331 ± 0.021	0.774HisArg: 0.774 ± 0.031	0.882HisSer: 0.882 ± 0.04	0.7HisThr: 0.7 ± 0.039	0.997HisVal: 0.997 ± 0.046	0.147HisTrp: 0.147 ± 0.015	0.591HisTyr: 0.591 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.85IleAla: 6.85 ± 0.121	0.946IleCys: 0.946 ± 0.041	5.31IleAsp: 5.31 ± 0.104	7.194IleGlu: 7.194 ± 0.126	3.707IlePhe: 3.707 ± 0.087	5.624IleGly: 5.624 ± 0.117	1.371IleHis: 1.371 ± 0.047	6.401IleIle: 6.401 ± 0.125	6.345IleLys: 6.345 ± 0.106	7.902IleLeu: 7.902 ± 0.131	1.901IleMet: 1.901 ± 0.057	3.183IleAsn: 3.183 ± 0.085	3.854IlePro: 3.854 ± 0.085	1.649IleGln: 1.649 ± 0.058	4.218IleArg: 4.218 ± 0.092	5.925IleSer: 5.925 ± 0.109	4.124IleThr: 4.124 ± 0.094	6.779IleVal: 6.779 ± 0.106	0.675IleTrp: 0.675 ± 0.037	2.981IleTyr: 2.981 ± 0.072	0.0IleXaa: 0.0 ± 0.0
Lys	5.611LysAla: 5.611 ± 0.106	0.83LysCys: 0.83 ± 0.038	4.15LysAsp: 4.15 ± 0.091	7.285LysGlu: 7.285 ± 0.133	2.939LysPhe: 2.939 ± 0.078	4.721LysGly: 4.721 ± 0.086	1.08LysHis: 1.08 ± 0.041	6.979LysIle: 6.979 ± 0.11	6.949LysLys: 6.949 ± 0.131	6.904LysLeu: 6.904 ± 0.118	1.881LysMet: 1.881 ± 0.059	3.179LysAsn: 3.179 ± 0.079	2.862LysPro: 2.862 ± 0.064	1.32LysGln: 1.32 ± 0.049	4.302LysArg: 4.302 ± 0.095	3.836LysSer: 3.836 ± 0.087	3.381LysThr: 3.381 ± 0.084	5.445LysVal: 5.445 ± 0.091	0.672LysTrp: 0.672 ± 0.033	2.81LysTyr: 2.81 ± 0.073	0.0LysXaa: 0.0 ± 0.0
Leu	6.704LeuAla: 6.704 ± 0.122	0.797LeuCys: 0.797 ± 0.042	4.906LeuAsp: 4.906 ± 0.095	7.531LeuGlu: 7.531 ± 0.126	3.677LeuPhe: 3.677 ± 0.098	6.062LeuGly: 6.062 ± 0.121	1.337LeuHis: 1.337 ± 0.053	7.796LeuIle: 7.796 ± 0.124	8.522LeuLys: 8.522 ± 0.118	8.175LeuLeu: 8.175 ± 0.147	2.499LeuMet: 2.499 ± 0.066	3.909LeuAsn: 3.909 ± 0.091	3.336LeuPro: 3.336 ± 0.081	1.614LeuGln: 1.614 ± 0.056	5.253LeuArg: 5.253 ± 0.09	6.564LeuSer: 6.564 ± 0.105	4.281LeuThr: 4.281 ± 0.096	5.796LeuVal: 5.796 ± 0.108	0.819LeuTrp: 0.819 ± 0.044	2.817LeuTyr: 2.817 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	1.773MetAla: 1.773 ± 0.054	0.223MetCys: 0.223 ± 0.021	1.727MetAsp: 1.727 ± 0.056	2.134MetGlu: 2.134 ± 0.064	1.032MetPhe: 1.032 ± 0.04	1.939MetGly: 1.939 ± 0.061	0.437MetHis: 0.437 ± 0.027	2.03MetIle: 2.03 ± 0.061	2.278MetLys: 2.278 ± 0.063	2.567MetLeu: 2.567 ± 0.071	0.609MetMet: 0.609 ± 0.035	1.072MetAsn: 1.072 ± 0.042	0.992MetPro: 0.992 ± 0.043	0.496MetGln: 0.496 ± 0.029	1.523MetArg: 1.523 ± 0.051	1.447MetSer: 1.447 ± 0.047	0.981MetThr: 0.981 ± 0.045	1.912MetVal: 1.912 ± 0.062	0.22MetTrp: 0.22 ± 0.021	0.703MetTyr: 0.703 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.769AsnAla: 2.769 ± 0.074	0.49AsnCys: 0.49 ± 0.03	1.643AsnAsp: 1.643 ± 0.049	2.688AsnGlu: 2.688 ± 0.077	1.826AsnPhe: 1.826 ± 0.053	2.625AsnGly: 2.625 ± 0.077	0.523AsnHis: 0.523 ± 0.031	3.31AsnIle: 3.31 ± 0.08	2.031AsnLys: 2.031 ± 0.058	4.077AsnLeu: 4.077 ± 0.096	0.764AsnMet: 0.764 ± 0.032	1.136AsnAsn: 1.136 ± 0.058	2.342AsnPro: 2.342 ± 0.063	0.68AsnGln: 0.68 ± 0.036	1.975AsnArg: 1.975 ± 0.061	2.273AsnSer: 2.273 ± 0.064	1.58AsnThr: 1.58 ± 0.055	2.638AsnVal: 2.638 ± 0.074	0.404AsnTrp: 0.404 ± 0.026	1.528AsnTyr: 1.528 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	2.21ProAla: 2.21 ± 0.063	0.361ProCys: 0.361 ± 0.025	2.251ProAsp: 2.251 ± 0.067	3.842ProGlu: 3.842 ± 0.082	1.666ProPhe: 1.666 ± 0.051	2.114ProGly: 2.114 ± 0.065	0.744ProHis: 0.744 ± 0.036	2.37ProIle: 2.37 ± 0.062	2.506ProLys: 2.506 ± 0.062	3.11ProLeu: 3.11 ± 0.073	0.842ProMet: 0.842 ± 0.031	1.33ProAsn: 1.33 ± 0.044	1.553ProPro: 1.553 ± 0.057	0.741ProGln: 0.741 ± 0.038	1.391ProArg: 1.391 ± 0.052	2.212ProSer: 2.212 ± 0.065	1.702ProThr: 1.702 ± 0.064	3.262ProVal: 3.262 ± 0.084	0.397ProTrp: 0.397 ± 0.026	1.566ProTyr: 1.566 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	1.226GlnAla: 1.226 ± 0.045	0.169GlnCys: 0.169 ± 0.02	0.748GlnAsp: 0.748 ± 0.039	1.244GlnGlu: 1.244 ± 0.054	0.652GlnPhe: 0.652 ± 0.034	0.892GlnGly: 0.892 ± 0.036	0.28GlnHis: 0.28 ± 0.024	1.679GlnIle: 1.679 ± 0.047	1.603GlnLys: 1.603 ± 0.063	1.684GlnLeu: 1.684 ± 0.054	0.518GlnMet: 0.518 ± 0.03	0.779GlnAsn: 0.779 ± 0.041	0.686GlnPro: 0.686 ± 0.033	0.382GlnGln: 0.382 ± 0.029	1.019GlnArg: 1.019 ± 0.046	0.855GlnSer: 0.855 ± 0.042	0.844GlnThr: 0.844 ± 0.045	1.067GlnVal: 1.067 ± 0.043	0.202GlnTrp: 0.202 ± 0.022	0.582GlnTyr: 0.582 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.082ArgAla: 3.082 ± 0.084	0.7ArgCys: 0.7 ± 0.034	3.369ArgAsp: 3.369 ± 0.08	4.772ArgGlu: 4.772 ± 0.105	2.541ArgPhe: 2.541 ± 0.064	3.273ArgGly: 3.273 ± 0.077	0.723ArgHis: 0.723 ± 0.037	5.416ArgIle: 5.416 ± 0.112	5.162ArgLys: 5.162 ± 0.109	4.632ArgLeu: 4.632 ± 0.103	1.552ArgMet: 1.552 ± 0.049	2.288ArgAsn: 2.288 ± 0.061	1.27ArgPro: 1.27 ± 0.048	0.935ArgGln: 0.935 ± 0.042	3.087ArgArg: 3.087 ± 0.079	2.26ArgSer: 2.26 ± 0.065	1.919ArgThr: 1.919 ± 0.056	4.378ArgVal: 4.378 ± 0.088	0.526ArgTrp: 0.526 ± 0.027	2.187ArgTyr: 2.187 ± 0.065	0.0ArgXaa: 0.0 ± 0.0
Ser	4.405SerAla: 4.405 ± 0.103	0.645SerCys: 0.645 ± 0.033	2.996SerAsp: 2.996 ± 0.08	4.802SerGlu: 4.802 ± 0.1	2.906SerPhe: 2.906 ± 0.069	4.491SerGly: 4.491 ± 0.088	0.89SerHis: 0.89 ± 0.037	4.931SerIle: 4.931 ± 0.105	4.339SerLys: 4.339 ± 0.087	5.455SerLeu: 5.455 ± 0.119	1.619SerMet: 1.619 ± 0.056	1.987SerAsn: 1.987 ± 0.058	2.182SerPro: 2.182 ± 0.067	1.09SerGln: 1.09 ± 0.046	3.11SerArg: 3.11 ± 0.066	3.583SerSer: 3.583 ± 0.095	2.516SerThr: 2.516 ± 0.078	3.94SerVal: 3.94 ± 0.084	0.557SerTrp: 0.557 ± 0.035	2.152SerTyr: 2.152 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	3.265ThrAla: 3.265 ± 0.077	0.468ThrCys: 0.468 ± 0.031	2.033ThrAsp: 2.033 ± 0.063	2.777ThrGlu: 2.777 ± 0.073	1.884ThrPhe: 1.884 ± 0.056	3.568ThrGly: 3.568 ± 0.08	0.776ThrHis: 0.776 ± 0.036	3.601ThrIle: 3.601 ± 0.085	2.643ThrLys: 2.643 ± 0.065	4.029ThrLeu: 4.029 ± 0.089	0.949ThrMet: 0.949 ± 0.046	1.464ThrAsn: 1.464 ± 0.055	2.304ThrPro: 2.304 ± 0.079	0.873ThrGln: 0.873 ± 0.044	1.846ThrArg: 1.846 ± 0.048	2.741ThrSer: 2.741 ± 0.071	2.205ThrThr: 2.205 ± 0.076	3.244ThrVal: 3.244 ± 0.091	0.349ThrTrp: 0.349 ± 0.029	1.59ThrTyr: 1.59 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	5.311ValAla: 5.311 ± 0.094	0.911ValCys: 0.911 ± 0.039	4.736ValAsp: 4.736 ± 0.091	7.164ValGlu: 7.164 ± 0.126	3.57ValPhe: 3.57 ± 0.084	5.037ValGly: 5.037 ± 0.111	1.072ValHis: 1.072 ± 0.042	6.292ValIle: 6.292 ± 0.109	5.789ValLys: 5.789 ± 0.105	6.899ValLeu: 6.899 ± 0.118	2.013ValMet: 2.013 ± 0.057	2.769ValAsn: 2.769 ± 0.077	2.516ValPro: 2.516 ± 0.071	1.234ValGln: 1.234 ± 0.042	4.284ValArg: 4.284 ± 0.087	4.676ValSer: 4.676 ± 0.091	3.24ValThr: 3.24 ± 0.093	7.065ValVal: 7.065 ± 0.125	0.695ValTrp: 0.695 ± 0.036	2.915ValTyr: 2.915 ± 0.071	0.0ValXaa: 0.0 ± 0.0
Trp	0.566TrpAla: 0.566 ± 0.031	0.109TrpCys: 0.109 ± 0.014	0.564TrpAsp: 0.564 ± 0.037	0.667TrpGlu: 0.667 ± 0.035	0.466TrpPhe: 0.466 ± 0.033	0.67TrpGly: 0.67 ± 0.035	0.172TrpHis: 0.172 ± 0.019	0.862TrpIle: 0.862 ± 0.044	0.825TrpLys: 0.825 ± 0.038	0.951TrpLeu: 0.951 ± 0.05	0.321TrpMet: 0.321 ± 0.022	0.47TrpAsn: 0.47 ± 0.04	0.184TrpPro: 0.184 ± 0.017	0.185TrpGln: 0.185 ± 0.019	0.567TrpArg: 0.567 ± 0.03	0.468TrpSer: 0.468 ± 0.025	0.38TrpThr: 0.38 ± 0.027	0.774TrpVal: 0.774 ± 0.037	0.172TrpTrp: 0.172 ± 0.018	0.38TrpTyr: 0.38 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.463TyrAla: 2.463 ± 0.068	0.516TyrCys: 0.516 ± 0.031	2.107TyrAsp: 2.107 ± 0.057	2.822TyrGlu: 2.822 ± 0.066	1.843TyrPhe: 1.843 ± 0.062	2.784TyrGly: 2.784 ± 0.074	0.63TyrHis: 0.63 ± 0.036	2.992TyrIle: 2.992 ± 0.075	2.008TyrLys: 2.008 ± 0.07	3.641TyrLeu: 3.641 ± 0.077	0.883TyrMet: 0.883 ± 0.039	1.414TyrAsn: 1.414 ± 0.053	1.707TyrPro: 1.707 ± 0.063	0.72TyrGln: 0.72 ± 0.034	2.215TyrArg: 2.215 ± 0.066	2.549TyrSer: 2.549 ± 0.069	1.719TyrThr: 1.719 ± 0.056	2.432TyrVal: 2.432 ± 0.077	0.471TyrTrp: 0.471 ± 0.029	1.641TyrTyr: 1.641 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2213 proteins (604556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---