Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA382A13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.329AlaAla: 4.329 ± 0.248
0.749AlaCys: 0.749 ± 0.095
3.403AlaAsp: 3.403 ± 0.192
5.464AlaGlu: 5.464 ± 0.25
2.342AlaPhe: 2.342 ± 0.171
4.298AlaGly: 4.298 ± 0.271
0.957AlaHis: 0.957 ± 0.082
4.579AlaIle: 4.579 ± 0.285
4.517AlaLys: 4.517 ± 0.232
5.89AlaLeu: 5.89 ± 0.265
1.551AlaMet: 1.551 ± 0.127
1.998AlaAsn: 1.998 ± 0.151
1.967AlaPro: 1.967 ± 0.151
1.426AlaGln: 1.426 ± 0.125
3.195AlaArg: 3.195 ± 0.184
3.632AlaSer: 3.632 ± 0.189
3.049AlaThr: 3.049 ± 0.197
3.996AlaVal: 3.996 ± 0.244
0.801AlaTrp: 0.801 ± 0.082
1.551AlaTyr: 1.551 ± 0.117
0.0AlaXaa: 0.0 ± 0.0
Cys
0.395CysAla: 0.395 ± 0.074
0.125CysCys: 0.125 ± 0.043
0.676CysAsp: 0.676 ± 0.088
0.864CysGlu: 0.864 ± 0.108
0.395CysPhe: 0.395 ± 0.066
1.322CysGly: 1.322 ± 0.146
0.146CysHis: 0.146 ± 0.038
0.718CysIle: 0.718 ± 0.091
0.479CysLys: 0.479 ± 0.076
0.77CysLeu: 0.77 ± 0.093
0.229CysMet: 0.229 ± 0.053
0.271CysAsn: 0.271 ± 0.052
0.791CysPro: 0.791 ± 0.095
0.156CysGln: 0.156 ± 0.049
0.51CysArg: 0.51 ± 0.07
0.833CysSer: 0.833 ± 0.104
0.427CysThr: 0.427 ± 0.064
0.583CysVal: 0.583 ± 0.093
0.083CysTrp: 0.083 ± 0.03
0.229CysTyr: 0.229 ± 0.047
0.0CysXaa: 0.0 ± 0.0
Asp
3.112AspAla: 3.112 ± 0.177
0.635AspCys: 0.635 ± 0.094
2.623AspAsp: 2.623 ± 0.19
5.724AspGlu: 5.724 ± 0.303
3.153AspPhe: 3.153 ± 0.187
3.58AspGly: 3.58 ± 0.208
1.02AspHis: 1.02 ± 0.093
4.173AspIle: 4.173 ± 0.237
4.152AspLys: 4.152 ± 0.225
6.265AspLeu: 6.265 ± 0.293
1.478AspMet: 1.478 ± 0.114
1.956AspAsn: 1.956 ± 0.133
2.425AspPro: 2.425 ± 0.143
1.249AspGln: 1.249 ± 0.101
2.883AspArg: 2.883 ± 0.195
3.184AspSer: 3.184 ± 0.172
2.31AspThr: 2.31 ± 0.16
4.152AspVal: 4.152 ± 0.224
0.926AspTrp: 0.926 ± 0.104
2.487AspTyr: 2.487 ± 0.164
0.0AspXaa: 0.0 ± 0.0
Glu
5.11GluAla: 5.11 ± 0.263
0.718GluCys: 0.718 ± 0.094
5.786GluAsp: 5.786 ± 0.319
11.843GluGlu: 11.843 ± 0.472
3.309GluPhe: 3.309 ± 0.242
5.63GluGly: 5.63 ± 0.252
1.301GluHis: 1.301 ± 0.11
8.721GluIle: 8.721 ± 0.319
12.499GluLys: 12.499 ± 0.438
8.044GluLeu: 8.044 ± 0.372
2.269GluMet: 2.269 ± 0.158
5.12GluAsn: 5.12 ± 0.228
2.758GluPro: 2.758 ± 0.179
1.863GluGln: 1.863 ± 0.15
4.995GluArg: 4.995 ± 0.248
4.527GluSer: 4.527 ± 0.209
4.912GluThr: 4.912 ± 0.211
6.046GluVal: 6.046 ± 0.265
1.145GluTrp: 1.145 ± 0.108
2.758GluTyr: 2.758 ± 0.169
0.0GluXaa: 0.0 ± 0.0
Phe
2.404PheAla: 2.404 ± 0.177
0.458PheCys: 0.458 ± 0.058
2.383PheAsp: 2.383 ± 0.154
3.861PheGlu: 3.861 ± 0.211
1.915PhePhe: 1.915 ± 0.19
2.883PheGly: 2.883 ± 0.166
0.728PheHis: 0.728 ± 0.084
2.123PheIle: 2.123 ± 0.192
2.456PheLys: 2.456 ± 0.172
3.923PheLeu: 3.923 ± 0.21
0.676PheMet: 0.676 ± 0.09
1.27PheAsn: 1.27 ± 0.109
1.384PhePro: 1.384 ± 0.104
0.968PheGln: 0.968 ± 0.1
1.759PheArg: 1.759 ± 0.142
3.237PheSer: 3.237 ± 0.188
1.821PheThr: 1.821 ± 0.122
2.57PheVal: 2.57 ± 0.159
0.479PheTrp: 0.479 ± 0.084
1.342PheTyr: 1.342 ± 0.126
0.0PheXaa: 0.0 ± 0.0
Gly
4.433GlyAla: 4.433 ± 0.202
0.687GlyCys: 0.687 ± 0.089
3.351GlyAsp: 3.351 ± 0.208
6.369GlyGlu: 6.369 ± 0.256
2.539GlyPhe: 2.539 ± 0.207
5.328GlyGly: 5.328 ± 0.334
1.27GlyHis: 1.27 ± 0.114
5.786GlyIle: 5.786 ± 0.276
6.359GlyLys: 6.359 ± 0.272
5.745GlyLeu: 5.745 ± 0.284
1.852GlyMet: 1.852 ± 0.132
2.362GlyAsn: 2.362 ± 0.141
2.518GlyPro: 2.518 ± 0.166
1.675GlyGln: 1.675 ± 0.137
3.424GlyArg: 3.424 ± 0.209
4.402GlySer: 4.402 ± 0.213
3.351GlyThr: 3.351 ± 0.214
4.974GlyVal: 4.974 ± 0.286
0.968GlyTrp: 0.968 ± 0.095
1.998GlyTyr: 1.998 ± 0.151
0.0GlyXaa: 0.0 ± 0.0
His
0.957HisAla: 0.957 ± 0.106
0.177HisCys: 0.177 ± 0.047
1.03HisAsp: 1.03 ± 0.092
1.395HisGlu: 1.395 ± 0.108
0.572HisPhe: 0.572 ± 0.068
1.301HisGly: 1.301 ± 0.127
0.385HisHis: 0.385 ± 0.071
1.114HisIle: 1.114 ± 0.098
0.874HisLys: 0.874 ± 0.077
1.478HisLeu: 1.478 ± 0.135
0.281HisMet: 0.281 ± 0.053
0.552HisAsn: 0.552 ± 0.071
1.124HisPro: 1.124 ± 0.125
0.427HisGln: 0.427 ± 0.069
0.926HisArg: 0.926 ± 0.087
0.968HisSer: 0.968 ± 0.119
0.697HisThr: 0.697 ± 0.083
1.093HisVal: 1.093 ± 0.109
0.156HisTrp: 0.156 ± 0.036
0.739HisTyr: 0.739 ± 0.105
0.0HisXaa: 0.0 ± 0.0
Ile
5.006IleAla: 5.006 ± 0.273
0.687IleCys: 0.687 ± 0.086
4.548IleAsp: 4.548 ± 0.221
7.264IleGlu: 7.264 ± 0.295
3.237IlePhe: 3.237 ± 0.192
5.505IleGly: 5.505 ± 0.293
1.124IleHis: 1.124 ± 0.115
5.547IleIle: 5.547 ± 0.287
4.912IleLys: 4.912 ± 0.241
6.733IleLeu: 6.733 ± 0.296
1.551IleMet: 1.551 ± 0.15
2.883IleAsn: 2.883 ± 0.203
3.684IlePro: 3.684 ± 0.198
1.946IleGln: 1.946 ± 0.141
4.121IleArg: 4.121 ± 0.195
5.526IleSer: 5.526 ± 0.257
3.684IleThr: 3.684 ± 0.226
5.037IleVal: 5.037 ± 0.238
0.708IleTrp: 0.708 ± 0.086
2.289IleTyr: 2.289 ± 0.16
0.0IleXaa: 0.0 ± 0.0
Lys
5.047LysAla: 5.047 ± 0.24
0.76LysCys: 0.76 ± 0.089
4.35LysAsp: 4.35 ± 0.225
8.742LysGlu: 8.742 ± 0.358
2.841LysPhe: 2.841 ± 0.177
5.297LysGly: 5.297 ± 0.235
1.29LysHis: 1.29 ± 0.108
7.43LysIle: 7.43 ± 0.345
8.939LysLys: 8.939 ± 0.417
7.118LysLeu: 7.118 ± 0.263
1.811LysMet: 1.811 ± 0.116
4.87LysAsn: 4.87 ± 0.255
2.685LysPro: 2.685 ± 0.161
1.988LysGln: 1.988 ± 0.153
4.121LysArg: 4.121 ± 0.219
4.902LysSer: 4.902 ± 0.223
4.465LysThr: 4.465 ± 0.203
4.922LysVal: 4.922 ± 0.222
0.718LysTrp: 0.718 ± 0.104
2.435LysTyr: 2.435 ± 0.177
0.0LysXaa: 0.0 ± 0.0
Leu
5.994LeuAla: 5.994 ± 0.308
0.718LeuCys: 0.718 ± 0.093
5.932LeuAsp: 5.932 ± 0.245
9.481LeuGlu: 9.481 ± 0.338
3.174LeuPhe: 3.174 ± 0.184
5.901LeuGly: 5.901 ± 0.267
1.176LeuHis: 1.176 ± 0.106
6.213LeuIle: 6.213 ± 0.293
7.326LeuLys: 7.326 ± 0.299
8.034LeuLeu: 8.034 ± 0.387
1.915LeuMet: 1.915 ± 0.138
4.069LeuAsn: 4.069 ± 0.209
3.413LeuPro: 3.413 ± 0.188
2.237LeuGln: 2.237 ± 0.156
4.298LeuArg: 4.298 ± 0.246
7.233LeuSer: 7.233 ± 0.253
4.475LeuThr: 4.475 ± 0.209
5.64LeuVal: 5.64 ± 0.244
0.874LeuTrp: 0.874 ± 0.117
2.269LeuTyr: 2.269 ± 0.161
0.0LeuXaa: 0.0 ± 0.0
Met
1.551MetAla: 1.551 ± 0.14
0.187MetCys: 0.187 ± 0.047
1.665MetAsp: 1.665 ± 0.142
2.237MetGlu: 2.237 ± 0.165
0.604MetPhe: 0.604 ± 0.073
1.738MetGly: 1.738 ± 0.146
0.333MetHis: 0.333 ± 0.056
1.634MetIle: 1.634 ± 0.137
2.081MetLys: 2.081 ± 0.14
1.759MetLeu: 1.759 ± 0.133
0.572MetMet: 0.572 ± 0.085
1.259MetAsn: 1.259 ± 0.116
0.885MetPro: 0.885 ± 0.088
0.458MetGln: 0.458 ± 0.074
1.02MetArg: 1.02 ± 0.101
1.488MetSer: 1.488 ± 0.138
1.134MetThr: 1.134 ± 0.11
1.478MetVal: 1.478 ± 0.124
0.177MetTrp: 0.177 ± 0.049
0.541MetTyr: 0.541 ± 0.08
0.0MetXaa: 0.0 ± 0.0
Asn
2.331AsnAla: 2.331 ± 0.134
0.624AsnCys: 0.624 ± 0.085
1.811AsnAsp: 1.811 ± 0.131
3.341AsnGlu: 3.341 ± 0.185
1.936AsnPhe: 1.936 ± 0.135
2.446AsnGly: 2.446 ± 0.186
0.791AsnHis: 0.791 ± 0.082
3.632AsnIle: 3.632 ± 0.206
2.966AsnLys: 2.966 ± 0.208
4.766AsnLeu: 4.766 ± 0.249
1.093AsnMet: 1.093 ± 0.109
1.478AsnAsn: 1.478 ± 0.149
2.664AsnPro: 2.664 ± 0.191
1.155AsnGln: 1.155 ± 0.112
2.154AsnArg: 2.154 ± 0.161
2.654AsnSer: 2.654 ± 0.162
2.05AsnThr: 2.05 ± 0.138
2.55AsnVal: 2.55 ± 0.179
0.562AsnTrp: 0.562 ± 0.084
1.405AsnTyr: 1.405 ± 0.139
0.0AsnXaa: 0.0 ± 0.0
Pro
1.998ProAla: 1.998 ± 0.152
0.479ProCys: 0.479 ± 0.067
2.57ProAsp: 2.57 ± 0.17
4.683ProGlu: 4.683 ± 0.226
1.415ProPhe: 1.415 ± 0.1
2.602ProGly: 2.602 ± 0.147
0.739ProHis: 0.739 ± 0.086
2.57ProIle: 2.57 ± 0.158
2.727ProLys: 2.727 ± 0.151
3.33ProLeu: 3.33 ± 0.212
0.77ProMet: 0.77 ± 0.083
1.634ProAsn: 1.634 ± 0.133
1.821ProPro: 1.821 ± 0.154
1.072ProGln: 1.072 ± 0.097
1.821ProArg: 1.821 ± 0.151
2.685ProSer: 2.685 ± 0.177
2.102ProThr: 2.102 ± 0.147
2.727ProVal: 2.727 ± 0.195
0.354ProTrp: 0.354 ± 0.062
1.384ProTyr: 1.384 ± 0.134
0.0ProXaa: 0.0 ± 0.0
Gln
1.665GlnAla: 1.665 ± 0.128
0.187GlnCys: 0.187 ± 0.044
1.405GlnAsp: 1.405 ± 0.113
2.446GlnGlu: 2.446 ± 0.17
0.822GlnPhe: 0.822 ± 0.106
1.571GlnGly: 1.571 ± 0.125
0.364GlnHis: 0.364 ± 0.059
2.206GlnIle: 2.206 ± 0.171
2.539GlnLys: 2.539 ± 0.174
1.988GlnLeu: 1.988 ± 0.128
0.656GlnMet: 0.656 ± 0.08
1.363GlnAsn: 1.363 ± 0.135
0.552GlnPro: 0.552 ± 0.072
0.604GlnGln: 0.604 ± 0.091
1.061GlnArg: 1.061 ± 0.111
1.218GlnSer: 1.218 ± 0.106
1.176GlnThr: 1.176 ± 0.11
1.426GlnVal: 1.426 ± 0.116
0.135GlnTrp: 0.135 ± 0.035
0.76GlnTyr: 0.76 ± 0.098
0.0GlnXaa: 0.0 ± 0.0
Arg
2.81ArgAla: 2.81 ± 0.189
0.51ArgCys: 0.51 ± 0.067
2.56ArgAsp: 2.56 ± 0.179
5.099ArgGlu: 5.099 ± 0.238
1.821ArgPhe: 1.821 ± 0.142
3.247ArgGly: 3.247 ± 0.217
0.697ArgHis: 0.697 ± 0.081
3.903ArgIle: 3.903 ± 0.207
5.526ArgLys: 5.526 ± 0.268
4.173ArgLeu: 4.173 ± 0.246
1.405ArgMet: 1.405 ± 0.124
2.383ArgAsn: 2.383 ± 0.158
1.769ArgPro: 1.769 ± 0.122
1.207ArgGln: 1.207 ± 0.117
3.122ArgArg: 3.122 ± 0.229
2.851ArgSer: 2.851 ± 0.179
2.321ArgThr: 2.321 ± 0.167
3.07ArgVal: 3.07 ± 0.198
0.427ArgTrp: 0.427 ± 0.085
1.623ArgTyr: 1.623 ± 0.141
0.0ArgXaa: 0.0 ± 0.0
Ser
3.465SerAla: 3.465 ± 0.222
0.604SerCys: 0.604 ± 0.078
3.746SerAsp: 3.746 ± 0.22
6.525SerGlu: 6.525 ± 0.264
2.591SerPhe: 2.591 ± 0.168
4.995SerGly: 4.995 ± 0.267
1.051SerHis: 1.051 ± 0.111
4.735SerIle: 4.735 ± 0.255
5.006SerLys: 5.006 ± 0.232
6.067SerLeu: 6.067 ± 0.257
1.436SerMet: 1.436 ± 0.125
2.862SerAsn: 2.862 ± 0.156
2.57SerPro: 2.57 ± 0.177
1.738SerGln: 1.738 ± 0.13
3.216SerArg: 3.216 ± 0.175
3.746SerSer: 3.746 ± 0.208
3.039SerThr: 3.039 ± 0.191
4.038SerVal: 4.038 ± 0.225
0.708SerTrp: 0.708 ± 0.086
1.696SerTyr: 1.696 ± 0.149
0.0SerXaa: 0.0 ± 0.0
Thr
3.018ThrAla: 3.018 ± 0.184
0.541ThrCys: 0.541 ± 0.075
2.987ThrAsp: 2.987 ± 0.167
4.027ThrGlu: 4.027 ± 0.2
1.78ThrPhe: 1.78 ± 0.14
4.132ThrGly: 4.132 ± 0.226
0.926ThrHis: 0.926 ± 0.11
4.007ThrIle: 4.007 ± 0.231
3.132ThrLys: 3.132 ± 0.199
4.569ThrLeu: 4.569 ± 0.218
0.989ThrMet: 0.989 ± 0.097
2.029ThrAsn: 2.029 ± 0.157
2.217ThrPro: 2.217 ± 0.156
1.197ThrGln: 1.197 ± 0.124
2.175ThrArg: 2.175 ± 0.131
3.268ThrSer: 3.268 ± 0.192
2.675ThrThr: 2.675 ± 0.196
3.403ThrVal: 3.403 ± 0.199
0.458ThrTrp: 0.458 ± 0.065
1.54ThrTyr: 1.54 ± 0.146
0.0ThrXaa: 0.0 ± 0.0
Val
3.726ValAla: 3.726 ± 0.184
0.645ValCys: 0.645 ± 0.077
4.132ValAsp: 4.132 ± 0.214
6.39ValGlu: 6.39 ± 0.309
2.602ValPhe: 2.602 ± 0.158
4.548ValGly: 4.548 ± 0.279
1.114ValHis: 1.114 ± 0.112
4.298ValIle: 4.298 ± 0.226
5.026ValLys: 5.026 ± 0.254
5.745ValLeu: 5.745 ± 0.284
1.478ValMet: 1.478 ± 0.137
2.394ValAsn: 2.394 ± 0.136
2.581ValPro: 2.581 ± 0.15
1.696ValGln: 1.696 ± 0.124
3.538ValArg: 3.538 ± 0.218
4.6ValSer: 4.6 ± 0.24
3.268ValThr: 3.268 ± 0.212
4.35ValVal: 4.35 ± 0.244
0.718ValTrp: 0.718 ± 0.079
1.728ValTyr: 1.728 ± 0.14
0.0ValXaa: 0.0 ± 0.0
Trp
0.583TrpAla: 0.583 ± 0.08
0.104TrpCys: 0.104 ± 0.032
0.583TrpAsp: 0.583 ± 0.082
0.968TrpGlu: 0.968 ± 0.091
0.323TrpPhe: 0.323 ± 0.06
0.749TrpGly: 0.749 ± 0.101
0.219TrpHis: 0.219 ± 0.051
0.843TrpIle: 0.843 ± 0.102
1.186TrpLys: 1.186 ± 0.119
0.885TrpLeu: 0.885 ± 0.093
0.26TrpMet: 0.26 ± 0.054
0.614TrpAsn: 0.614 ± 0.068
0.229TrpPro: 0.229 ± 0.057
0.219TrpGln: 0.219 ± 0.06
0.728TrpArg: 0.728 ± 0.1
0.812TrpSer: 0.812 ± 0.1
0.562TrpThr: 0.562 ± 0.077
0.666TrpVal: 0.666 ± 0.089
0.177TrpTrp: 0.177 ± 0.04
0.281TrpTyr: 0.281 ± 0.059
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.759TyrAla: 1.759 ± 0.171
0.406TyrCys: 0.406 ± 0.064
1.946TyrAsp: 1.946 ± 0.149
2.633TyrGlu: 2.633 ± 0.179
1.27TyrPhe: 1.27 ± 0.119
2.331TyrGly: 2.331 ± 0.147
0.614TyrHis: 0.614 ± 0.081
1.759TyrIle: 1.759 ± 0.128
2.029TyrLys: 2.029 ± 0.155
3.091TyrLeu: 3.091 ± 0.221
0.52TyrMet: 0.52 ± 0.068
1.041TyrAsn: 1.041 ± 0.107
1.447TyrPro: 1.447 ± 0.129
0.864TyrGln: 0.864 ± 0.084
1.457TyrArg: 1.457 ± 0.126
2.071TyrSer: 2.071 ± 0.149
1.551TyrThr: 1.551 ± 0.133
1.852TyrVal: 1.852 ± 0.143
0.416TyrTrp: 0.416 ± 0.063
1.207TyrTyr: 1.207 ± 0.114
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 450 proteins (96092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski