Amino acid dipepetide frequency for Salsuginibacillus halophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.507AlaAla: 10.507 ± 0.151	0.76AlaCys: 0.76 ± 0.033	5.089AlaAsp: 5.089 ± 0.176	7.87AlaGlu: 7.87 ± 0.121	3.954AlaPhe: 3.954 ± 0.083	7.786AlaGly: 7.786 ± 0.128	1.904AlaHis: 1.904 ± 0.046	4.483AlaIle: 4.483 ± 0.088	4.037AlaLys: 4.037 ± 0.079	9.048AlaLeu: 9.048 ± 0.123	2.471AlaMet: 2.471 ± 0.058	2.476AlaAsn: 2.476 ± 0.058	3.286AlaPro: 3.286 ± 0.062	2.871AlaGln: 2.871 ± 0.069	3.932AlaArg: 3.932 ± 0.08	5.162AlaSer: 5.162 ± 0.081	3.604AlaThr: 3.604 ± 0.067	7.783AlaVal: 7.783 ± 0.102	0.982AlaTrp: 0.982 ± 0.04	2.953AlaTyr: 2.953 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.582CysAla: 0.582 ± 0.039	0.083CysCys: 0.083 ± 0.011	0.353CysAsp: 0.353 ± 0.023	0.417CysGlu: 0.417 ± 0.024	0.251CysPhe: 0.251 ± 0.017	0.664CysGly: 0.664 ± 0.031	0.159CysHis: 0.159 ± 0.016	0.31CysIle: 0.31 ± 0.019	0.181CysLys: 0.181 ± 0.014	0.558CysLeu: 0.558 ± 0.027	0.168CysMet: 0.168 ± 0.014	0.201CysAsn: 0.201 ± 0.014	0.35CysPro: 0.35 ± 0.021	0.2CysGln: 0.2 ± 0.016	0.354CysArg: 0.354 ± 0.02	0.359CysSer: 0.359 ± 0.023	0.389CysThr: 0.389 ± 0.022	0.383CysVal: 0.383 ± 0.021	0.05CysTrp: 0.05 ± 0.008	0.209CysTyr: 0.209 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.872AspAla: 4.872 ± 0.176	0.313AspCys: 0.313 ± 0.021	3.629AspAsp: 3.629 ± 0.131	6.483AspGlu: 6.483 ± 0.127	2.164AspPhe: 2.164 ± 0.055	4.206AspGly: 4.206 ± 0.106	1.514AspHis: 1.514 ± 0.057	3.682AspIle: 3.682 ± 0.082	1.924AspLys: 1.924 ± 0.058	4.905AspLeu: 4.905 ± 0.074	1.704AspMet: 1.704 ± 0.04	1.629AspAsn: 1.629 ± 0.053	2.411AspPro: 2.411 ± 0.061	2.297AspGln: 2.297 ± 0.051	2.686AspArg: 2.686 ± 0.062	2.138AspSer: 2.138 ± 0.057	2.853AspThr: 2.853 ± 0.06	4.88AspVal: 4.88 ± 0.082	0.735AspTrp: 0.735 ± 0.035	1.905AspTyr: 1.905 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	9.811GluAla: 9.811 ± 0.13	0.303GluCys: 0.303 ± 0.022	5.65GluAsp: 5.65 ± 0.12	9.469GluGlu: 9.469 ± 0.184	2.063GluPhe: 2.063 ± 0.054	5.492GluGly: 5.492 ± 0.086	2.008GluHis: 2.008 ± 0.049	4.468GluIle: 4.468 ± 0.081	4.796GluLys: 4.796 ± 0.093	7.591GluLeu: 7.591 ± 0.097	2.586GluMet: 2.586 ± 0.054	3.49GluAsn: 3.49 ± 0.073	2.66GluPro: 2.66 ± 0.061	4.134GluGln: 4.134 ± 0.083	4.999GluArg: 4.999 ± 0.101	3.853GluSer: 3.853 ± 0.072	5.59GluThr: 5.59 ± 0.086	6.374GluVal: 6.374 ± 0.088	0.775GluTrp: 0.775 ± 0.028	1.719GluTyr: 1.719 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.406PheAla: 3.406 ± 0.064	0.275PheCys: 0.275 ± 0.021	2.25PheAsp: 2.25 ± 0.065	2.991PheGlu: 2.991 ± 0.054	2.046PhePhe: 2.046 ± 0.064	3.202PheGly: 3.202 ± 0.075	1.088PheHis: 1.088 ± 0.044	2.932PheIle: 2.932 ± 0.073	1.406PheLys: 1.406 ± 0.041	3.798PheLeu: 3.798 ± 0.082	1.219PheMet: 1.219 ± 0.041	1.387PheAsn: 1.387 ± 0.042	1.529PhePro: 1.529 ± 0.049	1.945PheGln: 1.945 ± 0.048	1.596PheArg: 1.596 ± 0.049	2.746PheSer: 2.746 ± 0.062	2.587PheThr: 2.587 ± 0.061	3.057PheVal: 3.057 ± 0.074	0.473PheTrp: 0.473 ± 0.024	1.433PheTyr: 1.433 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	6.478GlyAla: 6.478 ± 0.117	0.58GlyCys: 0.58 ± 0.027	3.75GlyAsp: 3.75 ± 0.088	5.898GlyGlu: 5.898 ± 0.087	3.271GlyPhe: 3.271 ± 0.069	5.682GlyGly: 5.682 ± 0.103	1.571GlyHis: 1.571 ± 0.048	4.735GlyIle: 4.735 ± 0.079	3.198GlyLys: 3.198 ± 0.074	6.775GlyLeu: 6.775 ± 0.11	2.381GlyMet: 2.381 ± 0.06	1.96GlyAsn: 1.96 ± 0.044	2.134GlyPro: 2.134 ± 0.056	2.309GlyGln: 2.309 ± 0.059	3.725GlyArg: 3.725 ± 0.072	4.153GlySer: 4.153 ± 0.08	4.233GlyThr: 4.233 ± 0.067	5.888GlyVal: 5.888 ± 0.093	0.932GlyTrp: 0.932 ± 0.035	2.705GlyTyr: 2.705 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.786HisAla: 1.786 ± 0.045	0.175HisCys: 0.175 ± 0.014	1.369HisAsp: 1.369 ± 0.038	2.048HisGlu: 2.048 ± 0.052	1.05HisPhe: 1.05 ± 0.042	1.741HisGly: 1.741 ± 0.042	0.814HisHis: 0.814 ± 0.036	1.518HisIle: 1.518 ± 0.042	0.901HisLys: 0.901 ± 0.034	2.244HisLeu: 2.244 ± 0.055	0.742HisMet: 0.742 ± 0.036	0.796HisAsn: 0.796 ± 0.025	1.295HisPro: 1.295 ± 0.044	0.925HisGln: 0.925 ± 0.035	1.204HisArg: 1.204 ± 0.037	1.073HisSer: 1.073 ± 0.037	1.378HisThr: 1.378 ± 0.046	1.87HisVal: 1.87 ± 0.043	0.305HisTrp: 0.305 ± 0.022	0.833HisTyr: 0.833 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.319IleAla: 5.319 ± 0.087	0.411IleCys: 0.411 ± 0.022	3.739IleAsp: 3.739 ± 0.072	5.209IleGlu: 5.209 ± 0.1	2.422IlePhe: 2.422 ± 0.066	4.731IleGly: 4.731 ± 0.086	1.503IleHis: 1.503 ± 0.049	3.548IleIle: 3.548 ± 0.08	2.084IleLys: 2.084 ± 0.061	4.823IleLeu: 4.823 ± 0.086	1.333IleMet: 1.333 ± 0.045	2.141IleAsn: 2.141 ± 0.048	2.535IlePro: 2.535 ± 0.055	2.665IleGln: 2.665 ± 0.06	2.59IleArg: 2.59 ± 0.067	3.521IleSer: 3.521 ± 0.071	3.5IleThr: 3.5 ± 0.069	4.302IleVal: 4.302 ± 0.073	0.508IleTrp: 0.508 ± 0.028	1.79IleTyr: 1.79 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.302LysAla: 4.302 ± 0.078	0.181LysCys: 0.181 ± 0.015	2.695LysAsp: 2.695 ± 0.055	4.44LysGlu: 4.44 ± 0.094	1.276LysPhe: 1.276 ± 0.035	2.817LysGly: 2.817 ± 0.065	1.136LysHis: 1.136 ± 0.038	2.16LysIle: 2.16 ± 0.058	3.236LysLys: 3.236 ± 0.075	3.908LysLeu: 3.908 ± 0.078	1.335LysMet: 1.335 ± 0.04	1.821LysAsn: 1.821 ± 0.051	1.749LysPro: 1.749 ± 0.049	2.726LysGln: 2.726 ± 0.063	2.854LysArg: 2.854 ± 0.055	2.307LysSer: 2.307 ± 0.056	2.854LysThr: 2.854 ± 0.062	3.189LysVal: 3.189 ± 0.067	0.431LysTrp: 0.431 ± 0.025	1.233LysTyr: 1.233 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	8.252LeuAla: 8.252 ± 0.106	0.586LeuCys: 0.586 ± 0.031	4.918LeuAsp: 4.918 ± 0.091	7.397LeuGlu: 7.397 ± 0.1	4.3LeuPhe: 4.3 ± 0.091	6.526LeuGly: 6.526 ± 0.104	2.392LeuHis: 2.392 ± 0.05	5.656LeuIle: 5.656 ± 0.097	4.755LeuLys: 4.755 ± 0.081	9.449LeuLeu: 9.449 ± 0.142	2.44LeuMet: 2.44 ± 0.058	3.75LeuAsn: 3.75 ± 0.07	4.282LeuPro: 4.282 ± 0.085	4.337LeuGln: 4.337 ± 0.087	4.175LeuArg: 4.175 ± 0.07	5.823LeuSer: 5.823 ± 0.085	5.78LeuThr: 5.78 ± 0.078	5.765LeuVal: 5.765 ± 0.091	0.863LeuTrp: 0.863 ± 0.032	2.902LeuTyr: 2.902 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.482MetAla: 2.482 ± 0.057	0.122MetCys: 0.122 ± 0.015	1.593MetAsp: 1.593 ± 0.042	2.011MetGlu: 2.011 ± 0.053	1.22MetPhe: 1.22 ± 0.04	1.627MetGly: 1.627 ± 0.049	0.614MetHis: 0.614 ± 0.025	1.84MetIle: 1.84 ± 0.045	2.04MetLys: 2.04 ± 0.048	2.819MetLeu: 2.819 ± 0.061	0.996MetMet: 0.996 ± 0.044	1.559MetAsn: 1.559 ± 0.044	1.151MetPro: 1.151 ± 0.039	1.321MetGln: 1.321 ± 0.04	1.375MetArg: 1.375 ± 0.045	1.672MetSer: 1.672 ± 0.048	1.876MetThr: 1.876 ± 0.043	1.743MetVal: 1.743 ± 0.051	0.203MetTrp: 0.203 ± 0.015	0.849MetTyr: 0.849 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.802AsnAla: 2.802 ± 0.067	0.233AsnCys: 0.233 ± 0.021	2.276AsnAsp: 2.276 ± 0.059	3.679AsnGlu: 3.679 ± 0.072	1.301AsnPhe: 1.301 ± 0.041	2.598AsnGly: 2.598 ± 0.07	0.873AsnHis: 0.873 ± 0.035	2.311AsnIle: 2.311 ± 0.048	1.41AsnLys: 1.41 ± 0.047	2.85AsnLeu: 2.85 ± 0.066	1.039AsnMet: 1.039 ± 0.04	1.299AsnAsn: 1.299 ± 0.047	1.573AsnPro: 1.573 ± 0.045	1.529AsnGln: 1.529 ± 0.047	1.823AsnArg: 1.823 ± 0.044	1.455AsnSer: 1.455 ± 0.042	1.756AsnThr: 1.756 ± 0.046	2.941AsnVal: 2.941 ± 0.062	0.362AsnTrp: 0.362 ± 0.021	1.106AsnTyr: 1.106 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.701ProAla: 3.701 ± 0.072	0.201ProCys: 0.201 ± 0.017	2.616ProAsp: 2.616 ± 0.062	4.168ProGlu: 4.168 ± 0.076	1.816ProPhe: 1.816 ± 0.047	2.911ProGly: 2.911 ± 0.06	0.913ProHis: 0.913 ± 0.031	1.908ProIle: 1.908 ± 0.049	1.805ProLys: 1.805 ± 0.049	3.904ProLeu: 3.904 ± 0.071	0.978ProMet: 0.978 ± 0.041	1.302ProAsn: 1.302 ± 0.045	1.495ProPro: 1.495 ± 0.055	1.245ProGln: 1.245 ± 0.042	1.399ProArg: 1.399 ± 0.048	2.155ProSer: 2.155 ± 0.049	1.659ProThr: 1.659 ± 0.045	3.605ProVal: 3.605 ± 0.075	0.462ProTrp: 0.462 ± 0.022	1.253ProTyr: 1.253 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.206GlnAla: 4.206 ± 0.088	0.178GlnCys: 0.178 ± 0.014	1.984GlnAsp: 1.984 ± 0.05	3.485GlnGlu: 3.485 ± 0.079	1.455GlnPhe: 1.455 ± 0.05	2.68GlnGly: 2.68 ± 0.056	1.018GlnHis: 1.018 ± 0.035	1.929GlnIle: 1.929 ± 0.047	2.193GlnLys: 2.193 ± 0.057	4.153GlnLeu: 4.153 ± 0.078	1.364GlnMet: 1.364 ± 0.041	1.432GlnAsn: 1.432 ± 0.045	1.776GlnPro: 1.776 ± 0.053	2.328GlnGln: 2.328 ± 0.081	1.917GlnArg: 1.917 ± 0.056	2.284GlnSer: 2.284 ± 0.051	2.538GlnThr: 2.538 ± 0.066	2.77GlnVal: 2.77 ± 0.06	0.411GlnTrp: 0.411 ± 0.024	0.967GlnTyr: 0.967 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.485ArgAla: 3.485 ± 0.061	0.291ArgCys: 0.291 ± 0.018	2.424ArgAsp: 2.424 ± 0.064	4.039ArgGlu: 4.039 ± 0.069	2.131ArgPhe: 2.131 ± 0.061	3.239ArgGly: 3.239 ± 0.078	1.127ArgHis: 1.127 ± 0.037	2.78ArgIle: 2.78 ± 0.062	2.553ArgLys: 2.553 ± 0.056	5.12ArgLeu: 5.12 ± 0.101	1.646ArgMet: 1.646 ± 0.044	1.577ArgAsn: 1.577 ± 0.05	1.832ArgPro: 1.832 ± 0.044	1.868ArgGln: 1.868 ± 0.053	2.906ArgArg: 2.906 ± 0.066	2.708ArgSer: 2.708 ± 0.055	2.672ArgThr: 2.672 ± 0.061	3.161ArgVal: 3.161 ± 0.058	0.607ArgTrp: 0.607 ± 0.032	1.628ArgTyr: 1.628 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.54SerAla: 4.54 ± 0.08	0.35SerCys: 0.35 ± 0.022	2.84SerAsp: 2.84 ± 0.06	4.443SerGlu: 4.443 ± 0.08	2.912SerPhe: 2.912 ± 0.07	4.535SerGly: 4.535 ± 0.075	1.136SerHis: 1.136 ± 0.034	3.41SerIle: 3.41 ± 0.063	2.194SerLys: 2.194 ± 0.06	5.486SerLeu: 5.486 ± 0.083	1.673SerMet: 1.673 ± 0.044	1.772SerAsn: 1.772 ± 0.048	2.072SerPro: 2.072 ± 0.05	1.798SerGln: 1.798 ± 0.05	2.587SerArg: 2.587 ± 0.055	3.528SerSer: 3.528 ± 0.07	2.891SerThr: 2.891 ± 0.062	3.985SerVal: 3.985 ± 0.07	0.671SerTrp: 0.671 ± 0.028	1.916SerTyr: 1.916 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.514ThrAla: 5.514 ± 0.107	0.333ThrCys: 0.333 ± 0.019	2.928ThrAsp: 2.928 ± 0.065	4.167ThrGlu: 4.167 ± 0.069	2.755ThrPhe: 2.755 ± 0.061	4.601ThrGly: 4.601 ± 0.075	1.24ThrHis: 1.24 ± 0.043	3.439ThrIle: 3.439 ± 0.061	2.698ThrLys: 2.698 ± 0.055	5.476ThrLeu: 5.476 ± 0.08	1.548ThrMet: 1.548 ± 0.038	2.138ThrAsn: 2.138 ± 0.058	2.549ThrPro: 2.549 ± 0.056	1.493ThrGln: 1.493 ± 0.042	2.071ThrArg: 2.071 ± 0.051	3.372ThrSer: 3.372 ± 0.059	3.123ThrThr: 3.123 ± 0.067	4.39ThrVal: 4.39 ± 0.07	0.61ThrTrp: 0.61 ± 0.025	2.067ThrTyr: 2.067 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	5.708ValAla: 5.708 ± 0.105	0.558ValCys: 0.558 ± 0.029	4.326ValAsp: 4.326 ± 0.076	5.937ValGlu: 5.937 ± 0.079	3.023ValPhe: 3.023 ± 0.071	4.344ValGly: 4.344 ± 0.075	1.881ValHis: 1.881 ± 0.047	4.912ValIle: 4.912 ± 0.083	3.545ValLys: 3.545 ± 0.077	7.393ValLeu: 7.393 ± 0.103	2.191ValMet: 2.191 ± 0.053	2.937ValAsn: 2.937 ± 0.066	3.154ValPro: 3.154 ± 0.061	3.092ValGln: 3.092 ± 0.069	3.496ValArg: 3.496 ± 0.077	4.422ValSer: 4.422 ± 0.082	4.844ValThr: 4.844 ± 0.072	5.6ValVal: 5.6 ± 0.096	0.743ValTrp: 0.743 ± 0.032	2.51ValTyr: 2.51 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.743TrpAla: 0.743 ± 0.038	0.071TrpCys: 0.071 ± 0.009	0.466TrpAsp: 0.466 ± 0.024	0.804TrpGlu: 0.804 ± 0.033	0.506TrpPhe: 0.506 ± 0.03	0.634TrpGly: 0.634 ± 0.032	0.33TrpHis: 0.33 ± 0.019	0.687TrpIle: 0.687 ± 0.028	0.459TrpLys: 0.459 ± 0.025	1.387TrpLeu: 1.387 ± 0.045	0.422TrpMet: 0.422 ± 0.022	0.372TrpAsn: 0.372 ± 0.019	0.351TrpPro: 0.351 ± 0.02	0.517TrpGln: 0.517 ± 0.025	0.528TrpArg: 0.528 ± 0.025	0.552TrpSer: 0.552 ± 0.023	0.556TrpThr: 0.556 ± 0.031	0.729TrpVal: 0.729 ± 0.03	0.124TrpTrp: 0.124 ± 0.012	0.33TrpTyr: 0.33 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.464TyrAla: 2.464 ± 0.057	0.22TyrCys: 0.22 ± 0.017	2.034TyrAsp: 2.034 ± 0.052	2.878TyrGlu: 2.878 ± 0.055	1.448TyrPhe: 1.448 ± 0.041	2.344TyrGly: 2.344 ± 0.059	0.847TyrHis: 0.847 ± 0.032	1.967TyrIle: 1.967 ± 0.054	1.236TyrLys: 1.236 ± 0.038	2.66TyrLeu: 2.66 ± 0.055	0.876TyrMet: 0.876 ± 0.033	1.175TyrAsn: 1.175 ± 0.035	1.312TyrPro: 1.312 ± 0.039	1.469TyrGln: 1.469 ± 0.043	1.573TyrArg: 1.573 ± 0.045	1.454TyrSer: 1.454 ± 0.042	1.831TyrThr: 1.831 ± 0.048	2.2TyrVal: 2.2 ± 0.052	0.32TyrTrp: 0.32 ± 0.02	1.169TyrTyr: 1.169 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2921 proteins (855502 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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