Amino acid dipepetide frequency for Fulvimarina pelagi HTCC2506

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.352AlaAla: 14.352 ± 0.169
0.929AlaCys: 0.929 ± 0.035
6.866AlaAsp: 6.866 ± 0.082
8.278AlaGlu: 8.278 ± 0.103
4.814AlaPhe: 4.814 ± 0.066
9.925AlaGly: 9.925 ± 0.113
1.837AlaHis: 1.837 ± 0.04
7.039AlaIle: 7.039 ± 0.086
4.215AlaLys: 4.215 ± 0.073
11.85AlaLeu: 11.85 ± 0.132
3.524AlaMet: 3.524 ± 0.061
3.129AlaAsn: 3.129 ± 0.069
4.65AlaPro: 4.65 ± 0.082
3.166AlaGln: 3.166 ± 0.061
7.716AlaArg: 7.716 ± 0.098
6.888AlaSer: 6.888 ± 0.092
5.617AlaThr: 5.617 ± 0.078
8.086AlaVal: 8.086 ± 0.104
1.224AlaTrp: 1.224 ± 0.036
2.566AlaTyr: 2.566 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.854CysAla: 0.854 ± 0.032
0.105CysCys: 0.105 ± 0.009
0.529CysAsp: 0.529 ± 0.023
0.494CysGlu: 0.494 ± 0.021
0.336CysPhe: 0.336 ± 0.018
0.964CysGly: 0.964 ± 0.036
0.24CysHis: 0.24 ± 0.015
0.364CysIle: 0.364 ± 0.019
0.171CysLys: 0.171 ± 0.011
0.822CysLeu: 0.822 ± 0.032
0.148CysMet: 0.148 ± 0.011
0.195CysAsn: 0.195 ± 0.013
0.427CysPro: 0.427 ± 0.021
0.205CysGln: 0.205 ± 0.014
0.602CysArg: 0.602 ± 0.023
0.456CysSer: 0.456 ± 0.022
0.352CysThr: 0.352 ± 0.019
0.558CysVal: 0.558 ± 0.025
0.094CysTrp: 0.094 ± 0.008
0.177CysTyr: 0.177 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.816AspAla: 6.816 ± 0.095
0.538AspCys: 0.538 ± 0.026
3.661AspAsp: 3.661 ± 0.09
4.503AspGlu: 4.503 ± 0.077
2.307AspPhe: 2.307 ± 0.049
5.575AspGly: 5.575 ± 0.084
1.299AspHis: 1.299 ± 0.044
3.28AspIle: 3.28 ± 0.073
1.668AspLys: 1.668 ± 0.041
6.216AspLeu: 6.216 ± 0.095
1.332AspMet: 1.332 ± 0.032
1.345AspAsn: 1.345 ± 0.036
3.482AspPro: 3.482 ± 0.06
1.817AspGln: 1.817 ± 0.047
4.92AspArg: 4.92 ± 0.07
2.21AspSer: 2.21 ± 0.039
2.726AspThr: 2.726 ± 0.054
4.277AspVal: 4.277 ± 0.065
0.958AspTrp: 0.958 ± 0.03
1.433AspTyr: 1.433 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
8.807GluAla: 8.807 ± 0.105
0.416GluCys: 0.416 ± 0.02
3.699GluAsp: 3.699 ± 0.066
4.387GluGlu: 4.387 ± 0.075
1.994GluPhe: 1.994 ± 0.046
5.083GluGly: 5.083 ± 0.077
1.237GluHis: 1.237 ± 0.038
4.192GluIle: 4.192 ± 0.064
2.836GluLys: 2.836 ± 0.069
5.374GluLeu: 5.374 ± 0.072
1.791GluMet: 1.791 ± 0.04
2.167GluAsn: 2.167 ± 0.046
3.244GluPro: 3.244 ± 0.082
1.867GluGln: 1.867 ± 0.053
5.66GluArg: 5.66 ± 0.093
3.018GluSer: 3.018 ± 0.064
4.861GluThr: 4.861 ± 0.076
4.053GluVal: 4.053 ± 0.062
0.712GluTrp: 0.712 ± 0.027
1.09GluTyr: 1.09 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.815PheAla: 4.815 ± 0.067
0.384PheCys: 0.384 ± 0.018
2.946PheAsp: 2.946 ± 0.056
2.713PheGlu: 2.713 ± 0.056
1.654PhePhe: 1.654 ± 0.051
3.906PheGly: 3.906 ± 0.068
0.682PheHis: 0.682 ± 0.025
1.722PheIle: 1.722 ± 0.045
1.04PheLys: 1.04 ± 0.03
3.633PheLeu: 3.633 ± 0.071
0.881PheMet: 0.881 ± 0.033
0.997PheAsn: 0.997 ± 0.033
1.591PhePro: 1.591 ± 0.038
1.055PheGln: 1.055 ± 0.033
2.279PheArg: 2.279 ± 0.042
2.505PheSer: 2.505 ± 0.045
1.962PheThr: 1.962 ± 0.045
3.231PheVal: 3.231 ± 0.062
0.523PheTrp: 0.523 ± 0.022
0.986PheTyr: 0.986 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
8.704GlyAla: 8.704 ± 0.088
0.774GlyCys: 0.774 ± 0.028
4.741GlyAsp: 4.741 ± 0.085
5.955GlyGlu: 5.955 ± 0.085
3.821GlyPhe: 3.821 ± 0.063
7.473GlyGly: 7.473 ± 0.108
1.803GlyHis: 1.803 ± 0.048
4.726GlyIle: 4.726 ± 0.072
3.177GlyLys: 3.177 ± 0.067
8.44GlyLeu: 8.44 ± 0.11
2.354GlyMet: 2.354 ± 0.05
2.166GlyAsn: 2.166 ± 0.052
3.407GlyPro: 3.407 ± 0.058
2.6GlyGln: 2.6 ± 0.056
6.108GlyArg: 6.108 ± 0.08
5.349GlySer: 5.349 ± 0.089
4.893GlyThr: 4.893 ± 0.081
5.876GlyVal: 5.876 ± 0.079
1.254GlyTrp: 1.254 ± 0.041
2.233GlyTyr: 2.233 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.026HisAla: 2.026 ± 0.041
0.251HisCys: 0.251 ± 0.013
1.141HisAsp: 1.141 ± 0.035
1.132HisGlu: 1.132 ± 0.038
0.806HisPhe: 0.806 ± 0.029
1.763HisGly: 1.763 ± 0.045
0.535HisHis: 0.535 ± 0.028
0.859HisIle: 0.859 ± 0.029
0.477HisLys: 0.477 ± 0.024
1.898HisLeu: 1.898 ± 0.046
0.459HisMet: 0.459 ± 0.021
0.418HisAsn: 0.418 ± 0.022
1.2HisPro: 1.2 ± 0.036
0.543HisGln: 0.543 ± 0.022
1.362HisArg: 1.362 ± 0.042
0.99HisSer: 0.99 ± 0.03
0.774HisThr: 0.774 ± 0.028
1.401HisVal: 1.401 ± 0.036
0.271HisTrp: 0.271 ± 0.017
0.509HisTyr: 0.509 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.778IleAla: 7.778 ± 0.094
0.526IleCys: 0.526 ± 0.024
3.964IleAsp: 3.964 ± 0.063
4.401IleGlu: 4.401 ± 0.074
1.956IlePhe: 1.956 ± 0.051
5.44IleGly: 5.44 ± 0.076
0.933IleHis: 0.933 ± 0.031
2.296IleIle: 2.296 ± 0.053
1.361IleLys: 1.361 ± 0.038
4.975IleLeu: 4.975 ± 0.08
1.053IleMet: 1.053 ± 0.034
1.274IleAsn: 1.274 ± 0.039
2.347IlePro: 2.347 ± 0.049
1.27IleGln: 1.27 ± 0.038
3.239IleArg: 3.239 ± 0.057
2.999IleSer: 2.999 ± 0.055
2.569IleThr: 2.569 ± 0.05
4.793IleVal: 4.793 ± 0.068
0.614IleTrp: 0.614 ± 0.027
1.139IleTyr: 1.139 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
4.278LysAla: 4.278 ± 0.069
0.154LysCys: 0.154 ± 0.012
1.868LysAsp: 1.868 ± 0.044
1.78LysGlu: 1.78 ± 0.041
0.892LysPhe: 0.892 ± 0.03
2.723LysGly: 2.723 ± 0.062
0.639LysHis: 0.639 ± 0.021
1.864LysIle: 1.864 ± 0.047
1.367LysLys: 1.367 ± 0.043
3.26LysLeu: 3.26 ± 0.059
0.741LysMet: 0.741 ± 0.029
0.937LysAsn: 0.937 ± 0.03
2.12LysPro: 2.12 ± 0.051
0.974LysGln: 0.974 ± 0.034
2.987LysArg: 2.987 ± 0.049
2.013LysSer: 2.013 ± 0.049
2.208LysThr: 2.208 ± 0.043
2.365LysVal: 2.365 ± 0.052
0.341LysTrp: 0.341 ± 0.018
0.54LysTyr: 0.54 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
12.202LeuAla: 12.202 ± 0.126
0.835LeuCys: 0.835 ± 0.025
6.002LeuAsp: 6.002 ± 0.089
5.527LeuGlu: 5.527 ± 0.066
3.875LeuPhe: 3.875 ± 0.087
7.849LeuGly: 7.849 ± 0.081
1.575LeuHis: 1.575 ± 0.035
5.052LeuIle: 5.052 ± 0.083
3.865LeuLys: 3.865 ± 0.056
8.389LeuLeu: 8.389 ± 0.121
2.24LeuMet: 2.24 ± 0.047
2.521LeuAsn: 2.521 ± 0.044
4.971LeuPro: 4.971 ± 0.074
2.521LeuGln: 2.521 ± 0.049
5.944LeuArg: 5.944 ± 0.078
6.767LeuSer: 6.767 ± 0.073
5.597LeuThr: 5.597 ± 0.075
7.303LeuVal: 7.303 ± 0.095
1.004LeuTrp: 1.004 ± 0.031
1.972LeuTyr: 1.972 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.955MetAla: 2.955 ± 0.055
0.139MetCys: 0.139 ± 0.011
1.207MetAsp: 1.207 ± 0.031
1.332MetGlu: 1.332 ± 0.041
0.712MetPhe: 0.712 ± 0.025
1.829MetGly: 1.829 ± 0.043
0.411MetHis: 0.411 ± 0.019
1.518MetIle: 1.518 ± 0.046
1.096MetLys: 1.096 ± 0.032
2.353MetLeu: 2.353 ± 0.05
0.764MetMet: 0.764 ± 0.031
0.803MetAsn: 0.803 ± 0.027
1.557MetPro: 1.557 ± 0.041
0.758MetGln: 0.758 ± 0.029
1.961MetArg: 1.961 ± 0.041
1.789MetSer: 1.789 ± 0.038
1.924MetThr: 1.924 ± 0.041
1.591MetVal: 1.591 ± 0.043
0.186MetTrp: 0.186 ± 0.015
0.287MetTyr: 0.287 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.357AsnAla: 3.357 ± 0.061
0.228AsnCys: 0.228 ± 0.014
1.517AsnAsp: 1.517 ± 0.04
1.665AsnGlu: 1.665 ± 0.041
1.0AsnPhe: 1.0 ± 0.035
2.657AsnGly: 2.657 ± 0.06
0.534AsnHis: 0.534 ± 0.021
1.342AsnIle: 1.342 ± 0.037
0.669AsnLys: 0.669 ± 0.025
2.574AsnLeu: 2.574 ± 0.048
0.632AsnMet: 0.632 ± 0.024
0.641AsnAsn: 0.641 ± 0.025
1.71AsnPro: 1.71 ± 0.044
0.835AsnGln: 0.835 ± 0.028
1.963AsnArg: 1.963 ± 0.047
1.311AsnSer: 1.311 ± 0.032
1.286AsnThr: 1.286 ± 0.036
1.929AsnVal: 1.929 ± 0.041
0.397AsnTrp: 0.397 ± 0.018
0.667AsnTyr: 0.667 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
5.086ProAla: 5.086 ± 0.077
0.269ProCys: 0.269 ± 0.016
3.616ProAsp: 3.616 ± 0.058
3.781ProGlu: 3.781 ± 0.088
2.12ProPhe: 2.12 ± 0.045
4.078ProGly: 4.078 ± 0.058
0.978ProHis: 0.978 ± 0.037
2.717ProIle: 2.717 ± 0.055
1.797ProLys: 1.797 ± 0.043
4.337ProLeu: 4.337 ± 0.068
1.201ProMet: 1.201 ± 0.03
1.52ProAsn: 1.52 ± 0.037
2.127ProPro: 2.127 ± 0.051
1.454ProGln: 1.454 ± 0.04
2.629ProArg: 2.629 ± 0.05
3.056ProSer: 3.056 ± 0.054
2.446ProThr: 2.446 ± 0.045
3.896ProVal: 3.896 ± 0.064
0.524ProTrp: 0.524 ± 0.023
1.124ProTyr: 1.124 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.39GlnAla: 3.39 ± 0.059
0.195GlnCys: 0.195 ± 0.012
1.405GlnAsp: 1.405 ± 0.032
1.53GlnGlu: 1.53 ± 0.041
0.999GlnPhe: 0.999 ± 0.03
1.989GlnGly: 1.989 ± 0.041
0.484GlnHis: 0.484 ± 0.021
1.835GlnIle: 1.835 ± 0.041
1.019GlnLys: 1.019 ± 0.03
2.529GlnLeu: 2.529 ± 0.051
0.863GlnMet: 0.863 ± 0.029
0.944GlnAsn: 0.944 ± 0.031
1.609GlnPro: 1.609 ± 0.037
0.966GlnGln: 0.966 ± 0.044
2.218GlnArg: 2.218 ± 0.048
1.898GlnSer: 1.898 ± 0.049
1.886GlnThr: 1.886 ± 0.046
1.908GlnVal: 1.908 ± 0.046
0.317GlnTrp: 0.317 ± 0.018
0.561GlnTyr: 0.561 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
6.9ArgAla: 6.9 ± 0.101
0.503ArgCys: 0.503 ± 0.023
4.081ArgAsp: 4.081 ± 0.067
4.652ArgGlu: 4.652 ± 0.079
3.209ArgPhe: 3.209 ± 0.055
4.746ArgGly: 4.746 ± 0.061
1.604ArgHis: 1.604 ± 0.042
4.143ArgIle: 4.143 ± 0.061
2.426ArgLys: 2.426 ± 0.05
7.666ArgLeu: 7.666 ± 0.096
1.893ArgMet: 1.893 ± 0.041
1.908ArgAsn: 1.908 ± 0.038
3.372ArgPro: 3.372 ± 0.063
2.409ArgGln: 2.409 ± 0.048
5.683ArgArg: 5.683 ± 0.093
4.351ArgSer: 4.351 ± 0.064
3.617ArgThr: 3.617 ± 0.059
4.353ArgVal: 4.353 ± 0.059
0.841ArgTrp: 0.841 ± 0.026
1.727ArgTyr: 1.727 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.466SerAla: 6.466 ± 0.081
0.442SerCys: 0.442 ± 0.023
3.641SerAsp: 3.641 ± 0.058
4.059SerGlu: 4.059 ± 0.077
2.487SerPhe: 2.487 ± 0.051
6.013SerGly: 6.013 ± 0.08
1.061SerHis: 1.061 ± 0.032
3.264SerIle: 3.264 ± 0.051
1.89SerLys: 1.89 ± 0.04
5.506SerLeu: 5.506 ± 0.075
1.442SerMet: 1.442 ± 0.038
1.636SerAsn: 1.636 ± 0.035
2.655SerPro: 2.655 ± 0.049
1.755SerGln: 1.755 ± 0.045
3.874SerArg: 3.874 ± 0.074
3.517SerSer: 3.517 ± 0.069
2.848SerThr: 2.848 ± 0.048
4.312SerVal: 4.312 ± 0.054
0.678SerTrp: 0.678 ± 0.029
1.335SerTyr: 1.335 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
6.043ThrAla: 6.043 ± 0.078
0.416ThrCys: 0.416 ± 0.022
3.006ThrAsp: 3.006 ± 0.052
3.211ThrGlu: 3.211 ± 0.055
2.17ThrPhe: 2.17 ± 0.045
5.279ThrGly: 5.279 ± 0.065
0.947ThrHis: 0.947 ± 0.027
3.422ThrIle: 3.422 ± 0.074
1.652ThrLys: 1.652 ± 0.044
5.532ThrLeu: 5.532 ± 0.065
1.333ThrMet: 1.333 ± 0.035
1.498ThrAsn: 1.498 ± 0.041
3.039ThrPro: 3.039 ± 0.057
1.374ThrGln: 1.374 ± 0.037
3.378ThrArg: 3.378 ± 0.062
3.117ThrSer: 3.117 ± 0.055
2.958ThrThr: 2.958 ± 0.05
4.451ThrVal: 4.451 ± 0.071
0.593ThrTrp: 0.593 ± 0.022
1.252ThrTyr: 1.252 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
8.47ValAla: 8.47 ± 0.093
0.64ValCys: 0.64 ± 0.027
4.335ValAsp: 4.335 ± 0.082
5.003ValGlu: 5.003 ± 0.069
2.94ValPhe: 2.94 ± 0.06
5.588ValGly: 5.588 ± 0.079
1.276ValHis: 1.276 ± 0.034
3.825ValIle: 3.825 ± 0.065
2.288ValLys: 2.288 ± 0.056
7.033ValLeu: 7.033 ± 0.084
1.812ValMet: 1.812 ± 0.048
1.892ValAsn: 1.892 ± 0.043
3.497ValPro: 3.497 ± 0.054
1.838ValGln: 1.838 ± 0.044
4.678ValArg: 4.678 ± 0.061
4.674ValSer: 4.674 ± 0.061
4.378ValThr: 4.378 ± 0.06
5.741ValVal: 5.741 ± 0.087
0.858ValTrp: 0.858 ± 0.031
1.526ValTyr: 1.526 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.042TrpAla: 1.042 ± 0.033
0.13TrpCys: 0.13 ± 0.011
0.569TrpAsp: 0.569 ± 0.022
0.574TrpGlu: 0.574 ± 0.022
0.548TrpPhe: 0.548 ± 0.022
0.774TrpGly: 0.774 ± 0.031
0.288TrpHis: 0.288 ± 0.017
0.625TrpIle: 0.625 ± 0.027
0.433TrpLys: 0.433 ± 0.022
1.469TrpLeu: 1.469 ± 0.041
0.314TrpMet: 0.314 ± 0.017
0.384TrpAsn: 0.384 ± 0.018
0.639TrpPro: 0.639 ± 0.026
0.46TrpGln: 0.46 ± 0.021
1.052TrpArg: 1.052 ± 0.032
0.761TrpSer: 0.761 ± 0.024
0.772TrpThr: 0.772 ± 0.026
0.657TrpVal: 0.657 ± 0.023
0.221TrpTrp: 0.221 ± 0.015
0.25TrpTyr: 0.25 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.33TyrAla: 2.33 ± 0.051
0.219TyrCys: 0.219 ± 0.015
1.571TyrAsp: 1.571 ± 0.037
1.51TyrGlu: 1.51 ± 0.038
0.863TyrPhe: 0.863 ± 0.03
2.202TyrGly: 2.202 ± 0.049
0.451TyrHis: 0.451 ± 0.018
0.843TyrIle: 0.843 ± 0.026
0.604TyrLys: 0.604 ± 0.023
2.155TyrLeu: 2.155 ± 0.047
0.394TyrMet: 0.394 ± 0.017
0.537TyrAsn: 0.537 ± 0.024
1.112TyrPro: 1.112 ± 0.035
0.676TyrGln: 0.676 ± 0.025
1.83TyrArg: 1.83 ± 0.046
1.212TyrSer: 1.212 ± 0.034
0.998TyrThr: 0.998 ± 0.032
1.513TyrVal: 1.513 ± 0.036
0.352TyrTrp: 0.352 ± 0.017
0.58TyrTyr: 0.58 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3739 proteins (1100244 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski