Amino acid dipepetide frequency for Mucilaginibacter lappiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.439AlaAla: 6.439 ± 0.083
0.646AlaCys: 0.646 ± 0.017
4.652AlaAsp: 4.652 ± 0.042
4.044AlaGlu: 4.044 ± 0.052
3.585AlaPhe: 3.585 ± 0.042
5.794AlaGly: 5.794 ± 0.069
1.328AlaHis: 1.328 ± 0.029
5.687AlaIle: 5.687 ± 0.057
4.684AlaLys: 4.684 ± 0.053
6.974AlaLeu: 6.974 ± 0.066
1.71AlaMet: 1.71 ± 0.032
3.834AlaAsn: 3.834 ± 0.052
2.502AlaPro: 2.502 ± 0.037
3.111AlaGln: 3.111 ± 0.041
2.483AlaArg: 2.483 ± 0.037
4.534AlaSer: 4.534 ± 0.058
4.293AlaThr: 4.293 ± 0.063
4.835AlaVal: 4.835 ± 0.063
0.849AlaTrp: 0.849 ± 0.021
3.062AlaTyr: 3.062 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.496CysAla: 0.496 ± 0.019
0.128CysCys: 0.128 ± 0.009
0.373CysAsp: 0.373 ± 0.013
0.33CysGlu: 0.33 ± 0.014
0.467CysPhe: 0.467 ± 0.018
0.593CysGly: 0.593 ± 0.021
0.191CysHis: 0.191 ± 0.011
0.614CysIle: 0.614 ± 0.017
0.504CysLys: 0.504 ± 0.014
0.835CysLeu: 0.835 ± 0.02
0.191CysMet: 0.191 ± 0.01
0.372CysAsn: 0.372 ± 0.012
0.296CysPro: 0.296 ± 0.013
0.238CysGln: 0.238 ± 0.011
0.312CysArg: 0.312 ± 0.013
0.525CysSer: 0.525 ± 0.016
0.45CysThr: 0.45 ± 0.016
0.442CysVal: 0.442 ± 0.015
0.107CysTrp: 0.107 ± 0.007
0.315CysTyr: 0.315 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.027AspAla: 4.027 ± 0.046
0.38AspCys: 0.38 ± 0.014
2.811AspAsp: 2.811 ± 0.048
3.255AspGlu: 3.255 ± 0.048
2.965AspPhe: 2.965 ± 0.041
3.887AspGly: 3.887 ± 0.052
1.226AspHis: 1.226 ± 0.028
4.11AspIle: 4.11 ± 0.053
3.889AspLys: 3.889 ± 0.05
4.862AspLeu: 4.862 ± 0.061
1.21AspMet: 1.21 ± 0.026
2.922AspAsn: 2.922 ± 0.043
2.176AspPro: 2.176 ± 0.034
2.019AspGln: 2.019 ± 0.035
2.019AspArg: 2.019 ± 0.035
2.939AspSer: 2.939 ± 0.042
2.805AspThr: 2.805 ± 0.04
3.482AspVal: 3.482 ± 0.046
0.809AspTrp: 0.809 ± 0.019
2.54AspTyr: 2.54 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
4.016GluAla: 4.016 ± 0.058
0.29GluCys: 0.29 ± 0.014
2.407GluAsp: 2.407 ± 0.033
2.924GluGlu: 2.924 ± 0.051
2.166GluPhe: 2.166 ± 0.037
3.04GluGly: 3.04 ± 0.043
1.125GluHis: 1.125 ± 0.026
3.889GluIle: 3.889 ± 0.053
4.066GluLys: 4.066 ± 0.057
5.441GluLeu: 5.441 ± 0.066
1.279GluMet: 1.279 ± 0.027
2.843GluAsn: 2.843 ± 0.039
1.627GluPro: 1.627 ± 0.03
2.398GluGln: 2.398 ± 0.044
2.24GluArg: 2.24 ± 0.038
2.6GluSer: 2.6 ± 0.039
2.672GluThr: 2.672 ± 0.033
3.426GluVal: 3.426 ± 0.042
0.609GluTrp: 0.609 ± 0.02
1.968GluTyr: 1.968 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.402PheAla: 3.402 ± 0.046
0.446PheCys: 0.446 ± 0.015
2.97PheAsp: 2.97 ± 0.043
2.513PheGlu: 2.513 ± 0.042
2.445PhePhe: 2.445 ± 0.041
3.405PheGly: 3.405 ± 0.042
0.873PheHis: 0.873 ± 0.026
3.745PheIle: 3.745 ± 0.051
3.378PheLys: 3.378 ± 0.043
4.255PheLeu: 4.255 ± 0.054
1.109PheMet: 1.109 ± 0.025
3.126PheAsn: 3.126 ± 0.045
1.724PhePro: 1.724 ± 0.028
1.364PheGln: 1.364 ± 0.03
1.752PheArg: 1.752 ± 0.031
3.49PheSer: 3.49 ± 0.047
3.369PheThr: 3.369 ± 0.045
2.803PheVal: 2.803 ± 0.043
0.617PheTrp: 0.617 ± 0.021
2.146PheTyr: 2.146 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
4.706GlyAla: 4.706 ± 0.062
0.573GlyCys: 0.573 ± 0.018
3.539GlyAsp: 3.539 ± 0.045
3.044GlyGlu: 3.044 ± 0.044
3.758GlyPhe: 3.758 ± 0.049
5.134GlyGly: 5.134 ± 0.067
1.373GlyHis: 1.373 ± 0.027
5.44GlyIle: 5.44 ± 0.061
5.201GlyLys: 5.201 ± 0.055
6.348GlyLeu: 6.348 ± 0.06
1.57GlyMet: 1.57 ± 0.034
3.745GlyAsn: 3.745 ± 0.053
1.767GlyPro: 1.767 ± 0.035
2.391GlyGln: 2.391 ± 0.035
2.528GlyArg: 2.528 ± 0.037
4.538GlySer: 4.538 ± 0.057
4.339GlyThr: 4.339 ± 0.067
4.403GlyVal: 4.403 ± 0.05
1.041GlyTrp: 1.041 ± 0.031
3.269GlyTyr: 3.269 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.225HisAla: 1.225 ± 0.027
0.196HisCys: 0.196 ± 0.01
1.059HisAsp: 1.059 ± 0.026
1.032HisGlu: 1.032 ± 0.025
1.186HisPhe: 1.186 ± 0.025
1.218HisGly: 1.218 ± 0.026
0.654HisHis: 0.654 ± 0.023
1.588HisIle: 1.588 ± 0.029
1.071HisLys: 1.071 ± 0.023
2.012HisLeu: 2.012 ± 0.037
0.406HisMet: 0.406 ± 0.014
1.024HisAsn: 1.024 ± 0.024
1.029HisPro: 1.029 ± 0.024
0.902HisGln: 0.902 ± 0.024
0.767HisArg: 0.767 ± 0.02
1.123HisSer: 1.123 ± 0.023
1.101HisThr: 1.101 ± 0.025
1.065HisVal: 1.065 ± 0.023
0.293HisTrp: 0.293 ± 0.012
0.953HisTyr: 0.953 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.042IleAla: 6.042 ± 0.065
0.687IleCys: 0.687 ± 0.02
4.32IleAsp: 4.32 ± 0.049
3.769IleGlu: 3.769 ± 0.056
3.194IlePhe: 3.194 ± 0.05
4.911IleGly: 4.911 ± 0.062
1.358IleHis: 1.358 ± 0.027
5.414IleIle: 5.414 ± 0.066
5.303IleLys: 5.303 ± 0.051
6.308IleLeu: 6.308 ± 0.062
1.44IleMet: 1.44 ± 0.032
4.665IleAsn: 4.665 ± 0.049
3.228IlePro: 3.228 ± 0.042
2.369IleGln: 2.369 ± 0.038
2.931IleArg: 2.931 ± 0.035
5.216IleSer: 5.216 ± 0.051
4.959IleThr: 4.959 ± 0.06
4.277IleVal: 4.277 ± 0.054
0.754IleTrp: 0.754 ± 0.021
2.775IleTyr: 2.775 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
5.305LysAla: 5.305 ± 0.061
0.296LysCys: 0.296 ± 0.012
3.963LysAsp: 3.963 ± 0.049
3.942LysGlu: 3.942 ± 0.053
2.565LysPhe: 2.565 ± 0.042
4.475LysGly: 4.475 ± 0.047
1.364LysHis: 1.364 ± 0.025
4.802LysIle: 4.802 ± 0.047
5.301LysLys: 5.301 ± 0.058
6.427LysLeu: 6.427 ± 0.065
1.759LysMet: 1.759 ± 0.034
4.224LysAsn: 4.224 ± 0.052
2.922LysPro: 2.922 ± 0.04
3.062LysGln: 3.062 ± 0.045
2.639LysArg: 2.639 ± 0.037
3.844LysSer: 3.844 ± 0.039
4.327LysThr: 4.327 ± 0.051
4.394LysVal: 4.394 ± 0.041
0.786LysTrp: 0.786 ± 0.021
2.881LysTyr: 2.881 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
6.922LeuAla: 6.922 ± 0.064
0.821LeuCys: 0.821 ± 0.019
4.613LeuAsp: 4.613 ± 0.049
4.265LeuGlu: 4.265 ± 0.057
4.821LeuPhe: 4.821 ± 0.058
5.741LeuGly: 5.741 ± 0.058
1.78LeuHis: 1.78 ± 0.032
6.982LeuIle: 6.982 ± 0.075
7.27LeuLys: 7.27 ± 0.071
9.753LeuLeu: 9.753 ± 0.093
2.135LeuMet: 2.135 ± 0.032
5.708LeuAsn: 5.708 ± 0.068
4.163LeuPro: 4.163 ± 0.049
3.782LeuGln: 3.782 ± 0.043
3.548LeuArg: 3.548 ± 0.043
6.844LeuSer: 6.844 ± 0.058
5.775LeuThr: 5.775 ± 0.063
5.525LeuVal: 5.525 ± 0.061
0.985LeuTrp: 0.985 ± 0.025
3.412LeuTyr: 3.412 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
1.842MetAla: 1.842 ± 0.033
0.14MetCys: 0.14 ± 0.007
1.191MetAsp: 1.191 ± 0.026
1.294MetGlu: 1.294 ± 0.026
0.829MetPhe: 0.829 ± 0.024
1.444MetGly: 1.444 ± 0.032
0.471MetHis: 0.471 ± 0.015
1.563MetIle: 1.563 ± 0.031
1.897MetLys: 1.897 ± 0.032
2.151MetLeu: 2.151 ± 0.038
0.585MetMet: 0.585 ± 0.021
1.234MetAsn: 1.234 ± 0.022
1.053MetPro: 1.053 ± 0.027
0.961MetGln: 0.961 ± 0.022
0.89MetArg: 0.89 ± 0.026
1.295MetSer: 1.295 ± 0.025
1.109MetThr: 1.109 ± 0.025
1.42MetVal: 1.42 ± 0.03
0.183MetTrp: 0.183 ± 0.011
0.639MetTyr: 0.639 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
4.037AsnAla: 4.037 ± 0.051
0.417AsnCys: 0.417 ± 0.016
2.98AsnAsp: 2.98 ± 0.044
2.781AsnGlu: 2.781 ± 0.04
2.696AsnPhe: 2.696 ± 0.041
4.176AsnGly: 4.176 ± 0.057
1.127AsnHis: 1.127 ± 0.027
4.252AsnIle: 4.252 ± 0.053
3.698AsnLys: 3.698 ± 0.047
5.038AsnLeu: 5.038 ± 0.053
1.24AsnMet: 1.24 ± 0.023
3.741AsnAsn: 3.741 ± 0.051
2.821AsnPro: 2.821 ± 0.04
2.284AsnGln: 2.284 ± 0.042
2.266AsnArg: 2.266 ± 0.035
3.515AsnSer: 3.515 ± 0.046
3.493AsnThr: 3.493 ± 0.064
3.227AsnVal: 3.227 ± 0.046
0.837AsnTrp: 0.837 ± 0.024
2.832AsnTyr: 2.832 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.423ProAla: 3.423 ± 0.047
0.212ProCys: 0.212 ± 0.01
2.714ProAsp: 2.714 ± 0.038
2.668ProGlu: 2.668 ± 0.043
1.946ProPhe: 1.946 ± 0.032
3.089ProGly: 3.089 ± 0.044
0.752ProHis: 0.752 ± 0.019
2.415ProIle: 2.415 ± 0.033
2.186ProLys: 2.186 ± 0.032
3.471ProLeu: 3.471 ± 0.047
0.727ProMet: 0.727 ± 0.018
2.009ProAsn: 2.009 ± 0.033
1.151ProPro: 1.151 ± 0.03
1.576ProGln: 1.576 ± 0.029
1.109ProArg: 1.109 ± 0.025
2.281ProSer: 2.281 ± 0.033
2.1ProThr: 2.1 ± 0.042
3.416ProVal: 3.416 ± 0.042
0.475ProTrp: 0.475 ± 0.016
1.624ProTyr: 1.624 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.801GlnAla: 2.801 ± 0.041
0.197GlnCys: 0.197 ± 0.011
1.691GlnAsp: 1.691 ± 0.025
1.961GlnGlu: 1.961 ± 0.036
1.755GlnPhe: 1.755 ± 0.031
2.128GlnGly: 2.128 ± 0.034
0.865GlnHis: 0.865 ± 0.024
2.69GlnIle: 2.69 ± 0.04
2.765GlnLys: 2.765 ± 0.038
4.15GlnLeu: 4.15 ± 0.054
0.943GlnMet: 0.943 ± 0.022
2.251GlnAsn: 2.251 ± 0.041
1.565GlnPro: 1.565 ± 0.028
2.321GlnGln: 2.321 ± 0.055
1.51GlnArg: 1.51 ± 0.029
2.326GlnSer: 2.326 ± 0.038
2.355GlnThr: 2.355 ± 0.033
2.579GlnVal: 2.579 ± 0.038
0.499GlnTrp: 0.499 ± 0.015
1.703GlnTyr: 1.703 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.357ArgAla: 2.357 ± 0.031
0.22ArgCys: 0.22 ± 0.01
2.02ArgAsp: 2.02 ± 0.034
2.065ArgGlu: 2.065 ± 0.034
2.046ArgPhe: 2.046 ± 0.03
2.129ArgGly: 2.129 ± 0.036
0.71ArgHis: 0.71 ± 0.018
2.997ArgIle: 2.997 ± 0.041
2.662ArgLys: 2.662 ± 0.038
3.718ArgLeu: 3.718 ± 0.038
0.953ArgMet: 0.953 ± 0.024
2.13ArgAsn: 2.13 ± 0.036
1.317ArgPro: 1.317 ± 0.029
1.462ArgGln: 1.462 ± 0.031
1.49ArgArg: 1.49 ± 0.031
2.236ArgSer: 2.236 ± 0.037
2.005ArgThr: 2.005 ± 0.035
2.427ArgVal: 2.427 ± 0.041
0.491ArgTrp: 0.491 ± 0.016
1.828ArgTyr: 1.828 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
4.792SerAla: 4.792 ± 0.055
0.616SerCys: 0.616 ± 0.018
3.021SerAsp: 3.021 ± 0.041
2.676SerGlu: 2.676 ± 0.041
3.588SerPhe: 3.588 ± 0.048
4.986SerGly: 4.986 ± 0.056
1.161SerHis: 1.161 ± 0.025
4.742SerIle: 4.742 ± 0.053
3.947SerLys: 3.947 ± 0.046
6.132SerLeu: 6.132 ± 0.063
1.26SerMet: 1.26 ± 0.032
3.3SerAsn: 3.3 ± 0.043
2.517SerPro: 2.517 ± 0.041
2.053SerGln: 2.053 ± 0.034
2.354SerArg: 2.354 ± 0.036
4.095SerSer: 4.095 ± 0.054
3.75SerThr: 3.75 ± 0.052
4.31SerVal: 4.31 ± 0.046
0.796SerTrp: 0.796 ± 0.021
2.81SerTyr: 2.81 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.841ThrAla: 4.841 ± 0.067
0.417ThrCys: 0.417 ± 0.015
3.655ThrAsp: 3.655 ± 0.047
2.934ThrGlu: 2.934 ± 0.041
2.814ThrPhe: 2.814 ± 0.036
5.038ThrGly: 5.038 ± 0.072
1.147ThrHis: 1.147 ± 0.025
4.487ThrIle: 4.487 ± 0.049
3.229ThrLys: 3.229 ± 0.047
5.634ThrLeu: 5.634 ± 0.063
1.041ThrMet: 1.041 ± 0.024
3.145ThrAsn: 3.145 ± 0.051
2.794ThrPro: 2.794 ± 0.044
2.092ThrGln: 2.092 ± 0.036
1.986ThrArg: 1.986 ± 0.033
3.683ThrSer: 3.683 ± 0.055
3.761ThrThr: 3.761 ± 0.058
4.034ThrVal: 4.034 ± 0.065
0.697ThrTrp: 0.697 ± 0.021
2.584ThrTyr: 2.584 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
4.649ValAla: 4.649 ± 0.059
0.588ValCys: 0.588 ± 0.02
3.376ValAsp: 3.376 ± 0.039
3.009ValGlu: 3.009 ± 0.045
3.14ValPhe: 3.14 ± 0.045
3.741ValGly: 3.741 ± 0.051
1.11ValHis: 1.11 ± 0.025
4.968ValIle: 4.968 ± 0.055
4.624ValLys: 4.624 ± 0.05
6.077ValLeu: 6.077 ± 0.06
1.465ValMet: 1.465 ± 0.027
3.829ValAsn: 3.829 ± 0.049
2.458ValPro: 2.458 ± 0.036
2.156ValGln: 2.156 ± 0.035
2.136ValArg: 2.136 ± 0.031
4.424ValSer: 4.424 ± 0.051
3.989ValThr: 3.989 ± 0.055
4.208ValVal: 4.208 ± 0.053
0.729ValTrp: 0.729 ± 0.018
2.572ValTyr: 2.572 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.826TrpAla: 0.826 ± 0.021
0.135TrpCys: 0.135 ± 0.009
0.685TrpAsp: 0.685 ± 0.019
0.637TrpGlu: 0.637 ± 0.019
0.638TrpPhe: 0.638 ± 0.02
0.878TrpGly: 0.878 ± 0.025
0.298TrpHis: 0.298 ± 0.013
0.803TrpIle: 0.803 ± 0.024
0.811TrpLys: 0.811 ± 0.022
1.244TrpLeu: 1.244 ± 0.029
0.344TrpMet: 0.344 ± 0.013
0.679TrpAsn: 0.679 ± 0.018
0.412TrpPro: 0.412 ± 0.015
0.624TrpGln: 0.624 ± 0.018
0.501TrpArg: 0.501 ± 0.018
0.683TrpSer: 0.683 ± 0.022
0.673TrpThr: 0.673 ± 0.022
0.729TrpVal: 0.729 ± 0.022
0.206TrpTrp: 0.206 ± 0.01
0.518TrpTyr: 0.518 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.898TyrAla: 2.898 ± 0.043
0.376TyrCys: 0.376 ± 0.013
2.295TyrAsp: 2.295 ± 0.036
1.88TyrGlu: 1.88 ± 0.035
2.331TyrPhe: 2.331 ± 0.034
2.898TyrGly: 2.898 ± 0.039
0.988TyrHis: 0.988 ± 0.022
2.731TyrIle: 2.731 ± 0.036
2.794TyrLys: 2.794 ± 0.044
4.015TyrLeu: 4.015 ± 0.052
0.825TyrMet: 0.825 ± 0.021
2.677TyrAsn: 2.677 ± 0.05
1.821TyrPro: 1.821 ± 0.029
1.891TyrGln: 1.891 ± 0.036
1.805TyrArg: 1.805 ± 0.03
2.712TyrSer: 2.712 ± 0.042
2.687TyrThr: 2.687 ± 0.043
2.246TyrVal: 2.246 ± 0.034
0.561TyrTrp: 0.561 ± 0.019
2.0TyrTyr: 2.0 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5808 proteins (1973590 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski