Amino acid dipepetide frequency for Fibrisoma limi BUZ 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.065AlaAla: 7.065 ± 0.07
0.69AlaCys: 0.69 ± 0.019
5.269AlaAsp: 5.269 ± 0.056
4.683AlaGlu: 4.683 ± 0.061
3.646AlaPhe: 3.646 ± 0.042
6.627AlaGly: 6.627 ± 0.073
1.336AlaHis: 1.336 ± 0.032
4.914AlaIle: 4.914 ± 0.066
3.444AlaLys: 3.444 ± 0.044
8.378AlaLeu: 8.378 ± 0.079
1.826AlaMet: 1.826 ± 0.03
3.763AlaAsn: 3.763 ± 0.055
3.285AlaPro: 3.285 ± 0.044
3.926AlaGln: 3.926 ± 0.049
4.335AlaArg: 4.335 ± 0.05
4.851AlaSer: 4.851 ± 0.065
5.443AlaThr: 5.443 ± 0.074
5.978AlaVal: 5.978 ± 0.054
0.982AlaTrp: 0.982 ± 0.023
3.106AlaTyr: 3.106 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.504CysAla: 0.504 ± 0.018
0.106CysCys: 0.106 ± 0.007
0.348CysAsp: 0.348 ± 0.012
0.361CysGlu: 0.361 ± 0.015
0.361CysPhe: 0.361 ± 0.016
0.548CysGly: 0.548 ± 0.019
0.188CysHis: 0.188 ± 0.01
0.428CysIle: 0.428 ± 0.014
0.249CysLys: 0.249 ± 0.011
0.828CysLeu: 0.828 ± 0.019
0.142CysMet: 0.142 ± 0.008
0.262CysAsn: 0.262 ± 0.012
0.351CysPro: 0.351 ± 0.013
0.352CysGln: 0.352 ± 0.014
0.491CysArg: 0.491 ± 0.016
0.466CysSer: 0.466 ± 0.017
0.45CysThr: 0.45 ± 0.026
0.486CysVal: 0.486 ± 0.017
0.112CysTrp: 0.112 ± 0.006
0.302CysTyr: 0.302 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
4.28AspAla: 4.28 ± 0.045
0.376AspCys: 0.376 ± 0.014
2.769AspAsp: 2.769 ± 0.042
3.429AspGlu: 3.429 ± 0.049
2.504AspPhe: 2.504 ± 0.034
4.143AspGly: 4.143 ± 0.051
0.921AspHis: 0.921 ± 0.021
2.891AspIle: 2.891 ± 0.041
2.596AspLys: 2.596 ± 0.034
5.104AspLeu: 5.104 ± 0.053
1.031AspMet: 1.031 ± 0.023
2.291AspAsn: 2.291 ± 0.035
2.571AspPro: 2.571 ± 0.041
2.359AspGln: 2.359 ± 0.035
3.342AspArg: 3.342 ± 0.047
2.757AspSer: 2.757 ± 0.041
2.839AspThr: 2.839 ± 0.039
3.978AspVal: 3.978 ± 0.049
0.9AspTrp: 0.9 ± 0.022
2.303AspTyr: 2.303 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
4.643GluAla: 4.643 ± 0.06
0.279GluCys: 0.279 ± 0.013
2.216GluAsp: 2.216 ± 0.039
2.906GluGlu: 2.906 ± 0.05
2.028GluPhe: 2.028 ± 0.033
3.303GluGly: 3.303 ± 0.044
0.997GluHis: 0.997 ± 0.022
2.796GluIle: 2.796 ± 0.043
2.965GluLys: 2.965 ± 0.049
5.516GluLeu: 5.516 ± 0.056
1.148GluMet: 1.148 ± 0.023
2.232GluAsn: 2.232 ± 0.035
2.283GluPro: 2.283 ± 0.037
2.958GluGln: 2.958 ± 0.04
3.519GluArg: 3.519 ± 0.042
2.723GluSer: 2.723 ± 0.036
3.188GluThr: 3.188 ± 0.044
3.652GluVal: 3.652 ± 0.048
0.691GluTrp: 0.691 ± 0.017
1.759GluTyr: 1.759 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
3.475PheAla: 3.475 ± 0.04
0.416PheCys: 0.416 ± 0.013
2.773PheAsp: 2.773 ± 0.039
2.163PheGlu: 2.163 ± 0.035
2.068PhePhe: 2.068 ± 0.038
3.501PheGly: 3.501 ± 0.04
0.732PheHis: 0.732 ± 0.021
2.413PheIle: 2.413 ± 0.042
1.688PheLys: 1.688 ± 0.031
4.096PheLeu: 4.096 ± 0.049
0.978PheMet: 0.978 ± 0.021
2.123PheAsn: 2.123 ± 0.039
1.786PhePro: 1.786 ± 0.028
1.683PheGln: 1.683 ± 0.03
2.807PheArg: 2.807 ± 0.035
3.067PheSer: 3.067 ± 0.043
3.046PheThr: 3.046 ± 0.048
3.127PheVal: 3.127 ± 0.037
0.658PheTrp: 0.658 ± 0.016
1.728PheTyr: 1.728 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
5.153GlyAla: 5.153 ± 0.058
0.695GlyCys: 0.695 ± 0.024
3.434GlyAsp: 3.434 ± 0.044
3.366GlyGlu: 3.366 ± 0.044
3.45GlyPhe: 3.45 ± 0.044
5.354GlyGly: 5.354 ± 0.075
1.341GlyHis: 1.341 ± 0.028
4.482GlyIle: 4.482 ± 0.049
3.856GlyLys: 3.856 ± 0.047
7.45GlyLeu: 7.45 ± 0.065
1.623GlyMet: 1.623 ± 0.034
3.294GlyAsn: 3.294 ± 0.052
2.405GlyPro: 2.405 ± 0.047
3.625GlyGln: 3.625 ± 0.049
4.241GlyArg: 4.241 ± 0.045
4.469GlySer: 4.469 ± 0.056
4.707GlyThr: 4.707 ± 0.07
5.173GlyVal: 5.173 ± 0.059
1.179GlyTrp: 1.179 ± 0.022
3.043GlyTyr: 3.043 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
1.202HisAla: 1.202 ± 0.025
0.179HisCys: 0.179 ± 0.009
0.944HisAsp: 0.944 ± 0.022
1.001HisGlu: 1.001 ± 0.024
0.979HisPhe: 0.979 ± 0.02
1.191HisGly: 1.191 ± 0.025
0.52HisHis: 0.52 ± 0.016
1.051HisIle: 1.051 ± 0.023
0.719HisLys: 0.719 ± 0.02
1.902HisLeu: 1.902 ± 0.033
0.33HisMet: 0.33 ± 0.012
0.747HisAsn: 0.747 ± 0.018
1.202HisPro: 1.202 ± 0.03
0.878HisGln: 0.878 ± 0.021
1.12HisArg: 1.12 ± 0.023
0.978HisSer: 0.978 ± 0.024
1.073HisThr: 1.073 ± 0.024
1.099HisVal: 1.099 ± 0.025
0.322HisTrp: 0.322 ± 0.013
0.792HisTyr: 0.792 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.843IleAla: 4.843 ± 0.055
0.47IleCys: 0.47 ± 0.017
3.486IleAsp: 3.486 ± 0.044
3.138IleGlu: 3.138 ± 0.047
1.979IlePhe: 1.979 ± 0.032
4.606IleGly: 4.606 ± 0.058
1.046IleHis: 1.046 ± 0.02
2.932IleIle: 2.932 ± 0.044
2.425IleLys: 2.425 ± 0.038
4.593IleLeu: 4.593 ± 0.054
0.957IleMet: 0.957 ± 0.02
2.894IleAsn: 2.894 ± 0.042
2.754IlePro: 2.754 ± 0.033
2.262IleGln: 2.262 ± 0.033
3.884IleArg: 3.884 ± 0.046
3.48IleSer: 3.48 ± 0.038
3.693IleThr: 3.693 ± 0.048
3.737IleVal: 3.737 ± 0.05
0.707IleTrp: 0.707 ± 0.02
1.836IleTyr: 1.836 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.368LysAla: 4.368 ± 0.048
0.179LysCys: 0.179 ± 0.009
2.347LysAsp: 2.347 ± 0.036
2.65LysGlu: 2.65 ± 0.042
1.409LysPhe: 1.409 ± 0.03
3.213LysGly: 3.213 ± 0.044
0.801LysHis: 0.801 ± 0.021
2.35LysIle: 2.35 ± 0.038
2.456LysLys: 2.456 ± 0.038
4.434LysLeu: 4.434 ± 0.045
1.019LysMet: 1.019 ± 0.025
2.018LysAsn: 2.018 ± 0.033
2.807LysPro: 2.807 ± 0.039
2.309LysGln: 2.309 ± 0.038
2.654LysArg: 2.654 ± 0.039
2.402LysSer: 2.402 ± 0.04
2.995LysThr: 2.995 ± 0.035
2.889LysVal: 2.889 ± 0.042
0.537LysTrp: 0.537 ± 0.015
1.506LysTyr: 1.506 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
8.829LeuAla: 8.829 ± 0.079
0.759LeuCys: 0.759 ± 0.018
4.918LeuAsp: 4.918 ± 0.051
4.499LeuGlu: 4.499 ± 0.049
4.535LeuPhe: 4.535 ± 0.056
6.473LeuGly: 6.473 ± 0.059
1.828LeuHis: 1.828 ± 0.032
5.837LeuIle: 5.837 ± 0.06
4.789LeuLys: 4.789 ± 0.05
11.178LeuLeu: 11.178 ± 0.099
2.155LeuMet: 2.155 ± 0.036
4.868LeuAsn: 4.868 ± 0.047
5.141LeuPro: 5.141 ± 0.052
3.994LeuGln: 3.994 ± 0.049
5.766LeuArg: 5.766 ± 0.058
6.829LeuSer: 6.829 ± 0.058
7.607LeuThr: 7.607 ± 0.066
6.572LeuVal: 6.572 ± 0.062
1.123LeuTrp: 1.123 ± 0.025
3.398LeuTyr: 3.398 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
1.943MetAla: 1.943 ± 0.036
0.115MetCys: 0.115 ± 0.008
0.971MetAsp: 0.971 ± 0.023
0.939MetGlu: 0.939 ± 0.02
0.61MetPhe: 0.61 ± 0.016
1.398MetGly: 1.398 ± 0.03
0.44MetHis: 0.44 ± 0.014
1.098MetIle: 1.098 ± 0.024
1.391MetLys: 1.391 ± 0.026
2.16MetLeu: 2.16 ± 0.036
0.493MetMet: 0.493 ± 0.017
1.168MetAsn: 1.168 ± 0.024
1.129MetPro: 1.129 ± 0.025
0.986MetGln: 0.986 ± 0.021
1.182MetArg: 1.182 ± 0.027
1.179MetSer: 1.179 ± 0.022
1.342MetThr: 1.342 ± 0.024
1.28MetVal: 1.28 ± 0.025
0.191MetTrp: 0.191 ± 0.009
0.575MetTyr: 0.575 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.72AsnAla: 3.72 ± 0.041
0.315AsnCys: 0.315 ± 0.013
2.378AsnAsp: 2.378 ± 0.036
2.407AsnGlu: 2.407 ± 0.034
1.896AsnPhe: 1.896 ± 0.034
3.854AsnGly: 3.854 ± 0.061
0.833AsnHis: 0.833 ± 0.021
2.275AsnIle: 2.275 ± 0.037
1.817AsnLys: 1.817 ± 0.032
4.357AsnLeu: 4.357 ± 0.052
0.776AsnMet: 0.776 ± 0.019
2.234AsnAsn: 2.234 ± 0.044
2.877AsnPro: 2.877 ± 0.037
2.401AsnGln: 2.401 ± 0.038
3.136AsnArg: 3.136 ± 0.042
2.45AsnSer: 2.45 ± 0.04
2.741AsnThr: 2.741 ± 0.053
3.243AsnVal: 3.243 ± 0.048
0.711AsnTrp: 0.711 ± 0.017
1.888AsnTyr: 1.888 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
4.592ProAla: 4.592 ± 0.047
0.23ProCys: 0.23 ± 0.012
3.497ProAsp: 3.497 ± 0.039
2.996ProGlu: 2.996 ± 0.039
2.122ProPhe: 2.122 ± 0.036
3.558ProGly: 3.558 ± 0.054
0.844ProHis: 0.844 ± 0.02
2.609ProIle: 2.609 ± 0.034
1.953ProLys: 1.953 ± 0.03
4.231ProLeu: 4.231 ± 0.045
0.941ProMet: 0.941 ± 0.021
2.358ProAsn: 2.358 ± 0.041
1.655ProPro: 1.655 ± 0.031
1.809ProGln: 1.809 ± 0.03
1.936ProArg: 1.936 ± 0.032
2.684ProSer: 2.684 ± 0.033
3.417ProThr: 3.417 ± 0.047
3.926ProVal: 3.926 ± 0.047
0.518ProTrp: 0.518 ± 0.015
1.755ProTyr: 1.755 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.077GlnAla: 4.077 ± 0.046
0.242GlnCys: 0.242 ± 0.011
1.721GlnAsp: 1.721 ± 0.031
2.178GlnGlu: 2.178 ± 0.035
2.075GlnPhe: 2.075 ± 0.031
2.581GlnGly: 2.581 ± 0.034
0.929GlnHis: 0.929 ± 0.025
2.485GlnIle: 2.485 ± 0.037
2.229GlnLys: 2.229 ± 0.035
4.962GlnLeu: 4.962 ± 0.057
0.935GlnMet: 0.935 ± 0.024
1.986GlnAsn: 1.986 ± 0.038
2.821GlnPro: 2.821 ± 0.042
2.916GlnGln: 2.916 ± 0.046
2.843GlnArg: 2.843 ± 0.038
2.67GlnSer: 2.67 ± 0.045
3.19GlnThr: 3.19 ± 0.04
3.075GlnVal: 3.075 ± 0.037
0.594GlnTrp: 0.594 ± 0.018
1.751GlnTyr: 1.751 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
4.052ArgAla: 4.052 ± 0.047
0.367ArgCys: 0.367 ± 0.014
2.818ArgAsp: 2.818 ± 0.043
2.987ArgGlu: 2.987 ± 0.038
3.024ArgPhe: 3.024 ± 0.04
3.127ArgGly: 3.127 ± 0.041
1.113ArgHis: 1.113 ± 0.023
3.735ArgIle: 3.735 ± 0.045
2.736ArgLys: 2.736 ± 0.038
6.444ArgLeu: 6.444 ± 0.059
1.447ArgMet: 1.447 ± 0.022
2.811ArgAsn: 2.811 ± 0.036
2.753ArgPro: 2.753 ± 0.042
3.427ArgGln: 3.427 ± 0.053
3.477ArgArg: 3.477 ± 0.05
3.386ArgSer: 3.386 ± 0.039
3.588ArgThr: 3.588 ± 0.035
3.895ArgVal: 3.895 ± 0.043
0.962ArgTrp: 0.962 ± 0.025
2.59ArgTyr: 2.59 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
4.987SerAla: 4.987 ± 0.052
0.472SerCys: 0.472 ± 0.015
3.043SerAsp: 3.043 ± 0.04
2.801SerGlu: 2.801 ± 0.037
3.077SerPhe: 3.077 ± 0.038
4.803SerGly: 4.803 ± 0.061
1.05SerHis: 1.05 ± 0.02
3.415SerIle: 3.415 ± 0.044
2.293SerLys: 2.293 ± 0.036
6.404SerLeu: 6.404 ± 0.062
1.192SerMet: 1.192 ± 0.022
2.492SerAsn: 2.492 ± 0.036
2.911SerPro: 2.911 ± 0.04
2.35SerGln: 2.35 ± 0.031
3.323SerArg: 3.323 ± 0.037
3.716SerSer: 3.716 ± 0.048
3.715SerThr: 3.715 ± 0.057
4.609SerVal: 4.609 ± 0.058
0.775SerTrp: 0.775 ± 0.02
2.325SerTyr: 2.325 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.627ThrAla: 5.627 ± 0.095
0.404ThrCys: 0.404 ± 0.018
3.923ThrAsp: 3.923 ± 0.046
3.058ThrGlu: 3.058 ± 0.04
2.999ThrPhe: 2.999 ± 0.04
5.33ThrGly: 5.33 ± 0.058
1.098ThrHis: 1.098 ± 0.022
3.79ThrIle: 3.79 ± 0.045
2.453ThrLys: 2.453 ± 0.038
6.718ThrLeu: 6.718 ± 0.057
1.127ThrMet: 1.127 ± 0.019
3.013ThrAsn: 3.013 ± 0.05
3.465ThrPro: 3.465 ± 0.049
2.445ThrGln: 2.445 ± 0.04
2.986ThrArg: 2.986 ± 0.042
3.755ThrSer: 3.755 ± 0.063
4.348ThrThr: 4.348 ± 0.091
5.021ThrVal: 5.021 ± 0.075
0.751ThrTrp: 0.751 ± 0.02
2.811ThrTyr: 2.811 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
6.206ValAla: 6.206 ± 0.06
0.616ValCys: 0.616 ± 0.017
3.733ValAsp: 3.733 ± 0.044
3.663ValGlu: 3.663 ± 0.043
3.031ValPhe: 3.031 ± 0.038
5.054ValGly: 5.054 ± 0.051
1.151ValHis: 1.151 ± 0.023
3.826ValIle: 3.826 ± 0.045
3.134ValLys: 3.134 ± 0.036
6.954ValLeu: 6.954 ± 0.068
1.48ValMet: 1.48 ± 0.03
3.277ValAsn: 3.277 ± 0.044
3.242ValPro: 3.242 ± 0.037
2.766ValGln: 2.766 ± 0.04
4.282ValArg: 4.282 ± 0.045
4.863ValSer: 4.863 ± 0.054
4.66ValThr: 4.66 ± 0.092
5.58ValVal: 5.58 ± 0.071
0.938ValTrp: 0.938 ± 0.023
2.5ValTyr: 2.5 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.023TrpAla: 1.023 ± 0.02
0.099TrpCys: 0.099 ± 0.006
0.631TrpAsp: 0.631 ± 0.018
0.619TrpGlu: 0.619 ± 0.018
0.649TrpPhe: 0.649 ± 0.018
0.889TrpGly: 0.889 ± 0.02
0.327TrpHis: 0.327 ± 0.012
0.664TrpIle: 0.664 ± 0.017
0.611TrpLys: 0.611 ± 0.017
1.675TrpLeu: 1.675 ± 0.032
0.358TrpMet: 0.358 ± 0.013
0.61TrpAsn: 0.61 ± 0.017
0.463TrpPro: 0.463 ± 0.016
0.832TrpGln: 0.832 ± 0.02
0.804TrpArg: 0.804 ± 0.019
0.793TrpSer: 0.793 ± 0.022
0.769TrpThr: 0.769 ± 0.02
0.908TrpVal: 0.908 ± 0.022
0.254TrpTrp: 0.254 ± 0.012
0.485TrpTyr: 0.485 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.96TyrAla: 2.96 ± 0.039
0.325TyrCys: 0.325 ± 0.011
2.167TyrAsp: 2.167 ± 0.033
1.958TyrGlu: 1.958 ± 0.033
1.889TyrPhe: 1.889 ± 0.031
2.785TyrGly: 2.785 ± 0.042
0.734TyrHis: 0.734 ± 0.019
1.732TyrIle: 1.732 ± 0.03
1.54TyrLys: 1.54 ± 0.028
3.712TyrLeu: 3.712 ± 0.046
0.632TyrMet: 0.632 ± 0.016
1.868TyrAsn: 1.868 ± 0.04
1.729TyrPro: 1.729 ± 0.029
1.984TyrGln: 1.984 ± 0.033
2.61TyrArg: 2.61 ± 0.029
2.233TyrSer: 2.233 ± 0.036
2.309TyrThr: 2.309 ± 0.036
2.726TyrVal: 2.726 ± 0.038
0.559TyrTrp: 0.559 ± 0.016
1.6TyrTyr: 1.6 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6341 proteins (2247638 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski