Amino acid dipepetide frequency for Streptococcus phage Javan244

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.611AlaAla: 4.611 ± 1.037
0.738AlaCys: 0.738 ± 0.267
3.228AlaAsp: 3.228 ± 0.434
4.519AlaGlu: 4.519 ± 0.922
2.398AlaPhe: 2.398 ± 0.573
4.15AlaGly: 4.15 ± 0.775
0.83AlaHis: 0.83 ± 0.282
4.795AlaIle: 4.795 ± 0.962
4.15AlaLys: 4.15 ± 0.554
6.64AlaLeu: 6.64 ± 1.035
1.752AlaMet: 1.752 ± 0.434
3.504AlaAsn: 3.504 ± 0.608
1.199AlaPro: 1.199 ± 0.31
2.767AlaGln: 2.767 ± 0.607
3.043AlaArg: 3.043 ± 0.711
4.795AlaSer: 4.795 ± 0.645
4.611AlaThr: 4.611 ± 0.649
5.164AlaVal: 5.164 ± 0.745
1.014AlaTrp: 1.014 ± 0.372
4.058AlaTyr: 4.058 ± 0.631
0.0AlaXaa: 0.0 ± 0.0
Cys
0.277CysAla: 0.277 ± 0.194
0.277CysCys: 0.277 ± 0.155
0.553CysAsp: 0.553 ± 0.234
0.553CysGlu: 0.553 ± 0.231
0.184CysPhe: 0.184 ± 0.131
0.646CysGly: 0.646 ± 0.259
0.184CysHis: 0.184 ± 0.136
0.553CysIle: 0.553 ± 0.208
0.277CysLys: 0.277 ± 0.164
0.922CysLeu: 0.922 ± 0.292
0.092CysMet: 0.092 ± 0.115
0.092CysAsn: 0.092 ± 0.1
0.553CysPro: 0.553 ± 0.203
0.738CysGln: 0.738 ± 0.255
0.646CysArg: 0.646 ± 0.214
0.461CysSer: 0.461 ± 0.231
0.184CysThr: 0.184 ± 0.124
0.369CysVal: 0.369 ± 0.173
0.0CysTrp: 0.0 ± 0.0
0.738CysTyr: 0.738 ± 0.277
0.0CysXaa: 0.0 ± 0.0
Asp
3.135AspAla: 3.135 ± 0.539
0.369AspCys: 0.369 ± 0.172
3.689AspAsp: 3.689 ± 0.857
5.349AspGlu: 5.349 ± 0.772
2.859AspPhe: 2.859 ± 0.452
4.703AspGly: 4.703 ± 0.616
0.83AspHis: 0.83 ± 0.243
4.611AspIle: 4.611 ± 0.617
4.887AspLys: 4.887 ± 0.71
5.625AspLeu: 5.625 ± 0.857
2.305AspMet: 2.305 ± 0.5
2.582AspAsn: 2.582 ± 0.461
1.199AspPro: 1.199 ± 0.447
1.844AspGln: 1.844 ± 0.396
3.135AspArg: 3.135 ± 0.578
3.504AspSer: 3.504 ± 0.547
2.582AspThr: 2.582 ± 0.609
2.859AspVal: 2.859 ± 0.397
0.922AspTrp: 0.922 ± 0.259
2.674AspTyr: 2.674 ± 0.747
0.0AspXaa: 0.0 ± 0.0
Glu
5.349GluAla: 5.349 ± 0.813
0.646GluCys: 0.646 ± 0.223
4.334GluAsp: 4.334 ± 0.692
5.902GluGlu: 5.902 ± 0.93
2.121GluPhe: 2.121 ± 0.331
4.242GluGly: 4.242 ± 0.49
0.922GluHis: 0.922 ± 0.235
3.596GluIle: 3.596 ± 0.518
6.363GluLys: 6.363 ± 0.807
8.3GluLeu: 8.3 ± 0.81
1.66GluMet: 1.66 ± 0.489
2.859GluAsn: 2.859 ± 0.579
1.383GluPro: 1.383 ± 0.407
3.689GluGln: 3.689 ± 0.746
2.951GluArg: 2.951 ± 0.615
3.873GluSer: 3.873 ± 0.432
5.256GluThr: 5.256 ± 0.653
4.426GluVal: 4.426 ± 0.555
0.461GluTrp: 0.461 ± 0.311
2.213GluTyr: 2.213 ± 0.418
0.0GluXaa: 0.0 ± 0.0
Phe
2.49PheAla: 2.49 ± 0.433
0.277PheCys: 0.277 ± 0.149
2.951PheAsp: 2.951 ± 0.534
2.767PheGlu: 2.767 ± 0.515
1.752PhePhe: 1.752 ± 0.469
3.228PheGly: 3.228 ± 0.49
0.83PheHis: 0.83 ± 0.295
2.213PheIle: 2.213 ± 0.572
3.135PheLys: 3.135 ± 0.597
2.859PheLeu: 2.859 ± 0.483
1.107PheMet: 1.107 ± 0.33
1.66PheAsn: 1.66 ± 0.323
0.83PhePro: 0.83 ± 0.281
1.199PheGln: 1.199 ± 0.353
1.383PheArg: 1.383 ± 0.384
2.49PheSer: 2.49 ± 0.428
2.305PheThr: 2.305 ± 0.514
2.029PheVal: 2.029 ± 0.417
0.646PheTrp: 0.646 ± 0.212
1.291PheTyr: 1.291 ± 0.39
0.0PheXaa: 0.0 ± 0.0
Gly
3.873GlyAla: 3.873 ± 0.586
0.092GlyCys: 0.092 ± 0.093
3.965GlyAsp: 3.965 ± 0.633
4.242GlyGlu: 4.242 ± 0.519
2.305GlyPhe: 2.305 ± 0.469
6.179GlyGly: 6.179 ± 0.928
1.752GlyHis: 1.752 ± 0.421
4.887GlyIle: 4.887 ± 0.832
5.902GlyLys: 5.902 ± 0.571
5.994GlyLeu: 5.994 ± 1.066
2.305GlyMet: 2.305 ± 0.397
3.689GlyAsn: 3.689 ± 0.725
0.83GlyPro: 0.83 ± 0.239
2.859GlyGln: 2.859 ± 0.508
3.412GlyArg: 3.412 ± 0.672
4.334GlySer: 4.334 ± 0.821
4.242GlyThr: 4.242 ± 0.548
4.887GlyVal: 4.887 ± 0.759
0.83GlyTrp: 0.83 ± 0.211
2.859GlyTyr: 2.859 ± 0.599
0.0GlyXaa: 0.0 ± 0.0
His
0.461HisAla: 0.461 ± 0.188
0.184HisCys: 0.184 ± 0.133
1.199HisAsp: 1.199 ± 0.284
0.83HisGlu: 0.83 ± 0.31
0.738HisPhe: 0.738 ± 0.316
1.199HisGly: 1.199 ± 0.304
0.922HisHis: 0.922 ± 0.258
1.014HisIle: 1.014 ± 0.318
1.014HisLys: 1.014 ± 0.248
1.844HisLeu: 1.844 ± 0.365
0.646HisMet: 0.646 ± 0.247
1.014HisAsn: 1.014 ± 0.274
1.014HisPro: 1.014 ± 0.386
1.014HisGln: 1.014 ± 0.312
0.646HisArg: 0.646 ± 0.202
0.922HisSer: 0.922 ± 0.279
1.014HisThr: 1.014 ± 0.343
1.383HisVal: 1.383 ± 0.343
0.553HisTrp: 0.553 ± 0.218
0.738HisTyr: 0.738 ± 0.319
0.0HisXaa: 0.0 ± 0.0
Ile
4.887IleAla: 4.887 ± 0.739
0.83IleCys: 0.83 ± 0.271
4.887IleAsp: 4.887 ± 0.638
3.596IleGlu: 3.596 ± 0.623
1.291IlePhe: 1.291 ± 0.521
5.072IleGly: 5.072 ± 0.738
1.107IleHis: 1.107 ± 0.282
3.596IleIle: 3.596 ± 0.457
4.98IleLys: 4.98 ± 0.801
4.334IleLeu: 4.334 ± 0.497
1.291IleMet: 1.291 ± 0.391
2.305IleAsn: 2.305 ± 0.604
1.844IlePro: 1.844 ± 0.376
2.767IleGln: 2.767 ± 0.649
1.844IleArg: 1.844 ± 0.308
5.81IleSer: 5.81 ± 1.095
4.98IleThr: 4.98 ± 0.543
3.873IleVal: 3.873 ± 0.683
1.291IleTrp: 1.291 ± 0.313
2.121IleTyr: 2.121 ± 0.426
0.0IleXaa: 0.0 ± 0.0
Lys
6.547LysAla: 6.547 ± 0.747
0.461LysCys: 0.461 ± 0.195
3.781LysAsp: 3.781 ± 0.66
6.363LysGlu: 6.363 ± 0.88
2.121LysPhe: 2.121 ± 0.258
4.058LysGly: 4.058 ± 0.786
1.844LysHis: 1.844 ± 0.407
4.15LysIle: 4.15 ± 0.605
4.334LysLys: 4.334 ± 0.82
4.611LysLeu: 4.611 ± 0.524
1.199LysMet: 1.199 ± 0.367
3.596LysAsn: 3.596 ± 0.655
2.767LysPro: 2.767 ± 0.391
3.228LysGln: 3.228 ± 0.509
4.058LysArg: 4.058 ± 0.566
4.98LysSer: 4.98 ± 0.585
4.611LysThr: 4.611 ± 0.574
5.533LysVal: 5.533 ± 0.847
1.107LysTrp: 1.107 ± 0.395
1.475LysTyr: 1.475 ± 0.525
0.0LysXaa: 0.0 ± 0.0
Leu
5.441LeuAla: 5.441 ± 1.002
0.461LeuCys: 0.461 ± 0.186
5.625LeuAsp: 5.625 ± 0.579
7.838LeuGlu: 7.838 ± 1.213
2.674LeuPhe: 2.674 ± 0.497
4.795LeuGly: 4.795 ± 0.724
1.199LeuHis: 1.199 ± 0.323
5.625LeuIle: 5.625 ± 0.663
6.455LeuLys: 6.455 ± 0.753
7.377LeuLeu: 7.377 ± 0.852
2.398LeuMet: 2.398 ± 0.441
4.058LeuAsn: 4.058 ± 0.675
3.596LeuPro: 3.596 ± 0.659
3.689LeuGln: 3.689 ± 0.528
3.965LeuArg: 3.965 ± 0.589
7.47LeuSer: 7.47 ± 0.758
6.824LeuThr: 6.824 ± 0.975
5.994LeuVal: 5.994 ± 0.759
0.738LeuTrp: 0.738 ± 0.163
3.228LeuTyr: 3.228 ± 0.716
0.0LeuXaa: 0.0 ± 0.0
Met
2.121MetAla: 2.121 ± 0.392
0.092MetCys: 0.092 ± 0.082
1.383MetAsp: 1.383 ± 0.458
1.475MetGlu: 1.475 ± 0.415
0.646MetPhe: 0.646 ± 0.259
1.844MetGly: 1.844 ± 0.46
0.277MetHis: 0.277 ± 0.234
1.844MetIle: 1.844 ± 0.463
1.844MetLys: 1.844 ± 0.428
2.029MetLeu: 2.029 ± 0.51
0.738MetMet: 0.738 ± 0.27
0.83MetAsn: 0.83 ± 0.282
0.369MetPro: 0.369 ± 0.163
0.738MetGln: 0.738 ± 0.252
1.291MetArg: 1.291 ± 0.272
1.844MetSer: 1.844 ± 0.417
2.951MetThr: 2.951 ± 0.504
1.383MetVal: 1.383 ± 0.349
0.092MetTrp: 0.092 ± 0.095
0.461MetTyr: 0.461 ± 0.227
0.0MetXaa: 0.0 ± 0.0
Asn
3.873AsnAla: 3.873 ± 0.63
0.277AsnCys: 0.277 ± 0.167
2.582AsnAsp: 2.582 ± 0.427
2.582AsnGlu: 2.582 ± 0.505
1.937AsnPhe: 1.937 ± 0.441
5.072AsnGly: 5.072 ± 0.656
0.83AsnHis: 0.83 ± 0.296
2.121AsnIle: 2.121 ± 0.496
2.582AsnLys: 2.582 ± 0.514
3.504AsnLeu: 3.504 ± 0.37
1.107AsnMet: 1.107 ± 0.285
1.752AsnAsn: 1.752 ± 0.346
2.49AsnPro: 2.49 ± 0.462
2.49AsnGln: 2.49 ± 0.339
2.49AsnArg: 2.49 ± 0.357
2.674AsnSer: 2.674 ± 0.581
2.951AsnThr: 2.951 ± 0.613
3.32AsnVal: 3.32 ± 0.565
0.738AsnTrp: 0.738 ± 0.188
0.83AsnTyr: 0.83 ± 0.224
0.0AsnXaa: 0.0 ± 0.0
Pro
1.107ProAla: 1.107 ± 0.301
0.277ProCys: 0.277 ± 0.141
1.937ProAsp: 1.937 ± 0.502
1.475ProGlu: 1.475 ± 0.497
1.014ProPhe: 1.014 ± 0.417
1.107ProGly: 1.107 ± 0.323
0.83ProHis: 0.83 ± 0.235
2.121ProIle: 2.121 ± 0.392
2.767ProLys: 2.767 ± 0.451
2.951ProLeu: 2.951 ± 0.483
0.646ProMet: 0.646 ± 0.224
1.291ProAsn: 1.291 ± 0.327
0.922ProPro: 0.922 ± 0.312
1.937ProGln: 1.937 ± 0.378
1.291ProArg: 1.291 ± 0.294
2.674ProSer: 2.674 ± 0.464
1.937ProThr: 1.937 ± 0.375
1.752ProVal: 1.752 ± 0.409
0.461ProTrp: 0.461 ± 0.239
1.568ProTyr: 1.568 ± 0.406
0.0ProXaa: 0.0 ± 0.0
Gln
4.15GlnAla: 4.15 ± 0.741
0.369GlnCys: 0.369 ± 0.19
2.121GlnAsp: 2.121 ± 0.376
3.596GlnGlu: 3.596 ± 0.709
2.121GlnPhe: 2.121 ± 0.393
2.674GlnGly: 2.674 ± 0.503
0.553GlnHis: 0.553 ± 0.224
2.582GlnIle: 2.582 ± 0.475
2.398GlnLys: 2.398 ± 0.502
4.887GlnLeu: 4.887 ± 0.655
1.199GlnMet: 1.199 ± 0.344
2.49GlnAsn: 2.49 ± 0.475
1.475GlnPro: 1.475 ± 0.393
1.568GlnGln: 1.568 ± 0.382
1.475GlnArg: 1.475 ± 0.355
2.767GlnSer: 2.767 ± 0.571
2.674GlnThr: 2.674 ± 0.47
3.412GlnVal: 3.412 ± 0.471
0.461GlnTrp: 0.461 ± 0.245
0.461GlnTyr: 0.461 ± 0.142
0.0GlnXaa: 0.0 ± 0.0
Arg
2.767ArgAla: 2.767 ± 0.557
0.461ArgCys: 0.461 ± 0.213
2.305ArgAsp: 2.305 ± 0.423
2.674ArgGlu: 2.674 ± 0.454
1.844ArgPhe: 1.844 ± 0.385
2.305ArgGly: 2.305 ± 0.503
0.646ArgHis: 0.646 ± 0.222
2.49ArgIle: 2.49 ± 0.454
3.32ArgLys: 3.32 ± 0.566
4.887ArgLeu: 4.887 ± 0.722
0.922ArgMet: 0.922 ± 0.292
2.582ArgAsn: 2.582 ± 0.753
1.199ArgPro: 1.199 ± 0.35
2.582ArgGln: 2.582 ± 0.482
2.49ArgArg: 2.49 ± 0.649
2.767ArgSer: 2.767 ± 0.418
2.213ArgThr: 2.213 ± 0.368
4.334ArgVal: 4.334 ± 0.698
0.83ArgTrp: 0.83 ± 0.312
1.844ArgTyr: 1.844 ± 0.433
0.0ArgXaa: 0.0 ± 0.0
Ser
3.781SerAla: 3.781 ± 0.781
0.461SerCys: 0.461 ± 0.249
3.965SerAsp: 3.965 ± 0.649
4.426SerGlu: 4.426 ± 0.609
2.767SerPhe: 2.767 ± 0.709
6.64SerGly: 6.64 ± 0.808
1.844SerHis: 1.844 ± 0.405
4.703SerIle: 4.703 ± 0.697
4.611SerLys: 4.611 ± 0.554
4.611SerLeu: 4.611 ± 0.709
1.199SerMet: 1.199 ± 0.339
3.596SerAsn: 3.596 ± 0.594
2.674SerPro: 2.674 ± 0.533
2.951SerGln: 2.951 ± 0.609
3.228SerArg: 3.228 ± 0.51
5.533SerSer: 5.533 ± 0.783
5.717SerThr: 5.717 ± 0.7
4.334SerVal: 4.334 ± 0.692
1.291SerTrp: 1.291 ± 0.294
2.305SerTyr: 2.305 ± 0.448
0.0SerXaa: 0.0 ± 0.0
Thr
4.611ThrAla: 4.611 ± 0.735
0.553ThrCys: 0.553 ± 0.28
3.596ThrAsp: 3.596 ± 0.569
3.781ThrGlu: 3.781 ± 0.549
3.228ThrPhe: 3.228 ± 0.469
4.058ThrGly: 4.058 ± 0.848
0.83ThrHis: 0.83 ± 0.266
5.072ThrIle: 5.072 ± 0.876
5.533ThrLys: 5.533 ± 0.612
7.193ThrLeu: 7.193 ± 0.902
1.291ThrMet: 1.291 ± 0.291
2.674ThrAsn: 2.674 ± 0.395
2.582ThrPro: 2.582 ± 0.562
1.937ThrGln: 1.937 ± 0.487
2.674ThrArg: 2.674 ± 0.528
5.072ThrSer: 5.072 ± 0.71
4.611ThrThr: 4.611 ± 0.552
5.625ThrVal: 5.625 ± 0.629
1.291ThrTrp: 1.291 ± 0.325
1.568ThrTyr: 1.568 ± 0.314
0.0ThrXaa: 0.0 ± 0.0
Val
4.334ValAla: 4.334 ± 0.62
0.553ValCys: 0.553 ± 0.23
3.873ValAsp: 3.873 ± 0.529
5.441ValGlu: 5.441 ± 0.745
2.582ValPhe: 2.582 ± 0.428
4.242ValGly: 4.242 ± 0.767
1.199ValHis: 1.199 ± 0.364
4.611ValIle: 4.611 ± 0.83
3.228ValLys: 3.228 ± 0.654
6.455ValLeu: 6.455 ± 0.758
1.568ValMet: 1.568 ± 0.341
3.043ValAsn: 3.043 ± 0.448
1.937ValPro: 1.937 ± 0.349
2.398ValGln: 2.398 ± 0.451
2.767ValArg: 2.767 ± 0.605
5.625ValSer: 5.625 ± 0.822
5.349ValThr: 5.349 ± 0.634
4.887ValVal: 4.887 ± 0.765
1.107ValTrp: 1.107 ± 0.287
2.951ValTyr: 2.951 ± 0.56
0.0ValXaa: 0.0 ± 0.0
Trp
1.291TrpAla: 1.291 ± 0.393
0.092TrpCys: 0.092 ± 0.098
0.646TrpAsp: 0.646 ± 0.252
1.014TrpGlu: 1.014 ± 0.273
1.107TrpPhe: 1.107 ± 0.318
0.461TrpGly: 0.461 ± 0.156
0.184TrpHis: 0.184 ± 0.13
0.83TrpIle: 0.83 ± 0.273
0.646TrpLys: 0.646 ± 0.291
1.475TrpLeu: 1.475 ± 0.26
0.369TrpMet: 0.369 ± 0.156
1.383TrpAsn: 1.383 ± 0.39
0.092TrpPro: 0.092 ± 0.085
0.922TrpGln: 0.922 ± 0.228
0.738TrpArg: 0.738 ± 0.306
1.107TrpSer: 1.107 ± 0.312
0.738TrpThr: 0.738 ± 0.235
0.738TrpVal: 0.738 ± 0.207
0.184TrpTrp: 0.184 ± 0.12
0.277TrpTyr: 0.277 ± 0.155
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.859TyrAla: 2.859 ± 0.399
0.83TyrCys: 0.83 ± 0.286
3.043TyrAsp: 3.043 ± 0.758
2.121TyrGlu: 2.121 ± 0.323
1.752TyrPhe: 1.752 ± 0.404
2.767TyrGly: 2.767 ± 0.428
0.738TyrHis: 0.738 ± 0.359
1.291TyrIle: 1.291 ± 0.323
2.49TyrLys: 2.49 ± 0.501
2.951TyrLeu: 2.951 ± 0.59
0.369TyrMet: 0.369 ± 0.167
1.199TyrAsn: 1.199 ± 0.385
1.107TyrPro: 1.107 ± 0.273
2.121TyrGln: 2.121 ± 0.478
1.937TyrArg: 1.937 ± 0.287
1.937TyrSer: 1.937 ± 0.382
2.029TyrThr: 2.029 ± 0.538
1.844TyrVal: 1.844 ± 0.382
0.277TyrTrp: 0.277 ± 0.178
1.383TyrTyr: 1.383 ± 0.351
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 36 proteins (10845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski