Amino acid dipepetide frequency for Franconibacter pulveris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.815AlaAla: 11.815 ± 0.144	1.161AlaCys: 1.161 ± 0.031	5.006AlaAsp: 5.006 ± 0.064	5.841AlaGlu: 5.841 ± 0.077	3.951AlaPhe: 3.951 ± 0.063	8.241AlaGly: 8.241 ± 0.111	1.915AlaHis: 1.915 ± 0.039	5.75AlaIle: 5.75 ± 0.069	3.914AlaLys: 3.914 ± 0.071	13.131AlaLeu: 13.131 ± 0.125	3.055AlaMet: 3.055 ± 0.052	3.096AlaAsn: 3.096 ± 0.061	4.239AlaPro: 4.239 ± 0.066	5.337AlaGln: 5.337 ± 0.069	6.447AlaArg: 6.447 ± 0.075	6.007AlaSer: 6.007 ± 0.075	5.017AlaThr: 5.017 ± 0.063	7.259AlaVal: 7.259 ± 0.087	1.857AlaTrp: 1.857 ± 0.038	2.068AlaTyr: 2.068 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.032CysAla: 1.032 ± 0.027	0.167CysCys: 0.167 ± 0.011	0.568CysAsp: 0.568 ± 0.024	0.622CysGlu: 0.622 ± 0.024	0.449CysPhe: 0.449 ± 0.021	1.053CysGly: 1.053 ± 0.034	0.291CysHis: 0.291 ± 0.015	0.501CysIle: 0.501 ± 0.019	0.291CysLys: 0.291 ± 0.016	0.974CysLeu: 0.974 ± 0.032	0.221CysMet: 0.221 ± 0.012	0.3CysAsn: 0.3 ± 0.014	0.487CysPro: 0.487 ± 0.02	0.435CysGln: 0.435 ± 0.019	0.646CysArg: 0.646 ± 0.026	0.568CysSer: 0.568 ± 0.02	0.446CysThr: 0.446 ± 0.018	0.696CysVal: 0.696 ± 0.023	0.191CysTrp: 0.191 ± 0.01	0.303CysTyr: 0.303 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.347AspAla: 5.347 ± 0.066	0.484AspCys: 0.484 ± 0.02	2.806AspAsp: 2.806 ± 0.045	3.673AspGlu: 3.673 ± 0.061	2.094AspPhe: 2.094 ± 0.039	3.705AspGly: 3.705 ± 0.065	0.901AspHis: 0.901 ± 0.023	3.144AspIle: 3.144 ± 0.044	2.35AspLys: 2.35 ± 0.051	4.512AspLeu: 4.512 ± 0.061	1.272AspMet: 1.272 ± 0.033	2.123AspAsn: 2.123 ± 0.052	2.292AspPro: 2.292 ± 0.042	1.495AspGln: 1.495 ± 0.04	2.648AspArg: 2.648 ± 0.051	2.574AspSer: 2.574 ± 0.047	2.395AspThr: 2.395 ± 0.043	3.619AspVal: 3.619 ± 0.054	0.834AspTrp: 0.834 ± 0.025	1.937AspTyr: 1.937 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.29GluAla: 6.29 ± 0.083	0.437GluCys: 0.437 ± 0.018	2.232GluAsp: 2.232 ± 0.044	3.69GluGlu: 3.69 ± 0.067	1.762GluPhe: 1.762 ± 0.042	3.896GluGly: 3.896 ± 0.055	1.349GluHis: 1.349 ± 0.031	3.145GluIle: 3.145 ± 0.059	3.271GluLys: 3.271 ± 0.058	5.864GluLeu: 5.864 ± 0.079	1.823GluMet: 1.823 ± 0.035	2.317GluAsn: 2.317 ± 0.044	2.315GluPro: 2.315 ± 0.045	3.563GluGln: 3.563 ± 0.064	3.957GluArg: 3.957 ± 0.06	2.884GluSer: 2.884 ± 0.049	3.094GluThr: 3.094 ± 0.046	3.859GluVal: 3.859 ± 0.067	0.806GluTrp: 0.806 ± 0.022	1.357GluTyr: 1.357 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.992PheAla: 3.992 ± 0.061	0.514PheCys: 0.514 ± 0.019	2.287PheAsp: 2.287 ± 0.047	1.718PheGlu: 1.718 ± 0.041	1.641PhePhe: 1.641 ± 0.042	3.18PheGly: 3.18 ± 0.049	0.814PheHis: 0.814 ± 0.029	2.479PheIle: 2.479 ± 0.045	1.164PheLys: 1.164 ± 0.032	3.312PheLeu: 3.312 ± 0.058	0.966PheMet: 0.966 ± 0.027	1.648PheAsn: 1.648 ± 0.031	1.565PhePro: 1.565 ± 0.038	1.165PheGln: 1.165 ± 0.027	1.962PheArg: 1.962 ± 0.034	2.964PheSer: 2.964 ± 0.05	2.489PheThr: 2.489 ± 0.044	2.416PheVal: 2.416 ± 0.045	0.664PheTrp: 0.664 ± 0.025	1.229PheTyr: 1.229 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.899GlyAla: 6.899 ± 0.11	0.984GlyCys: 0.984 ± 0.031	3.793GlyAsp: 3.793 ± 0.059	4.988GlyGlu: 4.988 ± 0.07	3.317GlyPhe: 3.317 ± 0.048	5.63GlyGly: 5.63 ± 0.139	1.64GlyHis: 1.64 ± 0.038	4.589GlyIle: 4.589 ± 0.064	3.854GlyLys: 3.854 ± 0.058	7.76GlyLeu: 7.76 ± 0.091	2.329GlyMet: 2.329 ± 0.043	2.646GlyAsn: 2.646 ± 0.066	2.156GlyPro: 2.156 ± 0.043	2.993GlyGln: 2.993 ± 0.049	3.972GlyArg: 3.972 ± 0.062	4.092GlySer: 4.092 ± 0.059	3.57GlyThr: 3.57 ± 0.078	6.103GlyVal: 6.103 ± 0.076	1.384GlyTrp: 1.384 ± 0.033	2.639GlyTyr: 2.639 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.031HisAla: 2.031 ± 0.043	0.298HisCys: 0.298 ± 0.015	1.144HisAsp: 1.144 ± 0.031	1.153HisGlu: 1.153 ± 0.027	1.035HisPhe: 1.035 ± 0.03	1.698HisGly: 1.698 ± 0.039	0.778HisHis: 0.778 ± 0.025	1.216HisIle: 1.216 ± 0.031	0.719HisLys: 0.719 ± 0.024	2.247HisLeu: 2.247 ± 0.037	0.507HisMet: 0.507 ± 0.018	0.853HisAsn: 0.853 ± 0.029	1.334HisPro: 1.334 ± 0.033	1.049HisGln: 1.049 ± 0.028	1.262HisArg: 1.262 ± 0.031	1.166HisSer: 1.166 ± 0.032	1.041HisThr: 1.041 ± 0.022	1.295HisVal: 1.295 ± 0.031	0.4HisTrp: 0.4 ± 0.017	0.904HisTyr: 0.904 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.286IleAla: 6.286 ± 0.087	0.601IleCys: 0.601 ± 0.02	3.309IleAsp: 3.309 ± 0.054	2.999IleGlu: 2.999 ± 0.051	1.92IlePhe: 1.92 ± 0.041	4.237IleGly: 4.237 ± 0.059	1.125IleHis: 1.125 ± 0.03	3.05IleIle: 3.05 ± 0.057	2.077IleLys: 2.077 ± 0.039	4.573IleLeu: 4.573 ± 0.064	1.091IleMet: 1.091 ± 0.032	2.462IleAsn: 2.462 ± 0.048	2.43IlePro: 2.43 ± 0.043	1.634IleGln: 1.634 ± 0.036	2.848IleArg: 2.848 ± 0.049	3.414IleSer: 3.414 ± 0.051	3.324IleThr: 3.324 ± 0.054	3.684IleVal: 3.684 ± 0.062	0.646IleTrp: 0.646 ± 0.025	1.457IleTyr: 1.457 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.586LysAla: 4.586 ± 0.081	0.24LysCys: 0.24 ± 0.012	1.731LysAsp: 1.731 ± 0.04	2.375LysGlu: 2.375 ± 0.05	1.061LysPhe: 1.061 ± 0.033	2.936LysGly: 2.936 ± 0.054	0.785LysHis: 0.785 ± 0.025	2.04LysIle: 2.04 ± 0.044	1.958LysLys: 1.958 ± 0.048	4.13LysLeu: 4.13 ± 0.065	1.13LysMet: 1.13 ± 0.029	1.512LysAsn: 1.512 ± 0.037	2.23LysPro: 2.23 ± 0.048	1.816LysGln: 1.816 ± 0.038	2.583LysArg: 2.583 ± 0.048	2.095LysSer: 2.095 ± 0.036	2.47LysThr: 2.47 ± 0.041	2.891LysVal: 2.891 ± 0.046	0.42LysTrp: 0.42 ± 0.017	0.952LysTyr: 0.952 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.599LeuAla: 12.599 ± 0.135	1.305LeuCys: 1.305 ± 0.036	5.341LeuAsp: 5.341 ± 0.068	5.752LeuGlu: 5.752 ± 0.07	4.302LeuPhe: 4.302 ± 0.065	7.5LeuGly: 7.5 ± 0.087	2.304LeuHis: 2.304 ± 0.044	5.609LeuIle: 5.609 ± 0.086	4.436LeuLys: 4.436 ± 0.068	12.571LeuLeu: 12.571 ± 0.155	2.861LeuMet: 2.861 ± 0.052	4.241LeuAsn: 4.241 ± 0.061	5.913LeuPro: 5.913 ± 0.079	4.09LeuGln: 4.09 ± 0.068	6.623LeuArg: 6.623 ± 0.084	7.138LeuSer: 7.138 ± 0.068	6.481LeuThr: 6.481 ± 0.077	7.192LeuVal: 7.192 ± 0.081	1.539LeuTrp: 1.539 ± 0.042	2.637LeuTyr: 2.637 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.913MetAla: 2.913 ± 0.049	0.167MetCys: 0.167 ± 0.011	1.121MetAsp: 1.121 ± 0.029	1.247MetGlu: 1.247 ± 0.032	0.802MetPhe: 0.802 ± 0.024	1.813MetGly: 1.813 ± 0.04	0.533MetHis: 0.533 ± 0.021	1.302MetIle: 1.302 ± 0.032	1.344MetLys: 1.344 ± 0.034	3.123MetLeu: 3.123 ± 0.057	0.826MetMet: 0.826 ± 0.026	1.026MetAsn: 1.026 ± 0.028	1.334MetPro: 1.334 ± 0.033	1.237MetGln: 1.237 ± 0.031	1.514MetArg: 1.514 ± 0.032	1.774MetSer: 1.774 ± 0.042	1.687MetThr: 1.687 ± 0.038	1.905MetVal: 1.905 ± 0.036	0.248MetTrp: 0.248 ± 0.014	0.486MetTyr: 0.486 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.763AsnAla: 3.763 ± 0.057	0.309AsnCys: 0.309 ± 0.015	2.034AsnAsp: 2.034 ± 0.043	1.948AsnGlu: 1.948 ± 0.041	1.238AsnPhe: 1.238 ± 0.039	3.082AsnGly: 3.082 ± 0.067	0.811AsnHis: 0.811 ± 0.026	2.021AsnIle: 2.021 ± 0.042	1.393AsnLys: 1.393 ± 0.034	3.431AsnLeu: 3.431 ± 0.054	0.828AsnMet: 0.828 ± 0.024	1.497AsnAsn: 1.497 ± 0.039	2.124AsnPro: 2.124 ± 0.041	1.514AsnGln: 1.514 ± 0.032	2.097AsnArg: 2.097 ± 0.037	1.862AsnSer: 1.862 ± 0.048	1.836AsnThr: 1.836 ± 0.047	2.502AsnVal: 2.502 ± 0.051	0.566AsnTrp: 0.566 ± 0.023	1.164AsnTyr: 1.164 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.084ProAla: 5.084 ± 0.081	0.382ProCys: 0.382 ± 0.016	2.854ProAsp: 2.854 ± 0.048	3.404ProGlu: 3.404 ± 0.053	1.887ProPhe: 1.887 ± 0.037	3.734ProGly: 3.734 ± 0.06	1.098ProHis: 1.098 ± 0.029	1.572ProIle: 1.572 ± 0.034	1.48ProLys: 1.48 ± 0.034	5.451ProLeu: 5.451 ± 0.074	1.055ProMet: 1.055 ± 0.025	1.222ProAsn: 1.222 ± 0.027	1.845ProPro: 1.845 ± 0.047	2.64ProGln: 2.64 ± 0.052	2.181ProArg: 2.181 ± 0.042	2.066ProSer: 2.066 ± 0.044	2.072ProThr: 2.072 ± 0.042	4.18ProVal: 4.18 ± 0.064	0.82ProTrp: 0.82 ± 0.025	1.167ProTyr: 1.167 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.244GlnAla: 5.244 ± 0.077	0.361GlnCys: 0.361 ± 0.017	1.718GlnAsp: 1.718 ± 0.034	2.416GlnGlu: 2.416 ± 0.046	1.394GlnPhe: 1.394 ± 0.033	3.284GlnGly: 3.284 ± 0.05	1.196GlnHis: 1.196 ± 0.032	2.117GlnIle: 2.117 ± 0.036	1.767GlnLys: 1.767 ± 0.038	4.983GlnLeu: 4.983 ± 0.076	1.213GlnMet: 1.213 ± 0.031	1.471GlnAsn: 1.471 ± 0.034	2.453GlnPro: 2.453 ± 0.055	3.326GlnGln: 3.326 ± 0.075	3.17GlnArg: 3.17 ± 0.06	2.287GlnSer: 2.287 ± 0.042	2.332GlnThr: 2.332 ± 0.049	3.027GlnVal: 3.027 ± 0.054	0.685GlnTrp: 0.685 ± 0.021	1.096GlnTyr: 1.096 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.213ArgAla: 5.213 ± 0.069	0.593ArgCys: 0.593 ± 0.025	3.1ArgAsp: 3.1 ± 0.055	4.245ArgGlu: 4.245 ± 0.069	2.743ArgPhe: 2.743 ± 0.046	3.536ArgGly: 3.536 ± 0.057	1.635ArgHis: 1.635 ± 0.037	3.266ArgIle: 3.266 ± 0.047	2.281ArgLys: 2.281 ± 0.046	7.139ArgLeu: 7.139 ± 0.09	1.597ArgMet: 1.597 ± 0.036	2.102ArgAsn: 2.102 ± 0.039	2.456ArgPro: 2.456 ± 0.052	3.202ArgGln: 3.202 ± 0.062	3.849ArgArg: 3.849 ± 0.063	2.772ArgSer: 2.772 ± 0.046	2.557ArgThr: 2.557 ± 0.038	4.043ArgVal: 4.043 ± 0.058	1.116ArgTrp: 1.116 ± 0.038	2.234ArgTyr: 2.234 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.793SerAla: 5.793 ± 0.078	0.485SerCys: 0.485 ± 0.02	2.89SerAsp: 2.89 ± 0.047	3.148SerGlu: 3.148 ± 0.045	2.209SerPhe: 2.209 ± 0.042	5.208SerGly: 5.208 ± 0.077	1.354SerHis: 1.354 ± 0.032	2.559SerIle: 2.559 ± 0.047	1.793SerLys: 1.793 ± 0.04	6.711SerLeu: 6.711 ± 0.068	1.344SerMet: 1.344 ± 0.031	1.678SerAsn: 1.678 ± 0.039	2.633SerPro: 2.633 ± 0.045	2.573SerGln: 2.573 ± 0.051	3.619SerArg: 3.619 ± 0.059	3.225SerSer: 3.225 ± 0.059	2.714SerThr: 2.714 ± 0.048	4.188SerVal: 4.188 ± 0.057	0.936SerTrp: 0.936 ± 0.03	1.504SerTyr: 1.504 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.159ThrAla: 5.159 ± 0.078	0.452ThrCys: 0.452 ± 0.017	2.501ThrAsp: 2.501 ± 0.056	2.52ThrGlu: 2.52 ± 0.049	1.992ThrPhe: 1.992 ± 0.039	4.612ThrGly: 4.612 ± 0.068	1.2ThrHis: 1.2 ± 0.029	2.582ThrIle: 2.582 ± 0.051	1.378ThrLys: 1.378 ± 0.036	7.705ThrLeu: 7.705 ± 0.086	1.091ThrMet: 1.091 ± 0.03	1.489ThrAsn: 1.489 ± 0.037	3.306ThrPro: 3.306 ± 0.063	2.195ThrGln: 2.195 ± 0.046	3.185ThrArg: 3.185 ± 0.054	2.71ThrSer: 2.71 ± 0.045	2.792ThrThr: 2.792 ± 0.055	3.958ThrVal: 3.958 ± 0.08	0.827ThrTrp: 0.827 ± 0.027	1.116ThrTyr: 1.116 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.491ValAla: 7.491 ± 0.076	0.755ValCys: 0.755 ± 0.025	3.571ValAsp: 3.571 ± 0.06	4.215ValGlu: 4.215 ± 0.06	2.544ValPhe: 2.544 ± 0.051	4.8ValGly: 4.8 ± 0.075	1.264ValHis: 1.264 ± 0.031	4.295ValIle: 4.295 ± 0.059	3.104ValLys: 3.104 ± 0.056	7.322ValLeu: 7.322 ± 0.08	2.219ValMet: 2.219 ± 0.049	2.861ValAsn: 2.861 ± 0.067	3.033ValPro: 3.033 ± 0.054	2.451ValGln: 2.451 ± 0.052	3.84ValArg: 3.84 ± 0.056	4.494ValSer: 4.494 ± 0.063	4.47ValThr: 4.47 ± 0.095	5.697ValVal: 5.697 ± 0.08	1.038ValTrp: 1.038 ± 0.032	1.721ValTyr: 1.721 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.095TrpAla: 1.095 ± 0.033	0.193TrpCys: 0.193 ± 0.014	0.639TrpAsp: 0.639 ± 0.023	0.653TrpGlu: 0.653 ± 0.025	0.693TrpPhe: 0.693 ± 0.024	0.963TrpGly: 0.963 ± 0.031	0.46TrpHis: 0.46 ± 0.018	0.645TrpIle: 0.645 ± 0.022	0.474TrpLys: 0.474 ± 0.021	2.484TrpLeu: 2.484 ± 0.053	0.395TrpMet: 0.395 ± 0.019	0.506TrpAsn: 0.506 ± 0.02	0.715TrpPro: 0.715 ± 0.026	1.227TrpGln: 1.227 ± 0.03	1.365TrpArg: 1.365 ± 0.037	0.827TrpSer: 0.827 ± 0.03	0.623TrpThr: 0.623 ± 0.021	1.002TrpVal: 1.002 ± 0.027	0.254TrpTrp: 0.254 ± 0.017	0.459TrpTyr: 0.459 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.473TyrAla: 2.473 ± 0.043	0.356TyrCys: 0.356 ± 0.017	1.56TyrAsp: 1.56 ± 0.038	1.304TyrGlu: 1.304 ± 0.03	1.134TyrPhe: 1.134 ± 0.026	2.226TyrGly: 2.226 ± 0.047	0.673TyrHis: 0.673 ± 0.023	1.283TyrIle: 1.283 ± 0.036	0.894TyrLys: 0.894 ± 0.03	3.016TyrLeu: 3.016 ± 0.045	0.579TyrMet: 0.579 ± 0.019	0.974TyrAsn: 0.974 ± 0.026	1.334TyrPro: 1.334 ± 0.035	1.595TyrGln: 1.595 ± 0.04	1.911TyrArg: 1.911 ± 0.038	1.647TyrSer: 1.647 ± 0.043	1.358TyrThr: 1.358 ± 0.033	1.669TyrVal: 1.669 ± 0.032	0.443TyrTrp: 0.443 ± 0.018	0.9TyrTyr: 0.9 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4200 proteins (1348315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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