Amino acid dipepetide frequency for Treponema sp. OMZ 838

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.578AlaAla: 10.578 ± 0.215
1.06AlaCys: 1.06 ± 0.045
5.056AlaAsp: 5.056 ± 0.111
6.679AlaGlu: 6.679 ± 0.118
4.039AlaPhe: 4.039 ± 0.072
6.664AlaGly: 6.664 ± 0.104
1.604AlaHis: 1.604 ± 0.048
5.112AlaIle: 5.112 ± 0.099
4.582AlaLys: 4.582 ± 0.09
8.86AlaLeu: 8.86 ± 0.124
1.927AlaMet: 1.927 ± 0.061
2.572AlaAsn: 2.572 ± 0.065
2.693AlaPro: 2.693 ± 0.072
3.357AlaGln: 3.357 ± 0.091
3.547AlaArg: 3.547 ± 0.084
4.815AlaSer: 4.815 ± 0.095
3.142AlaThr: 3.142 ± 0.067
7.549AlaVal: 7.549 ± 0.1
0.728AlaTrp: 0.728 ± 0.029
2.823AlaTyr: 2.823 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
1.082CysAla: 1.082 ± 0.041
0.232CysCys: 0.232 ± 0.02
0.609CysAsp: 0.609 ± 0.03
0.652CysGlu: 0.652 ± 0.028
0.671CysPhe: 0.671 ± 0.033
1.131CysGly: 1.131 ± 0.046
0.167CysHis: 0.167 ± 0.014
1.181CysIle: 1.181 ± 0.04
0.704CysLys: 0.704 ± 0.035
1.051CysLeu: 1.051 ± 0.042
0.335CysMet: 0.335 ± 0.02
0.471CysAsn: 0.471 ± 0.023
0.521CysPro: 0.521 ± 0.029
0.191CysGln: 0.191 ± 0.015
0.624CysArg: 0.624 ± 0.031
0.857CysSer: 0.857 ± 0.034
0.846CysThr: 0.846 ± 0.039
0.683CysVal: 0.683 ± 0.031
0.113CysTrp: 0.113 ± 0.012
0.433CysTyr: 0.433 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.423AspAla: 4.423 ± 0.092
0.636AspCys: 0.636 ± 0.035
2.568AspAsp: 2.568 ± 0.079
3.873AspGlu: 3.873 ± 0.079
2.872AspPhe: 2.872 ± 0.074
3.687AspGly: 3.687 ± 0.098
0.675AspHis: 0.675 ± 0.028
4.525AspIle: 4.525 ± 0.086
3.387AspLys: 3.387 ± 0.069
4.004AspLeu: 4.004 ± 0.065
1.379AspMet: 1.379 ± 0.043
2.081AspAsn: 2.081 ± 0.053
1.928AspPro: 1.928 ± 0.049
1.063AspGln: 1.063 ± 0.038
2.198AspArg: 2.198 ± 0.054
3.382AspSer: 3.382 ± 0.087
3.523AspThr: 3.523 ± 0.089
3.158AspVal: 3.158 ± 0.072
0.616AspTrp: 0.616 ± 0.032
2.16AspTyr: 2.16 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.9GluAla: 5.9 ± 0.101
0.645GluCys: 0.645 ± 0.03
3.045GluAsp: 3.045 ± 0.067
4.447GluGlu: 4.447 ± 0.088
2.268GluPhe: 2.268 ± 0.06
3.429GluGly: 3.429 ± 0.096
1.371GluHis: 1.371 ± 0.049
4.679GluIle: 4.679 ± 0.077
5.915GluLys: 5.915 ± 0.113
6.193GluLeu: 6.193 ± 0.105
1.639GluMet: 1.639 ± 0.047
3.258GluAsn: 3.258 ± 0.068
2.073GluPro: 2.073 ± 0.066
3.026GluGln: 3.026 ± 0.073
3.376GluArg: 3.376 ± 0.079
3.28GluSer: 3.28 ± 0.084
3.911GluThr: 3.911 ± 0.084
3.41GluVal: 3.41 ± 0.072
0.69GluTrp: 0.69 ± 0.032
