Amino acid dipepetide frequency for Halorubrum halodurans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.378AlaAla: 16.378 ± 0.221	0.768AlaCys: 0.768 ± 0.029	11.61AlaAsp: 11.61 ± 0.133	9.547AlaGlu: 9.547 ± 0.123	4.18AlaPhe: 4.18 ± 0.075	11.404AlaGly: 11.404 ± 0.145	1.817AlaHis: 1.817 ± 0.049	4.866AlaIle: 4.866 ± 0.069	1.607AlaLys: 1.607 ± 0.043	10.311AlaLeu: 10.311 ± 0.138	2.003AlaMet: 2.003 ± 0.052	2.227AlaAsn: 2.227 ± 0.059	4.225AlaPro: 4.225 ± 0.065	1.614AlaGln: 1.614 ± 0.046	6.701AlaArg: 6.701 ± 0.093	5.514AlaSer: 5.514 ± 0.091	7.173AlaThr: 7.173 ± 0.111	12.217AlaVal: 12.217 ± 0.138	1.18AlaTrp: 1.18 ± 0.041	2.843AlaTyr: 2.843 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.608CysAla: 0.608 ± 0.027	0.069CysCys: 0.069 ± 0.008	0.516CysAsp: 0.516 ± 0.023	0.524CysGlu: 0.524 ± 0.025	0.194CysPhe: 0.194 ± 0.015	0.847CysGly: 0.847 ± 0.034	0.185CysHis: 0.185 ± 0.017	0.21CysIle: 0.21 ± 0.015	0.097CysLys: 0.097 ± 0.011	0.502CysLeu: 0.502 ± 0.02	0.085CysMet: 0.085 ± 0.008	0.155CysAsn: 0.155 ± 0.013	0.553CysPro: 0.553 ± 0.03	0.134CysGln: 0.134 ± 0.012	0.467CysArg: 0.467 ± 0.024	0.381CysSer: 0.381 ± 0.022	0.381CysThr: 0.381 ± 0.021	0.494CysVal: 0.494 ± 0.028	0.068CysTrp: 0.068 ± 0.008	0.162CysTyr: 0.162 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	12.225AspAla: 12.225 ± 0.157	0.581AspCys: 0.581 ± 0.031	8.53AspAsp: 8.53 ± 0.145	7.331AspGlu: 7.331 ± 0.104	1.8AspPhe: 1.8 ± 0.052	9.506AspGly: 9.506 ± 0.166	1.959AspHis: 1.959 ± 0.048	2.023AspIle: 2.023 ± 0.059	0.801AspLys: 0.801 ± 0.035	7.716AspLeu: 7.716 ± 0.114	1.05AspMet: 1.05 ± 0.035	1.086AspAsn: 1.086 ± 0.041	5.762AspPro: 5.762 ± 0.088	1.307AspGln: 1.307 ± 0.039	7.991AspArg: 7.991 ± 0.12	3.087AspSer: 3.087 ± 0.069	3.83AspThr: 3.83 ± 0.092	8.371AspVal: 8.371 ± 0.097	0.929AspTrp: 0.929 ± 0.033	1.555AspTyr: 1.555 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	9.632GluAla: 9.632 ± 0.119	0.468GluCys: 0.468 ± 0.022	5.171GluAsp: 5.171 ± 0.099	6.893GluGlu: 6.893 ± 0.133	2.985GluPhe: 2.985 ± 0.063	5.955GluGly: 5.955 ± 0.092	1.858GluHis: 1.858 ± 0.053	3.602GluIle: 3.602 ± 0.074	1.609GluLys: 1.609 ± 0.047	7.16GluLeu: 7.16 ± 0.094	1.758GluMet: 1.758 ± 0.046	2.132GluAsn: 2.132 ± 0.065	4.497GluPro: 4.497 ± 0.067	1.774GluGln: 1.774 ± 0.047	7.968GluArg: 7.968 ± 0.105	4.951GluSer: 4.951 ± 0.074	6.558GluThr: 6.558 ± 0.106	5.951GluVal: 5.951 ± 0.097	1.137GluTrp: 1.137 ± 0.038	2.576GluTyr: 2.576 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.633PheAla: 3.633 ± 0.063	0.261PheCys: 0.261 ± 0.016	3.215PheAsp: 3.215 ± 0.066	3.106PheGlu: 3.106 ± 0.06	0.875PhePhe: 0.875 ± 0.031	3.136PheGly: 3.136 ± 0.067	0.603PheHis: 0.603 ± 0.022	0.92PheIle: 0.92 ± 0.034	0.425PheLys: 0.425 ± 0.021	2.831PheLeu: 2.831 ± 0.073	0.462PheMet: 0.462 ± 0.027	0.657PheAsn: 0.657 ± 0.029	1.362PhePro: 1.362 ± 0.039	0.619PheGln: 0.619 ± 0.029	1.909PheArg: 1.909 ± 0.05	1.625PheSer: 1.625 ± 0.044	1.825PheThr: 1.825 ± 0.052	3.065PheVal: 3.065 ± 0.061	0.326PheTrp: 0.326 ± 0.017	0.798PheTyr: 0.798 ± 0.032	0.001PheXaa: 0.001 ± 0.001
Gly	8.682GlyAla: 8.682 ± 0.119	0.664GlyCys: 0.664 ± 0.028	7.988GlyAsp: 7.988 ± 0.124	7.664GlyGlu: 7.664 ± 0.112	3.239GlyPhe: 3.239 ± 0.059	8.792GlyGly: 8.792 ± 0.119	1.736GlyHis: 1.736 ± 0.051	4.34GlyIle: 4.34 ± 0.078	1.673GlyLys: 1.673 ± 0.041	7.189GlyLeu: 7.189 ± 0.121	1.686GlyMet: 1.686 ± 0.047	1.962GlyAsn: 1.962 ± 0.057	3.549GlyPro: 3.549 ± 0.064	1.497GlyGln: 1.497 ± 0.039	5.695GlyArg: 5.695 ± 0.097	5.952GlySer: 5.952 ± 0.092	6.285GlyThr: 6.285 ± 0.105	8.314GlyVal: 8.314 ± 0.114	1.105GlyTrp: 1.105 ± 0.036	2.755GlyTyr: 2.755 ± 0.059	0.001GlyXaa: 0.001 ± 0.001
His	2.216HisAla: 2.216 ± 0.051	0.169HisCys: 0.169 ± 0.013	1.909HisAsp: 1.909 ± 0.049	1.611HisGlu: 1.611 ± 0.05	0.476HisPhe: 0.476 ± 0.021	2.049HisGly: 2.049 ± 0.047	0.553HisHis: 0.553 ± 0.029	0.465HisIle: 0.465 ± 0.023	0.253HisLys: 0.253 ± 0.018	1.609HisLeu: 1.609 ± 0.041	0.267HisMet: 0.267 ± 0.019	0.428HisAsn: 0.428 ± 0.021	1.231HisPro: 1.231 ± 0.043	0.4HisGln: 0.4 ± 0.024	1.331HisArg: 1.331 ± 0.043	0.773HisSer: 0.773 ± 0.032	1.021HisThr: 1.021 ± 0.035	1.907HisVal: 1.907 ± 0.05	0.186HisTrp: 0.186 ± 0.014	0.509HisTyr: 0.509 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.839IleAla: 4.839 ± 0.083	0.198IleCys: 0.198 ± 0.014	4.056IleAsp: 4.056 ± 0.067	3.991IleGlu: 3.991 ± 0.076	0.703IlePhe: 0.703 ± 0.034	3.683IleGly: 3.683 ± 0.08	0.786IleHis: 0.786 ± 0.029	0.965IleIle: 0.965 ± 0.041	0.595IleLys: 0.595 ± 0.025	2.447IleLeu: 2.447 ± 0.068	0.392IleMet: 0.392 ± 0.02	0.902IleAsn: 0.902 ± 0.033	1.971IlePro: 1.971 ± 0.057	0.884IleGln: 0.884 ± 0.038	2.639IleArg: 2.639 ± 0.054	1.704IleSer: 1.704 ± 0.048	2.123IleThr: 2.123 ± 0.066	3.421IleVal: 3.421 ± 0.073	0.253IleTrp: 0.253 ± 0.016	0.726IleTyr: 0.726 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	1.717LysAla: 1.717 ± 0.055	0.108LysCys: 0.108 ± 0.01	0.881LysAsp: 0.881 ± 0.035	1.15LysGlu: 1.15 ± 0.034	0.469LysPhe: 0.469 ± 0.023	1.279LysGly: 1.279 ± 0.037	0.424LysHis: 0.424 ± 0.024	0.65LysIle: 0.65 ± 0.026	0.428LysLys: 0.428 ± 0.026	1.392LysLeu: 1.392 ± 0.045	0.289LysMet: 0.289 ± 0.018	0.464LysAsn: 0.464 ± 0.025	0.894LysPro: 0.894 ± 0.03	0.586LysGln: 0.586 ± 0.024	1.628LysArg: 1.628 ± 0.042	0.964LysSer: 0.964 ± 0.038	1.135LysThr: 1.135 ± 0.037	1.073LysVal: 1.073 ± 0.032	0.216LysTrp: 0.216 ± 0.014	0.512LysTyr: 0.512 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.7LeuAla: 11.7 ± 0.151	0.522LeuCys: 0.522 ± 0.022	7.172LeuAsp: 7.172 ± 0.098	6.881LeuGlu: 6.881 ± 0.088	2.876LeuPhe: 2.876 ± 0.068	7.353LeuGly: 7.353 ± 0.115	1.437LeuHis: 1.437 ± 0.042	2.748LeuIle: 2.748 ± 0.061	1.455LeuLys: 1.455 ± 0.047	8.202LeuLeu: 8.202 ± 0.13	1.164LeuMet: 1.164 ± 0.041	1.646LeuAsn: 1.646 ± 0.046	4.183LeuPro: 4.183 ± 0.086	1.563LeuGln: 1.563 ± 0.042	6.029LeuArg: 6.029 ± 0.089	5.194LeuSer: 5.194 ± 0.083	4.911LeuThr: 4.911 ± 0.083	8.219LeuVal: 8.219 ± 0.12	0.827LeuTrp: 0.827 ± 0.032	2.122LeuTyr: 2.122 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.661MetAla: 1.661 ± 0.048	0.108MetCys: 0.108 ± 0.012	1.19MetAsp: 1.19 ± 0.037	1.101MetGlu: 1.101 ± 0.039	0.428MetPhe: 0.428 ± 0.023	1.303MetGly: 1.303 ± 0.038	0.228MetHis: 0.228 ± 0.017	0.617MetIle: 0.617 ± 0.028	0.422MetLys: 0.422 ± 0.022	1.261MetLeu: 1.261 ± 0.041	0.279MetMet: 0.279 ± 0.017	0.573MetAsn: 0.573 ± 0.026	0.77MetPro: 0.77 ± 0.031	0.295MetGln: 0.295 ± 0.015	1.055MetArg: 1.055 ± 0.039	1.458MetSer: 1.458 ± 0.034	1.477MetThr: 1.477 ± 0.042	1.19MetVal: 1.19 ± 0.037	0.149MetTrp: 0.149 ± 0.013	0.361MetTyr: 0.361 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.618AsnAla: 2.618 ± 0.063	0.183AsnCys: 0.183 ± 0.012	1.644AsnAsp: 1.644 ± 0.052	1.736AsnGlu: 1.736 ± 0.057	0.558AsnPhe: 0.558 ± 0.027	1.978AsnGly: 1.978 ± 0.053	0.443AsnHis: 0.443 ± 0.024	0.631AsnIle: 0.631 ± 0.029	0.417AsnLys: 0.417 ± 0.024	1.742AsnLeu: 1.742 ± 0.047	0.332AsnMet: 0.332 ± 0.018	0.504AsnAsn: 0.504 ± 0.026	1.497AsnPro: 1.497 ± 0.044	0.567AsnGln: 0.567 ± 0.025	1.604AsnArg: 1.604 ± 0.046	0.84AsnSer: 0.84 ± 0.035	1.239AsnThr: 1.239 ± 0.048	2.3AsnVal: 2.3 ± 0.065	0.254AsnTrp: 0.254 ± 0.019	0.596AsnTyr: 0.596 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.656ProAla: 5.656 ± 0.084	0.245ProCys: 0.245 ± 0.014	5.466ProAsp: 5.466 ± 0.071	4.756ProGlu: 4.756 ± 0.065	1.64ProPhe: 1.64 ± 0.044	4.085ProGly: 4.085 ± 0.072	0.909ProHis: 0.909 ± 0.034	1.878ProIle: 1.878 ± 0.052	0.782ProLys: 0.782 ± 0.027	3.579ProLeu: 3.579 ± 0.063	0.82ProMet: 0.82 ± 0.027	1.127ProAsn: 1.127 ± 0.033	2.415ProPro: 2.415 ± 0.057	0.762ProGln: 0.762 ± 0.028	2.529ProArg: 2.529 ± 0.059	2.654ProSer: 2.654 ± 0.053	3.316ProThr: 3.316 ± 0.067	4.506ProVal: 4.506 ± 0.078	0.507ProTrp: 0.507 ± 0.023	1.17ProTyr: 1.17 ± 0.035	0.003ProXaa: 0.003 ± 0.002
Gln	1.805GlnAla: 1.805 ± 0.043	0.131GlnCys: 0.131 ± 0.012	0.995GlnAsp: 0.995 ± 0.034	1.346GlnGlu: 1.346 ± 0.047	0.792GlnPhe: 0.792 ± 0.034	1.306GlnGly: 1.306 ± 0.041	0.445GlnHis: 0.445 ± 0.022	0.872GlnIle: 0.872 ± 0.031	0.419GlnLys: 0.419 ± 0.022	1.813GlnLeu: 1.813 ± 0.046	0.376GlnMet: 0.376 ± 0.022	0.592GlnAsn: 0.592 ± 0.024	0.894GlnPro: 0.894 ± 0.036	0.71GlnGln: 0.71 ± 0.031	1.574GlnArg: 1.574 ± 0.049	1.18GlnSer: 1.18 ± 0.038	1.233GlnThr: 1.233 ± 0.043	1.435GlnVal: 1.435 ± 0.045	0.267GlnTrp: 0.267 ± 0.018	0.686GlnTyr: 0.686 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.9ArgAla: 6.9 ± 0.104	0.464ArgCys: 0.464 ± 0.023	5.68ArgAsp: 5.68 ± 0.086	7.488ArgGlu: 7.488 ± 0.114	2.509ArgPhe: 2.509 ± 0.051	5.077ArgGly: 5.077 ± 0.081	1.319ArgHis: 1.319 ± 0.039	3.384ArgIle: 3.384 ± 0.059	1.35ArgLys: 1.35 ± 0.041	6.711ArgLeu: 6.711 ± 0.099	1.31ArgMet: 1.31 ± 0.036	1.669ArgAsn: 1.669 ± 0.045	2.948ArgPro: 2.948 ± 0.056	1.532ArgGln: 1.532 ± 0.044	5.667ArgArg: 5.667 ± 0.108	3.808ArgSer: 3.808 ± 0.074	4.338ArgThr: 4.338 ± 0.075	6.055ArgVal: 6.055 ± 0.093	0.82ArgTrp: 0.82 ± 0.032	2.022ArgTyr: 2.022 ± 0.05	0.004ArgXaa: 0.004 ± 0.002
Ser	5.522SerAla: 5.522 ± 0.077	0.308SerCys: 0.308 ± 0.022	4.197SerAsp: 4.197 ± 0.085	3.976SerGlu: 3.976 ± 0.065	1.699SerPhe: 1.699 ± 0.043	5.523SerGly: 5.523 ± 0.097	0.957SerHis: 0.957 ± 0.032	2.221SerIle: 2.221 ± 0.059	1.05SerLys: 1.05 ± 0.041	4.54SerLeu: 4.54 ± 0.078	0.944SerMet: 0.944 ± 0.033	1.234SerAsn: 1.234 ± 0.045	2.552SerPro: 2.552 ± 0.051	1.043SerGln: 1.043 ± 0.037	3.458SerArg: 3.458 ± 0.064	2.656SerSer: 2.656 ± 0.067	3.637SerThr: 3.637 ± 0.072	4.869SerVal: 4.869 ± 0.094	0.585SerTrp: 0.585 ± 0.027	1.261SerTyr: 1.261 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.187ThrAla: 7.187 ± 0.1	0.368ThrCys: 0.368 ± 0.02	5.519ThrAsp: 5.519 ± 0.099	4.42ThrGlu: 4.42 ± 0.088	2.185ThrPhe: 2.185 ± 0.05	6.026ThrGly: 6.026 ± 0.094	1.154ThrHis: 1.154 ± 0.039	2.578ThrIle: 2.578 ± 0.066	0.942ThrLys: 0.942 ± 0.035	5.739ThrLeu: 5.739 ± 0.086	0.935ThrMet: 0.935 ± 0.033	1.476ThrAsn: 1.476 ± 0.052	3.293ThrPro: 3.293 ± 0.063	1.186ThrGln: 1.186 ± 0.046	3.676ThrArg: 3.676 ± 0.072	2.664ThrSer: 2.664 ± 0.066	4.365ThrThr: 4.365 ± 0.104	7.175ThrVal: 7.175 ± 0.137	0.562ThrTrp: 0.562 ± 0.026	1.745ThrTyr: 1.745 ± 0.043	0.001ThrXaa: 0.001 ± 0.001
Val	11.428ValAla: 11.428 ± 0.139	0.693ValCys: 0.693 ± 0.029	8.482ValAsp: 8.482 ± 0.125	8.046ValGlu: 8.046 ± 0.106	2.906ValPhe: 2.906 ± 0.063	8.328ValGly: 8.328 ± 0.123	1.728ValHis: 1.728 ± 0.045	3.166ValIle: 3.166 ± 0.066	1.276ValLys: 1.276 ± 0.04	7.887ValLeu: 7.887 ± 0.123	1.238ValMet: 1.238 ± 0.04	1.954ValAsn: 1.954 ± 0.055	4.553ValPro: 4.553 ± 0.074	1.536ValGln: 1.536 ± 0.038	6.205ValArg: 6.205 ± 0.088	5.147ValSer: 5.147 ± 0.088	6.179ValThr: 6.179 ± 0.12	9.804ValVal: 9.804 ± 0.134	0.786ValTrp: 0.786 ± 0.031	2.145ValTyr: 2.145 ± 0.043	0.001ValXaa: 0.001 ± 0.001
Trp	0.906TrpAla: 0.906 ± 0.032	0.11TrpCys: 0.11 ± 0.012	0.706TrpAsp: 0.706 ± 0.034	0.821TrpGlu: 0.821 ± 0.028	0.411TrpPhe: 0.411 ± 0.023	0.754TrpGly: 0.754 ± 0.032	0.215TrpHis: 0.215 ± 0.017	0.543TrpIle: 0.543 ± 0.027	0.264TrpLys: 0.264 ± 0.019	1.097TrpLeu: 1.097 ± 0.038	0.205TrpMet: 0.205 ± 0.016	0.315TrpAsn: 0.315 ± 0.017	0.432TrpPro: 0.432 ± 0.024	0.282TrpGln: 0.282 ± 0.02	0.893TrpArg: 0.893 ± 0.032	0.571TrpSer: 0.571 ± 0.021	0.767TrpThr: 0.767 ± 0.032	0.784TrpVal: 0.784 ± 0.031	0.156TrpTrp: 0.156 ± 0.014	0.375TrpTyr: 0.375 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.871TyrAla: 2.871 ± 0.06	0.214TyrCys: 0.214 ± 0.016	2.508TyrAsp: 2.508 ± 0.053	2.244TyrGlu: 2.244 ± 0.054	0.726TyrPhe: 0.726 ± 0.028	2.386TyrGly: 2.386 ± 0.043	0.608TyrHis: 0.608 ± 0.028	0.599TyrIle: 0.599 ± 0.028	0.392TyrLys: 0.392 ± 0.022	2.478TyrLeu: 2.478 ± 0.057	0.329TyrMet: 0.329 ± 0.02	0.581TyrAsn: 0.581 ± 0.032	1.226TyrPro: 1.226 ± 0.038	0.578TyrGln: 0.578 ± 0.026	2.038TyrArg: 2.038 ± 0.057	1.108TyrSer: 1.108 ± 0.037	1.403TyrThr: 1.403 ± 0.042	2.338TyrVal: 2.338 ± 0.052	0.291TyrTrp: 0.291 ± 0.017	0.784TyrTyr: 0.784 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.003XaaGlu: 0.003 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3137 proteins (917458 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---