Amino acid dipepetide frequency for Methylocaldum marinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.89AlaAla: 11.89 ± 0.118	1.157AlaCys: 1.157 ± 0.035	5.532AlaAsp: 5.532 ± 0.077	7.449AlaGlu: 7.449 ± 0.084	3.891AlaPhe: 3.891 ± 0.055	8.503AlaGly: 8.503 ± 0.098	2.094AlaHis: 2.094 ± 0.042	5.146AlaIle: 5.146 ± 0.056	3.566AlaLys: 3.566 ± 0.054	11.882AlaLeu: 11.882 ± 0.114	2.475AlaMet: 2.475 ± 0.043	2.733AlaAsn: 2.733 ± 0.05	4.257AlaPro: 4.257 ± 0.062	3.297AlaGln: 3.297 ± 0.045	7.319AlaArg: 7.319 ± 0.076	5.269AlaSer: 5.269 ± 0.061	4.448AlaThr: 4.448 ± 0.063	7.799AlaVal: 7.799 ± 0.077	1.574AlaTrp: 1.574 ± 0.035	2.841AlaTyr: 2.841 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.002CysAla: 1.002 ± 0.025	0.156CysCys: 0.156 ± 0.011	0.479CysAsp: 0.479 ± 0.018	0.586CysGlu: 0.586 ± 0.016	0.385CysPhe: 0.385 ± 0.017	1.051CysGly: 1.051 ± 0.03	0.327CysHis: 0.327 ± 0.017	0.485CysIle: 0.485 ± 0.019	0.274CysLys: 0.274 ± 0.012	1.023CysLeu: 1.023 ± 0.026	0.189CysMet: 0.189 ± 0.011	0.275CysAsn: 0.275 ± 0.014	0.567CysPro: 0.567 ± 0.019	0.274CysGln: 0.274 ± 0.014	0.89CysArg: 0.89 ± 0.027	0.584CysSer: 0.584 ± 0.02	0.463CysThr: 0.463 ± 0.017	0.677CysVal: 0.677 ± 0.022	0.121CysTrp: 0.121 ± 0.009	0.275CysTyr: 0.275 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.629AspAla: 5.629 ± 0.075	0.542AspCys: 0.542 ± 0.019	2.851AspAsp: 2.851 ± 0.045	3.646AspGlu: 3.646 ± 0.044	2.452AspPhe: 2.452 ± 0.044	4.521AspGly: 4.521 ± 0.071	1.2AspHis: 1.2 ± 0.028	3.018AspIle: 3.018 ± 0.049	1.831AspLys: 1.831 ± 0.037	5.952AspLeu: 5.952 ± 0.07	1.026AspMet: 1.026 ± 0.025	1.303AspAsn: 1.303 ± 0.031	3.332AspPro: 3.332 ± 0.07	1.834AspGln: 1.834 ± 0.037	4.315AspArg: 4.315 ± 0.06	2.802AspSer: 2.802 ± 0.047	2.593AspThr: 2.593 ± 0.052	3.621AspVal: 3.621 ± 0.045	0.988AspTrp: 0.988 ± 0.023	1.835AspTyr: 1.835 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.849GluAla: 6.849 ± 0.079	0.512GluCys: 0.512 ± 0.017	3.024GluAsp: 3.024 ± 0.048	3.805GluGlu: 3.805 ± 0.069	2.362GluPhe: 2.362 ± 0.04	4.002GluGly: 4.002 ± 0.051	1.563GluHis: 1.563 ± 0.035	3.951GluIle: 3.951 ± 0.052	2.869GluLys: 2.869 ± 0.051	6.585GluLeu: 6.585 ± 0.073	1.345GluMet: 1.345 ± 0.029	2.187GluAsn: 2.187 ± 0.043	2.938GluPro: 2.938 ± 0.046	2.804GluGln: 2.804 ± 0.045	5.49GluArg: 5.49 ± 0.063	3.513GluSer: 3.513 ± 0.046	3.866GluThr: 3.866 ± 0.053	3.96GluVal: 3.96 ± 0.053	0.822GluTrp: 0.822 ± 0.023	1.475GluTyr: 1.475 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.805PheAla: 3.805 ± 0.053	0.459PheCys: 0.459 ± 0.018	2.659PheAsp: 2.659 ± 0.039	2.579PheGlu: 2.579 ± 0.046	1.77PhePhe: 1.77 ± 0.041	3.594PheGly: 3.594 ± 0.048	0.922PheHis: 0.922 ± 0.024	1.773PheIle: 1.773 ± 0.035	1.299PheLys: 1.299 ± 0.03	3.979PheLeu: 3.979 ± 0.06	0.792PheMet: 0.792 ± 0.023	1.214PheAsn: 1.214 ± 0.027	1.767PhePro: 1.767 ± 0.038	1.234PheGln: 1.234 ± 0.031	2.786PheArg: 2.786 ± 0.043	2.625PheSer: 2.625 ± 0.048	1.945PheThr: 1.945 ± 0.031	2.838PheVal: 2.838 ± 0.043	0.643PheTrp: 0.643 ± 0.024	1.146PheTyr: 1.146 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	6.794GlyAla: 6.794 ± 0.071	0.995GlyCys: 0.995 ± 0.028	4.08GlyAsp: 4.08 ± 0.064	4.899GlyGlu: 4.899 ± 0.051	3.634GlyPhe: 3.634 ± 0.058	6.24GlyGly: 6.24 ± 0.087	1.866GlyHis: 1.866 ± 0.036	4.591GlyIle: 4.591 ± 0.057	3.572GlyLys: 3.572 ± 0.049	8.614GlyLeu: 8.614 ± 0.078	1.922GlyMet: 1.922 ± 0.039	2.391GlyAsn: 2.391 ± 0.05	2.857GlyPro: 2.857 ± 0.047	2.721GlyGln: 2.721 ± 0.051	5.855GlyArg: 5.855 ± 0.085	4.517GlySer: 4.517 ± 0.058	4.156GlyThr: 4.156 ± 0.062	5.632GlyVal: 5.632 ± 0.058	1.267GlyTrp: 1.267 ± 0.03	2.454GlyTyr: 2.454 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.24HisAla: 2.24 ± 0.04	0.31HisCys: 0.31 ± 0.014	1.172HisAsp: 1.172 ± 0.026	1.19HisGlu: 1.19 ± 0.025	1.008HisPhe: 1.008 ± 0.027	2.011HisGly: 2.011 ± 0.039	0.647HisHis: 0.647 ± 0.023	1.134HisIle: 1.134 ± 0.026	0.665HisLys: 0.665 ± 0.024	2.405HisLeu: 2.405 ± 0.04	0.419HisMet: 0.419 ± 0.016	0.562HisAsn: 0.562 ± 0.018	1.55HisPro: 1.55 ± 0.034	0.752HisGln: 0.752 ± 0.028	1.748HisArg: 1.748 ± 0.037	1.167HisSer: 1.167 ± 0.027	1.026HisThr: 1.026 ± 0.029	1.482HisVal: 1.482 ± 0.03	0.423HisTrp: 0.423 ± 0.017	0.791HisTyr: 0.791 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.802IleAla: 5.802 ± 0.063	0.523IleCys: 0.523 ± 0.017	3.476IleAsp: 3.476 ± 0.055	3.898IleGlu: 3.898 ± 0.054	1.757IlePhe: 1.757 ± 0.038	4.57IleGly: 4.57 ± 0.062	1.192IleHis: 1.192 ± 0.024	2.192IleIle: 2.192 ± 0.045	1.865IleLys: 1.865 ± 0.036	4.843IleLeu: 4.843 ± 0.061	0.852IleMet: 0.852 ± 0.026	1.625IleAsn: 1.625 ± 0.035	2.81IlePro: 2.81 ± 0.04	1.628IleGln: 1.628 ± 0.033	3.894IleArg: 3.894 ± 0.05	2.943IleSer: 2.943 ± 0.041	2.487IleThr: 2.487 ± 0.042	3.853IleVal: 3.853 ± 0.047	0.558IleTrp: 0.558 ± 0.021	1.358IleTyr: 1.358 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.938LysAla: 3.938 ± 0.066	0.253LysCys: 0.253 ± 0.014	1.941LysAsp: 1.941 ± 0.036	2.083LysGlu: 2.083 ± 0.043	1.114LysPhe: 1.114 ± 0.028	2.559LysGly: 2.559 ± 0.045	0.851LysHis: 0.851 ± 0.022	2.025LysIle: 2.025 ± 0.039	1.743LysLys: 1.743 ± 0.042	3.802LysLeu: 3.802 ± 0.053	0.682LysMet: 0.682 ± 0.022	1.31LysAsn: 1.31 ± 0.033	2.287LysPro: 2.287 ± 0.041	1.452LysGln: 1.452 ± 0.035	2.731LysArg: 2.731 ± 0.046	2.176LysSer: 2.176 ± 0.043	2.346LysThr: 2.346 ± 0.042	2.472LysVal: 2.472 ± 0.041	0.371LysTrp: 0.371 ± 0.014	0.84LysTyr: 0.84 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.445LeuAla: 12.445 ± 0.12	1.07LeuCys: 1.07 ± 0.027	6.437LeuAsp: 6.437 ± 0.066	6.725LeuGlu: 6.725 ± 0.077	4.241LeuPhe: 4.241 ± 0.066	8.404LeuGly: 8.404 ± 0.082	2.244LeuHis: 2.244 ± 0.04	5.553LeuIle: 5.553 ± 0.075	4.337LeuLys: 4.337 ± 0.05	11.155LeuLeu: 11.155 ± 0.112	2.216LeuMet: 2.216 ± 0.04	3.387LeuAsn: 3.387 ± 0.048	5.944LeuPro: 5.944 ± 0.085	3.363LeuGln: 3.363 ± 0.042	7.684LeuArg: 7.684 ± 0.085	6.999LeuSer: 6.999 ± 0.075	5.405LeuThr: 5.405 ± 0.065	6.961LeuVal: 6.961 ± 0.064	1.382LeuTrp: 1.382 ± 0.03	2.609LeuTyr: 2.609 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.308MetAla: 2.308 ± 0.043	0.164MetCys: 0.164 ± 0.01	1.06MetAsp: 1.06 ± 0.026	1.172MetGlu: 1.172 ± 0.027	0.597MetPhe: 0.597 ± 0.021	1.454MetGly: 1.454 ± 0.032	0.433MetHis: 0.433 ± 0.018	1.112MetIle: 1.112 ± 0.029	0.986MetLys: 0.986 ± 0.03	2.156MetLeu: 2.156 ± 0.036	0.431MetMet: 0.431 ± 0.018	0.832MetAsn: 0.832 ± 0.023	1.243MetPro: 1.243 ± 0.026	0.729MetGln: 0.729 ± 0.02	1.409MetArg: 1.409 ± 0.031	1.353MetSer: 1.353 ± 0.03	1.267MetThr: 1.267 ± 0.028	1.33MetVal: 1.33 ± 0.032	0.165MetTrp: 0.165 ± 0.009	0.354MetTyr: 0.354 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.925AsnAla: 2.925 ± 0.042	0.305AsnCys: 0.305 ± 0.014	1.501AsnAsp: 1.501 ± 0.033	1.597AsnGlu: 1.597 ± 0.03	1.101AsnPhe: 1.101 ± 0.029	2.493AsnGly: 2.493 ± 0.048	0.696AsnHis: 0.696 ± 0.024	1.545AsnIle: 1.545 ± 0.033	0.852AsnLys: 0.852 ± 0.025	3.368AsnLeu: 3.368 ± 0.049	0.527AsnMet: 0.527 ± 0.018	0.896AsnAsn: 0.896 ± 0.027	2.266AsnPro: 2.266 ± 0.036	1.024AsnGln: 1.024 ± 0.027	2.436AsnArg: 2.436 ± 0.034	1.447AsnSer: 1.447 ± 0.033	1.541AsnThr: 1.541 ± 0.032	1.966AsnVal: 1.966 ± 0.045	0.489AsnTrp: 0.489 ± 0.019	0.853AsnTyr: 0.853 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.285ProAla: 5.285 ± 0.077	0.411ProCys: 0.411 ± 0.018	3.59ProAsp: 3.59 ± 0.047	4.412ProGlu: 4.412 ± 0.058	1.966ProPhe: 1.966 ± 0.037	4.434ProGly: 4.434 ± 0.06	1.084ProHis: 1.084 ± 0.025	2.463ProIle: 2.463 ± 0.038	1.844ProLys: 1.844 ± 0.038	5.043ProLeu: 5.043 ± 0.065	1.035ProMet: 1.035 ± 0.024	1.59ProAsn: 1.59 ± 0.033	2.77ProPro: 2.77 ± 0.051	1.579ProGln: 1.579 ± 0.033	2.934ProArg: 2.934 ± 0.044	2.843ProSer: 2.843 ± 0.045	2.293ProThr: 2.293 ± 0.044	3.982ProVal: 3.982 ± 0.052	0.745ProTrp: 0.745 ± 0.022	1.354ProTyr: 1.354 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.992GlnAla: 3.992 ± 0.056	0.296GlnCys: 0.296 ± 0.012	1.512GlnAsp: 1.512 ± 0.035	1.884GlnGlu: 1.884 ± 0.04	1.24GlnPhe: 1.24 ± 0.028	2.538GlnGly: 2.538 ± 0.043	0.767GlnHis: 0.767 ± 0.022	1.897GlnIle: 1.897 ± 0.036	1.37GlnLys: 1.37 ± 0.032	3.498GlnLeu: 3.498 ± 0.052	0.676GlnMet: 0.676 ± 0.022	1.005GlnAsn: 1.005 ± 0.024	1.807GlnPro: 1.807 ± 0.04	1.433GlnGln: 1.433 ± 0.038	2.693GlnArg: 2.693 ± 0.046	1.878GlnSer: 1.878 ± 0.032	1.834GlnThr: 1.834 ± 0.034	2.404GlnVal: 2.404 ± 0.046	0.503GlnTrp: 0.503 ± 0.017	0.873GlnTyr: 0.873 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.397ArgAla: 6.397 ± 0.076	0.761ArgCys: 0.761 ± 0.024	3.737ArgAsp: 3.737 ± 0.052	4.903ArgGlu: 4.903 ± 0.062	3.393ArgPhe: 3.393 ± 0.046	4.444ArgGly: 4.444 ± 0.054	1.995ArgHis: 1.995 ± 0.036	4.462ArgIle: 4.462 ± 0.06	2.947ArgLys: 2.947 ± 0.046	8.941ArgLeu: 8.941 ± 0.098	1.632ArgMet: 1.632 ± 0.029	2.432ArgAsn: 2.432 ± 0.039	3.421ArgPro: 3.421 ± 0.046	3.02ArgGln: 3.02 ± 0.042	5.908ArgArg: 5.908 ± 0.077	3.944ArgSer: 3.944 ± 0.052	3.511ArgThr: 3.511 ± 0.041	4.795ArgVal: 4.795 ± 0.057	1.191ArgTrp: 1.191 ± 0.028	2.455ArgTyr: 2.455 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.86SerAla: 5.86 ± 0.062	0.525SerCys: 0.525 ± 0.017	3.08SerAsp: 3.08 ± 0.04	3.552SerGlu: 3.552 ± 0.047	2.287SerPhe: 2.287 ± 0.041	5.407SerGly: 5.407 ± 0.074	1.173SerHis: 1.173 ± 0.031	2.786SerIle: 2.786 ± 0.037	1.783SerLys: 1.783 ± 0.033	6.268SerLeu: 6.268 ± 0.065	1.206SerMet: 1.206 ± 0.029	1.535SerAsn: 1.535 ± 0.032	3.102SerPro: 3.102 ± 0.046	1.627SerGln: 1.627 ± 0.035	4.019SerArg: 4.019 ± 0.045	3.139SerSer: 3.139 ± 0.051	2.664SerThr: 2.664 ± 0.042	4.115SerVal: 4.115 ± 0.055	0.705SerTrp: 0.705 ± 0.022	1.507SerTyr: 1.507 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.268ThrAla: 5.268 ± 0.064	0.429ThrCys: 0.429 ± 0.016	2.84ThrAsp: 2.84 ± 0.055	2.94ThrGlu: 2.94 ± 0.044	1.79ThrPhe: 1.79 ± 0.034	4.629ThrGly: 4.629 ± 0.062	1.101ThrHis: 1.101 ± 0.026	2.433ThrIle: 2.433 ± 0.044	1.321ThrLys: 1.321 ± 0.031	6.118ThrLeu: 6.118 ± 0.072	0.867ThrMet: 0.867 ± 0.023	1.184ThrAsn: 1.184 ± 0.032	3.084ThrPro: 3.084 ± 0.042	1.5ThrGln: 1.5 ± 0.031	3.399ThrArg: 3.399 ± 0.048	2.423ThrSer: 2.423 ± 0.045	2.318ThrThr: 2.318 ± 0.052	4.278ThrVal: 4.278 ± 0.069	0.687ThrTrp: 0.687 ± 0.022	1.312ThrTyr: 1.312 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	6.895ValAla: 6.895 ± 0.079	0.747ValCys: 0.747 ± 0.022	4.009ValAsp: 4.009 ± 0.064	4.406ValGlu: 4.406 ± 0.058	3.02ValPhe: 3.02 ± 0.043	5.109ValGly: 5.109 ± 0.061	1.547ValHis: 1.547 ± 0.031	3.716ValIle: 3.716 ± 0.049	2.542ValLys: 2.542 ± 0.042	7.765ValLeu: 7.765 ± 0.066	1.512ValMet: 1.512 ± 0.031	2.154ValAsn: 2.154 ± 0.039	3.537ValPro: 3.537 ± 0.053	2.161ValGln: 2.161 ± 0.045	4.916ValArg: 4.916 ± 0.061	4.362ValSer: 4.362 ± 0.053	3.669ValThr: 3.669 ± 0.059	5.22ValVal: 5.22 ± 0.067	0.94ValTrp: 0.94 ± 0.022	1.831ValTyr: 1.831 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.119TrpAla: 1.119 ± 0.026	0.138TrpCys: 0.138 ± 0.008	0.696TrpAsp: 0.696 ± 0.022	0.692TrpGlu: 0.692 ± 0.024	0.617TrpPhe: 0.617 ± 0.021	0.829TrpGly: 0.829 ± 0.025	0.368TrpHis: 0.368 ± 0.013	0.776TrpIle: 0.776 ± 0.024	0.528TrpLys: 0.528 ± 0.02	2.036TrpLeu: 2.036 ± 0.042	0.334TrpMet: 0.334 ± 0.014	0.523TrpAsn: 0.523 ± 0.019	0.688TrpPro: 0.688 ± 0.021	0.68TrpGln: 0.68 ± 0.019	1.209TrpArg: 1.209 ± 0.028	0.84TrpSer: 0.84 ± 0.025	0.715TrpThr: 0.715 ± 0.021	0.909TrpVal: 0.909 ± 0.024	0.222TrpTrp: 0.222 ± 0.012	0.34TrpTyr: 0.34 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.68TyrAla: 2.68 ± 0.04	0.329TyrCys: 0.329 ± 0.013	1.613TyrAsp: 1.613 ± 0.05	1.503TyrGlu: 1.503 ± 0.03	1.203TyrPhe: 1.203 ± 0.028	2.267TyrGly: 2.267 ± 0.039	0.63TyrHis: 0.63 ± 0.021	1.069TyrIle: 1.069 ± 0.026	0.782TyrLys: 0.782 ± 0.023	3.129TyrLeu: 3.129 ± 0.04	0.419TyrMet: 0.419 ± 0.018	0.692TyrAsn: 0.692 ± 0.022	1.429TyrPro: 1.429 ± 0.03	0.987TyrGln: 0.987 ± 0.026	2.653TyrArg: 2.653 ± 0.043	1.516TyrSer: 1.516 ± 0.032	1.376TyrThr: 1.376 ± 0.034	1.761TyrVal: 1.761 ± 0.032	0.463TyrTrp: 0.463 ± 0.017	0.817TyrTyr: 0.817 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5413 proteins (1677097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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