2.484GluTyr: 2.484 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
3.765PheAla: 3.765 ± 0.079
0.706PheCys: 0.706 ± 0.033
2.767PheAsp: 2.767 ± 0.059
2.609PheGlu: 2.609 ± 0.052
2.986PhePhe: 2.986 ± 0.087
3.123PheGly: 3.123 ± 0.083
0.765PheHis: 0.765 ± 0.036
3.86PheIle: 3.86 ± 0.091
2.541PheLys: 2.541 ± 0.07
4.706PheLeu: 4.706 ± 0.104
1.13PheMet: 1.13 ± 0.043
1.992PheAsn: 1.992 ± 0.057
1.816PhePro: 1.816 ± 0.052
1.235PheGln: 1.235 ± 0.047
1.742PheArg: 1.742 ± 0.052
3.839PheSer: 3.839 ± 0.079
3.111PheThr: 3.111 ± 0.079
2.812PheVal: 2.812 ± 0.075
0.491PheTrp: 0.491 ± 0.025
1.866PheTyr: 1.866 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
5.306GlyAla: 5.306 ± 0.11
0.956GlyCys: 0.956 ± 0.045
2.982GlyAsp: 2.982 ± 0.067
3.698GlyGlu: 3.698 ± 0.076
3.342GlyPhe: 3.342 ± 0.069
4.772GlyGly: 4.772 ± 0.149
1.081GlyHis: 1.081 ± 0.04
5.738GlyIle: 5.738 ± 0.096
5.338GlyLys: 5.338 ± 0.099
5.845GlyLeu: 5.845 ± 0.098
1.843GlyMet: 1.843 ± 0.058
2.853GlyAsn: 2.853 ± 0.08
1.135GlyPro: 1.135 ± 0.043
1.919GlyGln: 1.919 ± 0.056
2.922GlyArg: 2.922 ± 0.064
4.499GlySer: 4.499 ± 0.095
4.621GlyThr: 4.621 ± 0.113
4.254GlyVal: 4.254 ± 0.091
0.675GlyTrp: 0.675 ± 0.033
2.568GlyTyr: 2.568 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.287HisAla: 1.287 ± 0.041
0.308HisCys: 0.308 ± 0.023
0.868HisAsp: 0.868 ± 0.036
0.964HisGlu: 0.964 ± 0.036
0.933HisPhe: 0.933 ± 0.036
1.321HisGly: 1.321 ± 0.036
0.418HisHis: 0.418 ± 0.028
1.748HisIle: 1.748 ± 0.054
0.927HisLys: 0.927 ± 0.034
1.624HisLeu: 1.624 ± 0.051
0.244HisMet: 0.244 ± 0.017
0.776HisAsn: 0.776 ± 0.038
1.007HisPro: 1.007 ± 0.041
0.529HisGln: 0.529 ± 0.029
0.926HisArg: 0.926 ± 0.039
1.117HisSer: 1.117 ± 0.04
1.338HisThr: 1.338 ± 0.046
0.811HisVal: 0.811 ± 0.033
0.21HisTrp: 0.21 ± 0.017
0.75HisTyr: 0.75 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.856IleAla: 6.856 ± 0.105
0.971IleCys: 0.971 ± 0.039
4.354IleAsp: 4.354 ± 0.079
4.944IleGlu: 4.944 ± 0.098
3.387IlePhe: 3.387 ± 0.09
5.191IleGly: 5.191 ± 0.105
1.387IleHis: 1.387 ± 0.044
5.66IleIle: 5.66 ± 0.12
4.48IleLys: 4.48 ± 0.1
6.744IleLeu: 6.744 ± 0.128
1.524IleMet: 1.524 ± 0.061
3.003IleAsn: 3.003 ± 0.07
3.89IlePro: 3.89 ± 0.077
2.418IleGln: 2.418 ± 0.065
3.646IleArg: 3.646 ± 0.075
4.754IleSer: 4.754 ± 0.092
5.007IleThr: 5.007 ± 0.088
4.589IleVal: 4.589 ± 0.08
0.487IleTrp: 0.487 ± 0.026
2.33IleTyr: 2.33 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
5.184LysAla: 5.184 ± 0.104
0.428LysCys: 0.428 ± 0.026
3.671LysAsp: 3.671 ± 0.079
4.993LysGlu: 4.993 ± 0.1
1.718LysPhe: 1.718 ± 0.055
3.63LysGly: 3.63 ± 0.078
1.169LysHis: 1.169 ± 0.039
5.12LysIle: 5.12 ± 0.109
5.916LysLys: 5.916 ± 0.117
5.464LysLeu: 5.464 ± 0.101
1.707LysMet: 1.707 ± 0.051
3.881LysAsn: 3.881 ± 0.077
2.462LysPro: 2.462 ± 0.067
2.648LysGln: 2.648 ± 0.069
3.229LysArg: 3.229 ± 0.063
3.25LysSer: 3.25 ± 0.075
4.683LysThr: 4.683 ± 0.078
3.407LysVal: 3.407 ± 0.079
0.515LysTrp: 0.515 ± 0.026
2.336LysTyr: 2.336 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
7.673LeuAla: 7.673 ± 0.116
1.511LeuCys: 1.511 ± 0.048
4.504LeuAsp: 4.504 ± 0.088
5.421LeuGlu: 5.421 ± 0.079
5.154LeuPhe: 5.154 ± 0.107
5.284LeuGly: 5.284 ± 0.094
1.92LeuHis: 1.92 ± 0.053
6.755LeuIle: 6.755 ± 0.137
6.259LeuLys: 6.259 ± 0.088
9.612LeuLeu: 9.612 ± 0.167
2.117LeuMet: 2.117 ± 0.057
3.892LeuAsn: 3.892 ± 0.085
4.264LeuPro: 4.264 ± 0.087
3.63LeuGln: 3.63 ± 0.07
4.373LeuArg: 4.373 ± 0.091
7.105LeuSer: 7.105 ± 0.1
5.68LeuThr: 5.68 ± 0.092
4.978LeuVal: 4.978 ± 0.094
0.809LeuTrp: 0.809 ± 0.036
3.737LeuTyr: 3.737 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
1.685MetAla: 1.685 ± 0.049
0.21MetCys: 0.21 ± 0.02
1.066MetAsp: 1.066 ± 0.038
1.589MetGlu: 1.589 ± 0.053
0.862MetPhe: 0.862 ± 0.036
1.398MetGly: 1.398 ± 0.05
0.48MetHis: 0.48 ± 0.024
1.706MetIle: 1.706 ± 0.049
1.828MetLys: 1.828 ± 0.047
2.422MetLeu: 2.422 ± 0.067
0.633MetMet: 0.633 ± 0.029
1.314MetAsn: 1.314 ± 0.041
1.105MetPro: 1.105 ± 0.043
1.249MetGln: 1.249 ± 0.042
1.201MetArg: 1.201 ± 0.042
1.406MetSer: 1.406 ± 0.044
1.341MetThr: 1.341 ± 0.046
1.303MetVal: 1.303 ± 0.045
0.142MetTrp: 0.142 ± 0.015
0.801MetTyr: 0.801 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.57AsnAla: 3.57 ± 0.071
0.475AsnCys: 0.475 ± 0.027
2.038AsnAsp: 2.038 ± 0.063
2.607AsnGlu: 2.607 ± 0.057
1.778AsnPhe: 1.778 ± 0.053
3.281AsnGly: 3.281 ± 0.09
0.599AsnHis: 0.599 ± 0.031
3.592AsnIle: 3.592 ± 0.069
2.704AsnLys: 2.704 ± 0.068
3.775AsnLeu: 3.775 ± 0.082
1.139AsnMet: 1.139 ± 0.046
1.836AsnAsn: 1.836 ± 0.07
2.073AsnPro: 2.073 ± 0.048
1.176AsnGln: 1.176 ± 0.039
2.065AsnArg: 2.065 ± 0.05
2.222AsnSer: 2.222 ± 0.052
2.952AsnThr: 2.952 ± 0.075
2.243AsnVal: 2.243 ± 0.055
0.431AsnTrp: 0.431 ± 0.023
1.481AsnTyr: 1.481 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.601ProAla: 3.601 ± 0.095
0.4ProCys: 0.4 ± 0.025
2.367ProAsp: 2.367 ± 0.058
3.181ProGlu: 3.181 ± 0.078
2.079ProPhe: 2.079 ± 0.06
1.864ProGly: 1.864 ± 0.056
0.835ProHis: 0.835 ± 0.03
2.617ProIle: 2.617 ± 0.06
1.721ProLys: 1.721 ± 0.049
3.92ProLeu: 3.92 ± 0.079
0.769ProMet: 0.769 ± 0.035
1.426ProAsn: 1.426 ± 0.049
1.376ProPro: 1.376 ± 0.054
1.688ProGln: 1.688 ± 0.057
1.338ProArg: 1.338 ± 0.046
2.274ProSer: 2.274 ± 0.056
1.58ProThr: 1.58 ± 0.042
3.227ProVal: 3.227 ± 0.064
0.305ProTrp: 0.305 ± 0.022
1.516ProTyr: 1.516 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.17GlnAla: 3.17 ± 0.086
0.361GlnCys: 0.361 ± 0.022
1.641GlnAsp: 1.641 ± 0.048
2.443GlnGlu: 2.443 ± 0.059
1.36GlnPhe: 1.36 ± 0.037
2.075GlnGly: 2.075 ± 0.053
0.694GlnHis: 0.694 ± 0.029
2.098GlnIle: 2.098 ± 0.066
2.914GlnLys: 2.914 ± 0.069
3.269GlnLeu: 3.269 ± 0.071
0.826GlnMet: 0.826 ± 0.033
1.843GlnAsn: 1.843 ± 0.058
1.169GlnPro: 1.169 ± 0.047
1.592GlnGln: 1.592 ± 0.055
1.688GlnArg: 1.688 ± 0.057
2.113GlnSer: 2.113 ± 0.057
2.323GlnThr: 2.323 ± 0.063
1.737GlnVal: 1.737 ± 0.048
0.378GlnTrp: 0.378 ± 0.024
1.428GlnTyr: 1.428 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
3.375ArgAla: 3.375 ± 0.066
0.593ArgCys: 0.593 ± 0.03
2.142ArgAsp: 2.142 ± 0.058
2.888ArgGlu: 2.888 ± 0.07
2.498ArgPhe: 2.498 ± 0.06
2.536ArgGly: 2.536 ± 0.063
0.843ArgHis: 0.843 ± 0.039
3.925ArgIle: 3.925 ± 0.08
3.134ArgLys: 3.134 ± 0.077
4.622ArgLeu: 4.622 ± 0.099
1.285ArgMet: 1.285 ± 0.044
2.11ArgAsn: 2.11 ± 0.063
1.384ArgPro: 1.384 ± 0.046
1.616ArgGln: 1.616 ± 0.049
2.343ArgArg: 2.343 ± 0.072
2.69ArgSer: 2.69 ± 0.066
2.49ArgThr: 2.49 ± 0.075
2.473ArgVal: 2.473 ± 0.063
0.458ArgTrp: 0.458 ± 0.025
2.126ArgTyr: 2.126 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.527SerAla: 5.527 ± 0.101
0.843SerCys: 0.843 ± 0.035
3.42SerAsp: 3.42 ± 0.089
3.66SerGlu: 3.66 ± 0.085
3.531SerPhe: 3.531 ± 0.081
5.344SerGly: 5.344 ± 0.124
0.957SerHis: 0.957 ± 0.033
4.932SerIle: 4.932 ± 0.086
3.257SerLys: 3.257 ± 0.073
5.824SerLeu: 5.824 ± 0.096
1.435SerMet: 1.435 ± 0.048
2.156SerAsn: 2.156 ± 0.068
2.17SerPro: 2.17 ± 0.06
1.704SerGln: 1.704 ± 0.046
2.532SerArg: 2.532 ± 0.06
3.985SerSer: 3.985 ± 0.089
2.971SerThr: 2.971 ± 0.076
4.671SerVal: 4.671 ± 0.083
0.598SerTrp: 0.598 ± 0.028
2.27SerTyr: 2.27 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
6.572ThrAla: 6.572 ± 0.126
0.499ThrCys: 0.499 ± 0.025
3.573ThrAsp: 3.573 ± 0.079
4.065ThrGlu: 4.065 ± 0.087
2.452ThrPhe: 2.452 ± 0.063
5.003ThrGly: 5.003 ± 0.116
1.035ThrHis: 1.035 ± 0.035
4.187ThrIle: 4.187 ± 0.087
2.98ThrLys: 2.98 ± 0.068
5.691ThrLeu: 5.691 ± 0.093
1.294ThrMet: 1.294 ± 0.051
1.973ThrAsn: 1.973 ± 0.059
2.453ThrPro: 2.453 ± 0.062
1.905ThrGln: 1.905 ± 0.054
2.121ThrArg: 2.121 ± 0.056
2.866ThrSer: 2.866 ± 0.074
2.606ThrThr: 2.606 ± 0.07
5.311ThrVal: 5.311 ± 0.103
0.441ThrTrp: 0.441 ± 0.028
1.85ThrTyr: 1.85 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.266ValAla: 4.266 ± 0.075
1.01ValCys: 1.01 ± 0.04
2.849ValAsp: 2.849 ± 0.073
3.399ValGlu: 3.399 ± 0.073
3.558ValPhe: 3.558 ± 0.075
3.52ValGly: 3.52 ± 0.081
1.233ValHis: 1.233 ± 0.041
4.842ValIle: 4.842 ± 0.085
3.957ValLys: 3.957 ± 0.089
6.681ValLeu: 6.681 ± 0.117
1.582ValMet: 1.582 ± 0.053
2.428ValAsn: 2.428 ± 0.052
2.728ValPro: 2.728 ± 0.061
2.541ValGln: 2.541 ± 0.062
3.036ValArg: 3.036 ± 0.067
4.483ValSer: 4.483 ± 0.089
3.685ValThr: 3.685 ± 0.079
3.746ValVal: 3.746 ± 0.081
0.624ValTrp: 0.624 ± 0.035
2.618ValTyr: 2.618 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.597TrpAla: 0.597 ± 0.031
0.115TrpCys: 0.115 ± 0.014
0.515TrpAsp: 0.515 ± 0.029
0.644TrpGlu: 0.644 ± 0.029
0.525TrpPhe: 0.525 ± 0.026
0.54TrpGly: 0.54 ± 0.029
0.18TrpHis: 0.18 ± 0.016
0.644TrpIle: 0.644 ± 0.033
0.757TrpLys: 0.757 ± 0.027
0.873TrpLeu: 0.873 ± 0.037
0.26TrpMet: 0.26 ± 0.02
0.508TrpAsn: 0.508 ± 0.025
0.232TrpPro: 0.232 ± 0.02
0.437TrpGln: 0.437 ± 0.027
0.442TrpArg: 0.442 ± 0.027
0.472TrpSer: 0.472 ± 0.025
0.526TrpThr: 0.526 ± 0.028
0.494TrpVal: 0.494 ± 0.028
0.092TrpTrp: 0.092 ± 0.012
0.435TrpTyr: 0.435 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.971TyrAla: 2.971 ± 0.069
0.593TyrCys: 0.593 ± 0.033
2.102TyrAsp: 2.102 ± 0.059
2.285TyrGlu: 2.285 ± 0.064
1.85TyrPhe: 1.85 ± 0.054
2.555TyrGly: 2.555 ± 0.079
0.693TyrHis: 0.693 ± 0.03
2.7TyrIle: 2.7 ± 0.077
2.113TyrLys: 2.113 ± 0.067
3.497TyrLeu: 3.497 ± 0.081
0.674TyrMet: 0.674 ± 0.031
1.664TyrAsn: 1.664 ± 0.047
1.605TyrPro: 1.605 ± 0.054
1.196TyrGln: 1.196 ± 0.039
2.184TyrArg: 2.184 ± 0.057
2.376TyrSer: 2.376 ± 0.063
2.541TyrThr: 2.541 ± 0.059
1.931TyrVal: 1.931 ± 0.057
0.484TyrTrp: 0.484 ± 0.027
1.589TyrTyr: 1.589 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2218 proteins (737495 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski