Amino acid dipepetide frequency for Cutibacterium granulosum DSM 20700

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.999AlaAla: 13.999 ± 0.204	1.037AlaCys: 1.037 ± 0.049	7.505AlaAsp: 7.505 ± 0.118	6.403AlaGlu: 6.403 ± 0.118	2.663AlaPhe: 2.663 ± 0.074	9.979AlaGly: 9.979 ± 0.141	2.769AlaHis: 2.769 ± 0.074	5.225AlaIle: 5.225 ± 0.101	3.338AlaLys: 3.338 ± 0.097	10.275AlaLeu: 10.275 ± 0.156	3.038AlaMet: 3.038 ± 0.075	2.549AlaAsn: 2.549 ± 0.075	5.053AlaPro: 5.053 ± 0.116	4.384AlaGln: 4.384 ± 0.084	8.16AlaArg: 8.16 ± 0.123	6.658AlaSer: 6.658 ± 0.113	7.082AlaThr: 7.082 ± 0.126	9.154AlaVal: 9.154 ± 0.147	1.65AlaTrp: 1.65 ± 0.068	1.826AlaTyr: 1.826 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.109CysAla: 1.109 ± 0.051	0.153CysCys: 0.153 ± 0.019	0.671CysAsp: 0.671 ± 0.039	0.495CysGlu: 0.495 ± 0.028	0.25CysPhe: 0.25 ± 0.022	1.072CysGly: 1.072 ± 0.049	0.31CysHis: 0.31 ± 0.022	0.312CysIle: 0.312 ± 0.025	0.154CysLys: 0.154 ± 0.017	0.936CysLeu: 0.936 ± 0.038	0.19CysMet: 0.19 ± 0.019	0.203CysAsn: 0.203 ± 0.017	0.661CysPro: 0.661 ± 0.04	0.391CysGln: 0.391 ± 0.024	0.712CysArg: 0.712 ± 0.04	0.596CysSer: 0.596 ± 0.03	0.644CysThr: 0.644 ± 0.041	0.713CysVal: 0.713 ± 0.036	0.158CysTrp: 0.158 ± 0.016	0.213CysTyr: 0.213 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	7.25AspAla: 7.25 ± 0.11	0.475AspCys: 0.475 ± 0.029	5.005AspAsp: 5.005 ± 0.121	5.102AspGlu: 5.102 ± 0.118	1.683AspPhe: 1.683 ± 0.051	5.872AspGly: 5.872 ± 0.138	1.86AspHis: 1.86 ± 0.064	2.469AspIle: 2.469 ± 0.071	1.734AspLys: 1.734 ± 0.064	6.712AspLeu: 6.712 ± 0.115	1.292AspMet: 1.292 ± 0.045	1.333AspAsn: 1.333 ± 0.044	4.572AspPro: 4.572 ± 0.097	2.175AspGln: 2.175 ± 0.067	4.256AspArg: 4.256 ± 0.102	3.383AspSer: 3.383 ± 0.075	3.147AspThr: 3.147 ± 0.078	5.896AspVal: 5.896 ± 0.092	0.886AspTrp: 0.886 ± 0.043	1.235AspTyr: 1.235 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.698GluAla: 5.698 ± 0.121	0.401GluCys: 0.401 ± 0.026	2.877GluAsp: 2.877 ± 0.074	2.962GluGlu: 2.962 ± 0.091	1.615GluPhe: 1.615 ± 0.047	3.756GluGly: 3.756 ± 0.088	1.623GluHis: 1.623 ± 0.054	2.568GluIle: 2.568 ± 0.076	1.709GluLys: 1.709 ± 0.06	5.97GluLeu: 5.97 ± 0.128	1.264GluMet: 1.264 ± 0.049	1.281GluAsn: 1.281 ± 0.048	2.89GluPro: 2.89 ± 0.081	2.734GluGln: 2.734 ± 0.081	3.879GluArg: 3.879 ± 0.087	3.128GluSer: 3.128 ± 0.078	2.774GluThr: 2.774 ± 0.068	4.536GluVal: 4.536 ± 0.08	0.629GluTrp: 0.629 ± 0.032	1.089GluTyr: 1.089 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.882PheAla: 2.882 ± 0.07	0.331PheCys: 0.331 ± 0.021	2.19PheAsp: 2.19 ± 0.067	1.254PheGlu: 1.254 ± 0.049	0.895PhePhe: 0.895 ± 0.043	2.687PheGly: 2.687 ± 0.066	0.708PheHis: 0.708 ± 0.039	1.281PheIle: 1.281 ± 0.053	0.596PheLys: 0.596 ± 0.032	2.546PheLeu: 2.546 ± 0.072	0.559PheMet: 0.559 ± 0.032	0.801PheAsn: 0.801 ± 0.042	1.239PhePro: 1.239 ± 0.042	0.686PheGln: 0.686 ± 0.037	1.5PheArg: 1.5 ± 0.053	1.722PheSer: 1.722 ± 0.05	1.893PheThr: 1.893 ± 0.059	2.319PheVal: 2.319 ± 0.073	0.398PheTrp: 0.398 ± 0.028	0.46PheTyr: 0.46 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.66GlyAla: 8.66 ± 0.133	0.926GlyCys: 0.926 ± 0.044	4.699GlyAsp: 4.699 ± 0.102	4.488GlyGlu: 4.488 ± 0.105	2.684GlyPhe: 2.684 ± 0.072	6.655GlyGly: 6.655 ± 0.117	2.338GlyHis: 2.338 ± 0.063	4.06GlyIle: 4.06 ± 0.076	2.809GlyLys: 2.809 ± 0.073	8.172GlyLeu: 8.172 ± 0.123	2.346GlyMet: 2.346 ± 0.057	1.918GlyAsn: 1.918 ± 0.057	3.761GlyPro: 3.761 ± 0.084	3.157GlyGln: 3.157 ± 0.073	6.287GlyArg: 6.287 ± 0.122	5.458GlySer: 5.458 ± 0.105	5.669GlyThr: 5.669 ± 0.108	7.527GlyVal: 7.527 ± 0.122	1.628GlyTrp: 1.628 ± 0.057	1.954GlyTyr: 1.954 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.553HisAla: 2.553 ± 0.058	0.272HisCys: 0.272 ± 0.022	2.053HisAsp: 2.053 ± 0.053	1.484HisGlu: 1.484 ± 0.054	0.569HisPhe: 0.569 ± 0.031	2.465HisGly: 2.465 ± 0.069	0.851HisHis: 0.851 ± 0.041	1.083HisIle: 1.083 ± 0.046	0.514HisLys: 0.514 ± 0.028	2.474HisLeu: 2.474 ± 0.067	0.514HisMet: 0.514 ± 0.027	0.502HisAsn: 0.502 ± 0.031	1.969HisPro: 1.969 ± 0.06	0.876HisGln: 0.876 ± 0.035	2.167HisArg: 2.167 ± 0.062	1.428HisSer: 1.428 ± 0.055	1.546HisThr: 1.546 ± 0.05	2.217HisVal: 2.217 ± 0.061	0.339HisTrp: 0.339 ± 0.023	0.468HisTyr: 0.468 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.587IleAla: 5.587 ± 0.105	0.564IleCys: 0.564 ± 0.033	3.79IleAsp: 3.79 ± 0.084	2.517IleGlu: 2.517 ± 0.081	1.304IlePhe: 1.304 ± 0.052	4.404IleGly: 4.404 ± 0.095	1.049IleHis: 1.049 ± 0.045	2.288IleIle: 2.288 ± 0.078	1.168IleLys: 1.168 ± 0.048	3.944IleLeu: 3.944 ± 0.093	1.036IleMet: 1.036 ± 0.042	1.153IleAsn: 1.153 ± 0.045	2.345IlePro: 2.345 ± 0.061	0.985IleGln: 0.985 ± 0.048	2.642IleArg: 2.642 ± 0.061	2.672IleSer: 2.672 ± 0.057	2.915IleThr: 2.915 ± 0.07	4.409IleVal: 4.409 ± 0.099	0.465IleTrp: 0.465 ± 0.03	0.75IleTyr: 0.75 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.491LysAla: 3.491 ± 0.099	0.146LysCys: 0.146 ± 0.015	1.853LysAsp: 1.853 ± 0.073	1.462LysGlu: 1.462 ± 0.055	0.621LysPhe: 0.621 ± 0.036	2.048LysGly: 2.048 ± 0.073	0.648LysHis: 0.648 ± 0.037	1.304LysIle: 1.304 ± 0.054	1.245LysLys: 1.245 ± 0.065	2.445LysLeu: 2.445 ± 0.071	0.633LysMet: 0.633 ± 0.037	0.757LysAsn: 0.757 ± 0.04	1.571LysPro: 1.571 ± 0.067	0.957LysGln: 0.957 ± 0.042	1.579LysArg: 1.579 ± 0.059	1.507LysSer: 1.507 ± 0.063	1.497LysThr: 1.497 ± 0.048	2.563LysVal: 2.563 ± 0.077	0.253LysTrp: 0.253 ± 0.019	0.693LysTyr: 0.693 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	12.045LeuAla: 12.045 ± 0.19	1.007LeuCys: 1.007 ± 0.041	6.745LeuAsp: 6.745 ± 0.134	4.359LeuGlu: 4.359 ± 0.113	2.338LeuPhe: 2.338 ± 0.075	8.202LeuGly: 8.202 ± 0.132	2.207LeuHis: 2.207 ± 0.069	4.14LeuIle: 4.14 ± 0.11	2.209LeuLys: 2.209 ± 0.075	8.387LeuLeu: 8.387 ± 0.138	2.073LeuMet: 2.073 ± 0.071	2.009LeuAsn: 2.009 ± 0.054	4.969LeuPro: 4.969 ± 0.098	2.33LeuGln: 2.33 ± 0.054	6.159LeuArg: 6.159 ± 0.107	5.575LeuSer: 5.575 ± 0.089	6.567LeuThr: 6.567 ± 0.103	9.132LeuVal: 9.132 ± 0.143	1.215LeuTrp: 1.215 ± 0.051	1.373LeuTyr: 1.373 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.135MetAla: 3.135 ± 0.079	0.237MetCys: 0.237 ± 0.02	1.366MetAsp: 1.366 ± 0.053	0.99MetGlu: 0.99 ± 0.039	0.582MetPhe: 0.582 ± 0.034	2.026MetGly: 2.026 ± 0.059	0.509MetHis: 0.509 ± 0.029	1.158MetIle: 1.158 ± 0.043	0.666MetLys: 0.666 ± 0.039	2.084MetLeu: 2.084 ± 0.056	0.502MetMet: 0.502 ± 0.03	0.668MetAsn: 0.668 ± 0.034	1.341MetPro: 1.341 ± 0.044	0.586MetGln: 0.586 ± 0.032	1.536MetArg: 1.536 ± 0.054	2.093MetSer: 2.093 ± 0.062	2.034MetThr: 2.034 ± 0.061	1.972MetVal: 1.972 ± 0.061	0.352MetTrp: 0.352 ± 0.025	0.351MetTyr: 0.351 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.47AsnAla: 2.47 ± 0.069	0.222AsnCys: 0.222 ± 0.022	1.453AsnAsp: 1.453 ± 0.049	1.106AsnGlu: 1.106 ± 0.04	0.653AsnPhe: 0.653 ± 0.036	2.222AsnGly: 2.222 ± 0.07	0.727AsnHis: 0.727 ± 0.035	0.926AsnIle: 0.926 ± 0.038	0.629AsnLys: 0.629 ± 0.032	2.267AsnLeu: 2.267 ± 0.067	0.495AsnMet: 0.495 ± 0.03	0.584AsnAsn: 0.584 ± 0.038	1.943AsnPro: 1.943 ± 0.06	0.819AsnGln: 0.819 ± 0.043	1.573AsnArg: 1.573 ± 0.053	1.405AsnSer: 1.405 ± 0.053	1.338AsnThr: 1.338 ± 0.054	1.752AsnVal: 1.752 ± 0.059	0.373AsnTrp: 0.373 ± 0.025	0.581AsnTyr: 0.581 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.79ProAla: 5.79 ± 0.125	0.415ProCys: 0.415 ± 0.028	4.293ProAsp: 4.293 ± 0.097	3.383ProGlu: 3.383 ± 0.077	1.329ProPhe: 1.329 ± 0.044	5.003ProGly: 5.003 ± 0.094	1.467ProHis: 1.467 ± 0.046	2.126ProIle: 2.126 ± 0.066	1.336ProLys: 1.336 ± 0.06	4.14ProLeu: 4.14 ± 0.091	1.23ProMet: 1.23 ± 0.051	1.24ProAsn: 1.24 ± 0.043	1.861ProPro: 1.861 ± 0.061	2.13ProGln: 2.13 ± 0.06	3.451ProArg: 3.451 ± 0.085	3.771ProSer: 3.771 ± 0.101	3.733ProThr: 3.733 ± 0.118	4.614ProVal: 4.614 ± 0.084	0.908ProTrp: 0.908 ± 0.04	1.009ProTyr: 1.009 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.419GlnAla: 4.419 ± 0.096	0.285GlnCys: 0.285 ± 0.023	1.68GlnAsp: 1.68 ± 0.049	1.621GlnGlu: 1.621 ± 0.051	0.923GlnPhe: 0.923 ± 0.041	2.486GlnGly: 2.486 ± 0.068	0.797GlnHis: 0.797 ± 0.035	1.861GlnIle: 1.861 ± 0.06	0.864GlnLys: 0.864 ± 0.039	3.607GlnLeu: 3.607 ± 0.084	1.017GlnMet: 1.017 ± 0.043	0.796GlnAsn: 0.796 ± 0.04	1.843GlnPro: 1.843 ± 0.049	1.512GlnGln: 1.512 ± 0.061	2.58GlnArg: 2.58 ± 0.065	1.68GlnSer: 1.68 ± 0.063	2.054GlnThr: 2.054 ± 0.071	3.35GlnVal: 3.35 ± 0.084	0.596GlnTrp: 0.596 ± 0.031	0.675GlnTyr: 0.675 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	7.086ArgAla: 7.086 ± 0.108	0.72ArgCys: 0.72 ± 0.043	4.092ArgAsp: 4.092 ± 0.088	3.565ArgGlu: 3.565 ± 0.08	1.925ArgPhe: 1.925 ± 0.057	4.919ArgGly: 4.919 ± 0.09	2.276ArgHis: 2.276 ± 0.061	3.504ArgIle: 3.504 ± 0.081	2.007ArgLys: 2.007 ± 0.055	6.206ArgLeu: 6.206 ± 0.127	2.024ArgMet: 2.024 ± 0.06	1.734ArgAsn: 1.734 ± 0.06	3.733ArgPro: 3.733 ± 0.092	2.595ArgGln: 2.595 ± 0.07	6.742ArgArg: 6.742 ± 0.137	4.271ArgSer: 4.271 ± 0.081	4.582ArgThr: 4.582 ± 0.095	5.216ArgVal: 5.216 ± 0.094	1.198ArgTrp: 1.198 ± 0.044	1.445ArgTyr: 1.445 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	6.754SerAla: 6.754 ± 0.128	0.634SerCys: 0.634 ± 0.037	3.625SerAsp: 3.625 ± 0.084	2.93SerGlu: 2.93 ± 0.08	1.717SerPhe: 1.717 ± 0.055	6.045SerGly: 6.045 ± 0.115	1.673SerHis: 1.673 ± 0.049	2.563SerIle: 2.563 ± 0.062	1.499SerLys: 1.499 ± 0.059	5.253SerLeu: 5.253 ± 0.107	1.635SerMet: 1.635 ± 0.049	1.361SerAsn: 1.361 ± 0.049	3.15SerPro: 3.15 ± 0.091	2.382SerGln: 2.382 ± 0.062	4.365SerArg: 4.365 ± 0.075	4.513SerSer: 4.513 ± 0.111	4.275SerThr: 4.275 ± 0.085	4.797SerVal: 4.797 ± 0.091	1.165SerTrp: 1.165 ± 0.043	1.277SerTyr: 1.277 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.95ThrAla: 6.95 ± 0.131	0.686ThrCys: 0.686 ± 0.033	4.129ThrAsp: 4.129 ± 0.093	3.058ThrGlu: 3.058 ± 0.076	1.781ThrPhe: 1.781 ± 0.055	5.822ThrGly: 5.822 ± 0.117	1.556ThrHis: 1.556 ± 0.053	3.313ThrIle: 3.313 ± 0.077	1.69ThrLys: 1.69 ± 0.065	5.337ThrLeu: 5.337 ± 0.105	1.603ThrMet: 1.603 ± 0.054	1.536ThrAsn: 1.536 ± 0.054	4.03ThrPro: 4.03 ± 0.114	1.933ThrGln: 1.933 ± 0.055	3.919ThrArg: 3.919 ± 0.092	4.432ThrSer: 4.432 ± 0.1	4.986ThrThr: 4.986 ± 0.11	5.7ThrVal: 5.7 ± 0.112	1.13ThrTrp: 1.13 ± 0.046	1.244ThrTyr: 1.244 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	9.551ValAla: 9.551 ± 0.132	1.067ValCys: 1.067 ± 0.04	6.091ValAsp: 6.091 ± 0.114	4.657ValGlu: 4.657 ± 0.104	2.274ValPhe: 2.274 ± 0.073	6.801ValGly: 6.801 ± 0.119	2.115ValHis: 2.115 ± 0.063	4.402ValIle: 4.402 ± 0.091	2.299ValLys: 2.299 ± 0.076	8.522ValLeu: 8.522 ± 0.145	2.081ValMet: 2.081 ± 0.058	2.303ValAsn: 2.303 ± 0.066	4.629ValPro: 4.629 ± 0.103	2.445ValGln: 2.445 ± 0.063	5.659ValArg: 5.659 ± 0.104	5.262ValSer: 5.262 ± 0.091	6.047ValThr: 6.047 ± 0.106	8.432ValVal: 8.432 ± 0.155	1.141ValTrp: 1.141 ± 0.048	1.274ValTyr: 1.274 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.457TrpAla: 1.457 ± 0.06	0.176TrpCys: 0.176 ± 0.02	0.836TrpAsp: 0.836 ± 0.04	0.542TrpGlu: 0.542 ± 0.027	0.584TrpPhe: 0.584 ± 0.035	1.059TrpGly: 1.059 ± 0.041	0.368TrpHis: 0.368 ± 0.024	0.801TrpIle: 0.801 ± 0.041	0.399TrpLys: 0.399 ± 0.03	1.709TrpLeu: 1.709 ± 0.064	0.369TrpMet: 0.369 ± 0.025	0.379TrpAsn: 0.379 ± 0.028	0.656TrpPro: 0.656 ± 0.03	0.856TrpGln: 0.856 ± 0.043	1.185TrpArg: 1.185 ± 0.053	0.96TrpSer: 0.96 ± 0.042	0.958TrpThr: 0.958 ± 0.043	1.205TrpVal: 1.205 ± 0.048	0.381TrpTrp: 0.381 ± 0.026	0.322TrpTyr: 0.322 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.861TyrAla: 1.861 ± 0.055	0.191TyrCys: 0.191 ± 0.018	1.385TyrAsp: 1.385 ± 0.066	1.004TyrGlu: 1.004 ± 0.045	0.556TyrPhe: 0.556 ± 0.028	1.673TyrGly: 1.673 ± 0.056	0.492TyrHis: 0.492 ± 0.032	0.603TyrIle: 0.603 ± 0.032	0.408TyrLys: 0.408 ± 0.026	2.054TyrLeu: 2.054 ± 0.06	0.287TyrMet: 0.287 ± 0.023	0.433TyrAsn: 0.433 ± 0.029	1.014TyrPro: 1.014 ± 0.039	0.713TyrGln: 0.713 ± 0.035	1.49TyrArg: 1.49 ± 0.056	1.098TyrSer: 1.098 ± 0.043	1.091TyrThr: 1.091 ± 0.044	1.549TyrVal: 1.549 ± 0.056	0.337TyrTrp: 0.337 ± 0.023	0.426TyrTyr: 0.426 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1962 proteins (595837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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