Amino acid dipepetide frequency for Cricetid gammaherpesvirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.007AlaAla: 4.007 ± 0.362
1.989AlaCys: 1.989 ± 0.279
2.242AlaAsp: 2.242 ± 0.224
2.718AlaGlu: 2.718 ± 0.358
2.298AlaPhe: 2.298 ± 0.292
3.419AlaGly: 3.419 ± 0.262
1.373AlaHis: 1.373 ± 0.168
3.503AlaIle: 3.503 ± 0.31
3.026AlaLys: 3.026 ± 0.281
5.772AlaLeu: 5.772 ± 0.364
2.017AlaMet: 2.017 ± 0.248
2.69AlaAsn: 2.69 ± 0.295
3.839AlaPro: 3.839 ± 0.467
2.746AlaGln: 2.746 ± 0.348
2.466AlaArg: 2.466 ± 0.278
5.38AlaSer: 5.38 ± 0.353
4.679AlaThr: 4.679 ± 0.299
4.063AlaVal: 4.063 ± 0.367
0.785AlaTrp: 0.785 ± 0.175
1.933AlaTyr: 1.933 ± 0.222
0.0AlaXaa: 0.0 ± 0.0
Cys
1.877CysAla: 1.877 ± 0.337
0.869CysCys: 0.869 ± 0.163
1.093CysAsp: 1.093 ± 0.191
1.485CysGlu: 1.485 ± 0.193
1.373CysPhe: 1.373 ± 0.205
1.597CysGly: 1.597 ± 0.264
0.897CysHis: 0.897 ± 0.174
1.373CysIle: 1.373 ± 0.192
1.429CysLys: 1.429 ± 0.246
3.699CysLeu: 3.699 ± 0.295
0.841CysMet: 0.841 ± 0.153
1.289CysAsn: 1.289 ± 0.173
1.541CysPro: 1.541 ± 0.231
1.093CysGln: 1.093 ± 0.165
1.065CysArg: 1.065 ± 0.182
2.13CysSer: 2.13 ± 0.314
1.737CysThr: 1.737 ± 0.192
1.877CysVal: 1.877 ± 0.306
0.392CysTrp: 0.392 ± 0.094
1.149CysTyr: 1.149 ± 0.198
0.0CysXaa: 0.0 ± 0.0
Asp
2.858AspAla: 2.858 ± 0.318
1.065AspCys: 1.065 ± 0.171
1.961AspAsp: 1.961 ± 0.244
2.354AspGlu: 2.354 ± 0.313
1.989AspPhe: 1.989 ± 0.194
2.606AspGly: 2.606 ± 0.29
1.429AspHis: 1.429 ± 0.215
3.811AspIle: 3.811 ± 0.356
2.354AspLys: 2.354 ± 0.24
4.063AspLeu: 4.063 ± 0.315
1.625AspMet: 1.625 ± 0.246
1.205AspAsn: 1.205 ± 0.155
3.306AspPro: 3.306 ± 0.346
1.625AspGln: 1.625 ± 0.173
1.541AspArg: 1.541 ± 0.218
3.727AspSer: 3.727 ± 0.354
3.419AspThr: 3.419 ± 0.279
2.942AspVal: 2.942 ± 0.251
0.672AspTrp: 0.672 ± 0.131
1.653AspTyr: 1.653 ± 0.176
0.0AspXaa: 0.0 ± 0.0
Glu
3.419GluAla: 3.419 ± 0.284
1.289GluCys: 1.289 ± 0.222
3.25GluAsp: 3.25 ± 0.33
3.839GluGlu: 3.839 ± 0.396
1.597GluPhe: 1.597 ± 0.189
2.634GluGly: 2.634 ± 0.306
1.373GluHis: 1.373 ± 0.176
3.082GluIle: 3.082 ± 0.326
2.69GluLys: 2.69 ± 0.321
4.876GluLeu: 4.876 ± 0.328
1.009GluMet: 1.009 ± 0.158
2.942GluAsn: 2.942 ± 0.269
2.326GluPro: 2.326 ± 0.305
1.709GluGln: 1.709 ± 0.276
2.214GluArg: 2.214 ± 0.239
3.923GluSer: 3.923 ± 0.255
4.231GluThr: 4.231 ± 0.335
2.746GluVal: 2.746 ± 0.273
0.308GluTrp: 0.308 ± 0.08
1.681GluTyr: 1.681 ± 0.243
0.0GluXaa: 0.0 ± 0.0
Phe
1.653PheAla: 1.653 ± 0.187
1.149PheCys: 1.149 ± 0.217
2.046PheAsp: 2.046 ± 0.241
2.158PheGlu: 2.158 ± 0.196
2.354PhePhe: 2.354 ± 0.281
2.354PheGly: 2.354 ± 0.263
1.037PheHis: 1.037 ± 0.145
3.559PheIle: 3.559 ± 0.326
2.606PheLys: 2.606 ± 0.295
5.632PheLeu: 5.632 ± 0.459
1.177PheMet: 1.177 ± 0.209
1.541PheAsn: 1.541 ± 0.175
2.158PhePro: 2.158 ± 0.256
1.513PheGln: 1.513 ± 0.169
1.765PheArg: 1.765 ± 0.234
3.503PheSer: 3.503 ± 0.302
2.662PheThr: 2.662 ± 0.281
2.438PheVal: 2.438 ± 0.262
0.476PheTrp: 0.476 ± 0.114
1.821PheTyr: 1.821 ± 0.206
0.0PheXaa: 0.0 ± 0.0
Gly
3.054GlyAla: 3.054 ± 0.28
1.233GlyCys: 1.233 ± 0.203
2.158GlyAsp: 2.158 ± 0.249
2.578GlyGlu: 2.578 ± 0.296
2.438GlyPhe: 2.438 ± 0.331
2.27GlyGly: 2.27 ± 0.329
1.709GlyHis: 1.709 ± 0.257
2.466GlyIle: 2.466 ± 0.265
3.026GlyLys: 3.026 ± 0.369
5.296GlyLeu: 5.296 ± 0.338
1.485GlyMet: 1.485 ± 0.287
2.354GlyAsn: 2.354 ± 0.313
3.082GlyPro: 3.082 ± 0.267
2.298GlyGln: 2.298 ± 0.26
2.69GlyArg: 2.69 ± 0.35
4.119GlySer: 4.119 ± 0.436
3.811GlyThr: 3.811 ± 0.32
3.222GlyVal: 3.222 ± 0.314
0.532GlyTrp: 0.532 ± 0.117
1.849GlyTyr: 1.849 ± 0.249
0.0GlyXaa: 0.0 ± 0.0
His
1.793HisAla: 1.793 ± 0.249
0.729HisCys: 0.729 ± 0.145
0.897HisAsp: 0.897 ± 0.169
1.401HisGlu: 1.401 ± 0.176
1.065HisPhe: 1.065 ± 0.168
1.821HisGly: 1.821 ± 0.208
0.869HisHis: 0.869 ± 0.149
1.933HisIle: 1.933 ± 0.263
1.513HisLys: 1.513 ± 0.209
3.082HisLeu: 3.082 ± 0.391
0.701HisMet: 0.701 ± 0.155
1.261HisAsn: 1.261 ± 0.193
1.961HisPro: 1.961 ± 0.21
1.149HisGln: 1.149 ± 0.14
1.121HisArg: 1.121 ± 0.181
2.298HisSer: 2.298 ± 0.256
1.905HisThr: 1.905 ± 0.258
2.27HisVal: 2.27 ± 0.258
0.392HisTrp: 0.392 ± 0.116
0.644HisTyr: 0.644 ± 0.134
0.0HisXaa: 0.0 ± 0.0
Ile
2.998IleAla: 2.998 ± 0.328
1.821IleCys: 1.821 ± 0.215
2.83IleAsp: 2.83 ± 0.273
2.718IleGlu: 2.718 ± 0.454
3.026IlePhe: 3.026 ± 0.266
2.242IleGly: 2.242 ± 0.289
1.765IleHis: 1.765 ± 0.257
4.259IleIle: 4.259 ± 0.5
3.755IleLys: 3.755 ± 0.454
6.781IleLeu: 6.781 ± 0.534
1.569IleMet: 1.569 ± 0.217
3.334IleAsn: 3.334 ± 0.348
3.895IlePro: 3.895 ± 0.381
2.746IleGln: 2.746 ± 0.358
2.746IleArg: 2.746 ± 0.272
5.604IleSer: 5.604 ± 0.428
4.483IleThr: 4.483 ± 0.447
2.802IleVal: 2.802 ± 0.364
0.392IleTrp: 0.392 ± 0.107
2.41IleTyr: 2.41 ± 0.208
0.0IleXaa: 0.0 ± 0.0
Lys
2.802LysAla: 2.802 ± 0.238
1.625LysCys: 1.625 ± 0.245
3.222LysAsp: 3.222 ± 0.312
3.278LysGlu: 3.278 ± 0.302
2.326LysPhe: 2.326 ± 0.257
2.13LysGly: 2.13 ± 0.227
1.821LysHis: 1.821 ± 0.249
3.783LysIle: 3.783 ± 0.341
4.007LysLys: 4.007 ± 0.407
5.576LysLeu: 5.576 ± 0.458
1.541LysMet: 1.541 ± 0.243
2.858LysAsn: 2.858 ± 0.287
2.102LysPro: 2.102 ± 0.295
2.634LysGln: 2.634 ± 0.247
2.438LysArg: 2.438 ± 0.323
3.671LysSer: 3.671 ± 0.395
4.567LysThr: 4.567 ± 0.443
3.026LysVal: 3.026 ± 0.245
0.56LysTrp: 0.56 ± 0.137
1.513LysTyr: 1.513 ± 0.204
0.0LysXaa: 0.0 ± 0.0
Leu
6.501LeuAla: 6.501 ± 0.427
2.942LeuCys: 2.942 ± 0.323
5.044LeuAsp: 5.044 ± 0.311
5.296LeuGlu: 5.296 ± 0.318
4.96LeuPhe: 4.96 ± 0.391
4.651LeuGly: 4.651 ± 0.366
2.858LeuHis: 2.858 ± 0.274
5.352LeuIle: 5.352 ± 0.373
6.697LeuLys: 6.697 ± 0.464
12.245LeuLeu: 12.245 ± 0.767
2.382LeuMet: 2.382 ± 0.231
4.231LeuAsn: 4.231 ± 0.373
6.277LeuPro: 6.277 ± 0.401
4.707LeuGln: 4.707 ± 0.438
4.063LeuArg: 4.063 ± 0.397
9.079LeuSer: 9.079 ± 0.66
6.361LeuThr: 6.361 ± 0.345
5.492LeuVal: 5.492 ± 0.38
1.093LeuTrp: 1.093 ± 0.14
3.671LeuTyr: 3.671 ± 0.332
0.0LeuXaa: 0.0 ± 0.0
Met
2.522MetAla: 2.522 ± 0.286
1.093MetCys: 1.093 ± 0.221
1.345MetAsp: 1.345 ± 0.22
1.737MetGlu: 1.737 ± 0.235
1.261MetPhe: 1.261 ± 0.193
1.989MetGly: 1.989 ± 0.241
0.588MetHis: 0.588 ± 0.137
0.981MetIle: 0.981 ± 0.169
1.093MetLys: 1.093 ± 0.207
3.026MetLeu: 3.026 ± 0.298
0.757MetMet: 0.757 ± 0.164
0.925MetAsn: 0.925 ± 0.149
1.037MetPro: 1.037 ± 0.196
0.813MetGln: 0.813 ± 0.151
0.841MetArg: 0.841 ± 0.129
2.13MetSer: 2.13 ± 0.254
1.569MetThr: 1.569 ± 0.205
1.121MetVal: 1.121 ± 0.156
0.308MetTrp: 0.308 ± 0.093
1.205MetTyr: 1.205 ± 0.226
0.0MetXaa: 0.0 ± 0.0
Asn
1.877AsnAla: 1.877 ± 0.195
1.317AsnCys: 1.317 ± 0.183
1.485AsnAsp: 1.485 ± 0.194
1.821AsnGlu: 1.821 ± 0.203
1.569AsnPhe: 1.569 ± 0.202
2.662AsnGly: 2.662 ± 0.274
1.541AsnHis: 1.541 ± 0.214
4.063AsnIle: 4.063 ± 0.393
2.354AsnLys: 2.354 ± 0.289
4.707AsnLeu: 4.707 ± 0.376
1.401AsnMet: 1.401 ± 0.165
2.046AsnAsn: 2.046 ± 0.26
2.326AsnPro: 2.326 ± 0.255
1.429AsnGln: 1.429 ± 0.195
1.373AsnArg: 1.373 ± 0.177
4.035AsnSer: 4.035 ± 0.3
2.942AsnThr: 2.942 ± 0.257
2.718AsnVal: 2.718 ± 0.282
0.532AsnTrp: 0.532 ± 0.117
1.401AsnTyr: 1.401 ± 0.183
0.0AsnXaa: 0.0 ± 0.0
Pro
4.343ProAla: 4.343 ± 0.469
1.513ProCys: 1.513 ± 0.231
2.97ProAsp: 2.97 ± 0.267
3.643ProGlu: 3.643 ± 0.403
1.989ProPhe: 1.989 ± 0.239
3.811ProGly: 3.811 ± 0.295
1.541ProHis: 1.541 ± 0.228
3.531ProIle: 3.531 ± 0.361
3.25ProLys: 3.25 ± 0.374
4.932ProLeu: 4.932 ± 0.406
1.317ProMet: 1.317 ± 0.256
2.298ProAsn: 2.298 ± 0.28
5.016ProPro: 5.016 ± 0.943
2.466ProGln: 2.466 ± 0.3
2.97ProArg: 2.97 ± 0.355
5.24ProSer: 5.24 ± 0.39
4.679ProThr: 4.679 ± 0.944
3.25ProVal: 3.25 ± 0.286
1.037ProTrp: 1.037 ± 0.178
1.569ProTyr: 1.569 ± 0.194
0.0ProXaa: 0.0 ± 0.0
Gln
2.606GlnAla: 2.606 ± 0.266
1.065GlnCys: 1.065 ± 0.149
1.905GlnAsp: 1.905 ± 0.245
2.158GlnGlu: 2.158 ± 0.249
1.401GlnPhe: 1.401 ± 0.191
1.849GlnGly: 1.849 ± 0.193
1.569GlnHis: 1.569 ± 0.217
2.017GlnIle: 2.017 ± 0.275
2.41GlnLys: 2.41 ± 0.27
4.343GlnLeu: 4.343 ± 0.368
0.897GlnMet: 0.897 ± 0.136
1.793GlnAsn: 1.793 ± 0.217
2.466GlnPro: 2.466 ± 0.324
2.13GlnGln: 2.13 ± 0.283
1.541GlnArg: 1.541 ± 0.217
2.718GlnSer: 2.718 ± 0.301
3.334GlnThr: 3.334 ± 0.334
2.186GlnVal: 2.186 ± 0.226
0.757GlnTrp: 0.757 ± 0.124
1.317GlnTyr: 1.317 ± 0.188
0.0GlnXaa: 0.0 ± 0.0
Arg
2.69ArgAla: 2.69 ± 0.376
1.597ArgCys: 1.597 ± 0.27
1.989ArgAsp: 1.989 ± 0.23
2.438ArgGlu: 2.438 ± 0.291
1.793ArgPhe: 1.793 ± 0.227
2.69ArgGly: 2.69 ± 0.316
1.513ArgHis: 1.513 ± 0.202
1.961ArgIle: 1.961 ± 0.218
1.653ArgLys: 1.653 ± 0.194
3.895ArgLeu: 3.895 ± 0.359
1.065ArgMet: 1.065 ± 0.177
1.793ArgAsn: 1.793 ± 0.251
3.194ArgPro: 3.194 ± 0.312
1.765ArgGln: 1.765 ± 0.243
2.69ArgArg: 2.69 ± 0.396
2.186ArgSer: 2.186 ± 0.257
1.905ArgThr: 1.905 ± 0.246
2.662ArgVal: 2.662 ± 0.354
0.476ArgTrp: 0.476 ± 0.129
1.261ArgTyr: 1.261 ± 0.171
0.0ArgXaa: 0.0 ± 0.0
Ser
4.511SerAla: 4.511 ± 0.436
2.242SerCys: 2.242 ± 0.288
3.783SerAsp: 3.783 ± 0.34
3.447SerGlu: 3.447 ± 0.296
3.419SerPhe: 3.419 ± 0.271
4.259SerGly: 4.259 ± 0.46
2.41SerHis: 2.41 ± 0.24
5.212SerIle: 5.212 ± 0.574
4.848SerLys: 4.848 ± 0.464
8.911SerLeu: 8.911 ± 0.383
2.186SerMet: 2.186 ± 0.232
3.559SerAsn: 3.559 ± 0.415
6.024SerPro: 6.024 ± 0.64
3.447SerGln: 3.447 ± 0.348
3.25SerArg: 3.25 ± 0.346
7.622SerSer: 7.622 ± 0.543
5.296SerThr: 5.296 ± 0.541
4.932SerVal: 4.932 ± 0.471
0.897SerTrp: 0.897 ± 0.183
2.102SerTyr: 2.102 ± 0.229
0.0SerXaa: 0.0 ± 0.0
Thr
4.315ThrAla: 4.315 ± 0.356
1.989ThrCys: 1.989 ± 0.256
2.942ThrAsp: 2.942 ± 0.311
3.839ThrGlu: 3.839 ± 0.736
3.306ThrPhe: 3.306 ± 0.335
3.39ThrGly: 3.39 ± 0.358
2.074ThrHis: 2.074 ± 0.241
4.764ThrIle: 4.764 ± 0.501
3.447ThrLys: 3.447 ± 0.54
6.921ThrLeu: 6.921 ± 0.463
1.541ThrMet: 1.541 ± 0.198
2.578ThrAsn: 2.578 ± 0.226
4.735ThrPro: 4.735 ± 0.533
2.606ThrGln: 2.606 ± 0.275
2.326ThrArg: 2.326 ± 0.286
5.94ThrSer: 5.94 ± 0.495
4.567ThrThr: 4.567 ± 0.508
4.82ThrVal: 4.82 ± 0.397
0.701ThrTrp: 0.701 ± 0.149
2.214ThrTyr: 2.214 ± 0.265
0.0ThrXaa: 0.0 ± 0.0
Val
4.315ValAla: 4.315 ± 0.424
2.214ValCys: 2.214 ± 0.259
2.746ValAsp: 2.746 ± 0.272
2.382ValGlu: 2.382 ± 0.242
3.447ValPhe: 3.447 ± 0.35
2.942ValGly: 2.942 ± 0.34
1.289ValHis: 1.289 ± 0.172
3.278ValIle: 3.278 ± 0.353
2.998ValLys: 2.998 ± 0.286
6.193ValLeu: 6.193 ± 0.565
1.569ValMet: 1.569 ± 0.245
2.522ValAsn: 2.522 ± 0.312
3.615ValPro: 3.615 ± 0.353
2.017ValGln: 2.017 ± 0.276
2.382ValArg: 2.382 ± 0.292
5.296ValSer: 5.296 ± 0.395
3.951ValThr: 3.951 ± 0.381
3.334ValVal: 3.334 ± 0.392
0.42ValTrp: 0.42 ± 0.119
2.074ValTyr: 2.074 ± 0.21
0.0ValXaa: 0.0 ± 0.0
Trp
0.841TrpAla: 0.841 ± 0.156
0.252TrpCys: 0.252 ± 0.08
0.588TrpAsp: 0.588 ± 0.13
0.476TrpGlu: 0.476 ± 0.123
0.532TrpPhe: 0.532 ± 0.13
0.392TrpGly: 0.392 ± 0.106
0.308TrpHis: 0.308 ± 0.08
0.953TrpIle: 0.953 ± 0.191
0.785TrpLys: 0.785 ± 0.158
1.009TrpLeu: 1.009 ± 0.2
0.308TrpMet: 0.308 ± 0.091
0.392TrpAsn: 0.392 ± 0.101
0.588TrpPro: 0.588 ± 0.123
0.644TrpGln: 0.644 ± 0.146
0.336TrpArg: 0.336 ± 0.091
0.757TrpSer: 0.757 ± 0.179
0.925TrpThr: 0.925 ± 0.162
0.813TrpVal: 0.813 ± 0.135
0.112TrpTrp: 0.112 ± 0.048
0.308TrpTyr: 0.308 ± 0.101
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.961TyrAla: 1.961 ± 0.256
0.813TyrCys: 0.813 ± 0.166
1.709TyrAsp: 1.709 ± 0.228
1.373TyrGlu: 1.373 ± 0.174
1.485TyrPhe: 1.485 ± 0.191
1.961TyrGly: 1.961 ± 0.241
0.841TyrHis: 0.841 ± 0.13
2.298TyrIle: 2.298 ± 0.273
1.541TyrLys: 1.541 ± 0.233
2.942TyrLeu: 2.942 ± 0.231
0.925TyrMet: 0.925 ± 0.178
1.989TyrAsn: 1.989 ± 0.266
1.877TyrPro: 1.877 ± 0.238
0.925TyrGln: 0.925 ± 0.146
1.401TyrArg: 1.401 ± 0.238
2.998TyrSer: 2.998 ± 0.286
1.989TyrThr: 1.989 ± 0.273
2.27TyrVal: 2.27 ± 0.303
0.476TyrTrp: 0.476 ± 0.106
0.841TyrTyr: 0.841 ± 0.176
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 82 proteins (35689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski