Amino acid dipepetide frequency for Acidiphilium rubrum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.98AlaAla: 22.98 ± 0.239
1.21AlaCys: 1.21 ± 0.033
7.197AlaAsp: 7.197 ± 0.091
6.819AlaGlu: 6.819 ± 0.09
4.254AlaPhe: 4.254 ± 0.061
12.65AlaGly: 12.65 ± 0.132
2.875AlaHis: 2.875 ± 0.059
7.893AlaIle: 7.893 ± 0.09
3.525AlaLys: 3.525 ± 0.07
15.781AlaLeu: 15.781 ± 0.133
4.067AlaMet: 4.067 ± 0.06
3.038AlaAsn: 3.038 ± 0.057
7.274AlaPro: 7.274 ± 0.098
4.296AlaGln: 4.296 ± 0.067
10.245AlaArg: 10.245 ± 0.122
6.592AlaSer: 6.592 ± 0.088
7.766AlaThr: 7.766 ± 0.091
9.392AlaVal: 9.392 ± 0.112
1.734AlaTrp: 1.734 ± 0.036
2.449AlaTyr: 2.449 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.16CysAla: 1.16 ± 0.031
0.099CysCys: 0.099 ± 0.011
0.539CysAsp: 0.539 ± 0.022
0.323CysGlu: 0.323 ± 0.017
0.321CysPhe: 0.321 ± 0.017
0.918CysGly: 0.918 ± 0.029
0.273CysHis: 0.273 ± 0.017
0.387CysIle: 0.387 ± 0.018
0.163CysLys: 0.163 ± 0.012
0.771CysLeu: 0.771 ± 0.028
0.156CysMet: 0.156 ± 0.011
0.2CysAsn: 0.2 ± 0.014
0.479CysPro: 0.479 ± 0.02
0.214CysGln: 0.214 ± 0.015
0.673CysArg: 0.673 ± 0.024
0.394CysSer: 0.394 ± 0.02
0.478CysThr: 0.478 ± 0.019
0.583CysVal: 0.583 ± 0.023
0.107CysTrp: 0.107 ± 0.009
0.179CysTyr: 0.179 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.54AspAla: 7.54 ± 0.088
0.498AspCys: 0.498 ± 0.02
2.921AspAsp: 2.921 ± 0.06
2.677AspGlu: 2.677 ± 0.052
2.094AspPhe: 2.094 ± 0.044
4.63AspGly: 4.63 ± 0.067
1.612AspHis: 1.612 ± 0.044
2.993AspIle: 2.993 ± 0.058
1.107AspLys: 1.107 ± 0.034
5.804AspLeu: 5.804 ± 0.071
1.138AspMet: 1.138 ± 0.031
1.104AspAsn: 1.104 ± 0.034
3.669AspPro: 3.669 ± 0.058
1.995AspGln: 1.995 ± 0.041
4.317AspArg: 4.317 ± 0.067
1.836AspSer: 1.836 ± 0.043
2.453AspThr: 2.453 ± 0.048
3.573AspVal: 3.573 ± 0.055
0.939AspTrp: 0.939 ± 0.029
1.394AspTyr: 1.394 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.91GluAla: 6.91 ± 0.093
0.308GluCys: 0.308 ± 0.017
2.01GluAsp: 2.01 ± 0.051
1.48GluGlu: 1.48 ± 0.043
1.482GluPhe: 1.482 ± 0.033
3.099GluGly: 3.099 ± 0.055
1.105GluHis: 1.105 ± 0.033
2.932GluIle: 2.932 ± 0.052
1.146GluLys: 1.146 ± 0.035
3.938GluLeu: 3.938 ± 0.059
1.058GluMet: 1.058 ± 0.029
1.081GluAsn: 1.081 ± 0.03
2.542GluPro: 2.542 ± 0.046
1.722GluGln: 1.722 ± 0.04
4.012GluArg: 4.012 ± 0.068
1.955GluSer: 1.955 ± 0.043
3.37GluThr: 3.37 ± 0.062
2.542GluVal: 2.542 ± 0.055
0.426GluTrp: 0.426 ± 0.018
0.766GluTyr: 0.766 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
5.103PheAla: 5.103 ± 0.068
0.403PheCys: 0.403 ± 0.021
2.422PheAsp: 2.422 ± 0.053
1.705PheGlu: 1.705 ± 0.041
1.207PhePhe: 1.207 ± 0.044
3.847PheGly: 3.847 ± 0.067
0.858PheHis: 0.858 ± 0.027
1.889PheIle: 1.889 ± 0.044
0.82PheLys: 0.82 ± 0.028
3.181PheLeu: 3.181 ± 0.06
0.799PheMet: 0.799 ± 0.025
1.041PheAsn: 1.041 ± 0.033
1.506PhePro: 1.506 ± 0.036
0.913PheGln: 0.913 ± 0.03
2.179PheArg: 2.179 ± 0.045
1.821PheSer: 1.821 ± 0.041
2.299PheThr: 2.299 ± 0.046
2.501PheVal: 2.501 ± 0.05
0.493PheTrp: 0.493 ± 0.019
0.893PheTyr: 0.893 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
10.992GlyAla: 10.992 ± 0.136
0.846GlyCys: 0.846 ± 0.028
4.042GlyAsp: 4.042 ± 0.056
3.639GlyGlu: 3.639 ± 0.06
3.979GlyPhe: 3.979 ± 0.058
7.722GlyGly: 7.722 ± 0.15
2.004GlyHis: 2.004 ± 0.045
5.161GlyIle: 5.161 ± 0.067
2.745GlyLys: 2.745 ± 0.058
9.298GlyLeu: 9.298 ± 0.08
2.416GlyMet: 2.416 ± 0.043
2.184GlyAsn: 2.184 ± 0.046
3.768GlyPro: 3.768 ± 0.055
2.704GlyGln: 2.704 ± 0.049
5.87GlyArg: 5.87 ± 0.076
4.644GlySer: 4.644 ± 0.088
5.189GlyThr: 5.189 ± 0.082
6.467GlyVal: 6.467 ± 0.077
1.317GlyTrp: 1.317 ± 0.037
2.17GlyTyr: 2.17 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
3.089HisAla: 3.089 ± 0.066
0.255HisCys: 0.255 ± 0.015
1.49HisAsp: 1.49 ± 0.033
1.079HisGlu: 1.079 ± 0.03
0.857HisPhe: 0.857 ± 0.027
2.366HisGly: 2.366 ± 0.048
0.766HisHis: 0.766 ± 0.03
1.14HisIle: 1.14 ± 0.034
0.521HisLys: 0.521 ± 0.02
2.293HisLeu: 2.293 ± 0.04
0.48HisMet: 0.48 ± 0.021
0.567HisAsn: 0.567 ± 0.02
1.609HisPro: 1.609 ± 0.038
0.785HisGln: 0.785 ± 0.026
1.713HisArg: 1.713 ± 0.04
0.88HisSer: 0.88 ± 0.027
1.026HisThr: 1.026 ± 0.025
1.579HisVal: 1.579 ± 0.035
0.364HisTrp: 0.364 ± 0.02
0.631HisTyr: 0.631 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
9.534IleAla: 9.534 ± 0.105
0.473IleCys: 0.473 ± 0.021
4.112IleAsp: 4.112 ± 0.062
3.591IleGlu: 3.591 ± 0.059
1.65IlePhe: 1.65 ± 0.044
6.044IleGly: 6.044 ± 0.081
1.083IleHis: 1.083 ± 0.032
2.927IleIle: 2.927 ± 0.056
1.36IleLys: 1.36 ± 0.036
4.754IleLeu: 4.754 ± 0.084
1.13IleMet: 1.13 ± 0.031
1.548IleAsn: 1.548 ± 0.037
2.717IlePro: 2.717 ± 0.054
1.118IleGln: 1.118 ± 0.03
3.243IleArg: 3.243 ± 0.05
2.869IleSer: 2.869 ± 0.054
3.661IleThr: 3.661 ± 0.067
4.312IleVal: 4.312 ± 0.072
0.618IleTrp: 0.618 ± 0.025
1.037IleTyr: 1.037 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
