Amino acid dipepetide frequency for Gavia stellata (Red-throated diver) (Colymbus stellatus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.476AlaAla: 5.476 ± 0.053	1.309AlaCys: 1.309 ± 0.023	2.988AlaAsp: 2.988 ± 0.029	4.541AlaGlu: 4.541 ± 0.048	2.65AlaPhe: 2.65 ± 0.032	3.731AlaGly: 3.731 ± 0.047	1.334AlaHis: 1.334 ± 0.019	3.194AlaIle: 3.194 ± 0.038	3.78AlaLys: 3.78 ± 0.044	6.359AlaLeu: 6.359 ± 0.054	1.526AlaMet: 1.526 ± 0.024	2.31AlaAsn: 2.31 ± 0.028	2.772AlaPro: 2.772 ± 0.036	2.668AlaGln: 2.668 ± 0.035	2.878AlaArg: 2.878 ± 0.031	5.124AlaSer: 5.124 ± 0.049	3.343AlaThr: 3.343 ± 0.032	4.862AlaVal: 4.862 ± 0.047	0.679AlaTrp: 0.679 ± 0.016	1.658AlaTyr: 1.658 ± 0.025	0.002AlaXaa: 0.002 ± 0.001
Cys	1.169CysAla: 1.169 ± 0.024	0.643CysCys: 0.643 ± 0.021	1.032CysAsp: 1.032 ± 0.026	1.306CysGlu: 1.306 ± 0.032	0.961CysPhe: 0.961 ± 0.019	1.418CysGly: 1.418 ± 0.025	0.611CysHis: 0.611 ± 0.019	1.173CysIle: 1.173 ± 0.02	1.363CysLys: 1.363 ± 0.025	2.157CysLeu: 2.157 ± 0.027	0.459CysMet: 0.459 ± 0.013	0.912CysAsn: 0.912 ± 0.021	1.178CysPro: 1.178 ± 0.031	1.07CysGln: 1.07 ± 0.027	1.226CysArg: 1.226 ± 0.021	1.993CysSer: 1.993 ± 0.034	1.187CysThr: 1.187 ± 0.025	1.328CysVal: 1.328 ± 0.025	0.297CysTrp: 0.297 ± 0.009	0.696CysTyr: 0.696 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.873AspAla: 2.873 ± 0.03	1.119AspCys: 1.119 ± 0.021	2.864AspAsp: 2.864 ± 0.036	3.691AspGlu: 3.691 ± 0.043	2.309AspPhe: 2.309 ± 0.031	3.175AspGly: 3.175 ± 0.038	1.171AspHis: 1.171 ± 0.021	3.038AspIle: 3.038 ± 0.032	2.896AspLys: 2.896 ± 0.033	5.132AspLeu: 5.132 ± 0.048	1.171AspMet: 1.171 ± 0.019	1.989AspAsn: 1.989 ± 0.027	2.615AspPro: 2.615 ± 0.034	1.883AspGln: 1.883 ± 0.024	2.329AspArg: 2.329 ± 0.031	4.068AspSer: 4.068 ± 0.049	2.508AspThr: 2.508 ± 0.03	3.204AspVal: 3.204 ± 0.03	0.667AspTrp: 0.667 ± 0.015	1.664AspTyr: 1.664 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	4.645GluAla: 4.645 ± 0.045	1.302GluCys: 1.302 ± 0.036	4.535GluAsp: 4.535 ± 0.046	7.897GluGlu: 7.897 ± 0.097	2.272GluPhe: 2.272 ± 0.026	3.818GluGly: 3.818 ± 0.039	1.582GluHis: 1.582 ± 0.024	3.658GluIle: 3.658 ± 0.042	5.937GluLys: 5.937 ± 0.076	6.392GluLeu: 6.392 ± 0.069	1.816GluMet: 1.816 ± 0.024	3.556GluAsn: 3.556 ± 0.036	2.519GluPro: 2.519 ± 0.033	3.209GluGln: 3.209 ± 0.045	3.929GluArg: 3.929 ± 0.052	4.476GluSer: 4.476 ± 0.047	3.626GluThr: 3.626 ± 0.047	4.373GluVal: 4.373 ± 0.04	0.722GluTrp: 0.722 ± 0.016	1.866GluTyr: 1.866 ± 0.028	0.001GluXaa: 0.001 ± 0.0
Phe	2.193PheAla: 2.193 ± 0.028	1.019PheCys: 1.019 ± 0.02	1.853PheAsp: 1.853 ± 0.026	2.196PheGlu: 2.196 ± 0.029	1.918PhePhe: 1.918 ± 0.029	2.341PheGly: 2.341 ± 0.035	1.112PheHis: 1.112 ± 0.019	2.198PheIle: 2.198 ± 0.03	2.137PheLys: 2.137 ± 0.027	4.304PheLeu: 4.304 ± 0.047	0.808PheMet: 0.808 ± 0.019	1.591PheAsn: 1.591 ± 0.024	1.984PhePro: 1.984 ± 0.03	1.855PheGln: 1.855 ± 0.025	1.918PheArg: 1.918 ± 0.03	3.522PheSer: 3.522 ± 0.038	2.28PheThr: 2.28 ± 0.032	2.435PheVal: 2.435 ± 0.03	0.533PheTrp: 0.533 ± 0.015	1.367PheTyr: 1.367 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	3.3GlyAla: 3.3 ± 0.041	1.198GlyCys: 1.198 ± 0.024	2.895GlyAsp: 2.895 ± 0.035	3.703GlyGlu: 3.703 ± 0.05	2.498GlyPhe: 2.498 ± 0.039	3.713GlyGly: 3.713 ± 0.054	1.446GlyHis: 1.446 ± 0.021	3.16GlyIle: 3.16 ± 0.038	4.027GlyLys: 4.027 ± 0.044	5.029GlyLeu: 5.029 ± 0.05	1.367GlyMet: 1.367 ± 0.025	2.634GlyAsn: 2.634 ± 0.033	2.633GlyPro: 2.633 ± 0.075	2.451GlyGln: 2.451 ± 0.032	3.019GlyArg: 3.019 ± 0.041	4.896GlySer: 4.896 ± 0.058	3.43GlyThr: 3.43 ± 0.038	3.38GlyVal: 3.38 ± 0.037	0.755GlyTrp: 0.755 ± 0.018	1.867GlyTyr: 1.867 ± 0.03	0.002GlyXaa: 0.002 ± 0.001
His	1.344HisAla: 1.344 ± 0.024	0.709HisCys: 0.709 ± 0.015	0.932HisAsp: 0.932 ± 0.018	1.389HisGlu: 1.389 ± 0.022	1.1HisPhe: 1.1 ± 0.02	1.461HisGly: 1.461 ± 0.022	0.854HisHis: 0.854 ± 0.021	1.391HisIle: 1.391 ± 0.024	1.401HisLys: 1.401 ± 0.026	2.824HisLeu: 2.824 ± 0.032	0.597HisMet: 0.597 ± 0.015	0.995HisAsn: 0.995 ± 0.018	1.465HisPro: 1.465 ± 0.026	1.199HisGln: 1.199 ± 0.022	1.411HisArg: 1.411 ± 0.022	2.167HisSer: 2.167 ± 0.03	1.304HisThr: 1.304 ± 0.027	1.535HisVal: 1.535 ± 0.021	0.35HisTrp: 0.35 ± 0.011	0.866HisTyr: 0.866 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	3.13IleAla: 3.13 ± 0.035	1.224IleCys: 1.224 ± 0.025	2.398IleAsp: 2.398 ± 0.032	2.999IleGlu: 2.999 ± 0.037	2.266IlePhe: 2.266 ± 0.033	2.524IleGly: 2.524 ± 0.032	1.429IleHis: 1.429 ± 0.022	2.89IleIle: 2.89 ± 0.036	3.158IleLys: 3.158 ± 0.034	5.136IleLeu: 5.136 ± 0.053	1.117IleMet: 1.117 ± 0.022	2.263IleAsn: 2.263 ± 0.03	2.897IlePro: 2.897 ± 0.033	2.534IleGln: 2.534 ± 0.03	2.576IleArg: 2.576 ± 0.029	4.281IleSer: 4.281 ± 0.04	2.95IleThr: 2.95 ± 0.034	3.058IleVal: 3.058 ± 0.034	0.592IleTrp: 0.592 ± 0.014	1.692IleTyr: 1.692 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.182LysAla: 4.182 ± 0.047	1.225LysCys: 1.225 ± 0.023	3.566LysAsp: 3.566 ± 0.043	5.843LysGlu: 5.843 ± 0.073	1.977LysPhe: 1.977 ± 0.027	3.484LysGly: 3.484 ± 0.053	1.643LysHis: 1.643 ± 0.025	3.372LysIle: 3.372 ± 0.041	5.64LysLys: 5.64 ± 0.073	5.851LysLeu: 5.851 ± 0.055	1.626LysMet: 1.626 ± 0.023	2.953LysAsn: 2.953 ± 0.037	3.128LysPro: 3.128 ± 0.039	3.113LysGln: 3.113 ± 0.037	3.633LysArg: 3.633 ± 0.04	4.348LysSer: 4.348 ± 0.05	3.548LysThr: 3.548 ± 0.033	3.85LysVal: 3.85 ± 0.045	0.695LysTrp: 0.695 ± 0.018	1.948LysTyr: 1.948 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	6.128LeuAla: 6.128 ± 0.053	2.201LeuCys: 2.201 ± 0.033	4.793LeuAsp: 4.793 ± 0.041	7.034LeuGlu: 7.034 ± 0.072	3.667LeuPhe: 3.667 ± 0.051	5.113LeuGly: 5.113 ± 0.045	2.714LeuHis: 2.714 ± 0.033	4.392LeuIle: 4.392 ± 0.042	6.618LeuLys: 6.618 ± 0.054	10.088LeuLeu: 10.088 ± 0.099	2.086LeuMet: 2.086 ± 0.027	3.98LeuAsn: 3.98 ± 0.041	5.278LeuPro: 5.278 ± 0.049	5.646LeuGln: 5.646 ± 0.061	5.077LeuArg: 5.077 ± 0.047	7.848LeuSer: 7.848 ± 0.057	5.026LeuThr: 5.026 ± 0.044	5.454LeuVal: 5.454 ± 0.052	1.069LeuTrp: 1.069 ± 0.021	2.842LeuTyr: 2.842 ± 0.034	0.001LeuXaa: 0.001 ± 0.0
Met	1.617MetAla: 1.617 ± 0.024	0.455MetCys: 0.455 ± 0.012	1.293MetAsp: 1.293 ± 0.021	1.903MetGlu: 1.903 ± 0.03	0.867MetPhe: 0.867 ± 0.017	1.247MetGly: 1.247 ± 0.022	0.524MetHis: 0.524 ± 0.014	1.004MetIle: 1.004 ± 0.02	1.679MetLys: 1.679 ± 0.023	2.114MetLeu: 2.114 ± 0.032	0.623MetMet: 0.623 ± 0.018	1.038MetAsn: 1.038 ± 0.02	1.077MetPro: 1.077 ± 0.021	1.069MetGln: 1.069 ± 0.023	1.058MetArg: 1.058 ± 0.018	1.552MetSer: 1.552 ± 0.022	1.212MetThr: 1.212 ± 0.021	1.477MetVal: 1.477 ± 0.024	0.264MetTrp: 0.264 ± 0.009	0.684MetTyr: 0.684 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.391AsnAla: 2.391 ± 0.034	0.999AsnCys: 0.999 ± 0.022	1.763AsnAsp: 1.763 ± 0.026	2.687AsnGlu: 2.687 ± 0.036	1.702AsnPhe: 1.702 ± 0.024	2.791AsnGly: 2.791 ± 0.04	1.043AsnHis: 1.043 ± 0.02	2.628AsnIle: 2.628 ± 0.03	2.71AsnLys: 2.71 ± 0.032	4.165AsnLeu: 4.165 ± 0.047	1.057AsnMet: 1.057 ± 0.019	1.938AsnAsn: 1.938 ± 0.031	2.318AsnPro: 2.318 ± 0.033	1.747AsnGln: 1.747 ± 0.029	2.028AsnArg: 2.028 ± 0.028	3.562AsnSer: 3.562 ± 0.044	2.344AsnThr: 2.344 ± 0.031	2.555AsnVal: 2.555 ± 0.032	0.499AsnTrp: 0.499 ± 0.013	1.356AsnTyr: 1.356 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	3.518ProAla: 3.518 ± 0.046	1.023ProCys: 1.023 ± 0.025	2.612ProAsp: 2.612 ± 0.033	3.857ProGlu: 3.857 ± 0.046	1.943ProPhe: 1.943 ± 0.023	3.405ProGly: 3.405 ± 0.09	1.204ProHis: 1.204 ± 0.021	2.004ProIle: 2.004 ± 0.026	2.771ProLys: 2.771 ± 0.045	4.6ProLeu: 4.6 ± 0.046	0.952ProMet: 0.952 ± 0.022	1.966ProAsn: 1.966 ± 0.033	4.131ProPro: 4.131 ± 0.083	2.289ProGln: 2.289 ± 0.031	2.402ProArg: 2.402 ± 0.034	4.839ProSer: 4.839 ± 0.066	2.682ProThr: 2.682 ± 0.035	3.724ProVal: 3.724 ± 0.037	0.543ProTrp: 0.543 ± 0.015	1.484ProTyr: 1.484 ± 0.024	0.001ProXaa: 0.001 ± 0.001
Gln	3.026GlnAla: 3.026 ± 0.035	0.956GlnCys: 0.956 ± 0.023	2.241GlnAsp: 2.241 ± 0.025	3.729GlnGlu: 3.729 ± 0.044	1.481GlnPhe: 1.481 ± 0.022	2.42GlnGly: 2.42 ± 0.032	1.29GlnHis: 1.29 ± 0.023	2.322GlnIle: 2.322 ± 0.028	3.288GlnLys: 3.288 ± 0.045	4.606GlnLeu: 4.606 ± 0.058	1.133GlnMet: 1.133 ± 0.018	2.088GlnAsn: 2.088 ± 0.029	2.332GlnPro: 2.332 ± 0.039	3.035GlnGln: 3.035 ± 0.065	2.642GlnArg: 2.642 ± 0.028	3.231GlnSer: 3.231 ± 0.038	2.401GlnThr: 2.401 ± 0.029	2.749GlnVal: 2.749 ± 0.033	0.523GlnTrp: 0.523 ± 0.012	1.326GlnTyr: 1.326 ± 0.024	0.001GlnXaa: 0.001 ± 0.0
Arg	3.007ArgAla: 3.007 ± 0.034	1.089ArgCys: 1.089 ± 0.025	2.531ArgAsp: 2.531 ± 0.036	3.745ArgGlu: 3.745 ± 0.05	1.887ArgPhe: 1.887 ± 0.028	2.747ArgGly: 2.747 ± 0.043	1.414ArgHis: 1.414 ± 0.025	2.631ArgIle: 2.631 ± 0.029	3.926ArgLys: 3.926 ± 0.04	4.724ArgLeu: 4.724 ± 0.045	1.201ArgMet: 1.201 ± 0.018	2.278ArgAsn: 2.278 ± 0.029	2.334ArgPro: 2.334 ± 0.035	2.461ArgGln: 2.461 ± 0.036	3.575ArgArg: 3.575 ± 0.047	3.887ArgSer: 3.887 ± 0.055	2.664ArgThr: 2.664 ± 0.034	2.892ArgVal: 2.892 ± 0.034	0.595ArgTrp: 0.595 ± 0.014	1.623ArgTyr: 1.623 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	5.059SerAla: 5.059 ± 0.049	1.829SerCys: 1.829 ± 0.026	4.06SerAsp: 4.06 ± 0.042	5.124SerGlu: 5.124 ± 0.051	3.203SerPhe: 3.203 ± 0.038	4.876SerGly: 4.876 ± 0.051	2.022SerHis: 2.022 ± 0.028	3.626SerIle: 3.626 ± 0.037	4.581SerLys: 4.581 ± 0.053	7.949SerLeu: 7.949 ± 0.057	1.632SerMet: 1.632 ± 0.023	3.128SerAsn: 3.128 ± 0.033	5.008SerPro: 5.008 ± 0.072	3.65SerGln: 3.65 ± 0.049	3.963SerArg: 3.963 ± 0.054	8.983SerSer: 8.983 ± 0.12	4.56SerThr: 4.56 ± 0.048	5.151SerVal: 5.151 ± 0.048	0.984SerTrp: 0.984 ± 0.018	2.277SerTyr: 2.277 ± 0.029	0.002SerXaa: 0.002 ± 0.001
Thr	3.813ThrAla: 3.813 ± 0.034	1.315ThrCys: 1.315 ± 0.028	2.727ThrAsp: 2.727 ± 0.033	3.823ThrGlu: 3.823 ± 0.039	2.265ThrPhe: 2.265 ± 0.033	3.404ThrGly: 3.404 ± 0.036	1.195ThrHis: 1.195 ± 0.022	2.695ThrIle: 2.695 ± 0.032	3.013ThrLys: 3.013 ± 0.033	5.189ThrLeu: 5.189 ± 0.047	1.144ThrMet: 1.144 ± 0.021	2.007ThrAsn: 2.007 ± 0.027	3.122ThrPro: 3.122 ± 0.046	2.195ThrGln: 2.195 ± 0.026	2.277ThrArg: 2.277 ± 0.029	4.671ThrSer: 4.671 ± 0.054	3.079ThrThr: 3.079 ± 0.046	4.194ThrVal: 4.194 ± 0.036	0.679ThrTrp: 0.679 ± 0.017	1.595ThrTyr: 1.595 ± 0.024	0.001ThrXaa: 0.001 ± 0.001
Val	4.047ValAla: 4.047 ± 0.04	1.55ValCys: 1.55 ± 0.025	3.104ValAsp: 3.104 ± 0.04	4.02ValGlu: 4.02 ± 0.039	2.693ValPhe: 2.693 ± 0.031	3.317ValGly: 3.317 ± 0.036	1.575ValHis: 1.575 ± 0.023	3.391ValIle: 3.391 ± 0.04	3.98ValLys: 3.98 ± 0.043	6.3ValLeu: 6.3 ± 0.057	1.439ValMet: 1.439 ± 0.024	2.671ValAsn: 2.671 ± 0.03	3.346ValPro: 3.346 ± 0.037	2.846ValGln: 2.846 ± 0.032	2.915ValArg: 2.915 ± 0.029	4.968ValSer: 4.968 ± 0.048	3.91ValThr: 3.91 ± 0.045	4.273ValVal: 4.273 ± 0.043	0.711ValTrp: 0.711 ± 0.014	1.907ValTyr: 1.907 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.647TrpAla: 0.647 ± 0.015	0.244TrpCys: 0.244 ± 0.01	0.672TrpAsp: 0.672 ± 0.016	0.776TrpGlu: 0.776 ± 0.016	0.465TrpPhe: 0.465 ± 0.012	0.642TrpGly: 0.642 ± 0.02	0.31TrpHis: 0.31 ± 0.011	0.648TrpIle: 0.648 ± 0.014	0.905TrpLys: 0.905 ± 0.016	1.15TrpLeu: 1.15 ± 0.021	0.309TrpMet: 0.309 ± 0.012	0.621TrpAsn: 0.621 ± 0.014	0.444TrpPro: 0.444 ± 0.011	0.544TrpGln: 0.544 ± 0.014	0.646TrpArg: 0.646 ± 0.014	0.843TrpSer: 0.843 ± 0.018	0.668TrpThr: 0.668 ± 0.017	0.66TrpVal: 0.66 ± 0.015	0.185TrpTrp: 0.185 ± 0.008	0.373TrpTyr: 0.373 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.619TyrAla: 1.619 ± 0.022	0.769TyrCys: 0.769 ± 0.018	1.508TyrAsp: 1.508 ± 0.025	1.867TyrGlu: 1.867 ± 0.026	1.438TyrPhe: 1.438 ± 0.023	1.774TyrGly: 1.774 ± 0.03	0.822TyrHis: 0.822 ± 0.018	1.701TyrIle: 1.701 ± 0.024	1.817TyrLys: 1.817 ± 0.028	2.983TyrLeu: 2.983 ± 0.04	0.694TyrMet: 0.694 ± 0.018	1.359TyrAsn: 1.359 ± 0.021	1.368TyrPro: 1.368 ± 0.025	1.356TyrGln: 1.356 ± 0.022	1.709TyrArg: 1.709 ± 0.027	2.406TyrSer: 2.406 ± 0.031	1.681TyrThr: 1.681 ± 0.027	1.81TyrVal: 1.81 ± 0.026	0.408TyrTrp: 0.408 ± 0.013	1.115TyrTyr: 1.115 ± 0.019	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.053XaaXaa: 0.053 ± 0.009

Statistics based on 7730 proteins (3192604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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