Amino acid dipepetide frequency for Pseudogymnoascus sp. VKM F-4519 (FW-2642)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.009AlaAla: 10.009 ± 0.084	1.053AlaCys: 1.053 ± 0.014	4.409AlaAsp: 4.409 ± 0.027	5.446AlaGlu: 5.446 ± 0.045	3.131AlaPhe: 3.131 ± 0.025	6.195AlaGly: 6.195 ± 0.039	1.734AlaHis: 1.734 ± 0.017	4.599AlaIle: 4.599 ± 0.029	4.408AlaLys: 4.408 ± 0.038	7.842AlaLeu: 7.842 ± 0.048	2.036AlaMet: 2.036 ± 0.021	3.142AlaAsn: 3.142 ± 0.027	5.138AlaPro: 5.138 ± 0.047	3.43AlaGln: 3.43 ± 0.031	4.816AlaArg: 4.816 ± 0.037	7.204AlaSer: 7.204 ± 0.041	5.68AlaThr: 5.68 ± 0.039	5.607AlaVal: 5.607 ± 0.041	1.141AlaTrp: 1.141 ± 0.016	2.24AlaTyr: 2.24 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.973CysAla: 0.973 ± 0.016	0.239CysCys: 0.239 ± 0.008	0.658CysAsp: 0.658 ± 0.013	0.588CysGlu: 0.588 ± 0.013	0.519CysPhe: 0.519 ± 0.011	0.996CysGly: 0.996 ± 0.017	0.314CysHis: 0.314 ± 0.008	0.703CysIle: 0.703 ± 0.012	0.519CysLys: 0.519 ± 0.01	1.184CysLeu: 1.184 ± 0.015	0.268CysMet: 0.268 ± 0.007	0.422CysAsn: 0.422 ± 0.009	0.625CysPro: 0.625 ± 0.013	0.424CysGln: 0.424 ± 0.01	0.675CysArg: 0.675 ± 0.012	0.875CysSer: 0.875 ± 0.016	0.687CysThr: 0.687 ± 0.012	0.774CysVal: 0.774 ± 0.014	0.199CysTrp: 0.199 ± 0.006	0.36CysTyr: 0.36 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.862AspAla: 4.862 ± 0.033	0.607AspCys: 0.607 ± 0.012	4.11AspAsp: 4.11 ± 0.039	4.443AspGlu: 4.443 ± 0.042	2.197AspPhe: 2.197 ± 0.022	4.254AspGly: 4.254 ± 0.036	1.126AspHis: 1.126 ± 0.016	3.206AspIle: 3.206 ± 0.025	2.439AspLys: 2.439 ± 0.028	4.88AspLeu: 4.88 ± 0.033	1.245AspMet: 1.245 ± 0.014	1.99AspAsn: 1.99 ± 0.021	3.008AspPro: 3.008 ± 0.026	1.732AspGln: 1.732 ± 0.02	2.844AspArg: 2.844 ± 0.026	4.067AspSer: 4.067 ± 0.034	2.982AspThr: 2.982 ± 0.024	3.74AspVal: 3.74 ± 0.029	0.866AspTrp: 0.866 ± 0.012	1.624AspTyr: 1.624 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.74GluAla: 5.74 ± 0.043	0.614GluCys: 0.614 ± 0.011	4.203GluAsp: 4.203 ± 0.035	5.721GluGlu: 5.721 ± 0.065	1.969GluPhe: 1.969 ± 0.019	4.263GluGly: 4.263 ± 0.035	1.287GluHis: 1.287 ± 0.017	3.153GluIle: 3.153 ± 0.029	3.746GluLys: 3.746 ± 0.038	5.132GluLeu: 5.132 ± 0.037	1.511GluMet: 1.511 ± 0.019	2.257GluAsn: 2.257 ± 0.023	2.687GluPro: 2.687 ± 0.033	2.311GluGln: 2.311 ± 0.027	3.918GluArg: 3.918 ± 0.035	4.258GluSer: 4.258 ± 0.034	3.474GluThr: 3.474 ± 0.031	3.888GluVal: 3.888 ± 0.028	0.9GluTrp: 0.9 ± 0.014	1.703GluTyr: 1.703 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.099PheAla: 3.099 ± 0.027	0.539PheCys: 0.539 ± 0.01	2.218PheAsp: 2.218 ± 0.021	2.168PheGlu: 2.168 ± 0.022	1.551PhePhe: 1.551 ± 0.02	2.928PheGly: 2.928 ± 0.03	0.831PheHis: 0.831 ± 0.012	1.886PheIle: 1.886 ± 0.022	1.58PheLys: 1.58 ± 0.018	3.28PheLeu: 3.28 ± 0.03	0.795PheMet: 0.795 ± 0.015	1.468PheAsn: 1.468 ± 0.017	1.876PhePro: 1.876 ± 0.02	1.38PheGln: 1.38 ± 0.016	1.787PheArg: 1.787 ± 0.02	2.88PheSer: 2.88 ± 0.025	2.135PheThr: 2.135 ± 0.022	2.351PheVal: 2.351 ± 0.021	0.615PheTrp: 0.615 ± 0.011	1.099PheTyr: 1.099 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.93GlyAla: 5.93 ± 0.048	0.922GlyCys: 0.922 ± 0.016	3.863GlyAsp: 3.863 ± 0.033	4.136GlyGlu: 4.136 ± 0.036	2.875GlyPhe: 2.875 ± 0.026	6.867GlyGly: 6.867 ± 0.074	1.682GlyHis: 1.682 ± 0.023	3.747GlyIle: 3.747 ± 0.034	3.823GlyLys: 3.823 ± 0.032	6.117GlyLeu: 6.117 ± 0.037	1.715GlyMet: 1.715 ± 0.02	2.719GlyAsn: 2.719 ± 0.026	3.33GlyPro: 3.33 ± 0.032	2.586GlyGln: 2.586 ± 0.025	4.192GlyArg: 4.192 ± 0.035	5.839GlySer: 5.839 ± 0.042	4.141GlyThr: 4.141 ± 0.033	4.705GlyVal: 4.705 ± 0.035	1.204GlyTrp: 1.204 ± 0.018	2.177GlyTyr: 2.177 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.751HisAla: 1.751 ± 0.019	0.294HisCys: 0.294 ± 0.008	1.208HisAsp: 1.208 ± 0.015	1.237HisGlu: 1.237 ± 0.018	0.885HisPhe: 0.885 ± 0.014	1.677HisGly: 1.677 ± 0.02	0.745HisHis: 0.745 ± 0.014	1.247HisIle: 1.247 ± 0.015	0.919HisLys: 0.919 ± 0.013	2.093HisLeu: 2.093 ± 0.022	0.448HisMet: 0.448 ± 0.01	0.864HisAsn: 0.864 ± 0.015	1.552HisPro: 1.552 ± 0.017	0.894HisGln: 0.894 ± 0.014	1.364HisArg: 1.364 ± 0.02	1.657HisSer: 1.657 ± 0.02	1.255HisThr: 1.255 ± 0.014	1.34HisVal: 1.34 ± 0.015	0.314HisTrp: 0.314 ± 0.008	0.689HisTyr: 0.689 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.516IleAla: 4.516 ± 0.033	0.773IleCys: 0.773 ± 0.014	2.957IleAsp: 2.957 ± 0.025	3.008IleGlu: 3.008 ± 0.025	2.051IlePhe: 2.051 ± 0.023	3.399IleGly: 3.399 ± 0.029	1.153IleHis: 1.153 ± 0.015	2.779IleIle: 2.779 ± 0.026	2.328IleLys: 2.328 ± 0.022	4.613IleLeu: 4.613 ± 0.037	1.067IleMet: 1.067 ± 0.017	1.95IleAsn: 1.95 ± 0.02	3.115IlePro: 3.115 ± 0.026	1.913IleGln: 1.913 ± 0.022	2.732IleArg: 2.732 ± 0.023	4.049IleSer: 4.049 ± 0.026	3.125IleThr: 3.125 ± 0.025	3.261IleVal: 3.261 ± 0.03	0.717IleTrp: 0.717 ± 0.014	1.507IleTyr: 1.507 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.579LysAla: 4.579 ± 0.04	0.499LysCys: 0.499 ± 0.011	2.842LysAsp: 2.842 ± 0.028	3.546LysGlu: 3.546 ± 0.033	1.541LysPhe: 1.541 ± 0.016	3.301LysGly: 3.301 ± 0.03	1.088LysHis: 1.088 ± 0.015	2.423LysIle: 2.423 ± 0.024	3.421LysLys: 3.421 ± 0.05	4.233LysLeu: 4.233 ± 0.036	1.023LysMet: 1.023 ± 0.015	1.83LysAsn: 1.83 ± 0.018	2.696LysPro: 2.696 ± 0.028	1.775LysGln: 1.775 ± 0.02	3.315LysArg: 3.315 ± 0.031	3.649LysSer: 3.649 ± 0.029	2.925LysThr: 2.925 ± 0.028	2.988LysVal: 2.988 ± 0.028	0.698LysTrp: 0.698 ± 0.011	1.432LysTyr: 1.432 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.89LeuAla: 7.89 ± 0.051	1.148LeuCys: 1.148 ± 0.016	5.003LeuAsp: 5.003 ± 0.036	5.456LeuGlu: 5.456 ± 0.04	3.202LeuPhe: 3.202 ± 0.031	6.04LeuGly: 6.04 ± 0.034	2.105LeuHis: 2.105 ± 0.022	4.001LeuIle: 4.001 ± 0.028	4.335LeuLys: 4.335 ± 0.031	8.315LeuLeu: 8.315 ± 0.063	1.757LeuMet: 1.757 ± 0.021	3.106LeuAsn: 3.106 ± 0.023	5.394LeuPro: 5.394 ± 0.036	3.665LeuGln: 3.665 ± 0.037	5.378LeuArg: 5.378 ± 0.039	7.135LeuSer: 7.135 ± 0.046	4.805LeuThr: 4.805 ± 0.028	5.212LeuVal: 5.212 ± 0.038	1.181LeuTrp: 1.181 ± 0.018	2.314LeuTyr: 2.314 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.23MetAla: 2.23 ± 0.022	0.23MetCys: 0.23 ± 0.006	1.255MetAsp: 1.255 ± 0.017	1.35MetGlu: 1.35 ± 0.017	0.748MetPhe: 0.748 ± 0.012	1.603MetGly: 1.603 ± 0.02	0.489MetHis: 0.489 ± 0.01	0.995MetIle: 0.995 ± 0.017	1.075MetLys: 1.075 ± 0.016	1.808MetLeu: 1.808 ± 0.018	0.569MetMet: 0.569 ± 0.01	0.797MetAsn: 0.797 ± 0.012	1.222MetPro: 1.222 ± 0.014	0.829MetGln: 0.829 ± 0.013	1.254MetArg: 1.254 ± 0.016	1.841MetSer: 1.841 ± 0.019	1.233MetThr: 1.233 ± 0.016	1.356MetVal: 1.356 ± 0.016	0.263MetTrp: 0.263 ± 0.006	0.528MetTyr: 0.528 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.229AsnAla: 3.229 ± 0.029	0.477AsnCys: 0.477 ± 0.012	1.981AsnAsp: 1.981 ± 0.02	2.049AsnGlu: 2.049 ± 0.02	1.426AsnPhe: 1.426 ± 0.015	3.204AsnGly: 3.204 ± 0.031	0.807AsnHis: 0.807 ± 0.011	2.224AsnIle: 2.224 ± 0.02	1.595AsnLys: 1.595 ± 0.019	3.239AsnLeu: 3.239 ± 0.027	0.869AsnMet: 0.869 ± 0.013	1.622AsnAsn: 1.622 ± 0.021	2.453AsnPro: 2.453 ± 0.021	1.308AsnGln: 1.308 ± 0.017	1.906AsnArg: 1.906 ± 0.02	2.915AsnSer: 2.915 ± 0.026	2.285AsnThr: 2.285 ± 0.023	2.3AsnVal: 2.3 ± 0.021	0.561AsnTrp: 0.561 ± 0.01	1.112AsnTyr: 1.112 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.275ProAla: 5.275 ± 0.045	0.473ProCys: 0.473 ± 0.011	2.901ProAsp: 2.901 ± 0.028	3.627ProGlu: 3.627 ± 0.035	1.938ProPhe: 1.938 ± 0.019	3.875ProGly: 3.875 ± 0.033	1.262ProHis: 1.262 ± 0.018	2.645ProIle: 2.645 ± 0.025	2.741ProLys: 2.741 ± 0.028	4.71ProLeu: 4.71 ± 0.032	1.055ProMet: 1.055 ± 0.014	2.217ProAsn: 2.217 ± 0.023	5.001ProPro: 5.001 ± 0.063	2.398ProGln: 2.398 ± 0.032	3.27ProArg: 3.27 ± 0.037	5.682ProSer: 5.682 ± 0.049	4.223ProThr: 4.223 ± 0.034	3.498ProVal: 3.498 ± 0.03	0.727ProTrp: 0.727 ± 0.012	1.462ProTyr: 1.462 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.34GlnAla: 3.34 ± 0.027	0.424GlnCys: 0.424 ± 0.01	1.931GlnAsp: 1.931 ± 0.021	2.305GlnGlu: 2.305 ± 0.022	1.259GlnPhe: 1.259 ± 0.015	2.522GlnGly: 2.522 ± 0.024	0.973GlnHis: 0.973 ± 0.016	1.867GlnIle: 1.867 ± 0.02	1.947GlnLys: 1.947 ± 0.021	3.378GlnLeu: 3.378 ± 0.03	0.844GlnMet: 0.844 ± 0.014	1.555GlnAsn: 1.555 ± 0.019	2.382GlnPro: 2.382 ± 0.031	2.42GlnGln: 2.42 ± 0.049	2.485GlnArg: 2.485 ± 0.024	2.897GlnSer: 2.897 ± 0.027	2.253GlnThr: 2.253 ± 0.025	2.066GlnVal: 2.066 ± 0.022	0.558GlnTrp: 0.558 ± 0.01	1.185GlnTyr: 1.185 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.706ArgAla: 4.706 ± 0.037	0.675ArgCys: 0.675 ± 0.013	3.268ArgAsp: 3.268 ± 0.034	3.837ArgGlu: 3.837 ± 0.039	1.948ArgPhe: 1.948 ± 0.018	3.9ArgGly: 3.9 ± 0.039	1.45ArgHis: 1.45 ± 0.019	2.815ArgIle: 2.815 ± 0.023	3.309ArgLys: 3.309 ± 0.031	5.014ArgLeu: 5.014 ± 0.032	1.228ArgMet: 1.228 ± 0.015	2.21ArgAsn: 2.21 ± 0.021	3.199ArgPro: 3.199 ± 0.035	2.443ArgGln: 2.443 ± 0.026	4.769ArgArg: 4.769 ± 0.046	4.399ArgSer: 4.399 ± 0.042	3.2ArgThr: 3.2 ± 0.025	3.257ArgVal: 3.257 ± 0.026	0.839ArgTrp: 0.839 ± 0.013	1.543ArgTyr: 1.543 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.661SerAla: 6.661 ± 0.036	0.874SerCys: 0.874 ± 0.016	4.167SerAsp: 4.167 ± 0.034	4.066SerGlu: 4.066 ± 0.032	2.908SerPhe: 2.908 ± 0.024	5.709SerGly: 5.709 ± 0.043	1.837SerHis: 1.837 ± 0.022	4.149SerIle: 4.149 ± 0.027	3.829SerLys: 3.829 ± 0.033	6.982SerLeu: 6.982 ± 0.042	1.674SerMet: 1.674 ± 0.02	3.076SerAsn: 3.076 ± 0.026	5.371SerPro: 5.371 ± 0.048	3.134SerGln: 3.134 ± 0.033	4.634SerArg: 4.634 ± 0.04	8.152SerSer: 8.152 ± 0.063	5.63SerThr: 5.63 ± 0.042	4.494SerVal: 4.494 ± 0.029	1.104SerTrp: 1.104 ± 0.016	2.088SerTyr: 2.088 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.45ThrAla: 5.45 ± 0.034	0.767ThrCys: 0.767 ± 0.013	2.923ThrAsp: 2.923 ± 0.026	3.2ThrGlu: 3.2 ± 0.028	2.233ThrPhe: 2.233 ± 0.021	4.361ThrGly: 4.361 ± 0.033	1.24ThrHis: 1.24 ± 0.016	3.314ThrIle: 3.314 ± 0.028	2.772ThrLys: 2.772 ± 0.025	5.256ThrLeu: 5.256 ± 0.034	1.245ThrMet: 1.245 ± 0.016	2.229ThrAsn: 2.229 ± 0.021	4.446ThrPro: 4.446 ± 0.039	2.061ThrGln: 2.061 ± 0.02	2.993ThrArg: 2.993 ± 0.026	5.382ThrSer: 5.382 ± 0.036	4.727ThrThr: 4.727 ± 0.043	3.756ThrVal: 3.756 ± 0.031	0.867ThrTrp: 0.867 ± 0.013	1.678ThrTyr: 1.678 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.646ValAla: 5.646 ± 0.046	0.791ValCys: 0.791 ± 0.011	3.788ValAsp: 3.788 ± 0.03	4.141ValGlu: 4.141 ± 0.036	2.376ValPhe: 2.376 ± 0.023	4.3ValGly: 4.3 ± 0.037	1.284ValHis: 1.284 ± 0.016	3.047ValIle: 3.047 ± 0.028	3.035ValLys: 3.035 ± 0.025	5.489ValLeu: 5.489 ± 0.035	1.348ValMet: 1.348 ± 0.016	2.263ValAsn: 2.263 ± 0.021	3.441ValPro: 3.441 ± 0.027	2.268ValGln: 2.268 ± 0.023	3.26ValArg: 3.26 ± 0.027	4.486ValSer: 4.486 ± 0.031	3.59ValThr: 3.59 ± 0.03	4.588ValVal: 4.588 ± 0.041	0.856ValTrp: 0.856 ± 0.014	1.703ValTyr: 1.703 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.179TrpAla: 1.179 ± 0.016	0.189TrpCys: 0.189 ± 0.006	0.877TrpAsp: 0.877 ± 0.014	0.866TrpGlu: 0.866 ± 0.013	0.526TrpPhe: 0.526 ± 0.011	1.017TrpGly: 1.017 ± 0.017	0.329TrpHis: 0.329 ± 0.009	0.733TrpIle: 0.733 ± 0.011	0.788TrpLys: 0.788 ± 0.015	1.284TrpLeu: 1.284 ± 0.017	0.367TrpMet: 0.367 ± 0.008	0.618TrpAsn: 0.618 ± 0.01	0.585TrpPro: 0.585 ± 0.01	0.527TrpGln: 0.527 ± 0.01	0.894TrpArg: 0.894 ± 0.014	1.037TrpSer: 1.037 ± 0.015	0.888TrpThr: 0.888 ± 0.013	0.913TrpVal: 0.913 ± 0.014	0.266TrpTrp: 0.266 ± 0.007	0.413TrpTyr: 0.413 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.194TyrAla: 2.194 ± 0.025	0.412TyrCys: 0.412 ± 0.01	1.66TyrAsp: 1.66 ± 0.019	1.544TyrGlu: 1.544 ± 0.018	1.182TyrPhe: 1.182 ± 0.016	2.161TyrGly: 2.161 ± 0.025	0.698TyrHis: 0.698 ± 0.013	1.48TyrIle: 1.48 ± 0.017	1.194TyrLys: 1.194 ± 0.014	2.592TyrLeu: 2.592 ± 0.026	0.612TyrMet: 0.612 ± 0.012	1.227TyrAsn: 1.227 ± 0.016	1.462TyrPro: 1.462 ± 0.018	1.091TyrGln: 1.091 ± 0.016	1.525TyrArg: 1.525 ± 0.015	2.133TyrSer: 2.133 ± 0.021	1.665TyrThr: 1.665 ± 0.015	1.604TyrVal: 1.604 ± 0.017	0.419TyrTrp: 0.419 ± 0.01	0.951TyrTyr: 0.951 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10628 proteins (5361737 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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