2.917LysAla: 2.917 ± 0.066
0.122LysCys: 0.122 ± 0.011
1.08LysAsp: 1.08 ± 0.034
0.732LysGlu: 0.732 ± 0.028
0.889LysPhe: 0.889 ± 0.027
1.791LysGly: 1.791 ± 0.039
0.561LysHis: 0.561 ± 0.024
1.615LysIle: 1.615 ± 0.043
0.787LysLys: 0.787 ± 0.034
2.925LysLeu: 2.925 ± 0.063
0.56LysMet: 0.56 ± 0.023
0.598LysAsn: 0.598 ± 0.028
2.124LysPro: 2.124 ± 0.055
0.836LysGln: 0.836 ± 0.028
2.029LysArg: 2.029 ± 0.05
1.701LysSer: 1.701 ± 0.042
1.775LysThr: 1.775 ± 0.043
1.501LysVal: 1.501 ± 0.041
0.235LysTrp: 0.235 ± 0.015
0.517LysTyr: 0.517 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
16.012LeuAla: 16.012 ± 0.147
0.907LeuCys: 0.907 ± 0.028
6.188LeuAsp: 6.188 ± 0.079
3.946LeuGlu: 3.946 ± 0.061
3.549LeuPhe: 3.549 ± 0.058
8.784LeuGly: 8.784 ± 0.101
2.331LeuHis: 2.331 ± 0.047
6.182LeuIle: 6.182 ± 0.085
2.616LeuLys: 2.616 ± 0.058
10.075LeuLeu: 10.075 ± 0.138
2.234LeuMet: 2.234 ± 0.048
2.563LeuAsn: 2.563 ± 0.045
6.313LeuPro: 6.313 ± 0.074
2.501LeuGln: 2.501 ± 0.054
7.615LeuArg: 7.615 ± 0.104
5.434LeuSer: 5.434 ± 0.072
6.01LeuThr: 6.01 ± 0.083
7.133LeuVal: 7.133 ± 0.096
1.162LeuTrp: 1.162 ± 0.031
2.0LeuTyr: 2.0 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.326MetAla: 3.326 ± 0.049
0.122MetCys: 0.122 ± 0.009
1.024MetAsp: 1.024 ± 0.03
0.798MetGlu: 0.798 ± 0.029
0.758MetPhe: 0.758 ± 0.026
1.689MetGly: 1.689 ± 0.038
0.453MetHis: 0.453 ± 0.018
1.676MetIle: 1.676 ± 0.04
0.789MetLys: 0.789 ± 0.029
2.639MetLeu: 2.639 ± 0.046
0.671MetMet: 0.671 ± 0.025
0.807MetAsn: 0.807 ± 0.028
1.627MetPro: 1.627 ± 0.041
0.825MetGln: 0.825 ± 0.026
1.754MetArg: 1.754 ± 0.043
1.505MetSer: 1.505 ± 0.035
1.752MetThr: 1.752 ± 0.043
1.765MetVal: 1.765 ± 0.038
0.165MetTrp: 0.165 ± 0.013
0.282MetTyr: 0.282 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.312AsnAla: 3.312 ± 0.059
0.238AsnCys: 0.238 ± 0.015
1.248AsnAsp: 1.248 ± 0.037
1.042AsnGlu: 1.042 ± 0.027
0.97AsnPhe: 0.97 ± 0.031
2.242AsnGly: 2.242 ± 0.053
0.58AsnHis: 0.58 ± 0.022
1.354AsnIle: 1.354 ± 0.038
0.546AsnLys: 0.546 ± 0.02
2.654AsnLeu: 2.654 ± 0.051
0.483AsnMet: 0.483 ± 0.022
0.755AsnAsn: 0.755 ± 0.03
2.071AsnPro: 2.071 ± 0.049
0.864AsnGln: 0.864 ± 0.028
1.808AsnArg: 1.808 ± 0.037
1.025AsnSer: 1.025 ± 0.036
1.316AsnThr: 1.316 ± 0.042
1.587AsnVal: 1.587 ± 0.038
0.393AsnTrp: 0.393 ± 0.017
0.636AsnTyr: 0.636 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
7.909ProAla: 7.909 ± 0.1
0.364ProCys: 0.364 ± 0.017
4.089ProAsp: 4.089 ± 0.062
2.884ProGlu: 2.884 ± 0.053
2.015ProPhe: 2.015 ± 0.045
5.287ProGly: 5.287 ± 0.088
1.426ProHis: 1.426 ± 0.037
2.94ProIle: 2.94 ± 0.056
1.47ProLys: 1.47 ± 0.042
5.049ProLeu: 5.049 ± 0.072
1.372ProMet: 1.372 ± 0.034
1.5ProAsn: 1.5 ± 0.042
3.623ProPro: 3.623 ± 0.076
1.708ProGln: 1.708 ± 0.041
3.402ProArg: 3.402 ± 0.055
2.806ProSer: 2.806 ± 0.057
2.867ProThr: 2.867 ± 0.053
4.347ProVal: 4.347 ± 0.061
0.813ProTrp: 0.813 ± 0.024
1.253ProTyr: 1.253 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.469GlnAla: 4.469 ± 0.067
0.219GlnCys: 0.219 ± 0.014
1.354GlnAsp: 1.354 ± 0.035
0.947GlnGlu: 0.947 ± 0.033
1.147GlnPhe: 1.147 ± 0.031
2.37GlnGly: 2.37 ± 0.045
0.77GlnHis: 0.77 ± 0.028
1.934GlnIle: 1.934 ± 0.04
0.812GlnLys: 0.812 ± 0.027
2.523GlnLeu: 2.523 ± 0.054
0.737GlnMet: 0.737 ± 0.025
0.814GlnAsn: 0.814 ± 0.03
1.861GlnPro: 1.861 ± 0.04
1.109GlnGln: 1.109 ± 0.04
2.323GlnArg: 2.323 ± 0.045
1.909GlnSer: 1.909 ± 0.046
1.929GlnThr: 1.929 ± 0.043
2.058GlnVal: 2.058 ± 0.042
0.334GlnTrp: 0.334 ± 0.017
0.662GlnTyr: 0.662 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
9.738ArgAla: 9.738 ± 0.115
0.577ArgCys: 0.577 ± 0.022
3.992ArgAsp: 3.992 ± 0.066
3.068ArgGlu: 3.068 ± 0.057
2.993ArgPhe: 2.993 ± 0.054
4.94ArgGly: 4.94 ± 0.07
2.014ArgHis: 2.014 ± 0.043
4.248ArgIle: 4.248 ± 0.055
1.808ArgLys: 1.808 ± 0.044
8.454ArgLeu: 8.454 ± 0.112
1.769ArgMet: 1.769 ± 0.041
1.759ArgAsn: 1.759 ± 0.04
3.649ArgPro: 3.649 ± 0.067
2.329ArgGln: 2.329 ± 0.042
6.052ArgArg: 6.052 ± 0.089
3.318ArgSer: 3.318 ± 0.053
3.505ArgThr: 3.505 ± 0.054
4.47ArgVal: 4.47 ± 0.064
0.947ArgTrp: 0.947 ± 0.028
1.643ArgTyr: 1.643 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.146SerAla: 6.146 ± 0.077
0.432SerCys: 0.432 ± 0.02
2.467SerAsp: 2.467 ± 0.05
1.99SerGlu: 1.99 ± 0.046
2.075SerPhe: 2.075 ± 0.047
5.266SerGly: 5.266 ± 0.083
1.124SerHis: 1.124 ± 0.03
2.797SerIle: 2.797 ± 0.055
1.092SerLys: 1.092 ± 0.035
5.466SerLeu: 5.466 ± 0.076
1.21SerMet: 1.21 ± 0.036
1.342SerAsn: 1.342 ± 0.037
2.714SerPro: 2.714 ± 0.053
1.443SerGln: 1.443 ± 0.036
3.143SerArg: 3.143 ± 0.052
2.413SerSer: 2.413 ± 0.054
2.631SerThr: 2.631 ± 0.052
3.8SerVal: 3.8 ± 0.06
0.657SerTrp: 0.657 ± 0.028
1.118SerTyr: 1.118 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
7.471ThrAla: 7.471 ± 0.079
0.414ThrCys: 0.414 ± 0.019
2.938ThrAsp: 2.938 ± 0.052
2.644ThrGlu: 2.644 ± 0.046
1.551ThrPhe: 1.551 ± 0.042
5.529ThrGly: 5.529 ± 0.087
1.248ThrHis: 1.248 ± 0.032
3.988ThrIle: 3.988 ± 0.078
1.4ThrLys: 1.4 ± 0.044
6.564ThrLeu: 6.564 ± 0.092
1.552ThrMet: 1.552 ± 0.032
1.454ThrAsn: 1.454 ± 0.037
3.849ThrPro: 3.849 ± 0.067
1.514ThrGln: 1.514 ± 0.041
3.425ThrArg: 3.425 ± 0.049
2.703ThrSer: 2.703 ± 0.056
3.435ThrThr: 3.435 ± 0.069
3.998ThrVal: 3.998 ± 0.063
0.664ThrTrp: 0.664 ± 0.022
1.191ThrTyr: 1.191 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
9.597ValAla: 9.597 ± 0.101
0.556ValCys: 0.556 ± 0.022
3.392ValAsp: 3.392 ± 0.054
3.197ValGlu: 3.197 ± 0.061
2.656ValPhe: 2.656 ± 0.056
5.129ValGly: 5.129 ± 0.068
1.393ValHis: 1.393 ± 0.037
4.235ValIle: 4.235 ± 0.065
1.835ValLys: 1.835 ± 0.04
7.593ValLeu: 7.593 ± 0.093
1.925ValMet: 1.925 ± 0.04
1.795ValAsn: 1.795 ± 0.043
3.923ValPro: 3.923 ± 0.068
1.919ValGln: 1.919 ± 0.039
4.404ValArg: 4.404 ± 0.064
3.835ValSer: 3.835 ± 0.061
4.345ValThr: 4.345 ± 0.067
5.61ValVal: 5.61 ± 0.096
0.86ValTrp: 0.86 ± 0.03
1.236ValTyr: 1.236 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.173TrpAla: 1.173 ± 0.033
0.137TrpCys: 0.137 ± 0.01
0.56TrpAsp: 0.56 ± 0.025
0.409TrpGlu: 0.409 ± 0.02
0.584TrpPhe: 0.584 ± 0.024
0.82TrpGly: 0.82 ± 0.028
0.432TrpHis: 0.432 ± 0.02
0.597TrpIle: 0.597 ± 0.025
0.286TrpLys: 0.286 ± 0.017
1.671TrpLeu: 1.671 ± 0.044
0.311TrpMet: 0.311 ± 0.017
0.402TrpAsn: 0.402 ± 0.02
0.694TrpPro: 0.694 ± 0.027
0.649TrpGln: 0.649 ± 0.025
1.307TrpArg: 1.307 ± 0.038
0.735TrpSer: 0.735 ± 0.028
0.693TrpThr: 0.693 ± 0.025
0.786TrpVal: 0.786 ± 0.03
0.24TrpTrp: 0.24 ± 0.014
0.3TrpTyr: 0.3 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.656TyrAla: 2.656 ± 0.055
0.236TyrCys: 0.236 ± 0.014
1.231TyrAsp: 1.231 ± 0.035
0.918TyrGlu: 0.918 ± 0.027
0.848TyrPhe: 0.848 ± 0.03
2.033TyrGly: 2.033 ± 0.042
0.582TyrHis: 0.582 ± 0.024
0.893TyrIle: 0.893 ± 0.031
0.466TyrLys: 0.466 ± 0.022
2.122TyrLeu: 2.122 ± 0.047
0.359TyrMet: 0.359 ± 0.017
0.573TyrAsn: 0.573 ± 0.028
1.109TyrPro: 1.109 ± 0.032
0.837TyrGln: 0.837 ± 0.027
1.762TyrArg: 1.762 ± 0.043
0.952TyrSer: 0.952 ± 0.032
1.035TyrThr: 1.035 ± 0.035
1.428TyrVal: 1.428 ± 0.034
0.317TyrTrp: 0.317 ± 0.019
0.546TyrTyr: 0.546 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3677 proteins (1184703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski