Amino acid dipepetide frequency for Clostridium cavendishii DSM 21758

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.221AlaAla: 3.221 ± 0.063	0.646AlaCys: 0.646 ± 0.023	2.451AlaAsp: 2.451 ± 0.052	3.089AlaGlu: 3.089 ± 0.054	2.384AlaPhe: 2.384 ± 0.049	3.239AlaGly: 3.239 ± 0.061	0.747AlaHis: 0.747 ± 0.024	5.773AlaIle: 5.773 ± 0.076	4.659AlaLys: 4.659 ± 0.061	5.474AlaLeu: 5.474 ± 0.077	1.561AlaMet: 1.561 ± 0.04	2.81AlaAsn: 2.81 ± 0.045	1.39AlaPro: 1.39 ± 0.036	1.301AlaGln: 1.301 ± 0.031	1.684AlaArg: 1.684 ± 0.037	3.21AlaSer: 3.21 ± 0.045	2.933AlaThr: 2.933 ± 0.057	3.606AlaVal: 3.606 ± 0.065	0.399AlaTrp: 0.399 ± 0.02	2.197AlaTyr: 2.197 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.507CysAla: 0.507 ± 0.019	0.201CysCys: 0.201 ± 0.014	0.65CysAsp: 0.65 ± 0.024	0.805CysGlu: 0.805 ± 0.022	0.567CysPhe: 0.567 ± 0.021	0.959CysGly: 0.959 ± 0.028	0.195CysHis: 0.195 ± 0.013	1.155CysIle: 1.155 ± 0.031	0.979CysLys: 0.979 ± 0.029	0.835CysLeu: 0.835 ± 0.028	0.254CysMet: 0.254 ± 0.014	0.766CysAsn: 0.766 ± 0.024	0.401CysPro: 0.401 ± 0.021	0.19CysGln: 0.19 ± 0.009	0.361CysArg: 0.361 ± 0.016	0.772CysSer: 0.772 ± 0.025	0.535CysThr: 0.535 ± 0.021	0.609CysVal: 0.609 ± 0.021	0.075CysTrp: 0.075 ± 0.006	0.484CysTyr: 0.484 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.535AspAla: 2.535 ± 0.047	0.567AspCys: 0.567 ± 0.02	2.697AspAsp: 2.697 ± 0.053	4.562AspGlu: 4.562 ± 0.067	3.017AspPhe: 3.017 ± 0.047	3.446AspGly: 3.446 ± 0.056	0.466AspHis: 0.466 ± 0.02	6.337AspIle: 6.337 ± 0.07	5.856AspLys: 5.856 ± 0.068	4.957AspLeu: 4.957 ± 0.064	1.344AspMet: 1.344 ± 0.031	3.689AspAsn: 3.689 ± 0.058	1.166AspPro: 1.166 ± 0.038	0.711AspGln: 0.711 ± 0.021	1.69AspArg: 1.69 ± 0.03	3.324AspSer: 3.324 ± 0.049	2.526AspThr: 2.526 ± 0.046	3.456AspVal: 3.456 ± 0.054	0.413AspTrp: 0.413 ± 0.017	2.718AspTyr: 2.718 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.193GluAla: 4.193 ± 0.071	0.72GluCys: 0.72 ± 0.027	4.336GluAsp: 4.336 ± 0.058	6.692GluGlu: 6.692 ± 0.087	3.367GluPhe: 3.367 ± 0.051	3.963GluGly: 3.963 ± 0.063	0.901GluHis: 0.901 ± 0.03	7.296GluIle: 7.296 ± 0.082	7.634GluLys: 7.634 ± 0.085	6.844GluLeu: 6.844 ± 0.075	1.679GluMet: 1.679 ± 0.031	5.511GluAsn: 5.511 ± 0.065	1.34GluPro: 1.34 ± 0.034	1.781GluGln: 1.781 ± 0.043	2.468GluArg: 2.468 ± 0.042	3.502GluSer: 3.502 ± 0.052	3.073GluThr: 3.073 ± 0.05	4.948GluVal: 4.948 ± 0.075	0.472GluTrp: 0.472 ± 0.02	3.206GluTyr: 3.206 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.093PheAla: 2.093 ± 0.042	0.523PheCys: 0.523 ± 0.017	2.646PheAsp: 2.646 ± 0.041	2.988PheGlu: 2.988 ± 0.053	2.131PhePhe: 2.131 ± 0.041	2.721PheGly: 2.721 ± 0.053	0.499PheHis: 0.499 ± 0.018	5.133PheIle: 5.133 ± 0.074	4.569PheLys: 4.569 ± 0.063	4.161PheLeu: 4.161 ± 0.059	1.181PheMet: 1.181 ± 0.033	3.385PheAsn: 3.385 ± 0.052	1.074PhePro: 1.074 ± 0.027	0.907PheGln: 0.907 ± 0.028	1.285PheArg: 1.285 ± 0.03	3.277PheSer: 3.277 ± 0.049	2.321PheThr: 2.321 ± 0.047	2.627PheVal: 2.627 ± 0.041	0.325PheTrp: 0.325 ± 0.015	1.941PheTyr: 1.941 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	3.69GlyAla: 3.69 ± 0.07	0.805GlyCys: 0.805 ± 0.031	3.304GlyAsp: 3.304 ± 0.056	4.297GlyGlu: 4.297 ± 0.052	3.019GlyPhe: 3.019 ± 0.054	3.9GlyGly: 3.9 ± 0.065	0.894GlyHis: 0.894 ± 0.027	6.372GlyIle: 6.372 ± 0.081	5.237GlyLys: 5.237 ± 0.077	5.195GlyLeu: 5.195 ± 0.079	1.612GlyMet: 1.612 ± 0.037	3.324GlyAsn: 3.324 ± 0.055	1.119GlyPro: 1.119 ± 0.06	1.401GlyGln: 1.401 ± 0.034	1.978GlyArg: 1.978 ± 0.043	3.494GlySer: 3.494 ± 0.048	3.235GlyThr: 3.235 ± 0.049	4.539GlyVal: 4.539 ± 0.061	0.487GlyTrp: 0.487 ± 0.023	2.951GlyTyr: 2.951 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	0.577HisAla: 0.577 ± 0.021	0.192HisCys: 0.192 ± 0.012	0.631HisAsp: 0.631 ± 0.019	0.841HisGlu: 0.841 ± 0.023	0.61HisPhe: 0.61 ± 0.019	0.924HisGly: 0.924 ± 0.028	0.255HisHis: 0.255 ± 0.015	1.292HisIle: 1.292 ± 0.03	1.043HisLys: 1.043 ± 0.029	1.014HisLeu: 1.014 ± 0.024	0.295HisMet: 0.295 ± 0.014	0.822HisAsn: 0.822 ± 0.028	0.51HisPro: 0.51 ± 0.021	0.261HisGln: 0.261 ± 0.012	0.454HisArg: 0.454 ± 0.02	0.832HisSer: 0.832 ± 0.025	0.629HisThr: 0.629 ± 0.02	0.695HisVal: 0.695 ± 0.023	0.099HisTrp: 0.099 ± 0.01	0.56HisTyr: 0.56 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.56IleAla: 5.56 ± 0.077	1.23IleCys: 1.23 ± 0.032	5.815IleAsp: 5.815 ± 0.073	7.292IleGlu: 7.292 ± 0.089	4.563IlePhe: 4.563 ± 0.07	5.998IleGly: 5.998 ± 0.08	1.189IleHis: 1.189 ± 0.028	10.076IleIle: 10.076 ± 0.125	9.522IleLys: 9.522 ± 0.095	9.542IleLeu: 9.542 ± 0.102	2.285IleMet: 2.285 ± 0.046	7.39IleAsn: 7.39 ± 0.088	3.209IlePro: 3.209 ± 0.046	2.147IleGln: 2.147 ± 0.043	3.02IleArg: 3.02 ± 0.05	7.166IleSer: 7.166 ± 0.083	5.076IleThr: 5.076 ± 0.071	6.255IleVal: 6.255 ± 0.067	0.63IleTrp: 0.63 ± 0.022	3.981IleTyr: 3.981 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	5.026LysAla: 5.026 ± 0.068	0.889LysCys: 0.889 ± 0.026	6.298LysAsp: 6.298 ± 0.076	9.056LysGlu: 9.056 ± 0.097	3.592LysPhe: 3.592 ± 0.056	5.015LysGly: 5.015 ± 0.071	1.143LysHis: 1.143 ± 0.031	8.616LysIle: 8.616 ± 0.084	8.453LysLys: 8.453 ± 0.088	8.114LysLeu: 8.114 ± 0.086	2.317LysMet: 2.317 ± 0.046	7.283LysAsn: 7.283 ± 0.085	2.269LysPro: 2.269 ± 0.045	2.37LysGln: 2.37 ± 0.047	3.015LysArg: 3.015 ± 0.048	5.285LysSer: 5.285 ± 0.064	4.363LysThr: 4.363 ± 0.05	6.406LysVal: 6.406 ± 0.073	0.619LysTrp: 0.619 ± 0.021	4.281LysTyr: 4.281 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	4.969LeuAla: 4.969 ± 0.064	1.159LeuCys: 1.159 ± 0.032	5.185LeuAsp: 5.185 ± 0.062	6.475LeuGlu: 6.475 ± 0.08	3.746LeuPhe: 3.746 ± 0.061	5.712LeuGly: 5.712 ± 0.074	0.989LeuHis: 0.989 ± 0.031	8.786LeuIle: 8.786 ± 0.099	8.978LeuLys: 8.978 ± 0.086	7.916LeuLeu: 7.916 ± 0.093	2.147LeuMet: 2.147 ± 0.039	6.732LeuAsn: 6.732 ± 0.071	2.59LeuPro: 2.59 ± 0.046	2.047LeuGln: 2.047 ± 0.039	2.954LeuArg: 2.954 ± 0.058	6.513LeuSer: 6.513 ± 0.06	4.616LeuThr: 4.616 ± 0.07	5.409LeuVal: 5.409 ± 0.069	0.602LeuTrp: 0.602 ± 0.023	3.365LeuTyr: 3.365 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.531MetAla: 1.531 ± 0.038	0.256MetCys: 0.256 ± 0.014	1.4MetAsp: 1.4 ± 0.034	1.617MetGlu: 1.617 ± 0.034	1.07MetPhe: 1.07 ± 0.03	1.585MetGly: 1.585 ± 0.043	0.305MetHis: 0.305 ± 0.015	2.169MetIle: 2.169 ± 0.042	2.465MetLys: 2.465 ± 0.042	2.254MetLeu: 2.254 ± 0.044	0.561MetMet: 0.561 ± 0.022	1.658MetAsn: 1.658 ± 0.036	0.82MetPro: 0.82 ± 0.021	0.659MetGln: 0.659 ± 0.023	0.786MetArg: 0.786 ± 0.023	1.559MetSer: 1.559 ± 0.035	1.068MetThr: 1.068 ± 0.028	1.578MetVal: 1.578 ± 0.034	0.148MetTrp: 0.148 ± 0.01	0.908MetTyr: 0.908 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.863AsnAla: 2.863 ± 0.051	0.737AsnCys: 0.737 ± 0.025	3.422AsnAsp: 3.422 ± 0.056	4.949AsnGlu: 4.949 ± 0.063	3.064AsnPhe: 3.064 ± 0.052	3.976AsnGly: 3.976 ± 0.055	0.799AsnHis: 0.799 ± 0.022	8.034AsnIle: 8.034 ± 0.097	7.122AsnLys: 7.122 ± 0.084	6.396AsnLeu: 6.396 ± 0.086	1.676AsnMet: 1.676 ± 0.034	5.459AsnAsn: 5.459 ± 0.099	2.117AsnPro: 2.117 ± 0.043	1.536AsnGln: 1.536 ± 0.035	2.043AsnArg: 2.043 ± 0.035	4.574AsnSer: 4.574 ± 0.069	3.328AsnThr: 3.328 ± 0.058	3.845AsnVal: 3.845 ± 0.06	0.485AsnTrp: 0.485 ± 0.02	3.034AsnTyr: 3.034 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.225ProAla: 1.225 ± 0.034	0.289ProCys: 0.289 ± 0.017	1.326ProAsp: 1.326 ± 0.032	1.958ProGlu: 1.958 ± 0.04	1.316ProPhe: 1.316 ± 0.029	1.472ProGly: 1.472 ± 0.049	0.403ProHis: 0.403 ± 0.019	2.667ProIle: 2.667 ± 0.047	2.286ProLys: 2.286 ± 0.048	2.396ProLeu: 2.396 ± 0.038	0.672ProMet: 0.672 ± 0.022	1.837ProAsn: 1.837 ± 0.043	0.538ProPro: 0.538 ± 0.02	0.726ProGln: 0.726 ± 0.035	0.75ProArg: 0.75 ± 0.024	1.693ProSer: 1.693 ± 0.035	1.453ProThr: 1.453 ± 0.033	1.786ProVal: 1.786 ± 0.043	0.246ProTrp: 0.246 ± 0.015	1.247ProTyr: 1.247 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.361GlnAla: 1.361 ± 0.037	0.239GlnCys: 0.239 ± 0.013	1.222GlnAsp: 1.222 ± 0.029	1.634GlnGlu: 1.634 ± 0.037	0.94GlnPhe: 0.94 ± 0.03	1.559GlnGly: 1.559 ± 0.044	0.264GlnHis: 0.264 ± 0.013	2.09GlnIle: 2.09 ± 0.033	2.036GlnLys: 2.036 ± 0.039	1.85GlnLeu: 1.85 ± 0.037	0.603GlnMet: 0.603 ± 0.023	1.611GlnAsn: 1.611 ± 0.035	0.468GlnPro: 0.468 ± 0.019	0.597GlnGln: 0.597 ± 0.022	0.84GlnArg: 0.84 ± 0.025	1.286GlnSer: 1.286 ± 0.035	1.058GlnThr: 1.058 ± 0.031	1.498GlnVal: 1.498 ± 0.035	0.2GlnTrp: 0.2 ± 0.015	0.974GlnTyr: 0.974 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	1.695ArgAla: 1.695 ± 0.035	0.379ArgCys: 0.379 ± 0.018	1.764ArgAsp: 1.764 ± 0.037	2.73ArgGlu: 2.73 ± 0.049	1.407ArgPhe: 1.407 ± 0.031	1.898ArgGly: 1.898 ± 0.045	0.411ArgHis: 0.411 ± 0.016	3.046ArgIle: 3.046 ± 0.048	2.843ArgLys: 2.843 ± 0.048	2.787ArgLeu: 2.787 ± 0.043	0.877ArgMet: 0.877 ± 0.028	2.08ArgAsn: 2.08 ± 0.043	0.76ArgPro: 0.76 ± 0.026	0.815ArgGln: 0.815 ± 0.027	1.318ArgArg: 1.318 ± 0.034	1.502ArgSer: 1.502 ± 0.032	1.467ArgThr: 1.467 ± 0.038	2.13ArgVal: 2.13 ± 0.035	0.227ArgTrp: 0.227 ± 0.013	1.379ArgTyr: 1.379 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	2.845SerAla: 2.845 ± 0.053	0.63SerCys: 0.63 ± 0.022	3.131SerAsp: 3.131 ± 0.058	4.059SerGlu: 4.059 ± 0.052	3.314SerPhe: 3.314 ± 0.049	3.926SerGly: 3.926 ± 0.053	0.828SerHis: 0.828 ± 0.023	6.801SerIle: 6.801 ± 0.081	6.191SerLys: 6.191 ± 0.07	6.114SerLeu: 6.114 ± 0.068	1.534SerMet: 1.534 ± 0.034	4.358SerAsn: 4.358 ± 0.068	1.526SerPro: 1.526 ± 0.036	1.455SerGln: 1.455 ± 0.039	1.941SerArg: 1.941 ± 0.04	4.253SerSer: 4.253 ± 0.068	3.214SerThr: 3.214 ± 0.058	3.831SerVal: 3.831 ± 0.059	0.467SerTrp: 0.467 ± 0.019	2.82SerTyr: 2.82 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	2.82ThrAla: 2.82 ± 0.052	0.478ThrCys: 0.478 ± 0.019	2.438ThrAsp: 2.438 ± 0.043	3.064ThrGlu: 3.064 ± 0.051	2.268ThrPhe: 2.268 ± 0.044	3.382ThrGly: 3.382 ± 0.054	0.755ThrHis: 0.755 ± 0.021	5.069ThrIle: 5.069 ± 0.068	4.1ThrLys: 4.1 ± 0.055	4.862ThrLeu: 4.862 ± 0.065	1.107ThrMet: 1.107 ± 0.032	3.088ThrAsn: 3.088 ± 0.055	1.742ThrPro: 1.742 ± 0.035	1.08ThrGln: 1.08 ± 0.03	1.442ThrArg: 1.442 ± 0.033	3.373ThrSer: 3.373 ± 0.057	2.779ThrThr: 2.779 ± 0.049	3.301ThrVal: 3.301 ± 0.053	0.369ThrTrp: 0.369 ± 0.018	1.909ThrTyr: 1.909 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	3.805ValAla: 3.805 ± 0.061	0.761ValCys: 0.761 ± 0.023	3.824ValAsp: 3.824 ± 0.06	4.268ValGlu: 4.268 ± 0.062	2.974ValPhe: 2.974 ± 0.045	3.951ValGly: 3.951 ± 0.057	0.808ValHis: 0.808 ± 0.028	6.261ValIle: 6.261 ± 0.068	5.726ValLys: 5.726 ± 0.069	5.723ValLeu: 5.723 ± 0.064	1.51ValMet: 1.51 ± 0.034	4.061ValAsn: 4.061 ± 0.058	1.83ValPro: 1.83 ± 0.034	1.377ValGln: 1.377 ± 0.033	1.857ValArg: 1.857 ± 0.035	4.248ValSer: 4.248 ± 0.058	3.302ValThr: 3.302 ± 0.057	4.364ValVal: 4.364 ± 0.071	0.409ValTrp: 0.409 ± 0.016	2.527ValTyr: 2.527 ± 0.038	0.001ValXaa: 0.001 ± 0.001
Trp	0.365TrpAla: 0.365 ± 0.015	0.098TrpCys: 0.098 ± 0.008	0.425TrpAsp: 0.425 ± 0.021	0.45TrpGlu: 0.45 ± 0.021	0.346TrpPhe: 0.346 ± 0.016	0.548TrpGly: 0.548 ± 0.023	0.121TrpHis: 0.121 ± 0.01	0.675TrpIle: 0.675 ± 0.024	0.52TrpLys: 0.52 ± 0.021	0.608TrpLeu: 0.608 ± 0.021	0.183TrpMet: 0.183 ± 0.012	0.528TrpAsn: 0.528 ± 0.02	0.15TrpPro: 0.15 ± 0.01	0.249TrpGln: 0.249 ± 0.015	0.24TrpArg: 0.24 ± 0.012	0.436TrpSer: 0.436 ± 0.02	0.327TrpThr: 0.327 ± 0.017	0.425TrpVal: 0.425 ± 0.018	0.072TrpTrp: 0.072 ± 0.008	0.28TrpTyr: 0.28 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.893TyrAla: 1.893 ± 0.038	0.5TyrCys: 0.5 ± 0.021	2.511TyrAsp: 2.511 ± 0.045	3.098TyrGlu: 3.098 ± 0.055	2.09TyrPhe: 2.09 ± 0.037	2.681TyrGly: 2.681 ± 0.047	0.566TyrHis: 0.566 ± 0.02	4.298TyrIle: 4.298 ± 0.067	4.191TyrLys: 4.191 ± 0.065	3.851TyrLeu: 3.851 ± 0.056	0.998TyrMet: 0.998 ± 0.031	3.066TyrAsn: 3.066 ± 0.051	1.267TyrPro: 1.267 ± 0.034	0.717TyrGln: 0.717 ± 0.024	1.389TyrArg: 1.389 ± 0.033	2.939TyrSer: 2.939 ± 0.046	2.123TyrThr: 2.123 ± 0.044	2.279TyrVal: 2.279 ± 0.044	0.303TyrTrp: 0.303 ± 0.013	2.063TyrTyr: 2.063 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4475 proteins (1407850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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