Amino acid dipepetide frequency for Felis catus gammaherpesvirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.961AlaAla: 2.961 ± 0.313
0.932AlaCys: 0.932 ± 0.142
1.152AlaAsp: 1.152 ± 0.157
1.398AlaGlu: 1.398 ± 0.144
2.55AlaPhe: 2.55 ± 0.235
1.618AlaGly: 1.618 ± 0.314
1.81AlaHis: 1.81 ± 0.564
4.058AlaIle: 4.058 ± 0.351
2.385AlaLys: 2.385 ± 0.298
5.237AlaLeu: 5.237 ± 0.419
1.124AlaMet: 1.124 ± 0.151
2.577AlaAsn: 2.577 ± 0.242
2.769AlaPro: 2.769 ± 0.664
2.303AlaGln: 2.303 ± 0.548
1.316AlaArg: 1.316 ± 0.164
4.332AlaSer: 4.332 ± 0.273
3.235AlaThr: 3.235 ± 0.329
2.824AlaVal: 2.824 ± 0.323
0.603AlaTrp: 0.603 ± 0.21
1.618AlaTyr: 1.618 ± 0.173
0.0AlaXaa: 0.0 ± 0.0
Cys
0.96CysAla: 0.96 ± 0.161
0.685CysCys: 0.685 ± 0.173
1.426CysAsp: 1.426 ± 0.218
0.823CysGlu: 0.823 ± 0.137
1.673CysPhe: 1.673 ± 0.266
1.124CysGly: 1.124 ± 0.208
0.658CysHis: 0.658 ± 0.132
1.974CysIle: 1.974 ± 0.233
1.481CysLys: 1.481 ± 0.171
3.071CysLeu: 3.071 ± 0.343
0.521CysMet: 0.521 ± 0.095
1.316CysAsn: 1.316 ± 0.201
1.014CysPro: 1.014 ± 0.146
1.234CysGln: 1.234 ± 0.198
0.768CysArg: 0.768 ± 0.13
1.782CysSer: 1.782 ± 0.306
1.316CysThr: 1.316 ± 0.188
2.084CysVal: 2.084 ± 0.298
0.082CysTrp: 0.082 ± 0.054
1.069CysTyr: 1.069 ± 0.217
0.0CysXaa: 0.0 ± 0.0
Asp
1.673AspAla: 1.673 ± 0.188
0.96AspCys: 0.96 ± 0.133
2.193AspAsp: 2.193 ± 0.234
3.016AspGlu: 3.016 ± 0.401
2.139AspPhe: 2.139 ± 0.238
2.193AspGly: 2.193 ± 0.268
1.097AspHis: 1.097 ± 0.153
3.756AspIle: 3.756 ± 0.376
2.714AspLys: 2.714 ± 0.304
4.798AspLeu: 4.798 ± 0.34
1.234AspMet: 1.234 ± 0.204
2.166AspAsn: 2.166 ± 0.218
2.742AspPro: 2.742 ± 0.335
1.124AspGln: 1.124 ± 0.148
1.261AspArg: 1.261 ± 0.236
3.153AspSer: 3.153 ± 0.236
2.852AspThr: 2.852 ± 0.243
3.016AspVal: 3.016 ± 0.274
0.466AspTrp: 0.466 ± 0.132
1.453AspTyr: 1.453 ± 0.211
0.0AspXaa: 0.0 ± 0.0
Glu
2.906GluAla: 2.906 ± 0.25
1.097GluCys: 1.097 ± 0.181
3.153GluAsp: 3.153 ± 0.373
3.976GluGlu: 3.976 ± 0.928
1.81GluPhe: 1.81 ± 0.248
3.4GluGly: 3.4 ± 0.838
1.234GluHis: 1.234 ± 0.164
3.318GluIle: 3.318 ± 0.402
3.208GluLys: 3.208 ± 0.359
4.113GluLeu: 4.113 ± 0.384
1.097GluMet: 1.097 ± 0.211
3.482GluAsn: 3.482 ± 0.255
2.276GluPro: 2.276 ± 0.826
2.002GluGln: 2.002 ± 0.221
1.535GluArg: 1.535 ± 0.209
3.893GluSer: 3.893 ± 0.339
3.071GluThr: 3.071 ± 0.269
2.961GluVal: 2.961 ± 0.24
0.521GluTrp: 0.521 ± 0.13
1.398GluTyr: 1.398 ± 0.186
0.0GluXaa: 0.0 ± 0.0
Phe
1.563PheAla: 1.563 ± 0.253
1.289PheCys: 1.289 ± 0.287
1.919PheAsp: 1.919 ± 0.261
2.221PheGlu: 2.221 ± 0.251
3.126PhePhe: 3.126 ± 0.344
1.919PheGly: 1.919 ± 0.247
1.426PheHis: 1.426 ± 0.227
4.497PheIle: 4.497 ± 0.342
3.976PheLys: 3.976 ± 0.32
5.73PheLeu: 5.73 ± 0.621
1.727PheMet: 1.727 ± 0.193
2.797PheAsn: 2.797 ± 0.216
2.111PhePro: 2.111 ± 0.247
2.056PheGln: 2.056 ± 0.198
1.371PheArg: 1.371 ± 0.182
3.756PheSer: 3.756 ± 0.33
3.043PheThr: 3.043 ± 0.301
2.934PheVal: 2.934 ± 0.29
0.548PheTrp: 0.548 ± 0.122
3.126PheTyr: 3.126 ± 0.31
0.0PheXaa: 0.0 ± 0.0
Gly
1.864GlyAla: 1.864 ± 0.202
1.59GlyCys: 1.59 ± 0.246
2.632GlyAsp: 2.632 ± 0.341
2.056GlyGlu: 2.056 ± 0.273
2.303GlyPhe: 2.303 ± 0.275
2.44GlyGly: 2.44 ± 0.506
0.932GlyHis: 0.932 ± 0.22
2.44GlyIle: 2.44 ± 0.336
2.276GlyLys: 2.276 ± 0.209
6.306GlyLeu: 6.306 ± 1.113
0.768GlyMet: 0.768 ± 0.163
2.248GlyAsn: 2.248 ± 0.259
2.961GlyPro: 2.961 ± 0.714
2.056GlyGln: 2.056 ± 0.526
1.864GlyArg: 1.864 ± 0.261
3.372GlySer: 3.372 ± 0.283
2.66GlyThr: 2.66 ± 0.306
3.016GlyVal: 3.016 ± 0.289
0.466GlyTrp: 0.466 ± 0.102
1.645GlyTyr: 1.645 ± 0.206
0.0GlyXaa: 0.0 ± 0.0
His
1.042HisAla: 1.042 ± 0.165
0.384HisCys: 0.384 ± 0.087
1.014HisAsp: 1.014 ± 0.186
1.206HisGlu: 1.206 ± 0.174
1.371HisPhe: 1.371 ± 0.201
1.152HisGly: 1.152 ± 0.216
0.795HisHis: 0.795 ± 0.141
2.55HisIle: 2.55 ± 0.265
1.7HisLys: 1.7 ± 0.201
3.51HisLeu: 3.51 ± 0.367
0.768HisMet: 0.768 ± 0.141
1.535HisAsn: 1.535 ± 0.215
1.261HisPro: 1.261 ± 0.18
1.371HisGln: 1.371 ± 0.195
1.289HisArg: 1.289 ± 0.55
1.59HisSer: 1.59 ± 0.2
1.837HisThr: 1.837 ± 0.199
1.481HisVal: 1.481 ± 0.159
0.302HisTrp: 0.302 ± 0.092
1.042HisTyr: 1.042 ± 0.188
0.0HisXaa: 0.0 ± 0.0
Ile
2.934IleAla: 2.934 ± 0.303
2.385IleCys: 2.385 ± 0.329
3.263IleAsp: 3.263 ± 0.325
3.674IleGlu: 3.674 ± 0.378
4.058IlePhe: 4.058 ± 0.476
2.714IleGly: 2.714 ± 0.252
1.7IleHis: 1.7 ± 0.211
4.826IleIle: 4.826 ± 0.489
4.935IleLys: 4.935 ± 0.573
7.567IleLeu: 7.567 ± 0.483
1.289IleMet: 1.289 ± 0.2
4.853IleAsn: 4.853 ± 0.445
3.976IlePro: 3.976 ± 0.377
3.318IleGln: 3.318 ± 0.39
1.59IleArg: 1.59 ± 0.189
6.498IleSer: 6.498 ± 0.379
5.264IleThr: 5.264 ± 0.546
3.455IleVal: 3.455 ± 0.338
0.795IleTrp: 0.795 ± 0.161
3.29IleTyr: 3.29 ± 0.3
0.0IleXaa: 0.0 ± 0.0
Lys
3.181LysAla: 3.181 ± 0.285
1.673LysCys: 1.673 ± 0.247
2.714LysAsp: 2.714 ± 0.354
3.208LysGlu: 3.208 ± 0.349
2.468LysPhe: 2.468 ± 0.266
2.139LysGly: 2.139 ± 0.295
2.193LysHis: 2.193 ± 0.24
4.963LysIle: 4.963 ± 0.465
5.347LysLys: 5.347 ± 0.5
5.868LysLeu: 5.868 ± 0.386
1.59LysMet: 1.59 ± 0.212
4.222LysAsn: 4.222 ± 0.46
2.331LysPro: 2.331 ± 0.275
3.208LysGln: 3.208 ± 0.344
2.632LysArg: 2.632 ± 0.254
4.36LysSer: 4.36 ± 0.377
4.442LysThr: 4.442 ± 0.405
3.235LysVal: 3.235 ± 0.356
0.521LysTrp: 0.521 ± 0.128
2.413LysTyr: 2.413 ± 0.258
0.0LysXaa: 0.0 ± 0.0
Leu
4.634LeuAla: 4.634 ± 0.272
2.852LeuCys: 2.852 ± 0.301
4.113LeuAsp: 4.113 ± 0.338
5.209LeuGlu: 5.209 ± 0.482
5.593LeuPhe: 5.593 ± 0.586
4.25LeuGly: 4.25 ± 0.356
2.934LeuHis: 2.934 ± 0.217
6.032LeuIle: 6.032 ± 0.465
7.266LeuLys: 7.266 ± 0.556
10.556LeuLeu: 10.556 ± 0.819
1.892LeuMet: 1.892 ± 0.206
6.279LeuAsn: 6.279 ± 0.441
5.374LeuPro: 5.374 ± 0.667
5.73LeuGln: 5.73 ± 0.569
3.153LeuArg: 3.153 ± 0.38
8.061LeuSer: 8.061 ± 0.476
7.074LeuThr: 7.074 ± 0.482
5.511LeuVal: 5.511 ± 0.389
1.81LeuTrp: 1.81 ± 0.549
4.442LeuTyr: 4.442 ± 0.379
0.0LeuXaa: 0.0 ± 0.0
Met
1.481MetAla: 1.481 ± 0.158
0.466MetCys: 0.466 ± 0.124
1.343MetAsp: 1.343 ± 0.222
1.234MetGlu: 1.234 ± 0.168
1.755MetPhe: 1.755 ± 0.204
1.508MetGly: 1.508 ± 0.243
0.576MetHis: 0.576 ± 0.124
1.124MetIle: 1.124 ± 0.17
0.905MetLys: 0.905 ± 0.185
2.139MetLeu: 2.139 ± 0.233
0.494MetMet: 0.494 ± 0.131
0.96MetAsn: 0.96 ± 0.156
0.658MetPro: 0.658 ± 0.117
0.823MetGln: 0.823 ± 0.146
0.823MetArg: 0.823 ± 0.156
2.193MetSer: 2.193 ± 0.222
1.042MetThr: 1.042 ± 0.168
0.905MetVal: 0.905 ± 0.181
0.411MetTrp: 0.411 ± 0.091
1.124MetTyr: 1.124 ± 0.213
0.0MetXaa: 0.0 ± 0.0
Asn
2.385AsnAla: 2.385 ± 0.265
1.206AsnCys: 1.206 ± 0.178
1.7AsnAsp: 1.7 ± 0.264
1.892AsnGlu: 1.892 ± 0.242
2.797AsnPhe: 2.797 ± 0.276
2.303AsnGly: 2.303 ± 0.252
1.371AsnHis: 1.371 ± 0.208
5.456AsnIle: 5.456 ± 0.485
3.427AsnLys: 3.427 ± 0.283
5.977AsnLeu: 5.977 ± 0.447
1.453AsnMet: 1.453 ± 0.227
3.619AsnAsn: 3.619 ± 0.318
2.687AsnPro: 2.687 ± 0.267
2.632AsnGln: 2.632 ± 0.296
1.618AsnArg: 1.618 ± 0.219
5.292AsnSer: 5.292 ± 0.456
4.634AsnThr: 4.634 ± 0.466
3.592AsnVal: 3.592 ± 0.325
0.548AsnTrp: 0.548 ± 0.121
2.522AsnTyr: 2.522 ± 0.238
0.0AsnXaa: 0.0 ± 0.0
Pro
3.181ProAla: 3.181 ± 1.121
1.316ProCys: 1.316 ± 0.214
1.782ProAsp: 1.782 ± 0.233
2.879ProGlu: 2.879 ± 0.76
2.714ProPhe: 2.714 ± 0.232
2.714ProGly: 2.714 ± 0.479
1.59ProHis: 1.59 ± 0.226
4.25ProIle: 4.25 ± 0.398
2.577ProLys: 2.577 ± 0.222
4.908ProLeu: 4.908 ± 0.361
0.658ProMet: 0.658 ± 0.127
1.974ProAsn: 1.974 ± 0.212
2.769ProPro: 2.769 ± 0.375
2.084ProGln: 2.084 ± 0.246
2.385ProArg: 2.385 ± 0.591
4.277ProSer: 4.277 ± 0.683
4.387ProThr: 4.387 ± 1.121
2.961ProVal: 2.961 ± 0.398
1.152ProTrp: 1.152 ± 0.207
1.124ProTyr: 1.124 ± 0.166
0.0ProXaa: 0.0 ± 0.0
Gln
2.248GlnAla: 2.248 ± 0.226
0.85GlnCys: 0.85 ± 0.162
2.002GlnAsp: 2.002 ± 0.206
3.126GlnGlu: 3.126 ± 0.565
2.413GlnPhe: 2.413 ± 0.317
2.221GlnGly: 2.221 ± 0.229
1.371GlnHis: 1.371 ± 0.215
2.522GlnIle: 2.522 ± 0.217
2.906GlnLys: 2.906 ± 0.342
3.839GlnLeu: 3.839 ± 0.302
0.713GlnMet: 0.713 ± 0.164
2.687GlnAsn: 2.687 ± 0.283
2.029GlnPro: 2.029 ± 0.213
2.44GlnGln: 2.44 ± 0.436
1.426GlnArg: 1.426 ± 0.228
4.305GlnSer: 4.305 ± 0.572
3.4GlnThr: 3.4 ± 0.625
2.248GlnVal: 2.248 ± 0.265
1.124GlnTrp: 1.124 ± 0.552
1.453GlnTyr: 1.453 ± 0.219
0.0GlnXaa: 0.0 ± 0.0
Arg
2.385ArgAla: 2.385 ± 0.551
0.987ArgCys: 0.987 ± 0.179
1.563ArgAsp: 1.563 ± 0.215
1.837ArgGlu: 1.837 ± 0.209
1.124ArgPhe: 1.124 ± 0.189
1.837ArgGly: 1.837 ± 0.278
1.206ArgHis: 1.206 ± 0.205
2.111ArgIle: 2.111 ± 0.288
2.029ArgLys: 2.029 ± 0.241
3.674ArgLeu: 3.674 ± 0.258
0.795ArgMet: 0.795 ± 0.162
1.152ArgAsn: 1.152 ± 0.212
1.508ArgPro: 1.508 ± 0.254
1.782ArgGln: 1.782 ± 0.553
2.084ArgArg: 2.084 ± 0.43
1.892ArgSer: 1.892 ± 0.246
1.535ArgThr: 1.535 ± 0.209
2.522ArgVal: 2.522 ± 0.576
0.274ArgTrp: 0.274 ± 0.099
1.261ArgTyr: 1.261 ± 0.187
0.0ArgXaa: 0.0 ± 0.0
Ser
3.043SerAla: 3.043 ± 0.288
1.81SerCys: 1.81 ± 0.242
4.88SerAsp: 4.88 ± 0.445
3.729SerGlu: 3.729 ± 0.295
3.455SerPhe: 3.455 ± 0.299
3.866SerGly: 3.866 ± 0.447
1.81SerHis: 1.81 ± 0.247
5.895SerIle: 5.895 ± 0.508
5.621SerLys: 5.621 ± 0.443
8.088SerLeu: 8.088 ± 0.465
1.837SerMet: 1.837 ± 0.242
4.442SerAsn: 4.442 ± 0.409
5.374SerPro: 5.374 ± 1.117
3.51SerGln: 3.51 ± 0.352
2.714SerArg: 2.714 ± 0.279
8.143SerSer: 8.143 ± 0.69
6.306SerThr: 6.306 ± 0.519
4.689SerVal: 4.689 ± 0.421
0.795SerTrp: 0.795 ± 0.126
2.824SerTyr: 2.824 ± 0.236
0.0SerXaa: 0.0 ± 0.0
Thr
3.729ThrAla: 3.729 ± 0.506
1.481ThrCys: 1.481 ± 0.178
2.852ThrAsp: 2.852 ± 0.299
3.318ThrGlu: 3.318 ± 0.294
3.866ThrPhe: 3.866 ± 0.34
2.879ThrGly: 2.879 ± 0.311
1.837ThrHis: 1.837 ± 0.239
4.634ThrIle: 4.634 ± 0.397
3.208ThrLys: 3.208 ± 0.334
6.909ThrLeu: 6.909 ± 0.532
1.426ThrMet: 1.426 ± 0.19
3.756ThrAsn: 3.756 ± 0.406
4.332ThrPro: 4.332 ± 0.558
3.701ThrGln: 3.701 ± 0.59
2.221ThrArg: 2.221 ± 0.579
7.293ThrSer: 7.293 ± 0.784
5.703ThrThr: 5.703 ± 0.682
4.113ThrVal: 4.113 ± 0.323
0.576ThrTrp: 0.576 ± 0.136
2.193ThrTyr: 2.193 ± 0.241
0.0ThrXaa: 0.0 ± 0.0
Val
2.714ValAla: 2.714 ± 0.293
1.947ValCys: 1.947 ± 0.256
2.468ValAsp: 2.468 ± 0.273
2.852ValGlu: 2.852 ± 0.286
3.208ValPhe: 3.208 ± 0.259
2.879ValGly: 2.879 ± 0.637
1.508ValHis: 1.508 ± 0.201
3.976ValIle: 3.976 ± 0.324
3.016ValLys: 3.016 ± 0.367
6.032ValLeu: 6.032 ± 0.406
1.398ValMet: 1.398 ± 0.229
3.537ValAsn: 3.537 ± 0.377
2.961ValPro: 2.961 ± 0.399
2.139ValGln: 2.139 ± 0.227
1.755ValArg: 1.755 ± 0.278
5.1ValSer: 5.1 ± 0.377
4.003ValThr: 4.003 ± 0.308
3.756ValVal: 3.756 ± 0.365
0.384ValTrp: 0.384 ± 0.099
2.906ValTyr: 2.906 ± 0.281
0.0ValXaa: 0.0 ± 0.0
Trp
0.494TrpAla: 0.494 ± 0.104
0.302TrpCys: 0.302 ± 0.079
0.302TrpAsp: 0.302 ± 0.085
1.069TrpGlu: 1.069 ± 0.539
0.576TrpPhe: 0.576 ± 0.159
0.713TrpGly: 0.713 ± 0.206
0.274TrpHis: 0.274 ± 0.075
0.658TrpIle: 0.658 ± 0.147
0.603TrpLys: 0.603 ± 0.119
1.124TrpLeu: 1.124 ± 0.157
0.165TrpMet: 0.165 ± 0.063
0.85TrpAsn: 0.85 ± 0.136
1.097TrpPro: 1.097 ± 0.223
0.411TrpGln: 0.411 ± 0.111
0.356TrpArg: 0.356 ± 0.074
0.466TrpSer: 0.466 ± 0.126
1.261TrpThr: 1.261 ± 0.564
0.905TrpVal: 0.905 ± 0.175
0.0TrpTrp: 0.0 ± 0.0
0.329TrpTyr: 0.329 ± 0.077
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.426TyrAla: 1.426 ± 0.192
0.85TyrCys: 0.85 ± 0.205
1.535TyrAsp: 1.535 ± 0.176
1.727TyrGlu: 1.727 ± 0.303
2.139TyrPhe: 2.139 ± 0.284
2.029TyrGly: 2.029 ± 0.262
0.877TyrHis: 0.877 ± 0.154
3.372TyrIle: 3.372 ± 0.305
3.126TyrLys: 3.126 ± 0.28
3.318TyrLeu: 3.318 ± 0.308
0.987TyrMet: 0.987 ± 0.147
2.66TyrAsn: 2.66 ± 0.304
1.453TyrPro: 1.453 ± 0.251
1.398TyrGln: 1.398 ± 0.145
1.398TyrArg: 1.398 ± 0.197
3.071TyrSer: 3.071 ± 0.275
2.961TyrThr: 2.961 ± 0.286
2.331TyrVal: 2.331 ± 0.344
0.576TyrTrp: 0.576 ± 0.146
1.371TyrTyr: 1.371 ± 0.241
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 87 proteins (36473 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski