Amino acid dipepetide frequency for Acetatifactor muris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.058AlaAla: 8.058 ± 0.102	1.15AlaCys: 1.15 ± 0.029	4.738AlaAsp: 4.738 ± 0.059	6.568AlaGlu: 6.568 ± 0.076	3.142AlaPhe: 3.142 ± 0.05	6.967AlaGly: 6.967 ± 0.084	1.11AlaHis: 1.11 ± 0.027	4.196AlaIle: 4.196 ± 0.057	3.868AlaLys: 3.868 ± 0.053	7.107AlaLeu: 7.107 ± 0.083	2.283AlaMet: 2.283 ± 0.037	2.332AlaAsn: 2.332 ± 0.044	2.12AlaPro: 2.12 ± 0.046	2.447AlaGln: 2.447 ± 0.051	3.477AlaArg: 3.477 ± 0.046	3.647AlaSer: 3.647 ± 0.056	2.788AlaThr: 2.788 ± 0.052	6.538AlaVal: 6.538 ± 0.068	0.791AlaTrp: 0.791 ± 0.019	2.912AlaTyr: 2.912 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.039CysAla: 1.039 ± 0.026	0.335CysCys: 0.335 ± 0.015	0.869CysAsp: 0.869 ± 0.023	0.96CysGlu: 0.96 ± 0.026	0.74CysPhe: 0.74 ± 0.023	1.675CysGly: 1.675 ± 0.038	0.36CysHis: 0.36 ± 0.014	1.135CysIle: 1.135 ± 0.03	0.763CysLys: 0.763 ± 0.021	1.397CysLeu: 1.397 ± 0.032	0.521CysMet: 0.521 ± 0.017	0.602CysAsn: 0.602 ± 0.018	0.666CysPro: 0.666 ± 0.025	0.405CysGln: 0.405 ± 0.018	1.137CysArg: 1.137 ± 0.026	0.879CysSer: 0.879 ± 0.023	0.748CysThr: 0.748 ± 0.021	1.067CysVal: 1.067 ± 0.023	0.162CysTrp: 0.162 ± 0.009	0.662CysTyr: 0.662 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.89AspAla: 3.89 ± 0.053	0.907AspCys: 0.907 ± 0.021	2.496AspAsp: 2.496 ± 0.044	4.226AspGlu: 4.226 ± 0.048	2.742AspPhe: 2.742 ± 0.041	4.647AspGly: 4.647 ± 0.061	0.695AspHis: 0.695 ± 0.019	4.206AspIle: 4.206 ± 0.058	3.116AspLys: 3.116 ± 0.052	4.181AspLeu: 4.181 ± 0.048	1.916AspMet: 1.916 ± 0.035	2.206AspAsn: 2.206 ± 0.039	1.558AspPro: 1.558 ± 0.033	1.094AspGln: 1.094 ± 0.024	3.319AspArg: 3.319 ± 0.048	3.281AspSer: 3.281 ± 0.038	3.184AspThr: 3.184 ± 0.044	3.383AspVal: 3.383 ± 0.049	0.735AspTrp: 0.735 ± 0.022	2.764AspTyr: 2.764 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.196GluAla: 6.196 ± 0.072	0.947GluCys: 0.947 ± 0.027	4.45GluAsp: 4.45 ± 0.057	8.125GluGlu: 8.125 ± 0.102	2.54GluPhe: 2.54 ± 0.038	5.001GluGly: 5.001 ± 0.061	1.35GluHis: 1.35 ± 0.026	5.561GluIle: 5.561 ± 0.06	6.819GluLys: 6.819 ± 0.073	7.11GluLeu: 7.11 ± 0.067	2.572GluMet: 2.572 ± 0.038	4.286GluAsn: 4.286 ± 0.046	2.121GluPro: 2.121 ± 0.045	3.332GluGln: 3.332 ± 0.051	4.379GluArg: 4.379 ± 0.063	3.88GluSer: 3.88 ± 0.128	3.878GluThr: 3.878 ± 0.053	4.306GluVal: 4.306 ± 0.057	0.909GluTrp: 0.909 ± 0.025	3.52GluTyr: 3.52 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.975PheAla: 2.975 ± 0.044	0.867PheCys: 0.867 ± 0.023	2.389PheAsp: 2.389 ± 0.042	2.656PheGlu: 2.656 ± 0.041	1.911PhePhe: 1.911 ± 0.039	2.965PheGly: 2.965 ± 0.053	0.86PheHis: 0.86 ± 0.022	2.456PheIle: 2.456 ± 0.039	1.577PheLys: 1.577 ± 0.029	4.25PheLeu: 4.25 ± 0.054	1.098PheMet: 1.098 ± 0.026	1.381PheAsn: 1.381 ± 0.027	1.468PhePro: 1.468 ± 0.028	1.442PheGln: 1.442 ± 0.03	2.345PheArg: 2.345 ± 0.034	3.041PheSer: 3.041 ± 0.044	2.274PheThr: 2.274 ± 0.039	2.673PheVal: 2.673 ± 0.042	0.514PheTrp: 0.514 ± 0.019	1.888PheTyr: 1.888 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.9GlyAla: 4.9 ± 0.075	1.3GlyCys: 1.3 ± 0.028	3.595GlyAsp: 3.595 ± 0.055	5.748GlyGlu: 5.748 ± 0.068	3.106GlyPhe: 3.106 ± 0.045	5.165GlyGly: 5.165 ± 0.071	1.261GlyHis: 1.261 ± 0.03	5.868GlyIle: 5.868 ± 0.061	5.372GlyLys: 5.372 ± 0.056	5.92GlyLeu: 5.92 ± 0.063	2.589GlyMet: 2.589 ± 0.036	3.447GlyAsn: 3.447 ± 0.05	1.284GlyPro: 1.284 ± 0.037	2.398GlyGln: 2.398 ± 0.038	4.251GlyArg: 4.251 ± 0.054	4.123GlySer: 4.123 ± 0.058	4.067GlyThr: 4.067 ± 0.059	4.404GlyVal: 4.404 ± 0.055	0.871GlyTrp: 0.871 ± 0.023	3.426GlyTyr: 3.426 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.056HisAla: 1.056 ± 0.027	0.326HisCys: 0.326 ± 0.014	0.904HisAsp: 0.904 ± 0.027	1.049HisGlu: 1.049 ± 0.025	0.901HisPhe: 0.901 ± 0.025	1.238HisGly: 1.238 ± 0.029	0.385HisHis: 0.385 ± 0.019	1.335HisIle: 1.335 ± 0.026	0.856HisLys: 0.856 ± 0.023	1.491HisLeu: 1.491 ± 0.029	0.539HisMet: 0.539 ± 0.02	0.713HisAsn: 0.713 ± 0.022	0.846HisPro: 0.846 ± 0.026	0.521HisGln: 0.521 ± 0.017	1.05HisArg: 1.05 ± 0.026	1.015HisSer: 1.015 ± 0.021	0.92HisThr: 0.92 ± 0.023	1.0HisVal: 1.0 ± 0.027	0.217HisTrp: 0.217 ± 0.011	0.814HisTyr: 0.814 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.016IleAla: 5.016 ± 0.059	1.317IleCys: 1.317 ± 0.029	3.497IleAsp: 3.497 ± 0.05	4.138IleGlu: 4.138 ± 0.056	2.78IlePhe: 2.78 ± 0.046	4.238IleGly: 4.238 ± 0.058	1.275IleHis: 1.275 ± 0.026	4.156IleIle: 4.156 ± 0.061	3.199IleLys: 3.199 ± 0.048	6.982IleLeu: 6.982 ± 0.071	1.76IleMet: 1.76 ± 0.032	2.493IleAsn: 2.493 ± 0.04	3.003IlePro: 3.003 ± 0.042	2.168IleGln: 2.168 ± 0.035	4.102IleArg: 4.102 ± 0.052	4.477IleSer: 4.477 ± 0.054	3.665IleThr: 3.665 ± 0.04	4.277IleVal: 4.277 ± 0.061	0.731IleTrp: 0.731 ± 0.02	2.787IleTyr: 2.787 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.926LysAla: 4.926 ± 0.066	0.809LysCys: 0.809 ± 0.023	3.083LysAsp: 3.083 ± 0.048	5.749LysGlu: 5.749 ± 0.066	1.723LysPhe: 1.723 ± 0.033	3.967LysGly: 3.967 ± 0.054	0.906LysHis: 0.906 ± 0.025	4.053LysIle: 4.053 ± 0.054	4.977LysLys: 4.977 ± 0.068	4.942LysLeu: 4.942 ± 0.062	1.884LysMet: 1.884 ± 0.037	2.902LysAsn: 2.902 ± 0.043	1.893LysPro: 1.893 ± 0.032	2.152LysGln: 2.152 ± 0.036	3.262LysArg: 3.262 ± 0.047	3.142LysSer: 3.142 ± 0.044	3.166LysThr: 3.166 ± 0.044	3.77LysVal: 3.77 ± 0.05	0.687LysTrp: 0.687 ± 0.021	2.665LysTyr: 2.665 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.985LeuAla: 6.985 ± 0.078	1.679LeuCys: 1.679 ± 0.035	4.846LeuAsp: 4.846 ± 0.057	6.884LeuGlu: 6.884 ± 0.075	4.045LeuPhe: 4.045 ± 0.061	5.529LeuGly: 5.529 ± 0.06	1.586LeuHis: 1.586 ± 0.033	5.373LeuIle: 5.373 ± 0.061	5.693LeuLys: 5.693 ± 0.063	9.347LeuLeu: 9.347 ± 0.093	2.608LeuMet: 2.608 ± 0.037	3.772LeuAsn: 3.772 ± 0.043	3.856LeuPro: 3.856 ± 0.053	3.204LeuGln: 3.204 ± 0.049	4.51LeuArg: 4.51 ± 0.051	6.294LeuSer: 6.294 ± 0.072	5.307LeuThr: 5.307 ± 0.068	5.073LeuVal: 5.073 ± 0.06	1.011LeuTrp: 1.011 ± 0.029	3.91LeuTyr: 3.91 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.534MetAla: 2.534 ± 0.041	0.404MetCys: 0.404 ± 0.017	1.758MetAsp: 1.758 ± 0.032	2.922MetGlu: 2.922 ± 0.048	0.931MetPhe: 0.931 ± 0.021	2.08MetGly: 2.08 ± 0.036	0.432MetHis: 0.432 ± 0.015	1.878MetIle: 1.878 ± 0.042	2.271MetLys: 2.271 ± 0.039	2.854MetLeu: 2.854 ± 0.045	0.882MetMet: 0.882 ± 0.021	1.451MetAsn: 1.451 ± 0.033	1.119MetPro: 1.119 ± 0.026	1.11MetGln: 1.11 ± 0.025	1.516MetArg: 1.516 ± 0.029	1.666MetSer: 1.666 ± 0.032	1.682MetThr: 1.682 ± 0.032	1.814MetVal: 1.814 ± 0.033	0.298MetTrp: 0.298 ± 0.014	0.943MetTyr: 0.943 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.208AsnAla: 3.208 ± 0.045	0.671AsnCys: 0.671 ± 0.019	1.974AsnAsp: 1.974 ± 0.035	2.646AsnGlu: 2.646 ± 0.04	1.515AsnPhe: 1.515 ± 0.03	3.597AsnGly: 3.597 ± 0.047	0.769AsnHis: 0.769 ± 0.023	3.031AsnIle: 3.031 ± 0.048	1.949AsnLys: 1.949 ± 0.036	3.732AsnLeu: 3.732 ± 0.047	1.277AsnMet: 1.277 ± 0.028	1.703AsnAsn: 1.703 ± 0.036	1.982AsnPro: 1.982 ± 0.028	1.378AsnGln: 1.378 ± 0.033	2.461AsnArg: 2.461 ± 0.041	2.345AsnSer: 2.345 ± 0.042	2.173AsnThr: 2.173 ± 0.039	2.766AsnVal: 2.766 ± 0.044	0.447AsnTrp: 0.447 ± 0.017	1.823AsnTyr: 1.823 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.619ProAla: 2.619 ± 0.04	0.502ProCys: 0.502 ± 0.017	2.516ProAsp: 2.516 ± 0.039	3.951ProGlu: 3.951 ± 0.059	1.548ProPhe: 1.548 ± 0.031	2.647ProGly: 2.647 ± 0.043	0.583ProHis: 0.583 ± 0.021	1.696ProIle: 1.696 ± 0.03	1.652ProLys: 1.652 ± 0.033	2.75ProLeu: 2.75 ± 0.042	0.883ProMet: 0.883 ± 0.022	1.076ProAsn: 1.076 ± 0.025	0.912ProPro: 0.912 ± 0.027	1.115ProGln: 1.115 ± 0.022	1.261ProArg: 1.261 ± 0.028	1.642ProSer: 1.642 ± 0.036	1.439ProThr: 1.439 ± 0.033	3.136ProVal: 3.136 ± 0.041	0.368ProTrp: 0.368 ± 0.015	1.48ProTyr: 1.48 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.699GlnAla: 2.699 ± 0.044	0.388GlnCys: 0.388 ± 0.014	1.616GlnAsp: 1.616 ± 0.031	3.086GlnGlu: 3.086 ± 0.046	1.193GlnPhe: 1.193 ± 0.025	2.137GlnGly: 2.137 ± 0.045	0.488GlnHis: 0.488 ± 0.017	2.408GlnIle: 2.408 ± 0.036	2.54GlnLys: 2.54 ± 0.041	2.842GlnLeu: 2.842 ± 0.041	1.17GlnMet: 1.17 ± 0.026	1.68GlnAsn: 1.68 ± 0.033	1.016GlnPro: 1.016 ± 0.028	1.246GlnGln: 1.246 ± 0.027	1.728GlnArg: 1.728 ± 0.034	1.744GlnSer: 1.744 ± 0.035	1.812GlnThr: 1.812 ± 0.029	2.08GlnVal: 2.08 ± 0.037	0.4GlnTrp: 0.4 ± 0.014	1.474GlnTyr: 1.474 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.358ArgAla: 3.358 ± 0.048	0.707ArgCys: 0.707 ± 0.021	2.778ArgAsp: 2.778 ± 0.051	5.45ArgGlu: 5.45 ± 0.072	2.186ArgPhe: 2.186 ± 0.035	3.17ArgGly: 3.17 ± 0.045	1.002ArgHis: 1.002 ± 0.024	3.893ArgIle: 3.893 ± 0.05	4.196ArgLys: 4.196 ± 0.055	4.969ArgLeu: 4.969 ± 0.056	1.862ArgMet: 1.862 ± 0.038	2.414ArgAsn: 2.414 ± 0.04	1.638ArgPro: 1.638 ± 0.029	2.445ArgGln: 2.445 ± 0.043	3.472ArgArg: 3.472 ± 0.052	2.452ArgSer: 2.452 ± 0.04	2.736ArgThr: 2.736 ± 0.042	2.906ArgVal: 2.906 ± 0.048	0.574ArgTrp: 0.574 ± 0.019	2.364ArgTyr: 2.364 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.404SerAla: 4.404 ± 0.059	0.897SerCys: 0.897 ± 0.023	3.153SerAsp: 3.153 ± 0.05	4.118SerGlu: 4.118 ± 0.125	2.694SerPhe: 2.694 ± 0.04	5.22SerGly: 5.22 ± 0.066	1.042SerHis: 1.042 ± 0.023	3.561SerIle: 3.561 ± 0.05	2.54SerLys: 2.54 ± 0.04	5.259SerLeu: 5.259 ± 0.061	1.769SerMet: 1.769 ± 0.033	2.041SerAsn: 2.041 ± 0.036	1.917SerPro: 1.917 ± 0.036	1.811SerGln: 1.811 ± 0.038	3.271SerArg: 3.271 ± 0.037	3.287SerSer: 3.287 ± 0.055	2.723SerThr: 2.723 ± 0.12	4.322SerVal: 4.322 ± 0.06	0.658SerTrp: 0.658 ± 0.019	2.375SerTyr: 2.375 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.639ThrAla: 4.639 ± 0.059	0.666ThrCys: 0.666 ± 0.021	3.167ThrAsp: 3.167 ± 0.045	4.277ThrGlu: 4.277 ± 0.047	2.059ThrPhe: 2.059 ± 0.035	4.823ThrGly: 4.823 ± 0.065	0.857ThrHis: 0.857 ± 0.022	3.247ThrIle: 3.247 ± 0.041	2.414ThrLys: 2.414 ± 0.035	4.723ThrLeu: 4.723 ± 0.056	1.366ThrMet: 1.366 ± 0.031	1.68ThrAsn: 1.68 ± 0.03	2.063ThrPro: 2.063 ± 0.04	1.438ThrGln: 1.438 ± 0.029	2.18ThrArg: 2.18 ± 0.043	2.662ThrSer: 2.662 ± 0.107	2.3ThrThr: 2.3 ± 0.04	4.374ThrVal: 4.374 ± 0.063	0.524ThrTrp: 0.524 ± 0.018	1.97ThrTyr: 1.97 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	4.165ValAla: 4.165 ± 0.06	1.274ValCys: 1.274 ± 0.026	3.479ValAsp: 3.479 ± 0.05	4.66ValGlu: 4.66 ± 0.061	2.833ValPhe: 2.833 ± 0.044	3.898ValGly: 3.898 ± 0.058	1.06ValHis: 1.06 ± 0.024	4.495ValIle: 4.495 ± 0.056	3.994ValLys: 3.994 ± 0.06	6.447ValLeu: 6.447 ± 0.072	2.015ValMet: 2.015 ± 0.04	2.787ValAsn: 2.787 ± 0.043	2.462ValPro: 2.462 ± 0.04	1.962ValGln: 1.962 ± 0.036	3.6ValArg: 3.6 ± 0.047	4.495ValSer: 4.495 ± 0.072	3.89ValThr: 3.89 ± 0.056	4.161ValVal: 4.161 ± 0.065	0.8ValTrp: 0.8 ± 0.023	2.778ValTyr: 2.778 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.66TrpAla: 0.66 ± 0.022	0.22TrpCys: 0.22 ± 0.011	0.64TrpAsp: 0.64 ± 0.02	0.93TrpGlu: 0.93 ± 0.024	0.485TrpPhe: 0.485 ± 0.017	0.826TrpGly: 0.826 ± 0.023	0.238TrpHis: 0.238 ± 0.011	0.709TrpIle: 0.709 ± 0.02	0.858TrpLys: 0.858 ± 0.025	1.114TrpLeu: 1.114 ± 0.025	0.365TrpMet: 0.365 ± 0.016	0.67TrpAsn: 0.67 ± 0.019	0.255TrpPro: 0.255 ± 0.011	0.498TrpGln: 0.498 ± 0.016	0.554TrpArg: 0.554 ± 0.017	0.54TrpSer: 0.54 ± 0.021	0.491TrpThr: 0.491 ± 0.019	0.59TrpVal: 0.59 ± 0.018	0.16TrpTrp: 0.16 ± 0.01	0.545TrpTyr: 0.545 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.914TyrAla: 2.914 ± 0.042	0.758TyrCys: 0.758 ± 0.023	2.601TyrAsp: 2.601 ± 0.044	3.138TyrGlu: 3.138 ± 0.044	1.958TyrPhe: 1.958 ± 0.032	3.305TyrGly: 3.305 ± 0.047	0.918TyrHis: 0.918 ± 0.02	2.803TyrIle: 2.803 ± 0.042	2.004TyrLys: 2.004 ± 0.037	4.093TyrLeu: 4.093 ± 0.051	1.184TyrMet: 1.184 ± 0.025	1.811TyrAsn: 1.811 ± 0.03	1.595TyrPro: 1.595 ± 0.038	1.579TyrGln: 1.579 ± 0.025	2.698TyrArg: 2.698 ± 0.041	2.449TyrSer: 2.449 ± 0.045	2.186TyrThr: 2.186 ± 0.039	2.611TyrVal: 2.611 ± 0.038	0.493TyrTrp: 0.493 ± 0.018	1.994TyrTyr: 1.994 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5687 proteins (1754436 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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