Amino acid dipepetide frequency for Arthrobacter phage Ichor

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.837AlaAla: 12.837 ± 2.557
0.403AlaCys: 0.403 ± 0.208
6.39AlaAsp: 6.39 ± 0.767
5.929AlaGlu: 5.929 ± 0.667
2.533AlaPhe: 2.533 ± 0.462
7.944AlaGly: 7.944 ± 0.807
2.188AlaHis: 2.188 ± 0.37
5.066AlaIle: 5.066 ± 0.61
5.872AlaLys: 5.872 ± 0.856
8.923AlaLeu: 8.923 ± 0.639
2.591AlaMet: 2.591 ± 0.418
3.915AlaAsn: 3.915 ± 0.588
3.512AlaPro: 3.512 ± 0.454
4.087AlaGln: 4.087 ± 0.596
4.951AlaArg: 4.951 ± 0.527
5.757AlaSer: 5.757 ± 0.597
5.872AlaThr: 5.872 ± 0.719
6.16AlaVal: 6.16 ± 0.601
1.439AlaTrp: 1.439 ± 0.261
2.763AlaTyr: 2.763 ± 0.45
0.0AlaXaa: 0.0 ± 0.0
Cys
0.576CysAla: 0.576 ± 0.183
0.115CysCys: 0.115 ± 0.098
0.345CysAsp: 0.345 ± 0.163
0.345CysGlu: 0.345 ± 0.166
0.173CysPhe: 0.173 ± 0.106
0.748CysGly: 0.748 ± 0.282
0.173CysHis: 0.173 ± 0.098
0.173CysIle: 0.173 ± 0.111
0.345CysLys: 0.345 ± 0.149
0.461CysLeu: 0.461 ± 0.163
0.058CysMet: 0.058 ± 0.063
0.23CysAsn: 0.23 ± 0.115
0.576CysPro: 0.576 ± 0.165
0.461CysGln: 0.461 ± 0.164
0.403CysArg: 0.403 ± 0.165
0.576CysSer: 0.576 ± 0.257
0.288CysThr: 0.288 ± 0.118
0.461CysVal: 0.461 ± 0.222
0.115CysTrp: 0.115 ± 0.074
0.288CysTyr: 0.288 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
5.814AspAla: 5.814 ± 0.548
0.403AspCys: 0.403 ± 0.153
3.512AspAsp: 3.512 ± 0.47
4.145AspGlu: 4.145 ± 0.627
2.821AspPhe: 2.821 ± 0.405
4.433AspGly: 4.433 ± 0.429
0.576AspHis: 0.576 ± 0.215
3.396AspIle: 3.396 ± 0.407
3.627AspLys: 3.627 ± 0.493
4.893AspLeu: 4.893 ± 0.571
1.324AspMet: 1.324 ± 0.25
2.648AspAsn: 2.648 ± 0.396
2.706AspPro: 2.706 ± 0.387
1.382AspGln: 1.382 ± 0.298
3.799AspArg: 3.799 ± 0.592
3.512AspSer: 3.512 ± 0.49
3.684AspThr: 3.684 ± 0.364
3.569AspVal: 3.569 ± 0.442
1.324AspTrp: 1.324 ± 0.31
3.166AspTyr: 3.166 ± 0.49
0.0AspXaa: 0.0 ± 0.0
Glu
7.656GluAla: 7.656 ± 0.791
0.403GluCys: 0.403 ± 0.137
4.663GluAsp: 4.663 ± 0.6
4.375GluGlu: 4.375 ± 0.82
3.627GluPhe: 3.627 ± 0.572
4.605GluGly: 4.605 ± 0.588
1.439GluHis: 1.439 ± 0.474
3.915GluIle: 3.915 ± 0.453
3.627GluLys: 3.627 ± 0.559
7.196GluLeu: 7.196 ± 0.781
1.439GluMet: 1.439 ± 0.297
2.475GluAsn: 2.475 ± 0.335
2.533GluPro: 2.533 ± 0.481
2.878GluGln: 2.878 ± 0.443
4.087GluArg: 4.087 ± 0.5
3.454GluSer: 3.454 ± 0.558
4.145GluThr: 4.145 ± 0.546
5.296GluVal: 5.296 ± 0.579
1.324GluTrp: 1.324 ± 0.264
2.303GluTyr: 2.303 ± 0.411
0.0GluXaa: 0.0 ± 0.0
Phe
2.648PheAla: 2.648 ± 0.37
0.403PheCys: 0.403 ± 0.14
3.109PheAsp: 3.109 ± 0.463
2.072PheGlu: 2.072 ± 0.35
1.324PhePhe: 1.324 ± 0.246
2.821PheGly: 2.821 ± 0.43
0.864PheHis: 0.864 ± 0.244
1.727PheIle: 1.727 ± 0.336
1.497PheLys: 1.497 ± 0.252
2.13PheLeu: 2.13 ± 0.35
0.979PheMet: 0.979 ± 0.317
1.554PheAsn: 1.554 ± 0.34
1.036PhePro: 1.036 ± 0.28
1.612PheGln: 1.612 ± 0.277
1.727PheArg: 1.727 ± 0.34
2.648PheSer: 2.648 ± 0.375
2.591PheThr: 2.591 ± 0.379
3.281PheVal: 3.281 ± 0.447
0.288PheTrp: 0.288 ± 0.14
0.748PheTyr: 0.748 ± 0.199
0.0PheXaa: 0.0 ± 0.0
Gly
6.505GlyAla: 6.505 ± 0.903
0.518GlyCys: 0.518 ± 0.249
4.49GlyAsp: 4.49 ± 0.552
4.548GlyGlu: 4.548 ± 0.409
3.281GlyPhe: 3.281 ± 0.436
5.584GlyGly: 5.584 ± 0.555
1.324GlyHis: 1.324 ± 0.256
3.281GlyIle: 3.281 ± 0.531
4.663GlyLys: 4.663 ± 0.644
5.814GlyLeu: 5.814 ± 0.54
1.842GlyMet: 1.842 ± 0.316
4.087GlyAsn: 4.087 ± 0.605
2.533GlyPro: 2.533 ± 0.426
2.706GlyGln: 2.706 ± 0.358
2.936GlyArg: 2.936 ± 0.406
5.008GlySer: 5.008 ± 0.642
5.987GlyThr: 5.987 ± 0.628
7.081GlyVal: 7.081 ± 0.626
1.612GlyTrp: 1.612 ± 0.302
3.051GlyTyr: 3.051 ± 0.427
0.0GlyXaa: 0.0 ± 0.0
His
1.266HisAla: 1.266 ± 0.288
0.173HisCys: 0.173 ± 0.097
0.979HisAsp: 0.979 ± 0.284
1.324HisGlu: 1.324 ± 0.306
0.576HisPhe: 0.576 ± 0.162
1.266HisGly: 1.266 ± 0.283
0.461HisHis: 0.461 ± 0.187
1.094HisIle: 1.094 ± 0.282
0.979HisLys: 0.979 ± 0.274
1.554HisLeu: 1.554 ± 0.287
0.518HisMet: 0.518 ± 0.161
0.576HisAsn: 0.576 ± 0.169
1.151HisPro: 1.151 ± 0.245
0.461HisGln: 0.461 ± 0.19
1.266HisArg: 1.266 ± 0.38
0.979HisSer: 0.979 ± 0.278
1.151HisThr: 1.151 ± 0.269
1.612HisVal: 1.612 ± 0.327
0.461HisTrp: 0.461 ± 0.164
0.461HisTyr: 0.461 ± 0.155
0.0HisXaa: 0.0 ± 0.0
Ile
4.893IleAla: 4.893 ± 0.506
0.576IleCys: 0.576 ± 0.191
3.799IleAsp: 3.799 ± 0.41
4.663IleGlu: 4.663 ± 0.725
1.324IlePhe: 1.324 ± 0.274
3.684IleGly: 3.684 ± 0.546
0.518IleHis: 0.518 ± 0.182
2.36IleIle: 2.36 ± 0.464
2.763IleLys: 2.763 ± 0.505
2.533IleLeu: 2.533 ± 0.294
1.094IleMet: 1.094 ± 0.226
2.13IleAsn: 2.13 ± 0.335
2.188IlePro: 2.188 ± 0.398
1.9IleGln: 1.9 ± 0.448
2.821IleArg: 2.821 ± 0.396
2.993IleSer: 2.993 ± 0.41
3.339IleThr: 3.339 ± 0.416
3.627IleVal: 3.627 ± 0.48
1.094IleTrp: 1.094 ± 0.249
1.957IleTyr: 1.957 ± 0.307
0.0IleXaa: 0.0 ± 0.0
Lys
6.332LysAla: 6.332 ± 0.637
0.23LysCys: 0.23 ± 0.111
2.36LysAsp: 2.36 ± 0.328
3.684LysGlu: 3.684 ± 0.448
1.554LysPhe: 1.554 ± 0.353
3.569LysGly: 3.569 ± 0.396
1.612LysHis: 1.612 ± 0.409
2.878LysIle: 2.878 ± 0.43
2.936LysLys: 2.936 ± 0.437
5.008LysLeu: 5.008 ± 0.452
1.497LysMet: 1.497 ± 0.24
2.475LysAsn: 2.475 ± 0.295
1.842LysPro: 1.842 ± 0.299
2.418LysGln: 2.418 ± 0.441
2.763LysArg: 2.763 ± 0.416
2.936LysSer: 2.936 ± 0.483
4.087LysThr: 4.087 ± 0.418
3.915LysVal: 3.915 ± 0.501
0.921LysTrp: 0.921 ± 0.213
1.324LysTyr: 1.324 ± 0.245
0.0LysXaa: 0.0 ± 0.0
Leu
8.347LeuAla: 8.347 ± 0.926
0.288LeuCys: 0.288 ± 0.125
4.663LeuAsp: 4.663 ± 0.459
5.929LeuGlu: 5.929 ± 0.691
2.13LeuPhe: 2.13 ± 0.388
5.642LeuGly: 5.642 ± 0.586
1.785LeuHis: 1.785 ± 0.329
3.915LeuIle: 3.915 ± 0.416
3.799LeuLys: 3.799 ± 0.345
5.699LeuLeu: 5.699 ± 0.55
1.957LeuMet: 1.957 ± 0.312
3.281LeuAsn: 3.281 ± 0.452
3.512LeuPro: 3.512 ± 0.44
3.051LeuGln: 3.051 ± 0.405
4.318LeuArg: 4.318 ± 0.595
4.721LeuSer: 4.721 ± 0.497
5.929LeuThr: 5.929 ± 0.611
5.239LeuVal: 5.239 ± 0.633
1.382LeuTrp: 1.382 ± 0.354
2.015LeuTyr: 2.015 ± 0.281
0.0LeuXaa: 0.0 ± 0.0
Met
2.591MetAla: 2.591 ± 0.413
0.288MetCys: 0.288 ± 0.149
0.806MetAsp: 0.806 ± 0.18
1.669MetGlu: 1.669 ± 0.351
0.921MetPhe: 0.921 ± 0.262
1.727MetGly: 1.727 ± 0.329
0.461MetHis: 0.461 ± 0.186
0.979MetIle: 0.979 ± 0.216
1.036MetLys: 1.036 ± 0.246
1.497MetLeu: 1.497 ± 0.329
0.461MetMet: 0.461 ± 0.184
0.806MetAsn: 0.806 ± 0.187
1.209MetPro: 1.209 ± 0.302
0.921MetGln: 0.921 ± 0.226
2.072MetArg: 2.072 ± 0.394
1.957MetSer: 1.957 ± 0.321
1.554MetThr: 1.554 ± 0.318
1.497MetVal: 1.497 ± 0.306
0.23MetTrp: 0.23 ± 0.111
0.748MetTyr: 0.748 ± 0.189
0.0MetXaa: 0.0 ± 0.0
Asn
4.087AsnAla: 4.087 ± 0.519
0.173AsnCys: 0.173 ± 0.091
2.648AsnAsp: 2.648 ± 0.377
2.878AsnGlu: 2.878 ± 0.463
1.036AsnPhe: 1.036 ± 0.234
3.857AsnGly: 3.857 ± 0.447
0.461AsnHis: 0.461 ± 0.175
2.015AsnIle: 2.015 ± 0.334
2.13AsnLys: 2.13 ± 0.501
3.281AsnLeu: 3.281 ± 0.561
0.921AsnMet: 0.921 ± 0.242
2.13AsnAsn: 2.13 ± 0.416
2.706AsnPro: 2.706 ± 0.396
1.266AsnGln: 1.266 ± 0.328
2.475AsnArg: 2.475 ± 0.352
2.706AsnSer: 2.706 ± 0.501
2.13AsnThr: 2.13 ± 0.295
3.627AsnVal: 3.627 ± 0.597
0.518AsnTrp: 0.518 ± 0.163
1.957AsnTyr: 1.957 ± 0.416
0.0AsnXaa: 0.0 ± 0.0
Pro
3.454ProAla: 3.454 ± 0.422
0.345ProCys: 0.345 ± 0.136
2.936ProAsp: 2.936 ± 0.475
5.066ProGlu: 5.066 ± 0.587
1.439ProPhe: 1.439 ± 0.292
2.072ProGly: 2.072 ± 0.442
0.691ProHis: 0.691 ± 0.24
1.612ProIle: 1.612 ± 0.252
2.418ProLys: 2.418 ± 0.466
2.878ProLeu: 2.878 ± 0.467
1.036ProMet: 1.036 ± 0.259
1.727ProAsn: 1.727 ± 0.366
1.612ProPro: 1.612 ± 0.323
1.036ProGln: 1.036 ± 0.263
1.957ProArg: 1.957 ± 0.351
2.706ProSer: 2.706 ± 0.395
2.821ProThr: 2.821 ± 0.398
3.224ProVal: 3.224 ± 0.44
0.806ProTrp: 0.806 ± 0.253
1.842ProTyr: 1.842 ± 0.337
0.0ProXaa: 0.0 ± 0.0
Gln
3.799GlnAla: 3.799 ± 0.566
0.461GlnCys: 0.461 ± 0.169
1.957GlnAsp: 1.957 ± 0.308
3.109GlnGlu: 3.109 ± 0.405
1.727GlnPhe: 1.727 ± 0.294
2.475GlnGly: 2.475 ± 0.374
0.576GlnHis: 0.576 ± 0.191
1.842GlnIle: 1.842 ± 0.403
1.727GlnLys: 1.727 ± 0.258
2.763GlnLeu: 2.763 ± 0.381
0.921GlnMet: 0.921 ± 0.188
1.554GlnAsn: 1.554 ± 0.385
0.806GlnPro: 0.806 ± 0.209
2.072GlnGln: 2.072 ± 0.395
1.842GlnArg: 1.842 ± 0.326
2.533GlnSer: 2.533 ± 0.391
2.36GlnThr: 2.36 ± 0.43
2.475GlnVal: 2.475 ± 0.385
0.864GlnTrp: 0.864 ± 0.215
1.382GlnTyr: 1.382 ± 0.315
0.0GlnXaa: 0.0 ± 0.0
Arg
4.087ArgAla: 4.087 ± 0.557
0.288ArgCys: 0.288 ± 0.173
3.396ArgAsp: 3.396 ± 0.372
3.339ArgGlu: 3.339 ± 0.471
1.324ArgPhe: 1.324 ± 0.248
3.915ArgGly: 3.915 ± 0.583
1.036ArgHis: 1.036 ± 0.272
3.396ArgIle: 3.396 ± 0.493
3.339ArgLys: 3.339 ± 0.423
4.663ArgLeu: 4.663 ± 0.591
1.497ArgMet: 1.497 ± 0.232
2.303ArgAsn: 2.303 ± 0.418
2.591ArgPro: 2.591 ± 0.5
2.648ArgGln: 2.648 ± 0.479
2.648ArgArg: 2.648 ± 0.385
2.418ArgSer: 2.418 ± 0.386
2.993ArgThr: 2.993 ± 0.37
4.663ArgVal: 4.663 ± 0.546
0.806ArgTrp: 0.806 ± 0.204
1.669ArgTyr: 1.669 ± 0.312
0.0ArgXaa: 0.0 ± 0.0
Ser
7.023SerAla: 7.023 ± 0.907
0.461SerCys: 0.461 ± 0.161
4.548SerAsp: 4.548 ± 0.507
4.318SerGlu: 4.318 ± 0.694
2.533SerPhe: 2.533 ± 0.409
5.584SerGly: 5.584 ± 0.95
0.864SerHis: 0.864 ± 0.229
3.166SerIle: 3.166 ± 0.349
3.109SerLys: 3.109 ± 0.322
4.433SerLeu: 4.433 ± 0.495
1.727SerMet: 1.727 ± 0.276
2.591SerAsn: 2.591 ± 0.448
1.9SerPro: 1.9 ± 0.323
1.9SerGln: 1.9 ± 0.356
2.188SerArg: 2.188 ± 0.431
4.548SerSer: 4.548 ± 0.884
3.281SerThr: 3.281 ± 0.567
3.454SerVal: 3.454 ± 0.483
0.748SerTrp: 0.748 ± 0.253
1.9SerTyr: 1.9 ± 0.358
0.0SerXaa: 0.0 ± 0.0
Thr
6.332ThrAla: 6.332 ± 0.798
0.23ThrCys: 0.23 ± 0.115
3.109ThrAsp: 3.109 ± 0.411
4.663ThrGlu: 4.663 ± 0.461
2.821ThrPhe: 2.821 ± 0.485
6.563ThrGly: 6.563 ± 0.773
1.382ThrHis: 1.382 ± 0.355
3.627ThrIle: 3.627 ± 0.415
3.339ThrLys: 3.339 ± 0.418
5.066ThrLeu: 5.066 ± 0.476
0.979ThrMet: 0.979 ± 0.258
3.166ThrAsn: 3.166 ± 0.495
3.166ThrPro: 3.166 ± 0.458
2.188ThrGln: 2.188 ± 0.35
3.684ThrArg: 3.684 ± 0.468
3.684ThrSer: 3.684 ± 0.552
4.433ThrThr: 4.433 ± 0.663
5.296ThrVal: 5.296 ± 0.682
0.864ThrTrp: 0.864 ± 0.254
1.957ThrTyr: 1.957 ± 0.343
0.0ThrXaa: 0.0 ± 0.0
Val
6.448ValAla: 6.448 ± 0.555
0.806ValCys: 0.806 ± 0.282
3.857ValAsp: 3.857 ± 0.442
6.16ValGlu: 6.16 ± 0.701
1.727ValPhe: 1.727 ± 0.335
6.217ValGly: 6.217 ± 0.684
1.036ValHis: 1.036 ± 0.251
3.281ValIle: 3.281 ± 0.423
4.605ValLys: 4.605 ± 0.56
4.778ValLeu: 4.778 ± 0.503
1.669ValMet: 1.669 ± 0.346
3.051ValAsn: 3.051 ± 0.475
3.742ValPro: 3.742 ± 0.376
2.418ValGln: 2.418 ± 0.422
3.857ValArg: 3.857 ± 0.628
4.778ValSer: 4.778 ± 0.562
6.045ValThr: 6.045 ± 0.68
4.893ValVal: 4.893 ± 0.443
1.439ValTrp: 1.439 ± 0.348
2.36ValTyr: 2.36 ± 0.43
0.0ValXaa: 0.0 ± 0.0
Trp
1.842TrpAla: 1.842 ± 0.338
0.115TrpCys: 0.115 ± 0.073
1.209TrpAsp: 1.209 ± 0.248
1.324TrpGlu: 1.324 ± 0.26
0.633TrpPhe: 0.633 ± 0.196
1.151TrpGly: 1.151 ± 0.314
0.23TrpHis: 0.23 ± 0.128
0.633TrpIle: 0.633 ± 0.155
0.691TrpLys: 0.691 ± 0.235
1.554TrpLeu: 1.554 ± 0.385
0.23TrpMet: 0.23 ± 0.104
0.576TrpAsn: 0.576 ± 0.165
0.921TrpPro: 0.921 ± 0.256
0.748TrpGln: 0.748 ± 0.262
1.324TrpArg: 1.324 ± 0.286
0.748TrpSer: 0.748 ± 0.188
0.864TrpThr: 0.864 ± 0.246
1.439TrpVal: 1.439 ± 0.312
0.633TrpTrp: 0.633 ± 0.183
0.633TrpTyr: 0.633 ± 0.181
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.591TyrAla: 2.591 ± 0.577
0.23TyrCys: 0.23 ± 0.119
1.957TyrAsp: 1.957 ± 0.335
1.9TyrGlu: 1.9 ± 0.373
1.554TyrPhe: 1.554 ± 0.324
2.993TyrGly: 2.993 ± 0.461
0.633TyrHis: 0.633 ± 0.193
1.9TyrIle: 1.9 ± 0.343
1.842TyrLys: 1.842 ± 0.329
2.533TyrLeu: 2.533 ± 0.387
0.633TyrMet: 0.633 ± 0.239
1.727TyrAsn: 1.727 ± 0.315
1.439TyrPro: 1.439 ± 0.306
1.094TyrGln: 1.094 ± 0.271
1.9TyrArg: 1.9 ± 0.311
1.612TyrSer: 1.612 ± 0.215
2.993TyrThr: 2.993 ± 0.371
2.36TyrVal: 2.36 ± 0.404
0.633TyrTrp: 0.633 ± 0.204
0.979TyrTyr: 0.979 ± 0.208
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 84 proteins (17372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski