Amino acid dipepetide frequency for Candidatus Brocadia sinica JPN1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.876AlaAla: 4.876 ± 0.081	0.917AlaCys: 0.917 ± 0.03	3.401AlaAsp: 3.401 ± 0.062	4.477AlaGlu: 4.477 ± 0.071	3.074AlaPhe: 3.074 ± 0.06	5.105AlaGly: 5.105 ± 0.078	1.35AlaHis: 1.35 ± 0.041	5.791AlaIle: 5.791 ± 0.074	4.367AlaLys: 4.367 ± 0.078	6.616AlaLeu: 6.616 ± 0.084	1.801AlaMet: 1.801 ± 0.044	2.556AlaAsn: 2.556 ± 0.045	2.051AlaPro: 2.051 ± 0.049	2.146AlaGln: 2.146 ± 0.046	3.496AlaArg: 3.496 ± 0.058	4.191AlaSer: 4.191 ± 0.066	3.403AlaThr: 3.403 ± 0.06	4.847AlaVal: 4.847 ± 0.08	0.748AlaTrp: 0.748 ± 0.03	2.343AlaTyr: 2.343 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.791CysAla: 0.791 ± 0.027	0.238CysCys: 0.238 ± 0.015	0.662CysAsp: 0.662 ± 0.025	0.649CysGlu: 0.649 ± 0.026	0.613CysPhe: 0.613 ± 0.022	1.177CysGly: 1.177 ± 0.038	0.6CysHis: 0.6 ± 0.041	0.92CysIle: 0.92 ± 0.028	0.903CysLys: 0.903 ± 0.031	1.219CysLeu: 1.219 ± 0.034	0.295CysMet: 0.295 ± 0.015	0.62CysAsn: 0.62 ± 0.024	0.667CysPro: 0.667 ± 0.031	0.351CysGln: 0.351 ± 0.016	0.61CysArg: 0.61 ± 0.024	0.793CysSer: 0.793 ± 0.028	0.585CysThr: 0.585 ± 0.024	0.815CysVal: 0.815 ± 0.03	0.117CysTrp: 0.117 ± 0.011	0.472CysTyr: 0.472 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.927AspAla: 3.927 ± 0.067	0.662AspCys: 0.662 ± 0.029	2.545AspAsp: 2.545 ± 0.05	3.61AspGlu: 3.61 ± 0.058	2.546AspPhe: 2.546 ± 0.053	3.599AspGly: 3.599 ± 0.067	0.927AspHis: 0.927 ± 0.035	4.805AspIle: 4.805 ± 0.073	3.596AspLys: 3.596 ± 0.053	4.655AspLeu: 4.655 ± 0.075	1.307AspMet: 1.307 ± 0.033	2.101AspAsn: 2.101 ± 0.053	2.173AspPro: 2.173 ± 0.04	1.237AspGln: 1.237 ± 0.034	2.522AspArg: 2.522 ± 0.048	2.58AspSer: 2.58 ± 0.058	3.108AspThr: 3.108 ± 0.058	3.713AspVal: 3.713 ± 0.059	0.657AspTrp: 0.657 ± 0.025	2.084AspTyr: 2.084 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	4.64GluAla: 4.64 ± 0.083	0.68GluCys: 0.68 ± 0.025	3.365GluAsp: 3.365 ± 0.058	5.189GluGlu: 5.189 ± 0.087	2.572GluPhe: 2.572 ± 0.051	4.313GluGly: 4.313 ± 0.064	1.359GluHis: 1.359 ± 0.04	6.145GluIle: 6.145 ± 0.087	6.348GluLys: 6.348 ± 0.091	5.932GluLeu: 5.932 ± 0.081	1.824GluMet: 1.824 ± 0.046	3.108GluAsn: 3.108 ± 0.054	1.83GluPro: 1.83 ± 0.043	2.204GluGln: 2.204 ± 0.052	3.848GluArg: 3.848 ± 0.066	3.464GluSer: 3.464 ± 0.053	3.578GluThr: 3.578 ± 0.059	4.391GluVal: 4.391 ± 0.071	0.759GluTrp: 0.759 ± 0.026	2.242GluTyr: 2.242 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.669PheAla: 2.669 ± 0.053	0.702PheCys: 0.702 ± 0.025	2.421PheAsp: 2.421 ± 0.045	2.586PheGlu: 2.586 ± 0.049	2.405PhePhe: 2.405 ± 0.059	3.198PheGly: 3.198 ± 0.063	1.104PheHis: 1.104 ± 0.032	3.434PheIle: 3.434 ± 0.072	2.609PheLys: 2.609 ± 0.055	4.519PheLeu: 4.519 ± 0.082	1.03PheMet: 1.03 ± 0.03	1.793PheAsn: 1.793 ± 0.038	1.812PhePro: 1.812 ± 0.043	1.414PheGln: 1.414 ± 0.038	2.072PheArg: 2.072 ± 0.047	3.137PheSer: 3.137 ± 0.059	2.525PheThr: 2.525 ± 0.048	3.172PheVal: 3.172 ± 0.062	0.534PheTrp: 0.534 ± 0.023	1.676PheTyr: 1.676 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.489GlyAla: 4.489 ± 0.072	1.049GlyCys: 1.049 ± 0.034	3.325GlyAsp: 3.325 ± 0.067	4.319GlyGlu: 4.319 ± 0.07	3.213GlyPhe: 3.213 ± 0.067	4.793GlyGly: 4.793 ± 0.093	1.458GlyHis: 1.458 ± 0.045	6.491GlyIle: 6.491 ± 0.082	5.685GlyLys: 5.685 ± 0.079	6.216GlyLeu: 6.216 ± 0.069	1.911GlyMet: 1.911 ± 0.042	3.378GlyAsn: 3.378 ± 0.073	1.688GlyPro: 1.688 ± 0.044	2.02GlyGln: 2.02 ± 0.05	3.495GlyArg: 3.495 ± 0.06	3.952GlySer: 3.952 ± 0.073	4.016GlyThr: 4.016 ± 0.079	4.664GlyVal: 4.664 ± 0.075	0.869GlyTrp: 0.869 ± 0.029	2.827GlyTyr: 2.827 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.53HisAla: 1.53 ± 0.037	0.336HisCys: 0.336 ± 0.017	1.105HisAsp: 1.105 ± 0.03	1.358HisGlu: 1.358 ± 0.036	1.004HisPhe: 1.004 ± 0.03	1.653HisGly: 1.653 ± 0.043	0.572HisHis: 0.572 ± 0.027	1.775HisIle: 1.775 ± 0.047	1.244HisLys: 1.244 ± 0.037	2.013HisLeu: 2.013 ± 0.055	0.472HisMet: 0.472 ± 0.018	0.924HisAsn: 0.924 ± 0.028	1.137HisPro: 1.137 ± 0.033	0.651HisGln: 0.651 ± 0.026	1.056HisArg: 1.056 ± 0.029	1.176HisSer: 1.176 ± 0.032	1.19HisThr: 1.19 ± 0.032	1.329HisVal: 1.329 ± 0.035	0.273HisTrp: 0.273 ± 0.015	0.877HisTyr: 0.877 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.906IleAla: 5.906 ± 0.084	1.073IleCys: 1.073 ± 0.033	4.523IleAsp: 4.523 ± 0.061	5.514IleGlu: 5.514 ± 0.078	3.407IlePhe: 3.407 ± 0.062	5.258IleGly: 5.258 ± 0.081	1.828IleHis: 1.828 ± 0.04	5.888IleIle: 5.888 ± 0.094	5.41IleLys: 5.41 ± 0.079	7.418IleLeu: 7.418 ± 0.099	1.623IleMet: 1.623 ± 0.041	3.331IleAsn: 3.331 ± 0.053	3.832IlePro: 3.832 ± 0.067	2.678IleGln: 2.678 ± 0.045	3.815IleArg: 3.815 ± 0.058	5.194IleSer: 5.194 ± 0.074	4.704IleThr: 4.704 ± 0.077	5.381IleVal: 5.381 ± 0.081	0.67IleTrp: 0.67 ± 0.023	2.443IleTyr: 2.443 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.638LysAla: 4.638 ± 0.069	0.702LysCys: 0.702 ± 0.031	4.251LysAsp: 4.251 ± 0.065	6.339LysGlu: 6.339 ± 0.097	2.271LysPhe: 2.271 ± 0.05	4.942LysGly: 4.942 ± 0.075	1.375LysHis: 1.375 ± 0.033	5.989LysIle: 5.989 ± 0.085	6.56LysLys: 6.56 ± 0.09	5.87LysLeu: 5.87 ± 0.073	1.949LysMet: 1.949 ± 0.048	3.737LysAsn: 3.737 ± 0.065	2.678LysPro: 2.678 ± 0.058	2.372LysGln: 2.372 ± 0.053	3.966LysArg: 3.966 ± 0.064	3.747LysSer: 3.747 ± 0.058	4.262LysThr: 4.262 ± 0.066	4.542LysVal: 4.542 ± 0.074	0.64LysTrp: 0.64 ± 0.027	2.505LysTyr: 2.505 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	6.4LeuAla: 6.4 ± 0.078	1.275LeuCys: 1.275 ± 0.038	4.748LeuAsp: 4.748 ± 0.067	6.113LeuGlu: 6.113 ± 0.09	4.295LeuPhe: 4.295 ± 0.071	6.328LeuGly: 6.328 ± 0.077	1.915LeuHis: 1.915 ± 0.04	6.495LeuIle: 6.495 ± 0.086	7.248LeuLys: 7.248 ± 0.094	8.951LeuLeu: 8.951 ± 0.111	2.199LeuMet: 2.199 ± 0.042	4.02LeuAsn: 4.02 ± 0.064	4.052LeuPro: 4.052 ± 0.068	3.063LeuGln: 3.063 ± 0.055	5.003LeuArg: 5.003 ± 0.06	6.727LeuSer: 6.727 ± 0.085	4.893LeuThr: 4.893 ± 0.068	5.504LeuVal: 5.504 ± 0.067	1.037LeuTrp: 1.037 ± 0.037	2.926LeuTyr: 2.926 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.897MetAla: 1.897 ± 0.04	0.249MetCys: 0.249 ± 0.017	1.277MetAsp: 1.277 ± 0.037	1.617MetGlu: 1.617 ± 0.034	0.795MetPhe: 0.795 ± 0.026	1.836MetGly: 1.836 ± 0.046	0.495MetHis: 0.495 ± 0.022	1.71MetIle: 1.71 ± 0.042	2.161MetLys: 2.161 ± 0.048	2.083MetLeu: 2.083 ± 0.042	0.575MetMet: 0.575 ± 0.023	1.206MetAsn: 1.206 ± 0.032	1.082MetPro: 1.082 ± 0.036	0.812MetGln: 0.812 ± 0.028	1.165MetArg: 1.165 ± 0.028	1.46MetSer: 1.46 ± 0.04	1.281MetThr: 1.281 ± 0.034	1.72MetVal: 1.72 ± 0.04	0.175MetTrp: 0.175 ± 0.012	0.613MetTyr: 0.613 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.009AsnAla: 3.009 ± 0.063	0.537AsnCys: 0.537 ± 0.023	2.165AsnAsp: 2.165 ± 0.05	2.552AsnGlu: 2.552 ± 0.051	1.94AsnPhe: 1.94 ± 0.046	2.799AsnGly: 2.799 ± 0.063	0.925AsnHis: 0.925 ± 0.03	3.825AsnIle: 3.825 ± 0.07	2.981AsnLys: 2.981 ± 0.064	4.283AsnLeu: 4.283 ± 0.065	0.911AsnMet: 0.911 ± 0.032	2.213AsnAsn: 2.213 ± 0.049	2.376AsnPro: 2.376 ± 0.041	1.364AsnGln: 1.364 ± 0.034	2.177AsnArg: 2.177 ± 0.041	2.318AsnSer: 2.318 ± 0.058	2.578AsnThr: 2.578 ± 0.057	2.773AsnVal: 2.773 ± 0.054	0.521AsnTrp: 0.521 ± 0.022	1.631AsnTyr: 1.631 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.552ProAla: 2.552 ± 0.049	0.498ProCys: 0.498 ± 0.018	2.557ProAsp: 2.557 ± 0.051	3.169ProGlu: 3.169 ± 0.056	2.032ProPhe: 2.032 ± 0.045	2.793ProGly: 2.793 ± 0.054	0.901ProHis: 0.901 ± 0.03	2.624ProIle: 2.624 ± 0.047	2.31ProLys: 2.31 ± 0.049	3.765ProLeu: 3.765 ± 0.061	0.818ProMet: 0.818 ± 0.031	1.48ProAsn: 1.48 ± 0.034	1.686ProPro: 1.686 ± 0.046	1.298ProGln: 1.298 ± 0.033	1.616ProArg: 1.616 ± 0.039	2.358ProSer: 2.358 ± 0.05	2.013ProThr: 2.013 ± 0.048	3.144ProVal: 3.144 ± 0.056	0.432ProTrp: 0.432 ± 0.019	1.464ProTyr: 1.464 ± 0.042	0.001ProXaa: 0.001 ± 0.001
Gln	2.088GlnAla: 2.088 ± 0.042	0.379GlnCys: 0.379 ± 0.02	1.504GlnAsp: 1.504 ± 0.04	2.386GlnGlu: 2.386 ± 0.049	1.264GlnPhe: 1.264 ± 0.038	1.974GlnGly: 1.974 ± 0.04	0.622GlnHis: 0.622 ± 0.026	2.541GlnIle: 2.541 ± 0.049	2.773GlnLys: 2.773 ± 0.066	2.71GlnLeu: 2.71 ± 0.059	0.875GlnMet: 0.875 ± 0.029	1.428GlnAsn: 1.428 ± 0.035	1.177GlnPro: 1.177 ± 0.032	1.181GlnGln: 1.181 ± 0.035	1.782GlnArg: 1.782 ± 0.036	1.718GlnSer: 1.718 ± 0.04	1.728GlnThr: 1.728 ± 0.038	2.006GlnVal: 2.006 ± 0.047	0.378GlnTrp: 0.378 ± 0.018	1.127GlnTyr: 1.127 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.955ArgAla: 2.955 ± 0.062	0.682ArgCys: 0.682 ± 0.028	2.592ArgAsp: 2.592 ± 0.052	3.815ArgGlu: 3.815 ± 0.057	2.422ArgPhe: 2.422 ± 0.048	3.071ArgGly: 3.071 ± 0.055	1.214ArgHis: 1.214 ± 0.037	4.235ArgIle: 4.235 ± 0.074	3.9ArgLys: 3.9 ± 0.064	5.082ArgLeu: 5.082 ± 0.08	1.377ArgMet: 1.377 ± 0.034	2.34ArgAsn: 2.34 ± 0.044	1.66ArgPro: 1.66 ± 0.033	1.762ArgGln: 1.762 ± 0.038	2.707ArgArg: 2.707 ± 0.062	2.476ArgSer: 2.476 ± 0.048	2.318ArgThr: 2.318 ± 0.04	3.152ArgVal: 3.152 ± 0.059	0.606ArgTrp: 0.606 ± 0.023	1.945ArgTyr: 1.945 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.866SerAla: 3.866 ± 0.069	0.735SerCys: 0.735 ± 0.03	3.044SerAsp: 3.044 ± 0.06	3.698SerGlu: 3.698 ± 0.064	2.976SerPhe: 2.976 ± 0.056	4.781SerGly: 4.781 ± 0.076	1.256SerHis: 1.256 ± 0.037	4.561SerIle: 4.561 ± 0.071	3.752SerLys: 3.752 ± 0.059	6.021SerLeu: 6.021 ± 0.092	1.485SerMet: 1.485 ± 0.037	2.378SerAsn: 2.378 ± 0.059	2.65SerPro: 2.65 ± 0.058	1.902SerGln: 1.902 ± 0.044	2.77SerArg: 2.77 ± 0.05	3.603SerSer: 3.603 ± 0.071	3.063SerThr: 3.063 ± 0.061	4.071SerVal: 4.071 ± 0.065	0.744SerTrp: 0.744 ± 0.025	1.964SerTyr: 1.964 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	3.831ThrAla: 3.831 ± 0.07	0.676ThrCys: 0.676 ± 0.026	2.789ThrAsp: 2.789 ± 0.055	3.349ThrGlu: 3.349 ± 0.055	2.431ThrPhe: 2.431 ± 0.048	4.481ThrGly: 4.481 ± 0.077	1.229ThrHis: 1.229 ± 0.035	4.38ThrIle: 4.38 ± 0.07	3.351ThrLys: 3.351 ± 0.056	5.191ThrLeu: 5.191 ± 0.079	1.217ThrMet: 1.217 ± 0.033	2.229ThrAsn: 2.229 ± 0.054	2.587ThrPro: 2.587 ± 0.062	1.678ThrGln: 1.678 ± 0.041	2.39ThrArg: 2.39 ± 0.047	3.285ThrSer: 3.285 ± 0.074	3.115ThrThr: 3.115 ± 0.07	4.006ThrVal: 4.006 ± 0.063	0.619ThrTrp: 0.619 ± 0.026	1.83ThrTyr: 1.83 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.633ValAla: 4.633 ± 0.072	1.017ValCys: 1.017 ± 0.032	3.481ValAsp: 3.481 ± 0.06	4.114ValGlu: 4.114 ± 0.066	3.247ValPhe: 3.247 ± 0.058	4.452ValGly: 4.452 ± 0.063	1.38ValHis: 1.38 ± 0.039	5.251ValIle: 5.251 ± 0.076	4.788ValLys: 4.788 ± 0.065	5.997ValLeu: 5.997 ± 0.078	1.602ValMet: 1.602 ± 0.042	2.866ValAsn: 2.866 ± 0.052	2.506ValPro: 2.506 ± 0.052	1.882ValGln: 1.882 ± 0.038	3.231ValArg: 3.231 ± 0.053	4.606ValSer: 4.606 ± 0.068	4.015ValThr: 4.015 ± 0.077	4.931ValVal: 4.931 ± 0.07	0.702ValTrp: 0.702 ± 0.028	2.184ValTyr: 2.184 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.662TrpAla: 0.662 ± 0.022	0.168TrpCys: 0.168 ± 0.012	0.605TrpAsp: 0.605 ± 0.024	0.733TrpGlu: 0.733 ± 0.024	0.542TrpPhe: 0.542 ± 0.022	0.795TrpGly: 0.795 ± 0.028	0.278TrpHis: 0.278 ± 0.015	0.837TrpIle: 0.837 ± 0.027	0.816TrpLys: 0.816 ± 0.031	1.124TrpLeu: 1.124 ± 0.041	0.291TrpMet: 0.291 ± 0.019	0.537TrpAsn: 0.537 ± 0.023	0.326TrpPro: 0.326 ± 0.017	0.442TrpGln: 0.442 ± 0.02	0.603TrpArg: 0.603 ± 0.028	0.558TrpSer: 0.558 ± 0.023	0.522TrpThr: 0.522 ± 0.023	0.665TrpVal: 0.665 ± 0.027	0.162TrpTrp: 0.162 ± 0.013	0.385TrpTyr: 0.385 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.196TyrAla: 2.196 ± 0.053	0.522TyrCys: 0.522 ± 0.021	1.993TyrAsp: 1.993 ± 0.052	2.205TyrGlu: 2.205 ± 0.05	1.765TyrPhe: 1.765 ± 0.046	2.51TyrGly: 2.51 ± 0.057	0.889TyrHis: 0.889 ± 0.03	2.197TyrIle: 2.197 ± 0.046	2.531TyrLys: 2.531 ± 0.047	3.527TyrLeu: 3.527 ± 0.057	0.645TyrMet: 0.645 ± 0.023	1.636TyrAsn: 1.636 ± 0.044	1.54TyrPro: 1.54 ± 0.037	1.185TyrGln: 1.185 ± 0.033	1.988TyrArg: 1.988 ± 0.042	1.976TyrSer: 1.976 ± 0.045	1.767TyrThr: 1.767 ± 0.044	2.056TyrVal: 2.056 ± 0.046	0.408TyrTrp: 0.408 ± 0.02	1.431TyrTyr: 1.431 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3878 proteins (1138923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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