Amino acid dipepetide frequency for Paracoccus seriniphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.184AlaAla: 16.184 ± 0.173	1.104AlaCys: 1.104 ± 0.028	6.779AlaAsp: 6.779 ± 0.077	7.978AlaGlu: 7.978 ± 0.096	3.973AlaPhe: 3.973 ± 0.065	10.58AlaGly: 10.58 ± 0.105	2.338AlaHis: 2.338 ± 0.045	6.258AlaIle: 6.258 ± 0.077	3.182AlaLys: 3.182 ± 0.059	13.064AlaLeu: 13.064 ± 0.12	4.047AlaMet: 4.047 ± 0.056	2.69AlaAsn: 2.69 ± 0.048	5.396AlaPro: 5.396 ± 0.08	4.74AlaGln: 4.74 ± 0.075	9.407AlaArg: 9.407 ± 0.107	5.855AlaSer: 5.855 ± 0.073	5.924AlaThr: 5.924 ± 0.075	8.038AlaVal: 8.038 ± 0.084	1.43AlaTrp: 1.43 ± 0.033	2.333AlaTyr: 2.333 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.086CysAla: 1.086 ± 0.029	0.124CysCys: 0.124 ± 0.01	0.668CysAsp: 0.668 ± 0.024	0.441CysGlu: 0.441 ± 0.023	0.328CysPhe: 0.328 ± 0.017	0.997CysGly: 0.997 ± 0.029	0.304CysHis: 0.304 ± 0.015	0.423CysIle: 0.423 ± 0.019	0.223CysLys: 0.223 ± 0.014	0.927CysLeu: 0.927 ± 0.029	0.195CysMet: 0.195 ± 0.013	0.246CysAsn: 0.246 ± 0.013	0.528CysPro: 0.528 ± 0.021	0.274CysGln: 0.274 ± 0.015	0.612CysArg: 0.612 ± 0.025	0.514CysSer: 0.514 ± 0.02	0.428CysThr: 0.428 ± 0.018	0.607CysVal: 0.607 ± 0.023	0.122CysTrp: 0.122 ± 0.01	0.199CysTyr: 0.199 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.775AspAla: 6.775 ± 0.095	0.599AspCys: 0.599 ± 0.021	3.557AspAsp: 3.557 ± 0.059	3.641AspGlu: 3.641 ± 0.053	2.307AspPhe: 2.307 ± 0.046	5.297AspGly: 5.297 ± 0.08	1.509AspHis: 1.509 ± 0.034	3.197AspIle: 3.197 ± 0.053	1.587AspLys: 1.587 ± 0.036	6.644AspLeu: 6.644 ± 0.076	1.781AspMet: 1.781 ± 0.034	1.358AspAsn: 1.358 ± 0.034	3.836AspPro: 3.836 ± 0.052	2.117AspGln: 2.117 ± 0.045	4.547AspArg: 4.547 ± 0.061	2.704AspSer: 2.704 ± 0.047	2.41AspThr: 2.41 ± 0.052	3.916AspVal: 3.916 ± 0.05	1.181AspTrp: 1.181 ± 0.031	1.535AspTyr: 1.535 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.419GluAla: 7.419 ± 0.102	0.377GluCys: 0.377 ± 0.02	3.307GluAsp: 3.307 ± 0.062	3.369GluGlu: 3.369 ± 0.063	1.915GluPhe: 1.915 ± 0.041	4.555GluGly: 4.555 ± 0.062	1.192GluHis: 1.192 ± 0.034	3.716GluIle: 3.716 ± 0.057	1.963GluLys: 1.963 ± 0.048	5.482GluLeu: 5.482 ± 0.067	1.853GluMet: 1.853 ± 0.037	1.747GluAsn: 1.747 ± 0.04	2.425GluPro: 2.425 ± 0.043	2.091GluGln: 2.091 ± 0.044	4.135GluArg: 4.135 ± 0.066	2.389GluSer: 2.389 ± 0.044	3.442GluThr: 3.442 ± 0.058	3.925GluVal: 3.925 ± 0.067	0.755GluTrp: 0.755 ± 0.026	1.141GluTyr: 1.141 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.333PheAla: 4.333 ± 0.068	0.452PheCys: 0.452 ± 0.017	2.831PheAsp: 2.831 ± 0.047	1.946PheGlu: 1.946 ± 0.044	1.298PhePhe: 1.298 ± 0.035	3.557PheGly: 3.557 ± 0.057	0.774PheHis: 0.774 ± 0.026	1.703PheIle: 1.703 ± 0.037	0.782PheLys: 0.782 ± 0.027	3.54PheLeu: 3.54 ± 0.069	0.882PheMet: 0.882 ± 0.026	0.982PheAsn: 0.982 ± 0.031	1.612PhePro: 1.612 ± 0.038	1.078PheGln: 1.078 ± 0.031	2.293PheArg: 2.293 ± 0.04	2.238PheSer: 2.238 ± 0.043	1.953PheThr: 1.953 ± 0.044	2.533PheVal: 2.533 ± 0.054	0.618PheTrp: 0.618 ± 0.02	0.83PheTyr: 0.83 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.349GlyAla: 9.349 ± 0.087	0.872GlyCys: 0.872 ± 0.024	4.542GlyAsp: 4.542 ± 0.071	4.648GlyGlu: 4.648 ± 0.066	3.653GlyPhe: 3.653 ± 0.059	7.126GlyGly: 7.126 ± 0.104	2.019GlyHis: 2.019 ± 0.042	4.682GlyIle: 4.682 ± 0.072	3.17GlyLys: 3.17 ± 0.053	9.455GlyLeu: 9.455 ± 0.114	2.706GlyMet: 2.706 ± 0.038	2.269GlyAsn: 2.269 ± 0.052	3.657GlyPro: 3.657 ± 0.052	3.433GlyGln: 3.433 ± 0.057	6.101GlyArg: 6.101 ± 0.075	4.386GlySer: 4.386 ± 0.064	4.309GlyThr: 4.309 ± 0.073	6.222GlyVal: 6.222 ± 0.077	1.538GlyTrp: 1.538 ± 0.038	2.254GlyTyr: 2.254 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.343HisAla: 2.343 ± 0.043	0.252HisCys: 0.252 ± 0.015	1.539HisAsp: 1.539 ± 0.041	1.17HisGlu: 1.17 ± 0.031	0.838HisPhe: 0.838 ± 0.024	2.037HisGly: 2.037 ± 0.042	0.579HisHis: 0.579 ± 0.023	0.991HisIle: 0.991 ± 0.03	0.505HisLys: 0.505 ± 0.019	2.217HisLeu: 2.217 ± 0.046	0.633HisMet: 0.633 ± 0.024	0.438HisAsn: 0.438 ± 0.02	1.41HisPro: 1.41 ± 0.037	0.648HisGln: 0.648 ± 0.023	1.476HisArg: 1.476 ± 0.039	1.054HisSer: 1.054 ± 0.028	0.647HisThr: 0.647 ± 0.023	1.606HisVal: 1.606 ± 0.037	0.328HisTrp: 0.328 ± 0.016	0.513HisTyr: 0.513 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.467IleAla: 7.467 ± 0.083	0.673IleCys: 0.673 ± 0.022	3.517IleAsp: 3.517 ± 0.057	3.441IleGlu: 3.441 ± 0.05	1.877IlePhe: 1.877 ± 0.046	5.196IleGly: 5.196 ± 0.069	1.017IleHis: 1.017 ± 0.031	2.442IleIle: 2.442 ± 0.058	1.234IleLys: 1.234 ± 0.034	5.095IleLeu: 5.095 ± 0.069	1.242IleMet: 1.242 ± 0.033	1.386IleAsn: 1.386 ± 0.033	2.477IlePro: 2.477 ± 0.042	1.237IleGln: 1.237 ± 0.03	3.672IleArg: 3.672 ± 0.053	3.43IleSer: 3.43 ± 0.051	2.841IleThr: 2.841 ± 0.054	3.781IleVal: 3.781 ± 0.065	0.784IleTrp: 0.784 ± 0.027	1.15IleTyr: 1.15 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.542LysAla: 3.542 ± 0.053	0.165LysCys: 0.165 ± 0.012	1.564LysAsp: 1.564 ± 0.037	1.39LysGlu: 1.39 ± 0.035	0.85LysPhe: 0.85 ± 0.026	2.487LysGly: 2.487 ± 0.049	0.54LysHis: 0.54 ± 0.02	1.6LysIle: 1.6 ± 0.042	1.024LysLys: 1.024 ± 0.037	2.849LysLeu: 2.849 ± 0.058	0.824LysMet: 0.824 ± 0.026	0.742LysAsn: 0.742 ± 0.025	1.707LysPro: 1.707 ± 0.04	0.869LysGln: 0.869 ± 0.027	1.997LysArg: 1.997 ± 0.046	1.745LysSer: 1.745 ± 0.04	1.707LysThr: 1.707 ± 0.039	2.077LysVal: 2.077 ± 0.049	0.375LysTrp: 0.375 ± 0.018	0.61LysTyr: 0.61 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.02LeuAla: 13.02 ± 0.135	0.992LeuCys: 0.992 ± 0.029	6.106LeuAsp: 6.106 ± 0.087	5.113LeuGlu: 5.113 ± 0.07	3.459LeuPhe: 3.459 ± 0.061	8.53LeuGly: 8.53 ± 0.105	1.991LeuHis: 1.991 ± 0.047	5.683LeuIle: 5.683 ± 0.078	2.943LeuLys: 2.943 ± 0.045	9.291LeuLeu: 9.291 ± 0.141	2.78LeuMet: 2.78 ± 0.054	2.689LeuAsn: 2.689 ± 0.042	5.961LeuPro: 5.961 ± 0.079	3.155LeuGln: 3.155 ± 0.048	7.376LeuArg: 7.376 ± 0.09	6.868LeuSer: 6.868 ± 0.082	6.214LeuThr: 6.214 ± 0.073	6.759LeuVal: 6.759 ± 0.089	1.281LeuTrp: 1.281 ± 0.037	1.921LeuTyr: 1.921 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.731MetAla: 3.731 ± 0.056	0.182MetCys: 0.182 ± 0.012	1.395MetAsp: 1.395 ± 0.031	1.242MetGlu: 1.242 ± 0.035	0.854MetPhe: 0.854 ± 0.027	2.348MetGly: 2.348 ± 0.042	0.452MetHis: 0.452 ± 0.02	1.747MetIle: 1.747 ± 0.04	1.104MetLys: 1.104 ± 0.032	2.789MetLeu: 2.789 ± 0.049	0.856MetMet: 0.856 ± 0.026	0.952MetAsn: 0.952 ± 0.028	1.637MetPro: 1.637 ± 0.036	1.115MetGln: 1.115 ± 0.03	2.019MetArg: 2.019 ± 0.041	1.877MetSer: 1.877 ± 0.038	2.196MetThr: 2.196 ± 0.036	1.999MetVal: 1.999 ± 0.042	0.267MetTrp: 0.267 ± 0.016	0.336MetTyr: 0.336 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.064AsnAla: 3.064 ± 0.05	0.29AsnCys: 0.29 ± 0.016	1.471AsnAsp: 1.471 ± 0.04	1.213AsnGlu: 1.213 ± 0.032	0.979AsnPhe: 0.979 ± 0.027	2.376AsnGly: 2.376 ± 0.048	0.54AsnHis: 0.54 ± 0.02	1.407AsnIle: 1.407 ± 0.037	0.658AsnLys: 0.658 ± 0.023	2.622AsnLeu: 2.622 ± 0.048	0.726AsnMet: 0.726 ± 0.024	0.655AsnAsn: 0.655 ± 0.024	1.838AsnPro: 1.838 ± 0.037	0.735AsnGln: 0.735 ± 0.025	1.883AsnArg: 1.883 ± 0.041	1.309AsnSer: 1.309 ± 0.031	1.172AsnThr: 1.172 ± 0.033	1.797AsnVal: 1.797 ± 0.035	0.51AsnTrp: 0.51 ± 0.022	0.653AsnTyr: 0.653 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.209ProAla: 6.209 ± 0.082	0.407ProCys: 0.407 ± 0.022	4.152ProAsp: 4.152 ± 0.062	4.234ProGlu: 4.234 ± 0.075	1.932ProPhe: 1.932 ± 0.04	4.438ProGly: 4.438 ± 0.063	1.066ProHis: 1.066 ± 0.032	2.248ProIle: 2.248 ± 0.043	1.413ProLys: 1.413 ± 0.035	4.762ProLeu: 4.762 ± 0.058	1.324ProMet: 1.324 ± 0.032	1.186ProAsn: 1.186 ± 0.033	2.229ProPro: 2.229 ± 0.046	1.847ProGln: 1.847 ± 0.036	3.116ProArg: 3.116 ± 0.05	2.602ProSer: 2.602 ± 0.047	2.268ProThr: 2.268 ± 0.053	4.405ProVal: 4.405 ± 0.067	0.69ProTrp: 0.69 ± 0.025	1.125ProTyr: 1.125 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.41GlnAla: 4.41 ± 0.07	0.224GlnCys: 0.224 ± 0.014	1.923GlnAsp: 1.923 ± 0.04	1.704GlnGlu: 1.704 ± 0.038	1.073GlnPhe: 1.073 ± 0.028	2.886GlnGly: 2.886 ± 0.055	0.67GlnHis: 0.67 ± 0.023	2.309GlnIle: 2.309 ± 0.04	1.068GlnLys: 1.068 ± 0.031	3.147GlnLeu: 3.147 ± 0.05	1.158GlnMet: 1.158 ± 0.028	0.981GlnAsn: 0.981 ± 0.026	1.966GlnPro: 1.966 ± 0.042	1.421GlnGln: 1.421 ± 0.038	2.555GlnArg: 2.555 ± 0.049	1.897GlnSer: 1.897 ± 0.037	1.839GlnThr: 1.839 ± 0.034	2.425GlnVal: 2.425 ± 0.043	0.441GlnTrp: 0.441 ± 0.019	0.604GlnTyr: 0.604 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.103ArgAla: 8.103 ± 0.097	0.521ArgCys: 0.521 ± 0.021	4.619ArgAsp: 4.619 ± 0.068	3.944ArgGlu: 3.944 ± 0.067	2.758ArgPhe: 2.758 ± 0.053	4.779ArgGly: 4.779 ± 0.056	1.851ArgHis: 1.851 ± 0.039	4.352ArgIle: 4.352 ± 0.066	2.358ArgLys: 2.358 ± 0.053	7.961ArgLeu: 7.961 ± 0.097	2.16ArgMet: 2.16 ± 0.042	2.059ArgAsn: 2.059 ± 0.038	3.656ArgPro: 3.656 ± 0.061	2.851ArgGln: 2.851 ± 0.049	5.465ArgArg: 5.465 ± 0.077	3.544ArgSer: 3.544 ± 0.059	2.743ArgThr: 2.743 ± 0.047	4.587ArgVal: 4.587 ± 0.067	0.98ArgTrp: 0.98 ± 0.027	1.473ArgTyr: 1.473 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.186SerAla: 6.186 ± 0.076	0.497SerCys: 0.497 ± 0.019	3.368SerAsp: 3.368 ± 0.058	2.858SerGlu: 2.858 ± 0.056	2.314SerPhe: 2.314 ± 0.046	5.853SerGly: 5.853 ± 0.083	1.141SerHis: 1.141 ± 0.034	2.641SerIle: 2.641 ± 0.047	1.387SerLys: 1.387 ± 0.036	5.426SerLeu: 5.426 ± 0.067	1.468SerMet: 1.468 ± 0.034	1.332SerAsn: 1.332 ± 0.036	2.782SerPro: 2.782 ± 0.043	1.808SerGln: 1.808 ± 0.041	3.796SerArg: 3.796 ± 0.057	2.757SerSer: 2.757 ± 0.051	2.567SerThr: 2.567 ± 0.045	3.708SerVal: 3.708 ± 0.058	0.755SerTrp: 0.755 ± 0.023	1.334SerTyr: 1.334 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.967ThrAla: 5.967 ± 0.075	0.516ThrCys: 0.516 ± 0.02	3.023ThrAsp: 3.023 ± 0.056	2.861ThrGlu: 2.861 ± 0.052	1.698ThrPhe: 1.698 ± 0.04	5.196ThrGly: 5.196 ± 0.065	1.065ThrHis: 1.065 ± 0.028	2.688ThrIle: 2.688 ± 0.05	1.186ThrLys: 1.186 ± 0.035	5.495ThrLeu: 5.495 ± 0.071	1.329ThrMet: 1.329 ± 0.037	1.199ThrAsn: 1.199 ± 0.03	3.241ThrPro: 3.241 ± 0.057	1.601ThrGln: 1.601 ± 0.036	3.597ThrArg: 3.597 ± 0.05	2.718ThrSer: 2.718 ± 0.052	2.7ThrThr: 2.7 ± 0.05	3.931ThrVal: 3.931 ± 0.048	0.621ThrTrp: 0.621 ± 0.02	1.05ThrTyr: 1.05 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.508ValAla: 8.508 ± 0.101	0.611ValCys: 0.611 ± 0.024	3.852ValAsp: 3.852 ± 0.05	4.249ValGlu: 4.249 ± 0.066	2.646ValPhe: 2.646 ± 0.052	5.092ValGly: 5.092 ± 0.071	1.271ValHis: 1.271 ± 0.035	4.282ValIle: 4.282 ± 0.064	1.924ValLys: 1.924 ± 0.046	7.34ValLeu: 7.34 ± 0.089	2.24ValMet: 2.24 ± 0.045	1.968ValAsn: 1.968 ± 0.039	3.506ValPro: 3.506 ± 0.051	2.218ValGln: 2.218 ± 0.044	3.952ValArg: 3.952 ± 0.058	4.155ValSer: 4.155 ± 0.056	4.597ValThr: 4.597 ± 0.065	5.325ValVal: 5.325 ± 0.074	0.947ValTrp: 0.947 ± 0.031	1.3ValTyr: 1.3 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.341TrpAla: 1.341 ± 0.036	0.148TrpCys: 0.148 ± 0.009	0.742TrpAsp: 0.742 ± 0.028	0.595TrpGlu: 0.595 ± 0.023	0.611TrpPhe: 0.611 ± 0.023	1.003TrpGly: 1.003 ± 0.031	0.36TrpHis: 0.36 ± 0.016	0.725TrpIle: 0.725 ± 0.029	0.442TrpLys: 0.442 ± 0.02	1.793TrpLeu: 1.793 ± 0.037	0.404TrpMet: 0.404 ± 0.018	0.452TrpAsn: 0.452 ± 0.02	0.71TrpPro: 0.71 ± 0.02	0.727TrpGln: 0.727 ± 0.026	1.163TrpArg: 1.163 ± 0.035	0.819TrpSer: 0.819 ± 0.023	0.753TrpThr: 0.753 ± 0.026	0.878TrpVal: 0.878 ± 0.028	0.234TrpTrp: 0.234 ± 0.014	0.285TrpTyr: 0.285 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.263TyrAla: 2.263 ± 0.047	0.243TyrCys: 0.243 ± 0.014	1.543TyrAsp: 1.543 ± 0.037	1.161TyrGlu: 1.161 ± 0.034	0.873TyrPhe: 0.873 ± 0.026	2.056TyrGly: 2.056 ± 0.042	0.543TyrHis: 0.543 ± 0.021	0.864TyrIle: 0.864 ± 0.03	0.511TyrLys: 0.511 ± 0.023	2.232TyrLeu: 2.232 ± 0.042	0.491TyrMet: 0.491 ± 0.02	0.569TyrAsn: 0.569 ± 0.021	1.076TyrPro: 1.076 ± 0.031	0.735TyrGln: 0.735 ± 0.025	1.601TyrArg: 1.601 ± 0.037	1.118TyrSer: 1.118 ± 0.032	0.972TyrThr: 0.972 ± 0.03	1.464TyrVal: 1.464 ± 0.034	0.329TyrTrp: 0.329 ± 0.015	0.562TyrTyr: 0.562 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3981 proteins (1275686 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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