Amino acid dipepetide frequency for Janthinobacterium sp. KBS0711

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.817AlaAla: 17.817 ± 0.172	1.359AlaCys: 1.359 ± 0.031	6.389AlaAsp: 6.389 ± 0.059	5.877AlaGlu: 5.877 ± 0.075	3.98AlaPhe: 3.98 ± 0.052	10.591AlaGly: 10.591 ± 0.091	2.54AlaHis: 2.54 ± 0.041	6.112AlaIle: 6.112 ± 0.061	4.218AlaLys: 4.218 ± 0.068	14.437AlaLeu: 14.437 ± 0.122	3.748AlaMet: 3.748 ± 0.049	3.216AlaAsn: 3.216 ± 0.047	6.354AlaPro: 6.354 ± 0.09	6.362AlaGln: 6.362 ± 0.075	7.988AlaArg: 7.988 ± 0.08	7.615AlaSer: 7.615 ± 0.075	6.269AlaThr: 6.269 ± 0.079	8.466AlaVal: 8.466 ± 0.082	1.786AlaTrp: 1.786 ± 0.036	2.971AlaTyr: 2.971 ± 0.036	0.01AlaXaa: 0.01 ± 0.002
Cys	1.247CysAla: 1.247 ± 0.029	0.134CysCys: 0.134 ± 0.009	0.498CysAsp: 0.498 ± 0.017	0.421CysGlu: 0.421 ± 0.014	0.32CysPhe: 0.32 ± 0.014	0.923CysGly: 0.923 ± 0.022	0.261CysHis: 0.261 ± 0.013	0.408CysIle: 0.408 ± 0.017	0.237CysLys: 0.237 ± 0.013	0.905CysLeu: 0.905 ± 0.022	0.226CysMet: 0.226 ± 0.012	0.222CysAsn: 0.222 ± 0.012	0.401CysPro: 0.401 ± 0.015	0.309CysGln: 0.309 ± 0.013	0.527CysArg: 0.527 ± 0.02	0.508CysSer: 0.508 ± 0.017	0.419CysThr: 0.419 ± 0.016	0.661CysVal: 0.661 ± 0.021	0.137CysTrp: 0.137 ± 0.008	0.235CysTyr: 0.235 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.096AspAla: 7.096 ± 0.064	0.466AspCys: 0.466 ± 0.015	2.881AspAsp: 2.881 ± 0.048	2.838AspGlu: 2.838 ± 0.045	2.126AspPhe: 2.126 ± 0.032	5.073AspGly: 5.073 ± 0.069	0.984AspHis: 0.984 ± 0.028	2.86AspIle: 2.86 ± 0.04	2.13AspLys: 2.13 ± 0.038	4.985AspLeu: 4.985 ± 0.055	1.326AspMet: 1.326 ± 0.026	1.586AspAsn: 1.586 ± 0.029	2.492AspPro: 2.492 ± 0.036	1.642AspGln: 1.642 ± 0.037	2.456AspArg: 2.456 ± 0.038	2.7AspSer: 2.7 ± 0.04	2.747AspThr: 2.747 ± 0.038	3.911AspVal: 3.911 ± 0.046	0.871AspTrp: 0.871 ± 0.02	1.613AspTyr: 1.613 ± 0.03	0.001AspXaa: 0.001 ± 0.001
Glu	5.874GluAla: 5.874 ± 0.076	0.339GluCys: 0.339 ± 0.016	1.944GluAsp: 1.944 ± 0.037	2.636GluGlu: 2.636 ± 0.052	1.634GluPhe: 1.634 ± 0.032	3.169GluGly: 3.169 ± 0.049	1.361GluHis: 1.361 ± 0.03	2.49GluIle: 2.49 ± 0.035	2.149GluLys: 2.149 ± 0.049	5.704GluLeu: 5.704 ± 0.066	1.263GluMet: 1.263 ± 0.027	1.491GluAsn: 1.491 ± 0.029	1.872GluPro: 1.872 ± 0.034	3.057GluGln: 3.057 ± 0.048	3.973GluArg: 3.973 ± 0.049	2.286GluSer: 2.286 ± 0.036	2.518GluThr: 2.518 ± 0.037	3.386GluVal: 3.386 ± 0.043	0.679GluTrp: 0.679 ± 0.02	1.148GluTyr: 1.148 ± 0.026	0.001GluXaa: 0.001 ± 0.001
Phe	4.133PheAla: 4.133 ± 0.056	0.4PheCys: 0.4 ± 0.016	2.466PheAsp: 2.466 ± 0.041	1.772PheGlu: 1.772 ± 0.032	1.429PhePhe: 1.429 ± 0.035	3.293PheGly: 3.293 ± 0.053	0.74PheHis: 0.74 ± 0.019	1.799PheIle: 1.799 ± 0.031	1.243PheLys: 1.243 ± 0.03	3.262PheLeu: 3.262 ± 0.042	0.841PheMet: 0.841 ± 0.021	1.238PheAsn: 1.238 ± 0.03	1.468PhePro: 1.468 ± 0.032	1.176PheGln: 1.176 ± 0.023	1.724PheArg: 1.724 ± 0.031	2.446PheSer: 2.446 ± 0.041	2.022PheThr: 2.022 ± 0.035	2.53PheVal: 2.53 ± 0.04	0.483PheTrp: 0.483 ± 0.019	1.025PheTyr: 1.025 ± 0.026	0.001PheXaa: 0.001 ± 0.001
Gly	9.219GlyAla: 9.219 ± 0.091	0.813GlyCys: 0.813 ± 0.022	3.949GlyAsp: 3.949 ± 0.048	4.051GlyGlu: 4.051 ± 0.05	3.067GlyPhe: 3.067 ± 0.044	6.675GlyGly: 6.675 ± 0.084	1.809GlyHis: 1.809 ± 0.036	4.185GlyIle: 4.185 ± 0.052	4.106GlyLys: 4.106 ± 0.063	8.332GlyLeu: 8.332 ± 0.073	2.467GlyMet: 2.467 ± 0.041	2.574GlyAsn: 2.574 ± 0.047	2.575GlyPro: 2.575 ± 0.041	3.463GlyGln: 3.463 ± 0.05	4.517GlyArg: 4.517 ± 0.054	4.775GlySer: 4.775 ± 0.063	4.348GlyThr: 4.348 ± 0.077	6.233GlyVal: 6.233 ± 0.063	1.292GlyTrp: 1.292 ± 0.031	2.442GlyTyr: 2.442 ± 0.037	0.004GlyXaa: 0.004 ± 0.001
His	2.975HisAla: 2.975 ± 0.04	0.276HisCys: 0.276 ± 0.013	1.28HisAsp: 1.28 ± 0.025	1.049HisGlu: 1.049 ± 0.023	0.95HisPhe: 0.95 ± 0.024	2.222HisGly: 2.222 ± 0.038	0.594HisHis: 0.594 ± 0.017	1.052HisIle: 1.052 ± 0.026	0.632HisLys: 0.632 ± 0.021	2.162HisLeu: 2.162 ± 0.035	0.503HisMet: 0.503 ± 0.015	0.538HisAsn: 0.538 ± 0.02	1.271HisPro: 1.271 ± 0.028	0.773HisGln: 0.773 ± 0.021	1.158HisArg: 1.158 ± 0.027	1.125HisSer: 1.125 ± 0.026	1.031HisThr: 1.031 ± 0.024	1.54HisVal: 1.54 ± 0.027	0.344HisTrp: 0.344 ± 0.015	0.702HisTyr: 0.702 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.778IleAla: 6.778 ± 0.068	0.453IleCys: 0.453 ± 0.016	3.456IleAsp: 3.456 ± 0.047	2.899IleGlu: 2.899 ± 0.041	1.559IlePhe: 1.559 ± 0.033	4.351IleGly: 4.351 ± 0.054	0.894IleHis: 0.894 ± 0.024	2.126IleIle: 2.126 ± 0.04	1.808IleLys: 1.808 ± 0.031	4.069IleLeu: 4.069 ± 0.05	0.948IleMet: 0.948 ± 0.028	1.632IleAsn: 1.632 ± 0.029	2.023IlePro: 2.023 ± 0.039	1.144IleGln: 1.144 ± 0.025	2.446IleArg: 2.446 ± 0.041	2.913IleSer: 2.913 ± 0.047	2.724IleThr: 2.724 ± 0.037	3.857IleVal: 3.857 ± 0.044	0.477IleTrp: 0.477 ± 0.019	1.086IleTyr: 1.086 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.176LysAla: 4.176 ± 0.06	0.171LysCys: 0.171 ± 0.011	1.765LysAsp: 1.765 ± 0.039	1.778LysGlu: 1.778 ± 0.031	1.049LysPhe: 1.049 ± 0.025	2.441LysGly: 2.441 ± 0.043	0.756LysHis: 0.756 ± 0.021	1.856LysIle: 1.856 ± 0.031	1.704LysLys: 1.704 ± 0.036	4.156LysLeu: 4.156 ± 0.054	1.08LysMet: 1.08 ± 0.024	1.308LysAsn: 1.308 ± 0.03	2.117LysPro: 2.117 ± 0.052	1.622LysGln: 1.622 ± 0.03	2.155LysArg: 2.155 ± 0.036	1.953LysSer: 1.953 ± 0.032	2.118LysThr: 2.118 ± 0.036	2.936LysVal: 2.936 ± 0.039	0.351LysTrp: 0.351 ± 0.015	0.801LysTyr: 0.801 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.613LeuAla: 15.613 ± 0.125	1.078LeuCys: 1.078 ± 0.024	6.041LeuAsp: 6.041 ± 0.06	5.122LeuGlu: 5.122 ± 0.061	3.689LeuPhe: 3.689 ± 0.051	8.234LeuGly: 8.234 ± 0.075	2.479LeuHis: 2.479 ± 0.043	4.574LeuIle: 4.574 ± 0.055	3.623LeuLys: 3.623 ± 0.05	12.256LeuLeu: 12.256 ± 0.127	2.541LeuMet: 2.541 ± 0.039	3.115LeuAsn: 3.115 ± 0.045	6.228LeuPro: 6.228 ± 0.066	4.522LeuGln: 4.522 ± 0.06	7.342LeuArg: 7.342 ± 0.081	6.579LeuSer: 6.579 ± 0.067	5.455LeuThr: 5.455 ± 0.054	7.038LeuVal: 7.038 ± 0.077	1.203LeuTrp: 1.203 ± 0.028	2.383LeuTyr: 2.383 ± 0.037	0.001LeuXaa: 0.001 ± 0.001
Met	3.167MetAla: 3.167 ± 0.046	0.156MetCys: 0.156 ± 0.011	1.17MetAsp: 1.17 ± 0.032	1.131MetGlu: 1.131 ± 0.026	0.739MetPhe: 0.739 ± 0.022	1.791MetGly: 1.791 ± 0.034	0.632MetHis: 0.632 ± 0.015	1.05MetIle: 1.05 ± 0.026	1.056MetLys: 1.056 ± 0.024	3.139MetLeu: 3.139 ± 0.039	0.683MetMet: 0.683 ± 0.023	0.901MetAsn: 0.901 ± 0.022	1.542MetPro: 1.542 ± 0.03	1.315MetGln: 1.315 ± 0.027	1.756MetArg: 1.756 ± 0.029	1.58MetSer: 1.58 ± 0.028	1.6MetThr: 1.6 ± 0.027	1.684MetVal: 1.684 ± 0.032	0.205MetTrp: 0.205 ± 0.01	0.443MetTyr: 0.443 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.566AsnAla: 3.566 ± 0.053	0.264AsnCys: 0.264 ± 0.012	1.518AsnAsp: 1.518 ± 0.032	1.312AsnGlu: 1.312 ± 0.029	1.074AsnPhe: 1.074 ± 0.028	2.728AsnGly: 2.728 ± 0.05	0.566AsnHis: 0.566 ± 0.018	1.583AsnIle: 1.583 ± 0.029	1.086AsnLys: 1.086 ± 0.027	3.036AsnLeu: 3.036 ± 0.045	0.741AsnMet: 0.741 ± 0.019	1.014AsnAsn: 1.014 ± 0.026	1.731AsnPro: 1.731 ± 0.035	1.014AsnGln: 1.014 ± 0.025	1.613AsnArg: 1.613 ± 0.031	1.566AsnSer: 1.566 ± 0.036	1.752AsnThr: 1.752 ± 0.035	2.246AsnVal: 2.246 ± 0.044	0.455AsnTrp: 0.455 ± 0.015	0.899AsnTyr: 0.899 ± 0.028	0.001AsnXaa: 0.001 ± 0.001
Pro	7.102ProAla: 7.102 ± 0.093	0.337ProCys: 0.337 ± 0.015	2.964ProAsp: 2.964 ± 0.042	2.764ProGlu: 2.764 ± 0.041	1.793ProPhe: 1.793 ± 0.027	4.141ProGly: 4.141 ± 0.048	1.027ProHis: 1.027 ± 0.024	1.83ProIle: 1.83 ± 0.031	1.473ProLys: 1.473 ± 0.033	5.244ProLeu: 5.244 ± 0.063	1.14ProMet: 1.14 ± 0.027	1.337ProAsn: 1.337 ± 0.028	2.481ProPro: 2.481 ± 0.05	2.327ProGln: 2.327 ± 0.036	2.475ProArg: 2.475 ± 0.042	2.55ProSer: 2.55 ± 0.038	2.203ProThr: 2.203 ± 0.048	4.043ProVal: 4.043 ± 0.063	0.642ProTrp: 0.642 ± 0.019	1.19ProTyr: 1.19 ± 0.026	0.004ProXaa: 0.004 ± 0.001
Gln	6.063GlnAla: 6.063 ± 0.076	0.282GlnCys: 0.282 ± 0.012	1.869GlnAsp: 1.869 ± 0.032	1.943GlnGlu: 1.943 ± 0.042	1.529GlnPhe: 1.529 ± 0.033	3.124GlnGly: 3.124 ± 0.048	1.096GlnHis: 1.096 ± 0.023	1.962GlnIle: 1.962 ± 0.034	1.275GlnLys: 1.275 ± 0.031	5.074GlnLeu: 5.074 ± 0.069	1.104GlnMet: 1.104 ± 0.024	1.09GlnAsn: 1.09 ± 0.024	2.161GlnPro: 2.161 ± 0.034	2.584GlnGln: 2.584 ± 0.044	3.278GlnArg: 3.278 ± 0.052	2.083GlnSer: 2.083 ± 0.034	1.995GlnThr: 1.995 ± 0.032	3.204GlnVal: 3.204 ± 0.048	0.61GlnTrp: 0.61 ± 0.017	1.008GlnTyr: 1.008 ± 0.028	0.001GlnXaa: 0.001 ± 0.001
Arg	6.996ArgAla: 6.996 ± 0.064	0.506ArgCys: 0.506 ± 0.017	3.401ArgAsp: 3.401 ± 0.053	3.381ArgGlu: 3.381 ± 0.054	2.36ArgPhe: 2.36 ± 0.04	3.989ArgGly: 3.989 ± 0.052	1.775ArgHis: 1.775 ± 0.037	3.242ArgIle: 3.242 ± 0.04	2.155ArgLys: 2.155 ± 0.037	7.079ArgLeu: 7.079 ± 0.072	1.66ArgMet: 1.66 ± 0.034	1.815ArgAsn: 1.815 ± 0.029	2.619ArgPro: 2.619 ± 0.039	3.217ArgGln: 3.217 ± 0.059	4.241ArgArg: 4.241 ± 0.075	3.215ArgSer: 3.215 ± 0.044	2.79ArgThr: 2.79 ± 0.037	3.884ArgVal: 3.884 ± 0.046	0.95ArgTrp: 0.95 ± 0.025	1.967ArgTyr: 1.967 ± 0.032	0.002ArgXaa: 0.002 ± 0.001
Ser	6.654SerAla: 6.654 ± 0.071	0.495SerCys: 0.495 ± 0.017	2.875SerAsp: 2.875 ± 0.039	2.466SerGlu: 2.466 ± 0.045	2.168SerPhe: 2.168 ± 0.036	5.347SerGly: 5.347 ± 0.075	1.233SerHis: 1.233 ± 0.026	2.816SerIle: 2.816 ± 0.041	2.003SerLys: 2.003 ± 0.033	6.411SerLeu: 6.411 ± 0.07	1.529SerMet: 1.529 ± 0.031	1.781SerAsn: 1.781 ± 0.033	2.663SerPro: 2.663 ± 0.037	1.993SerGln: 1.993 ± 0.034	3.169SerArg: 3.169 ± 0.04	3.526SerSer: 3.526 ± 0.052	3.142SerThr: 3.142 ± 0.055	4.179SerVal: 4.179 ± 0.053	0.817SerTrp: 0.817 ± 0.022	1.66SerTyr: 1.66 ± 0.035	0.003SerXaa: 0.003 ± 0.001
Thr	6.183ThrAla: 6.183 ± 0.072	0.392ThrCys: 0.392 ± 0.016	2.568ThrAsp: 2.568 ± 0.042	2.193ThrGlu: 2.193 ± 0.034	1.82ThrPhe: 1.82 ± 0.032	4.715ThrGly: 4.715 ± 0.069	1.111ThrHis: 1.111 ± 0.026	2.529ThrIle: 2.529 ± 0.04	1.353ThrLys: 1.353 ± 0.031	6.031ThrLeu: 6.031 ± 0.065	1.243ThrMet: 1.243 ± 0.028	1.331ThrAsn: 1.331 ± 0.033	3.55ThrPro: 3.55 ± 0.062	2.1ThrGln: 2.1 ± 0.035	2.977ThrArg: 2.977 ± 0.049	2.897ThrSer: 2.897 ± 0.044	2.764ThrThr: 2.764 ± 0.056	4.356ThrVal: 4.356 ± 0.06	0.621ThrTrp: 0.621 ± 0.018	1.33ThrTyr: 1.33 ± 0.034	0.002ThrXaa: 0.002 ± 0.001
Val	9.211ValAla: 9.211 ± 0.082	0.673ValCys: 0.673 ± 0.021	3.714ValAsp: 3.714 ± 0.044	3.706ValGlu: 3.706 ± 0.047	2.615ValPhe: 2.615 ± 0.044	5.085ValGly: 5.085 ± 0.057	1.419ValHis: 1.419 ± 0.032	3.549ValIle: 3.549 ± 0.054	2.66ValLys: 2.66 ± 0.037	8.116ValLeu: 8.116 ± 0.079	1.808ValMet: 1.808 ± 0.034	2.344ValAsn: 2.344 ± 0.044	3.639ValPro: 3.639 ± 0.052	2.749ValGln: 2.749 ± 0.037	4.501ValArg: 4.501 ± 0.052	4.329ValSer: 4.329 ± 0.057	4.087ValThr: 4.087 ± 0.054	5.257ValVal: 5.257 ± 0.061	0.851ValTrp: 0.851 ± 0.023	1.657ValTyr: 1.657 ± 0.031	0.001ValXaa: 0.001 ± 0.0
Trp	1.086TrpAla: 1.086 ± 0.027	0.131TrpCys: 0.131 ± 0.009	0.619TrpAsp: 0.619 ± 0.02	0.511TrpGlu: 0.511 ± 0.017	0.509TrpPhe: 0.509 ± 0.018	0.827TrpGly: 0.827 ± 0.024	0.364TrpHis: 0.364 ± 0.014	0.649TrpIle: 0.649 ± 0.021	0.491TrpLys: 0.491 ± 0.018	1.975TrpLeu: 1.975 ± 0.038	0.394TrpMet: 0.394 ± 0.015	0.459TrpAsn: 0.459 ± 0.014	0.617TrpPro: 0.617 ± 0.019	0.817TrpGln: 0.817 ± 0.023	1.135TrpArg: 1.135 ± 0.028	0.828TrpSer: 0.828 ± 0.024	0.67TrpThr: 0.67 ± 0.019	0.763TrpVal: 0.763 ± 0.022	0.238TrpTrp: 0.238 ± 0.012	0.328TrpTyr: 0.328 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.144TyrAla: 3.144 ± 0.039	0.272TyrCys: 0.272 ± 0.013	1.417TyrAsp: 1.417 ± 0.032	1.122TyrGlu: 1.122 ± 0.026	1.081TyrPhe: 1.081 ± 0.025	2.174TyrGly: 2.174 ± 0.033	0.538TyrHis: 0.538 ± 0.018	0.973TyrIle: 0.973 ± 0.022	0.89TyrLys: 0.89 ± 0.026	2.745TyrLeu: 2.745 ± 0.041	0.495TyrMet: 0.495 ± 0.015	0.775TyrAsn: 0.775 ± 0.022	1.251TyrPro: 1.251 ± 0.029	1.147TyrGln: 1.147 ± 0.027	1.806TyrArg: 1.806 ± 0.031	1.457TyrSer: 1.457 ± 0.033	1.407TyrThr: 1.407 ± 0.029	1.796TyrVal: 1.796 ± 0.031	0.399TyrTrp: 0.399 ± 0.014	0.769TyrTyr: 0.769 ± 0.023	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.004XaaAla: 0.004 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.004XaaGly: 0.004 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.007XaaPro: 0.007 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.005XaaArg: 0.005 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.313XaaXaa: 0.313 ± 0.043

Statistics based on 5384 proteins (1820683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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