Amino acid dipepetide frequency for Cellulomonas bogoriensis 69B4 = DSM 16987

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.112AlaAla: 19.112 ± 0.21
0.896AlaCys: 0.896 ± 0.032
7.953AlaAsp: 7.953 ± 0.111
7.707AlaGlu: 7.707 ± 0.107
3.148AlaPhe: 3.148 ± 0.064
13.126AlaGly: 13.126 ± 0.135
2.938AlaHis: 2.938 ± 0.06
3.351AlaIle: 3.351 ± 0.068
1.689AlaLys: 1.689 ± 0.046
14.447AlaLeu: 14.447 ± 0.166
2.667AlaMet: 2.667 ± 0.057
1.734AlaAsn: 1.734 ± 0.046
7.204AlaPro: 7.204 ± 0.106
4.157AlaGln: 4.157 ± 0.083
10.781AlaArg: 10.781 ± 0.126
5.613AlaSer: 5.613 ± 0.089
7.954AlaThr: 7.954 ± 0.11
13.544AlaVal: 13.544 ± 0.149
1.968AlaTrp: 1.968 ± 0.058
2.259AlaTyr: 2.259 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.799CysAla: 0.799 ± 0.034
0.052CysCys: 0.052 ± 0.009
0.368CysAsp: 0.368 ± 0.022
0.359CysGlu: 0.359 ± 0.021
0.185CysPhe: 0.185 ± 0.015
0.756CysGly: 0.756 ± 0.029
0.15CysHis: 0.15 ± 0.015
0.157CysIle: 0.157 ± 0.013
0.056CysLys: 0.056 ± 0.008
0.565CysLeu: 0.565 ± 0.028
0.095CysMet: 0.095 ± 0.01
0.101CysAsn: 0.101 ± 0.012
0.423CysPro: 0.423 ± 0.018
0.137CysGln: 0.137 ± 0.013
0.457CysArg: 0.457 ± 0.023
0.346CysSer: 0.346 ± 0.018
0.484CysThr: 0.484 ± 0.023
0.524CysVal: 0.524 ± 0.026
0.086CysTrp: 0.086 ± 0.01
0.113CysTyr: 0.113 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.285AspAla: 8.285 ± 0.106
0.302AspCys: 0.302 ± 0.019
4.105AspAsp: 4.105 ± 0.079
4.128AspGlu: 4.128 ± 0.073
1.241AspPhe: 1.241 ± 0.038
7.016AspGly: 7.016 ± 0.106
1.646AspHis: 1.646 ± 0.05
1.381AspIle: 1.381 ± 0.043
0.703AspLys: 0.703 ± 0.03
7.683AspLeu: 7.683 ± 0.108
0.815AspMet: 0.815 ± 0.027
0.747AspAsn: 0.747 ± 0.032
5.136AspPro: 5.136 ± 0.077
1.933AspGln: 1.933 ± 0.05
5.109AspArg: 5.109 ± 0.092
2.021AspSer: 2.021 ± 0.053
2.792AspThr: 2.792 ± 0.06
7.381AspVal: 7.381 ± 0.089
0.831AspTrp: 0.831 ± 0.033
0.972AspTyr: 0.972 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.105GluAla: 7.105 ± 0.082
0.299GluCys: 0.299 ± 0.018
3.456GluAsp: 3.456 ± 0.062
3.138GluGlu: 3.138 ± 0.079
1.237GluPhe: 1.237 ± 0.04
4.528GluGly: 4.528 ± 0.087
1.822GluHis: 1.822 ± 0.046
2.068GluIle: 2.068 ± 0.054
0.849GluLys: 0.849 ± 0.038
6.182GluLeu: 6.182 ± 0.101
0.909GluMet: 0.909 ± 0.034
0.851GluAsn: 0.851 ± 0.032
3.668GluPro: 3.668 ± 0.092
2.414GluGln: 2.414 ± 0.068
5.044GluArg: 5.044 ± 0.083
2.163GluSer: 2.163 ± 0.05
2.408GluThr: 2.408 ± 0.053
6.015GluVal: 6.015 ± 0.097
0.642GluTrp: 0.642 ± 0.03
0.892GluTyr: 0.892 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.209PheAla: 3.209 ± 0.066
0.202PheCys: 0.202 ± 0.017
1.836PheAsp: 1.836 ± 0.045
1.4PheGlu: 1.4 ± 0.04
0.773PhePhe: 0.773 ± 0.036
2.678PheGly: 2.678 ± 0.061
0.533PheHis: 0.533 ± 0.023
0.746PheIle: 0.746 ± 0.034
0.307PheLys: 0.307 ± 0.017
2.297PheLeu: 2.297 ± 0.05
0.377PheMet: 0.377 ± 0.023
0.458PheAsn: 0.458 ± 0.023
1.142PhePro: 1.142 ± 0.038
0.584PheGln: 0.584 ± 0.025
1.541PheArg: 1.541 ± 0.044
1.3PheSer: 1.3 ± 0.038
1.878PheThr: 1.878 ± 0.055
2.466PheVal: 2.466 ± 0.059
0.41PheTrp: 0.41 ± 0.025
0.505PheTyr: 0.505 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
11.88GlyAla: 11.88 ± 0.131
0.716GlyCys: 0.716 ± 0.031
5.39GlyAsp: 5.39 ± 0.089
5.149GlyGlu: 5.149 ± 0.098
2.737GlyPhe: 2.737 ± 0.068
8.231GlyGly: 8.231 ± 0.113
2.246GlyHis: 2.246 ± 0.056
3.103GlyIle: 3.103 ± 0.058
1.577GlyLys: 1.577 ± 0.048
9.649GlyLeu: 9.649 ± 0.12
2.075GlyMet: 2.075 ± 0.051
1.448GlyAsn: 1.448 ± 0.045
5.654GlyPro: 5.654 ± 0.089
2.905GlyGln: 2.905 ± 0.058
7.769GlyArg: 7.769 ± 0.11
5.186GlySer: 5.186 ± 0.077
6.843GlyThr: 6.843 ± 0.096
8.918GlyVal: 8.918 ± 0.101
1.737GlyTrp: 1.737 ± 0.051
2.072GlyTyr: 2.072 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.779HisAla: 2.779 ± 0.054
0.136HisCys: 0.136 ± 0.011
1.63HisAsp: 1.63 ± 0.048
1.309HisGlu: 1.309 ± 0.039
0.447HisPhe: 0.447 ± 0.02
2.534HisGly: 2.534 ± 0.054
0.731HisHis: 0.731 ± 0.028
0.483HisIle: 0.483 ± 0.027
0.258HisLys: 0.258 ± 0.018
2.843HisLeu: 2.843 ± 0.07
0.33HisMet: 0.33 ± 0.021
0.322HisAsn: 0.322 ± 0.018
1.792HisPro: 1.792 ± 0.05
0.676HisGln: 0.676 ± 0.023
2.082HisArg: 2.082 ± 0.057
0.834HisSer: 0.834 ± 0.03
1.189HisThr: 1.189 ± 0.03
2.439HisVal: 2.439 ± 0.063
0.298HisTrp: 0.298 ± 0.018
0.403HisTyr: 0.403 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
4.189IleAla: 4.189 ± 0.08
0.189IleCys: 0.189 ± 0.016
2.221IleAsp: 2.221 ± 0.058
1.857IleGlu: 1.857 ± 0.046
0.662IlePhe: 0.662 ± 0.028
3.3IleGly: 3.3 ± 0.067
0.501IleHis: 0.501 ± 0.024
0.903IleIle: 0.903 ± 0.038
0.512IleLys: 0.512 ± 0.029
2.242IleLeu: 2.242 ± 0.059
0.434IleMet: 0.434 ± 0.022
0.645IleAsn: 0.645 ± 0.026
1.541IlePro: 1.541 ± 0.046
0.66IleGln: 0.66 ± 0.029
1.849IleArg: 1.849 ± 0.042
1.489IleSer: 1.489 ± 0.044
2.035IleThr: 2.035 ± 0.047
2.584IleVal: 2.584 ± 0.053
0.32IleTrp: 0.32 ± 0.02
0.45IleTyr: 0.45 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
1.704LysAla: 1.704 ± 0.055
0.06LysCys: 0.06 ± 0.009
0.866LysAsp: 0.866 ± 0.032
0.704LysGlu: 0.704 ± 0.034
0.256LysPhe: 0.256 ± 0.019
1.17LysGly: 1.17 ± 0.043
0.324LysHis: 0.324 ± 0.018
0.582LysIle: 0.582 ± 0.026
0.405LysLys: 0.405 ± 0.027
1.026LysLeu: 1.026 ± 0.039
0.221LysMet: 0.221 ± 0.016
0.266LysAsn: 0.266 ± 0.015
0.778LysPro: 0.778 ± 0.033
0.426LysGln: 0.426 ± 0.024
0.956LysArg: 0.956 ± 0.036
0.664LysSer: 0.664 ± 0.03
0.783LysThr: 0.783 ± 0.032
1.376LysVal: 1.376 ± 0.043
0.148LysTrp: 0.148 ± 0.014
0.272LysTyr: 0.272 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
15.077LeuAla: 15.077 ± 0.165
0.611LeuCys: 0.611 ± 0.024
7.389LeuAsp: 7.389 ± 0.115
5.433LeuGlu: 5.433 ± 0.079
2.17LeuPhe: 2.17 ± 0.063
9.893LeuGly: 9.893 ± 0.121
2.246LeuHis: 2.246 ± 0.052
2.606LeuIle: 2.606 ± 0.067
1.196LeuLys: 1.196 ± 0.045
10.559LeuLeu: 10.559 ± 0.168
1.638LeuMet: 1.638 ± 0.049
1.446LeuAsn: 1.446 ± 0.042
5.875LeuPro: 5.875 ± 0.087
2.576LeuGln: 2.576 ± 0.062
8.174LeuArg: 8.174 ± 0.093
4.71LeuSer: 4.71 ± 0.068
7.408LeuThr: 7.408 ± 0.092
11.622LeuVal: 11.622 ± 0.143
1.265LeuTrp: 1.265 ± 0.036
1.508LeuTyr: 1.508 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.255MetAla: 2.255 ± 0.057
0.115MetCys: 0.115 ± 0.012
1.017MetAsp: 1.017 ± 0.033
0.71MetGlu: 0.71 ± 0.028
0.463MetPhe: 0.463 ± 0.02
1.358MetGly: 1.358 ± 0.04
0.374MetHis: 0.374 ± 0.022
0.717MetIle: 0.717 ± 0.031
0.252MetLys: 0.252 ± 0.016
1.732MetLeu: 1.732 ± 0.046
0.264MetMet: 0.264 ± 0.018
0.363MetAsn: 0.363 ± 0.023
1.047MetPro: 1.047 ± 0.037
0.421MetGln: 0.421 ± 0.021
1.499MetArg: 1.499 ± 0.044
1.379MetSer: 1.379 ± 0.041
1.767MetThr: 1.767 ± 0.038
1.658MetVal: 1.658 ± 0.046
0.203MetTrp: 0.203 ± 0.015
0.244MetTyr: 0.244 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
1.874AsnAla: 1.874 ± 0.059
0.096AsnCys: 0.096 ± 0.011
0.917AsnAsp: 0.917 ± 0.036
0.706AsnGlu: 0.706 ± 0.031
0.384AsnPhe: 0.384 ± 0.023
1.453AsnGly: 1.453 ± 0.046
0.35AsnHis: 0.35 ± 0.019
0.53AsnIle: 0.53 ± 0.026
0.243AsnLys: 0.243 ± 0.018
1.655AsnLeu: 1.655 ± 0.043
0.234AsnMet: 0.234 ± 0.018
0.312AsnAsn: 0.312 ± 0.022
1.244AsnPro: 1.244 ± 0.036
0.494AsnGln: 0.494 ± 0.027
1.114AsnArg: 1.114 ± 0.033
0.614AsnSer: 0.614 ± 0.032
0.867AsnThr: 0.867 ± 0.037
1.425AsnVal: 1.425 ± 0.04
0.204AsnTrp: 0.204 ± 0.017
0.328AsnTyr: 0.328 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.878ProAla: 7.878 ± 0.112
0.306ProCys: 0.306 ± 0.019
4.93ProAsp: 4.93 ± 0.09
3.979ProGlu: 3.979 ± 0.082
1.447ProPhe: 1.447 ± 0.04
6.763ProGly: 6.763 ± 0.109
1.372ProHis: 1.372 ± 0.043
1.134ProIle: 1.134 ± 0.036
0.605ProLys: 0.605 ± 0.031
4.897ProLeu: 4.897 ± 0.074
0.996ProMet: 0.996 ± 0.034
0.721ProAsn: 0.721 ± 0.029
3.373ProPro: 3.373 ± 0.079
1.789ProGln: 1.789 ± 0.058
4.164ProArg: 4.164 ± 0.067
3.087ProSer: 3.087 ± 0.067
4.094ProThr: 4.094 ± 0.083
6.345ProVal: 6.345 ± 0.093
1.047ProTrp: 1.047 ± 0.036
1.03ProTyr: 1.03 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.985GlnAla: 3.985 ± 0.076
0.126GlnCys: 0.126 ± 0.013
1.895GlnAsp: 1.895 ± 0.051
1.555GlnGlu: 1.555 ± 0.044
0.674GlnPhe: 0.674 ± 0.029
2.518GlnGly: 2.518 ± 0.055
0.697GlnHis: 0.697 ± 0.026
1.152GlnIle: 1.152 ± 0.04
0.37GlnLys: 0.37 ± 0.021
2.787GlnLeu: 2.787 ± 0.052
0.65GlnMet: 0.65 ± 0.026
0.462GlnAsn: 0.462 ± 0.024
1.548GlnPro: 1.548 ± 0.043
1.161GlnGln: 1.161 ± 0.053
2.267GlnArg: 2.267 ± 0.053
1.123GlnSer: 1.123 ± 0.036
1.44GlnThr: 1.44 ± 0.043
3.903GlnVal: 3.903 ± 0.071
0.481GlnTrp: 0.481 ± 0.027
0.502GlnTyr: 0.502 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
10.352ArgAla: 10.352 ± 0.126
0.525ArgCys: 0.525 ± 0.025
4.661ArgAsp: 4.661 ± 0.086
4.472ArgGlu: 4.472 ± 0.088
2.099ArgPhe: 2.099 ± 0.045
6.067ArgGly: 6.067 ± 0.079
2.06ArgHis: 2.06 ± 0.046
2.461ArgIle: 2.461 ± 0.054
0.994ArgLys: 0.994 ± 0.041
8.234ArgLeu: 8.234 ± 0.103
1.735ArgMet: 1.735 ± 0.04
1.144ArgAsn: 1.144 ± 0.036
4.717ArgPro: 4.717 ± 0.079
2.271ArgGln: 2.271 ± 0.059
8.159ArgArg: 8.159 ± 0.113
4.312ArgSer: 4.312 ± 0.069
5.702ArgThr: 5.702 ± 0.077
7.044ArgVal: 7.044 ± 0.097
1.543ArgTrp: 1.543 ± 0.039
1.728ArgTyr: 1.728 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.95SerAla: 5.95 ± 0.091
0.309SerCys: 0.309 ± 0.018
2.421SerAsp: 2.421 ± 0.055
2.113SerGlu: 2.113 ± 0.054
1.362SerPhe: 1.362 ± 0.043
5.251SerGly: 5.251 ± 0.092
0.922SerHis: 0.922 ± 0.034
1.474SerIle: 1.474 ± 0.045
0.58SerLys: 0.58 ± 0.028
4.483SerLeu: 4.483 ± 0.083
1.078SerMet: 1.078 ± 0.036
0.809SerAsn: 0.809 ± 0.033
2.947SerPro: 2.947 ± 0.056
1.351SerGln: 1.351 ± 0.037
3.746SerArg: 3.746 ± 0.074
2.681SerSer: 2.681 ± 0.068
3.697SerThr: 3.697 ± 0.077
4.46SerVal: 4.46 ± 0.069
0.874SerTrp: 0.874 ± 0.033
0.984SerTyr: 0.984 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
8.411ThrAla: 8.411 ± 0.109
0.406ThrCys: 0.406 ± 0.023
3.931ThrAsp: 3.931 ± 0.068
3.2ThrGlu: 3.2 ± 0.061
1.938ThrPhe: 1.938 ± 0.053
7.057ThrGly: 7.057 ± 0.094
1.391ThrHis: 1.391 ± 0.04
1.992ThrIle: 1.992 ± 0.053
0.776ThrLys: 0.776 ± 0.029
6.148ThrLeu: 6.148 ± 0.082
1.076ThrMet: 1.076 ± 0.035
0.978ThrAsn: 0.978 ± 0.033
4.16ThrPro: 4.16 ± 0.08
1.51ThrGln: 1.51 ± 0.046
4.408ThrArg: 4.408 ± 0.07
3.626ThrSer: 3.626 ± 0.078
4.833ThrThr: 4.833 ± 0.082
7.215ThrVal: 7.215 ± 0.096
1.123ThrTrp: 1.123 ± 0.034
1.366ThrTyr: 1.366 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
13.489ValAla: 13.489 ± 0.144
0.628ValCys: 0.628 ± 0.026
7.049ValAsp: 7.049 ± 0.102
6.038ValGlu: 6.038 ± 0.09
2.347ValPhe: 2.347 ± 0.054
8.739ValGly: 8.739 ± 0.122
2.511ValHis: 2.511 ± 0.052
2.941ValIle: 2.941 ± 0.063
1.167ValLys: 1.167 ± 0.04
12.287ValLeu: 12.287 ± 0.157
1.689ValMet: 1.689 ± 0.039
1.553ValAsn: 1.553 ± 0.044
6.099ValPro: 6.099 ± 0.087
2.736ValGln: 2.736 ± 0.06
8.242ValArg: 8.242 ± 0.118
4.455ValSer: 4.455 ± 0.067
7.324ValThr: 7.324 ± 0.1
12.856ValVal: 12.856 ± 0.174
1.286ValTrp: 1.286 ± 0.037
1.461ValTyr: 1.461 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.748TrpAla: 1.748 ± 0.048
0.125TrpCys: 0.125 ± 0.011
0.933TrpAsp: 0.933 ± 0.033
0.75TrpGlu: 0.75 ± 0.026
0.534TrpPhe: 0.534 ± 0.027
1.113TrpGly: 1.113 ± 0.038
0.368TrpHis: 0.368 ± 0.02
0.416TrpIle: 0.416 ± 0.024
0.222TrpLys: 0.222 ± 0.016
1.57TrpLeu: 1.57 ± 0.045
0.321TrpMet: 0.321 ± 0.02
0.343TrpAsn: 0.343 ± 0.024
0.727TrpPro: 0.727 ± 0.03
0.542TrpGln: 0.542 ± 0.026
1.322TrpArg: 1.322 ± 0.036
1.002TrpSer: 1.002 ± 0.041
0.982TrpThr: 0.982 ± 0.036
1.407TrpVal: 1.407 ± 0.044
0.392TrpTrp: 0.392 ± 0.023
0.287TrpTyr: 0.287 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.167TyrAla: 2.167 ± 0.048
0.116TyrCys: 0.116 ± 0.011
1.259TyrAsp: 1.259 ± 0.053
0.985TyrGlu: 0.985 ± 0.032
0.534TyrPhe: 0.534 ± 0.023
1.733TyrGly: 1.733 ± 0.04
0.332TyrHis: 0.332 ± 0.022
0.383TyrIle: 0.383 ± 0.021
0.229TyrLys: 0.229 ± 0.016
2.118TyrLeu: 2.118 ± 0.052
0.234TyrMet: 0.234 ± 0.016
0.339TyrAsn: 0.339 ± 0.021
0.885TyrPro: 0.885 ± 0.035
0.553TyrGln: 0.553 ± 0.023
1.597TyrArg: 1.597 ± 0.039
0.887TyrSer: 0.887 ± 0.039
1.066TyrThr: 1.066 ± 0.044
1.715TyrVal: 1.715 ± 0.046
0.244TyrTrp: 0.244 ± 0.017
0.389TyrTyr: 0.389 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2898 proteins (906499 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski