Amino acid dipepetide frequency for Pseudomonas lundensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.598AlaAla: 11.598 ± 0.146	1.2AlaCys: 1.2 ± 0.031	5.685AlaAsp: 5.685 ± 0.072	6.07AlaGlu: 6.07 ± 0.071	3.768AlaPhe: 3.768 ± 0.05	8.207AlaGly: 8.207 ± 0.086	2.429AlaHis: 2.429 ± 0.049	5.168AlaIle: 5.168 ± 0.071	3.967AlaLys: 3.967 ± 0.068	13.483AlaLeu: 13.483 ± 0.132	2.87AlaMet: 2.87 ± 0.048	2.987AlaAsn: 2.987 ± 0.052	4.645AlaPro: 4.645 ± 0.072	5.551AlaGln: 5.551 ± 0.078	6.544AlaArg: 6.544 ± 0.085	6.101AlaSer: 6.101 ± 0.066	4.827AlaThr: 4.827 ± 0.068	7.215AlaVal: 7.215 ± 0.092	1.459AlaTrp: 1.459 ± 0.037	2.647AlaTyr: 2.647 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.104CysAla: 1.104 ± 0.029	0.13CysCys: 0.13 ± 0.009	0.599CysAsp: 0.599 ± 0.023	0.542CysGlu: 0.542 ± 0.02	0.33CysPhe: 0.33 ± 0.015	0.92CysGly: 0.92 ± 0.03	0.268CysHis: 0.268 ± 0.016	0.486CysIle: 0.486 ± 0.022	0.334CysLys: 0.334 ± 0.017	1.115CysLeu: 1.115 ± 0.03	0.219CysMet: 0.219 ± 0.015	0.291CysAsn: 0.291 ± 0.018	0.482CysPro: 0.482 ± 0.023	0.403CysGln: 0.403 ± 0.018	0.584CysArg: 0.584 ± 0.025	0.597CysSer: 0.597 ± 0.02	0.488CysThr: 0.488 ± 0.022	0.747CysVal: 0.747 ± 0.028	0.147CysTrp: 0.147 ± 0.011	0.243CysTyr: 0.243 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.827AspAla: 5.827 ± 0.078	0.518AspCys: 0.518 ± 0.024	2.903AspAsp: 2.903 ± 0.053	3.387AspGlu: 3.387 ± 0.056	2.049AspPhe: 2.049 ± 0.044	4.143AspGly: 4.143 ± 0.065	1.223AspHis: 1.223 ± 0.033	2.764AspIle: 2.764 ± 0.052	2.09AspLys: 2.09 ± 0.05	5.855AspLeu: 5.855 ± 0.074	1.278AspMet: 1.278 ± 0.031	1.671AspAsn: 1.671 ± 0.035	2.889AspPro: 2.889 ± 0.053	2.195AspGln: 2.195 ± 0.041	2.917AspArg: 2.917 ± 0.048	2.875AspSer: 2.875 ± 0.048	2.624AspThr: 2.624 ± 0.042	3.941AspVal: 3.941 ± 0.063	0.917AspTrp: 0.917 ± 0.029	1.736AspTyr: 1.736 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.071GluAla: 6.071 ± 0.085	0.482GluCys: 0.482 ± 0.019	2.477GluAsp: 2.477 ± 0.045	2.957GluGlu: 2.957 ± 0.063	1.841GluPhe: 1.841 ± 0.041	3.965GluGly: 3.965 ± 0.059	1.837GluHis: 1.837 ± 0.038	2.706GluIle: 2.706 ± 0.055	2.301GluLys: 2.301 ± 0.051	6.599GluLeu: 6.599 ± 0.094	1.359GluMet: 1.359 ± 0.03	1.556GluAsn: 1.556 ± 0.039	2.459GluPro: 2.459 ± 0.05	3.68GluGln: 3.68 ± 0.056	4.47GluArg: 4.47 ± 0.068	2.664GluSer: 2.664 ± 0.051	2.574GluThr: 2.574 ± 0.044	4.085GluVal: 4.085 ± 0.064	0.743GluTrp: 0.743 ± 0.024	1.29GluTyr: 1.29 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.854PheAla: 3.854 ± 0.056	0.461PheCys: 0.461 ± 0.018	2.383PheAsp: 2.383 ± 0.039	2.108PheGlu: 2.108 ± 0.04	1.494PhePhe: 1.494 ± 0.039	3.136PheGly: 3.136 ± 0.05	0.75PheHis: 0.75 ± 0.025	1.952PheIle: 1.952 ± 0.041	1.465PheLys: 1.465 ± 0.032	3.184PheLeu: 3.184 ± 0.054	0.924PheMet: 0.924 ± 0.03	1.542PheAsn: 1.542 ± 0.038	1.443PhePro: 1.443 ± 0.033	1.145PheGln: 1.145 ± 0.03	1.653PheArg: 1.653 ± 0.036	2.692PheSer: 2.692 ± 0.053	2.031PheThr: 2.031 ± 0.039	2.575PheVal: 2.575 ± 0.042	0.586PheTrp: 0.586 ± 0.024	1.091PheTyr: 1.091 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.0GlyAla: 7.0 ± 0.091	0.929GlyCys: 0.929 ± 0.027	3.764GlyAsp: 3.764 ± 0.059	4.425GlyGlu: 4.425 ± 0.057	3.312GlyPhe: 3.312 ± 0.055	5.624GlyGly: 5.624 ± 0.106	1.925GlyHis: 1.925 ± 0.043	4.11GlyIle: 4.11 ± 0.057	3.492GlyLys: 3.492 ± 0.066	9.027GlyLeu: 9.027 ± 0.107	2.224GlyMet: 2.224 ± 0.048	2.504GlyAsn: 2.504 ± 0.05	2.625GlyPro: 2.625 ± 0.046	3.581GlyGln: 3.581 ± 0.059	4.451GlyArg: 4.451 ± 0.071	4.406GlySer: 4.406 ± 0.06	3.816GlyThr: 3.816 ± 0.069	6.021GlyVal: 6.021 ± 0.081	1.365GlyTrp: 1.365 ± 0.038	2.412GlyTyr: 2.412 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.483HisAla: 2.483 ± 0.051	0.329HisCys: 0.329 ± 0.018	1.317HisAsp: 1.317 ± 0.03	1.249HisGlu: 1.249 ± 0.033	1.015HisPhe: 1.015 ± 0.032	1.97HisGly: 1.97 ± 0.041	0.692HisHis: 0.692 ± 0.025	1.091HisIle: 1.091 ± 0.03	0.737HisLys: 0.737 ± 0.023	2.712HisLeu: 2.712 ± 0.046	0.597HisMet: 0.597 ± 0.025	0.721HisAsn: 0.721 ± 0.024	1.47HisPro: 1.47 ± 0.04	0.974HisGln: 0.974 ± 0.027	1.325HisArg: 1.325 ± 0.034	1.331HisSer: 1.331 ± 0.031	1.223HisThr: 1.223 ± 0.03	1.677HisVal: 1.677 ± 0.039	0.468HisTrp: 0.468 ± 0.021	0.822HisTyr: 0.822 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.688IleAla: 5.688 ± 0.077	0.502IleCys: 0.502 ± 0.02	3.314IleAsp: 3.314 ± 0.05	3.53IleGlu: 3.53 ± 0.058	1.54IlePhe: 1.54 ± 0.036	4.457IleGly: 4.457 ± 0.057	1.021IleHis: 1.021 ± 0.029	2.137IleIle: 2.137 ± 0.047	2.084IleLys: 2.084 ± 0.042	4.115IleLeu: 4.115 ± 0.063	0.84IleMet: 0.84 ± 0.026	1.982IleAsn: 1.982 ± 0.04	2.276IlePro: 2.276 ± 0.041	1.612IleGln: 1.612 ± 0.04	2.819IleArg: 2.819 ± 0.054	3.231IleSer: 3.231 ± 0.05	2.795IleThr: 2.795 ± 0.051	3.35IleVal: 3.35 ± 0.057	0.508IleTrp: 0.508 ± 0.022	1.14IleTyr: 1.14 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.409LysAla: 4.409 ± 0.069	0.198LysCys: 0.198 ± 0.013	1.982LysAsp: 1.982 ± 0.048	1.888LysGlu: 1.888 ± 0.046	0.939LysPhe: 0.939 ± 0.032	2.892LysGly: 2.892 ± 0.055	0.927LysHis: 0.927 ± 0.026	1.782LysIle: 1.782 ± 0.041	1.632LysLys: 1.632 ± 0.049	3.831LysLeu: 3.831 ± 0.067	0.859LysMet: 0.859 ± 0.028	1.283LysAsn: 1.283 ± 0.034	2.26LysPro: 2.26 ± 0.047	1.722LysGln: 1.722 ± 0.042	2.551LysArg: 2.551 ± 0.053	2.011LysSer: 2.011 ± 0.044	2.23LysThr: 2.23 ± 0.052	3.025LysVal: 3.025 ± 0.052	0.393LysTrp: 0.393 ± 0.018	0.779LysTyr: 0.779 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.937LeuAla: 12.937 ± 0.122	1.224LeuCys: 1.224 ± 0.028	6.496LeuAsp: 6.496 ± 0.078	6.371LeuGlu: 6.371 ± 0.085	4.058LeuPhe: 4.058 ± 0.07	8.731LeuGly: 8.731 ± 0.094	2.599LeuHis: 2.599 ± 0.044	5.859LeuIle: 5.859 ± 0.08	4.818LeuLys: 4.818 ± 0.068	12.741LeuLeu: 12.741 ± 0.161	2.834LeuMet: 2.834 ± 0.052	4.309LeuAsn: 4.309 ± 0.067	6.101LeuPro: 6.101 ± 0.077	4.596LeuGln: 4.596 ± 0.064	6.902LeuArg: 6.902 ± 0.08	7.516LeuSer: 7.516 ± 0.084	6.184LeuThr: 6.184 ± 0.078	7.469LeuVal: 7.469 ± 0.088	1.341LeuTrp: 1.341 ± 0.036	2.623LeuTyr: 2.623 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.719MetAla: 2.719 ± 0.045	0.194MetCys: 0.194 ± 0.012	1.093MetAsp: 1.093 ± 0.033	0.955MetGlu: 0.955 ± 0.029	0.768MetPhe: 0.768 ± 0.026	1.819MetGly: 1.819 ± 0.04	0.522MetHis: 0.522 ± 0.019	1.21MetIle: 1.21 ± 0.037	0.951MetLys: 0.951 ± 0.027	2.754MetLeu: 2.754 ± 0.046	0.569MetMet: 0.569 ± 0.022	0.914MetAsn: 0.914 ± 0.027	1.434MetPro: 1.434 ± 0.036	1.035MetGln: 1.035 ± 0.028	1.538MetArg: 1.538 ± 0.037	1.854MetSer: 1.854 ± 0.035	1.658MetThr: 1.658 ± 0.037	1.561MetVal: 1.561 ± 0.035	0.214MetTrp: 0.214 ± 0.014	0.404MetTyr: 0.404 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.496AsnAla: 3.496 ± 0.06	0.302AsnCys: 0.302 ± 0.014	1.767AsnAsp: 1.767 ± 0.038	1.66AsnGlu: 1.66 ± 0.038	1.076AsnPhe: 1.076 ± 0.027	2.716AsnGly: 2.716 ± 0.045	0.696AsnHis: 0.696 ± 0.026	1.554AsnIle: 1.554 ± 0.038	1.117AsnLys: 1.117 ± 0.033	3.538AsnLeu: 3.538 ± 0.059	0.648AsnMet: 0.648 ± 0.022	1.115AsnAsn: 1.115 ± 0.031	2.169AsnPro: 2.169 ± 0.044	1.368AsnGln: 1.368 ± 0.036	1.844AsnArg: 1.844 ± 0.044	1.703AsnSer: 1.703 ± 0.042	1.705AsnThr: 1.705 ± 0.041	2.159AsnVal: 2.159 ± 0.046	0.502AsnTrp: 0.502 ± 0.022	0.868AsnTyr: 0.868 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.479ProAla: 5.479 ± 0.085	0.387ProCys: 0.387 ± 0.019	3.023ProAsp: 3.023 ± 0.053	3.253ProGlu: 3.253 ± 0.053	1.808ProPhe: 1.808 ± 0.042	3.761ProGly: 3.761 ± 0.059	1.219ProHis: 1.219 ± 0.028	2.109ProIle: 2.109 ± 0.042	1.747ProLys: 1.747 ± 0.04	5.677ProLeu: 5.677 ± 0.081	1.178ProMet: 1.178 ± 0.03	1.46ProAsn: 1.46 ± 0.039	1.879ProPro: 1.879 ± 0.051	2.386ProGln: 2.386 ± 0.053	2.456ProArg: 2.456 ± 0.052	2.524ProSer: 2.524 ± 0.046	2.386ProThr: 2.386 ± 0.048	4.005ProVal: 4.005 ± 0.065	0.73ProTrp: 0.73 ± 0.03	1.281ProTyr: 1.281 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.695GlnAla: 5.695 ± 0.08	0.344GlnCys: 0.344 ± 0.015	1.897GlnAsp: 1.897 ± 0.034	1.938GlnGlu: 1.938 ± 0.037	1.359GlnPhe: 1.359 ± 0.036	3.437GlnGly: 3.437 ± 0.052	1.291GlnHis: 1.291 ± 0.038	2.098GlnIle: 2.098 ± 0.046	1.372GlnLys: 1.372 ± 0.039	5.729GlnLeu: 5.729 ± 0.079	1.103GlnMet: 1.103 ± 0.029	1.193GlnAsn: 1.193 ± 0.035	2.474GlnPro: 2.474 ± 0.046	2.71GlnGln: 2.71 ± 0.06	3.525GlnArg: 3.525 ± 0.06	2.276GlnSer: 2.276 ± 0.049	2.199GlnThr: 2.199 ± 0.045	3.465GlnVal: 3.465 ± 0.056	0.822GlnTrp: 0.822 ± 0.029	1.098GlnTyr: 1.098 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.699ArgAla: 5.699 ± 0.074	0.588ArgCys: 0.588 ± 0.019	3.399ArgAsp: 3.399 ± 0.055	4.043ArgGlu: 4.043 ± 0.064	2.628ArgPhe: 2.628 ± 0.039	3.756ArgGly: 3.756 ± 0.059	1.707ArgHis: 1.707 ± 0.039	3.205ArgIle: 3.205 ± 0.047	2.182ArgLys: 2.182 ± 0.043	7.758ArgLeu: 7.758 ± 0.09	1.573ArgMet: 1.573 ± 0.039	1.882ArgAsn: 1.882 ± 0.039	2.643ArgPro: 2.643 ± 0.046	3.178ArgGln: 3.178 ± 0.052	3.749ArgArg: 3.749 ± 0.058	3.185ArgSer: 3.185 ± 0.051	2.809ArgThr: 2.809 ± 0.051	4.374ArgVal: 4.374 ± 0.065	1.01ArgTrp: 1.01 ± 0.035	2.047ArgTyr: 2.047 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.03SerAla: 6.03 ± 0.07	0.48SerCys: 0.48 ± 0.021	3.052SerAsp: 3.052 ± 0.053	3.025SerGlu: 3.025 ± 0.051	2.163SerPhe: 2.163 ± 0.038	5.07SerGly: 5.07 ± 0.062	1.392SerHis: 1.392 ± 0.036	2.863SerIle: 2.863 ± 0.044	1.987SerLys: 1.987 ± 0.039	6.902SerLeu: 6.902 ± 0.079	1.404SerMet: 1.404 ± 0.033	1.774SerAsn: 1.774 ± 0.036	2.79SerPro: 2.79 ± 0.048	2.567SerGln: 2.567 ± 0.046	3.525SerArg: 3.525 ± 0.054	3.337SerSer: 3.337 ± 0.063	3.116SerThr: 3.116 ± 0.056	4.24SerVal: 4.24 ± 0.054	0.793SerTrp: 0.793 ± 0.026	1.519SerTyr: 1.519 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.132ThrAla: 5.132 ± 0.072	0.53ThrCys: 0.53 ± 0.02	2.637ThrAsp: 2.637 ± 0.046	2.492ThrGlu: 2.492 ± 0.049	2.034ThrPhe: 2.034 ± 0.043	4.308ThrGly: 4.308 ± 0.084	1.322ThrHis: 1.322 ± 0.03	2.047ThrIle: 2.047 ± 0.041	1.284ThrLys: 1.284 ± 0.034	7.171ThrLeu: 7.171 ± 0.079	0.798ThrMet: 0.798 ± 0.026	1.207ThrAsn: 1.207 ± 0.032	3.387ThrPro: 3.387 ± 0.061	2.274ThrGln: 2.274 ± 0.042	3.362ThrArg: 3.362 ± 0.059	2.738ThrSer: 2.738 ± 0.053	2.547ThrThr: 2.547 ± 0.056	3.747ThrVal: 3.747 ± 0.058	0.707ThrTrp: 0.707 ± 0.023	1.382ThrTyr: 1.382 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.346ValAla: 7.346 ± 0.095	0.757ValCys: 0.757 ± 0.024	3.895ValAsp: 3.895 ± 0.054	4.318ValGlu: 4.318 ± 0.069	2.726ValPhe: 2.726 ± 0.049	5.132ValGly: 5.132 ± 0.07	1.411ValHis: 1.411 ± 0.031	4.043ValIle: 4.043 ± 0.067	2.629ValLys: 2.629 ± 0.055	8.307ValLeu: 8.307 ± 0.096	1.972ValMet: 1.972 ± 0.04	2.358ValAsn: 2.358 ± 0.045	3.319ValPro: 3.319 ± 0.051	2.885ValGln: 2.885 ± 0.053	4.202ValArg: 4.202 ± 0.056	4.549ValSer: 4.549 ± 0.068	3.889ValThr: 3.889 ± 0.054	5.378ValVal: 5.378 ± 0.072	0.937ValTrp: 0.937 ± 0.031	1.728ValTyr: 1.728 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.208TrpAla: 1.208 ± 0.031	0.165TrpCys: 0.165 ± 0.012	0.641TrpAsp: 0.641 ± 0.024	0.601TrpGlu: 0.601 ± 0.024	0.524TrpPhe: 0.524 ± 0.021	0.929TrpGly: 0.929 ± 0.03	0.388TrpHis: 0.388 ± 0.019	0.7TrpIle: 0.7 ± 0.023	0.496TrpLys: 0.496 ± 0.018	2.202TrpLeu: 2.202 ± 0.053	0.41TrpMet: 0.41 ± 0.017	0.439TrpAsn: 0.439 ± 0.019	0.642TrpPro: 0.642 ± 0.027	0.877TrpGln: 0.877 ± 0.032	1.069TrpArg: 1.069 ± 0.034	0.806TrpSer: 0.806 ± 0.025	0.622TrpThr: 0.622 ± 0.025	1.021TrpVal: 1.021 ± 0.031	0.22TrpTrp: 0.22 ± 0.015	0.319TrpTyr: 0.319 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.648TyrAla: 2.648 ± 0.047	0.306TyrCys: 0.306 ± 0.016	1.477TyrAsp: 1.477 ± 0.046	1.307TyrGlu: 1.307 ± 0.032	1.037TyrPhe: 1.037 ± 0.029	2.04TyrGly: 2.04 ± 0.039	0.582TyrHis: 0.582 ± 0.02	1.057TyrIle: 1.057 ± 0.031	0.907TyrLys: 0.907 ± 0.027	3.008TyrLeu: 3.008 ± 0.052	0.504TyrMet: 0.504 ± 0.021	0.816TyrAsn: 0.816 ± 0.031	1.361TyrPro: 1.361 ± 0.033	1.288TyrGln: 1.288 ± 0.033	1.928TyrArg: 1.928 ± 0.042	1.633TyrSer: 1.633 ± 0.035	1.382TyrThr: 1.382 ± 0.037	1.726TyrVal: 1.726 ± 0.038	0.417TyrTrp: 0.417 ± 0.019	0.733TyrTyr: 0.733 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3977 proteins (1276776 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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