Amino acid dipepetide frequency for Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.025AlaAla: 5.025 ± 0.043	1.178AlaCys: 1.178 ± 0.016	3.114AlaAsp: 3.114 ± 0.024	3.542AlaGlu: 3.542 ± 0.033	2.756AlaPhe: 2.756 ± 0.022	3.235AlaGly: 3.235 ± 0.028	1.609AlaHis: 1.609 ± 0.017	4.34AlaIle: 4.34 ± 0.028	3.883AlaLys: 3.883 ± 0.034	6.26AlaLeu: 6.26 ± 0.039	1.805AlaMet: 1.805 ± 0.018	2.876AlaAsn: 2.876 ± 0.027	2.734AlaPro: 2.734 ± 0.028	2.486AlaGln: 2.486 ± 0.026	3.125AlaArg: 3.125 ± 0.025	5.216AlaSer: 5.216 ± 0.034	4.122AlaThr: 4.122 ± 0.029	4.16AlaVal: 4.16 ± 0.03	0.719AlaTrp: 0.719 ± 0.013	2.152AlaTyr: 2.152 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.935CysAla: 0.935 ± 0.016	0.378CysCys: 0.378 ± 0.009	0.835CysAsp: 0.835 ± 0.013	0.803CysGlu: 0.803 ± 0.012	0.813CysPhe: 0.813 ± 0.012	1.067CysGly: 1.067 ± 0.017	0.62CysHis: 0.62 ± 0.012	1.131CysIle: 1.131 ± 0.015	0.964CysLys: 0.964 ± 0.012	1.858CysLeu: 1.858 ± 0.02	0.392CysMet: 0.392 ± 0.009	0.825CysAsn: 0.825 ± 0.014	0.868CysPro: 0.868 ± 0.013	0.686CysGln: 0.686 ± 0.012	0.885CysArg: 0.885 ± 0.012	1.372CysSer: 1.372 ± 0.015	0.984CysThr: 0.984 ± 0.015	1.046CysVal: 1.046 ± 0.015	0.206CysTrp: 0.206 ± 0.006	0.566CysTyr: 0.566 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.182AspAla: 3.182 ± 0.028	0.836AspCys: 0.836 ± 0.014	3.453AspAsp: 3.453 ± 0.03	3.856AspGlu: 3.856 ± 0.031	2.488AspPhe: 2.488 ± 0.02	2.712AspGly: 2.712 ± 0.024	1.362AspHis: 1.362 ± 0.018	4.013AspIle: 4.013 ± 0.03	2.875AspLys: 2.875 ± 0.023	4.923AspLeu: 4.923 ± 0.033	1.515AspMet: 1.515 ± 0.017	2.683AspAsn: 2.683 ± 0.027	2.648AspPro: 2.648 ± 0.024	2.117AspGln: 2.117 ± 0.02	2.473AspArg: 2.473 ± 0.021	4.025AspSer: 4.025 ± 0.031	3.22AspThr: 3.22 ± 0.026	3.234AspVal: 3.234 ± 0.025	0.689AspTrp: 0.689 ± 0.011	1.958AspTyr: 1.958 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	3.944GluAla: 3.944 ± 0.034	0.879GluCys: 0.879 ± 0.013	3.914GluAsp: 3.914 ± 0.029	5.077GluGlu: 5.077 ± 0.047	2.238GluPhe: 2.238 ± 0.017	2.538GluGly: 2.538 ± 0.024	1.452GluHis: 1.452 ± 0.017	3.696GluIle: 3.696 ± 0.026	4.176GluLys: 4.176 ± 0.035	5.14GluLeu: 5.14 ± 0.036	1.536GluMet: 1.536 ± 0.017	3.118GluAsn: 3.118 ± 0.025	2.156GluPro: 2.156 ± 0.023	2.446GluGln: 2.446 ± 0.027	3.309GluArg: 3.309 ± 0.026	4.315GluSer: 4.315 ± 0.029	3.49GluThr: 3.49 ± 0.028	3.15GluVal: 3.15 ± 0.028	0.765GluTrp: 0.765 ± 0.012	2.14GluTyr: 2.14 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.568PheAla: 2.568 ± 0.024	0.924PheCys: 0.924 ± 0.013	2.553PheAsp: 2.553 ± 0.019	2.541PheGlu: 2.541 ± 0.024	1.995PhePhe: 1.995 ± 0.022	2.795PheGly: 2.795 ± 0.026	1.043PheHis: 1.043 ± 0.019	2.489PheIle: 2.489 ± 0.023	2.26PheLys: 2.26 ± 0.02	4.058PheLeu: 4.058 ± 0.03	1.018PheMet: 1.018 ± 0.013	1.887PheAsn: 1.887 ± 0.02	1.86PhePro: 1.86 ± 0.023	1.586PheGln: 1.586 ± 0.019	1.864PheArg: 1.864 ± 0.018	3.645PheSer: 3.645 ± 0.025	2.368PheThr: 2.368 ± 0.021	2.944PheVal: 2.944 ± 0.026	0.623PheTrp: 0.623 ± 0.01	1.513PheTyr: 1.513 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	3.057GlyAla: 3.057 ± 0.028	0.946GlyCys: 0.946 ± 0.015	2.469GlyAsp: 2.469 ± 0.02	2.653GlyGlu: 2.653 ± 0.023	2.494GlyPhe: 2.494 ± 0.021	3.138GlyGly: 3.138 ± 0.036	1.496GlyHis: 1.496 ± 0.019	3.242GlyIle: 3.242 ± 0.029	3.077GlyLys: 3.077 ± 0.029	4.783GlyLeu: 4.783 ± 0.032	1.179GlyMet: 1.179 ± 0.014	2.337GlyAsn: 2.337 ± 0.023	2.102GlyPro: 2.102 ± 0.021	2.067GlyGln: 2.067 ± 0.023	2.727GlyArg: 2.727 ± 0.037	4.404GlySer: 4.404 ± 0.026	3.128GlyThr: 3.128 ± 0.044	3.358GlyVal: 3.358 ± 0.027	0.784GlyTrp: 0.784 ± 0.012	1.942GlyTyr: 1.942 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.538HisAla: 1.538 ± 0.019	0.561HisCys: 0.561 ± 0.009	1.25HisAsp: 1.25 ± 0.014	1.274HisGlu: 1.274 ± 0.016	1.168HisPhe: 1.168 ± 0.016	1.402HisGly: 1.402 ± 0.019	0.956HisHis: 0.956 ± 0.018	1.722HisIle: 1.722 ± 0.02	1.379HisLys: 1.379 ± 0.015	2.88HisLeu: 2.88 ± 0.024	0.606HisMet: 0.606 ± 0.01	1.327HisAsn: 1.327 ± 0.017	1.516HisPro: 1.516 ± 0.018	1.286HisGln: 1.286 ± 0.018	1.446HisArg: 1.446 ± 0.018	2.157HisSer: 2.157 ± 0.022	1.62HisThr: 1.62 ± 0.016	1.616HisVal: 1.616 ± 0.024	0.335HisTrp: 0.335 ± 0.008	0.974HisTyr: 0.974 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.862IleAla: 3.862 ± 0.027	1.188IleCys: 1.188 ± 0.016	3.649IleAsp: 3.649 ± 0.027	3.69IleGlu: 3.69 ± 0.023	2.539IlePhe: 2.539 ± 0.024	3.185IleGly: 3.185 ± 0.029	1.685IleHis: 1.685 ± 0.015	3.6IleIle: 3.6 ± 0.033	3.926IleLys: 3.926 ± 0.028	5.763IleLeu: 5.763 ± 0.032	1.399IleMet: 1.399 ± 0.015	3.022IleAsn: 3.022 ± 0.026	3.242IlePro: 3.242 ± 0.023	2.64IleGln: 2.64 ± 0.022	3.094IleArg: 3.094 ± 0.03	5.061IleSer: 5.061 ± 0.035	3.392IleThr: 3.392 ± 0.025	3.812IleVal: 3.812 ± 0.03	0.714IleTrp: 0.714 ± 0.013	2.158IleTyr: 2.158 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.204LysAla: 4.204 ± 0.033	0.937LysCys: 0.937 ± 0.013	3.502LysAsp: 3.502 ± 0.029	4.127LysGlu: 4.127 ± 0.031	2.029LysPhe: 2.029 ± 0.018	2.843LysGly: 2.843 ± 0.027	1.672LysHis: 1.672 ± 0.018	3.64LysIle: 3.64 ± 0.028	4.868LysLys: 4.868 ± 0.046	5.022LysLeu: 5.022 ± 0.036	1.438LysMet: 1.438 ± 0.014	3.16LysAsn: 3.16 ± 0.024	2.646LysPro: 2.646 ± 0.027	2.545LysGln: 2.545 ± 0.024	3.764LysArg: 3.764 ± 0.029	4.371LysSer: 4.371 ± 0.03	3.866LysThr: 3.866 ± 0.031	3.331LysVal: 3.331 ± 0.028	0.683LysTrp: 0.683 ± 0.011	2.201LysTyr: 2.201 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	6.373LeuAla: 6.373 ± 0.039	1.697LeuCys: 1.697 ± 0.02	5.197LeuAsp: 5.197 ± 0.034	5.79LeuGlu: 5.79 ± 0.037	4.049LeuPhe: 4.049 ± 0.033	4.964LeuGly: 4.964 ± 0.038	2.527LeuHis: 2.527 ± 0.023	4.768LeuIle: 4.768 ± 0.032	5.767LeuLys: 5.767 ± 0.042	9.149LeuLeu: 9.149 ± 0.05	2.185LeuMet: 2.185 ± 0.02	3.948LeuAsn: 3.948 ± 0.03	5.305LeuPro: 5.305 ± 0.043	4.043LeuGln: 4.043 ± 0.033	4.744LeuArg: 4.744 ± 0.03	7.974LeuSer: 7.974 ± 0.045	5.237LeuThr: 5.237 ± 0.03	6.137LeuVal: 6.137 ± 0.041	1.176LeuTrp: 1.176 ± 0.015	3.015LeuTyr: 3.015 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.86MetAla: 1.86 ± 0.017	0.391MetCys: 0.391 ± 0.008	1.419MetAsp: 1.419 ± 0.016	1.439MetGlu: 1.439 ± 0.018	1.0MetPhe: 1.0 ± 0.014	1.17MetGly: 1.17 ± 0.016	0.682MetHis: 0.682 ± 0.012	1.415MetIle: 1.415 ± 0.016	1.382MetLys: 1.382 ± 0.015	2.135MetLeu: 2.135 ± 0.02	0.678MetMet: 0.678 ± 0.01	1.198MetAsn: 1.198 ± 0.015	1.204MetPro: 1.204 ± 0.013	0.885MetGln: 0.885 ± 0.013	1.182MetArg: 1.182 ± 0.018	2.383MetSer: 2.383 ± 0.021	1.6MetThr: 1.6 ± 0.016	1.535MetVal: 1.535 ± 0.018	0.288MetTrp: 0.288 ± 0.007	0.778MetTyr: 0.778 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.88AsnAla: 2.88 ± 0.022	0.775AsnCys: 0.775 ± 0.012	2.604AsnAsp: 2.604 ± 0.026	2.693AsnGlu: 2.693 ± 0.023	1.789AsnPhe: 1.789 ± 0.019	2.619AsnGly: 2.619 ± 0.024	1.271AsnHis: 1.271 ± 0.016	3.308AsnIle: 3.308 ± 0.027	2.882AsnLys: 2.882 ± 0.025	4.205AsnLeu: 4.205 ± 0.029	1.315AsnMet: 1.315 ± 0.015	3.071AsnAsn: 3.071 ± 0.033	2.403AsnPro: 2.403 ± 0.021	2.047AsnGln: 2.047 ± 0.022	2.293AsnArg: 2.293 ± 0.02	3.934AsnSer: 3.934 ± 0.033	3.291AsnThr: 3.291 ± 0.026	2.808AsnVal: 2.808 ± 0.023	0.576AsnTrp: 0.576 ± 0.011	1.604AsnTyr: 1.604 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	3.176ProAla: 3.176 ± 0.031	0.659ProCys: 0.659 ± 0.012	2.419ProAsp: 2.419 ± 0.022	3.05ProGlu: 3.05 ± 0.028	2.1ProPhe: 2.1 ± 0.018	2.258ProGly: 2.258 ± 0.03	1.248ProHis: 1.248 ± 0.017	2.852ProIle: 2.852 ± 0.023	2.832ProLys: 2.832 ± 0.02	4.516ProLeu: 4.516 ± 0.035	1.06ProMet: 1.06 ± 0.014	2.259ProAsn: 2.259 ± 0.017	2.977ProPro: 2.977 ± 0.036	1.844ProGln: 1.844 ± 0.021	2.283ProArg: 2.283 ± 0.023	4.829ProSer: 4.829 ± 0.043	3.537ProThr: 3.537 ± 0.033	3.274ProVal: 3.274 ± 0.028	0.481ProTrp: 0.481 ± 0.01	1.395ProTyr: 1.395 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	2.692GlnAla: 2.692 ± 0.025	0.635GlnCys: 0.635 ± 0.013	2.133GlnAsp: 2.133 ± 0.021	2.522GlnGlu: 2.522 ± 0.026	1.603GlnPhe: 1.603 ± 0.02	1.896GlnGly: 1.896 ± 0.035	1.255GlnHis: 1.255 ± 0.017	2.344GlnIle: 2.344 ± 0.022	2.664GlnLys: 2.664 ± 0.024	3.866GlnLeu: 3.866 ± 0.031	0.962GlnMet: 0.962 ± 0.013	1.937GlnAsn: 1.937 ± 0.023	2.017GlnPro: 2.017 ± 0.025	2.686GlnGln: 2.686 ± 0.049	2.237GlnArg: 2.237 ± 0.02	3.381GlnSer: 3.381 ± 0.025	2.53GlnThr: 2.53 ± 0.023	2.289GlnVal: 2.289 ± 0.024	0.537GlnTrp: 0.537 ± 0.01	1.417GlnTyr: 1.417 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	3.154ArgAla: 3.154 ± 0.027	0.835ArgCys: 0.835 ± 0.014	2.528ArgAsp: 2.528 ± 0.021	2.881ArgGlu: 2.881 ± 0.025	2.205ArgPhe: 2.205 ± 0.036	2.317ArgGly: 2.317 ± 0.025	1.548ArgHis: 1.548 ± 0.019	3.151ArgIle: 3.151 ± 0.027	3.358ArgLys: 3.358 ± 0.028	5.166ArgLeu: 5.166 ± 0.033	1.293ArgMet: 1.293 ± 0.014	2.337ArgAsn: 2.337 ± 0.021	2.473ArgPro: 2.473 ± 0.023	2.376ArgGln: 2.376 ± 0.023	3.401ArgArg: 3.401 ± 0.03	4.031ArgSer: 4.031 ± 0.032	2.882ArgThr: 2.882 ± 0.022	2.926ArgVal: 2.926 ± 0.025	0.724ArgTrp: 0.724 ± 0.01	1.66ArgTyr: 1.66 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	5.009SerAla: 5.009 ± 0.033	1.28SerCys: 1.28 ± 0.015	4.195SerAsp: 4.195 ± 0.031	4.182SerGlu: 4.182 ± 0.03	3.704SerPhe: 3.704 ± 0.028	4.338SerGly: 4.338 ± 0.033	2.128SerHis: 2.128 ± 0.025	5.279SerIle: 5.279 ± 0.032	4.517SerLys: 4.517 ± 0.03	8.047SerLeu: 8.047 ± 0.046	2.01SerMet: 2.01 ± 0.022	4.053SerAsn: 4.053 ± 0.032	4.461SerPro: 4.461 ± 0.042	3.372SerGln: 3.372 ± 0.025	4.085SerArg: 4.085 ± 0.033	8.492SerSer: 8.492 ± 0.073	5.602SerThr: 5.602 ± 0.037	5.124SerVal: 5.124 ± 0.031	1.018SerTrp: 1.018 ± 0.013	2.491SerTyr: 2.491 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	3.984ThrAla: 3.984 ± 0.029	1.019ThrCys: 1.019 ± 0.015	2.846ThrAsp: 2.846 ± 0.023	3.153ThrGlu: 3.153 ± 0.028	2.615ThrPhe: 2.615 ± 0.022	3.268ThrGly: 3.268 ± 0.028	1.637ThrHis: 1.637 ± 0.018	4.136ThrIle: 4.136 ± 0.03	3.536ThrLys: 3.536 ± 0.025	5.811ThrLeu: 5.811 ± 0.04	1.515ThrMet: 1.515 ± 0.016	3.053ThrAsn: 3.053 ± 0.027	3.435ThrPro: 3.435 ± 0.031	2.185ThrGln: 2.185 ± 0.024	2.974ThrArg: 2.974 ± 0.026	5.439ThrSer: 5.439 ± 0.038	4.429ThrThr: 4.429 ± 0.041	3.76ThrVal: 3.76 ± 0.028	0.678ThrTrp: 0.678 ± 0.012	1.85ThrTyr: 1.85 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.182ValAla: 4.182 ± 0.035	1.18ValCys: 1.18 ± 0.014	3.678ValAsp: 3.678 ± 0.027	3.725ValGlu: 3.725 ± 0.029	2.803ValPhe: 2.803 ± 0.023	3.138ValGly: 3.138 ± 0.032	1.649ValHis: 1.649 ± 0.019	3.506ValIle: 3.506 ± 0.03	3.607ValLys: 3.607 ± 0.032	5.974ValLeu: 5.974 ± 0.038	1.457ValMet: 1.457 ± 0.016	2.868ValAsn: 2.868 ± 0.027	3.057ValPro: 3.057 ± 0.025	2.424ValGln: 2.424 ± 0.024	2.864ValArg: 2.864 ± 0.024	4.73ValSer: 4.73 ± 0.032	3.228ValThr: 3.228 ± 0.029	4.255ValVal: 4.255 ± 0.036	0.79ValTrp: 0.79 ± 0.014	2.25ValTyr: 2.25 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.756TrpAla: 0.756 ± 0.012	0.25TrpCys: 0.25 ± 0.007	0.67TrpAsp: 0.67 ± 0.012	0.646TrpGlu: 0.646 ± 0.011	0.548TrpPhe: 0.548 ± 0.01	0.589TrpGly: 0.589 ± 0.01	0.322TrpHis: 0.322 ± 0.008	0.835TrpIle: 0.835 ± 0.012	0.911TrpLys: 0.911 ± 0.013	1.201TrpLeu: 1.201 ± 0.015	0.336TrpMet: 0.336 ± 0.008	0.643TrpAsn: 0.643 ± 0.012	0.44TrpPro: 0.44 ± 0.009	0.448TrpGln: 0.448 ± 0.009	0.794TrpArg: 0.794 ± 0.014	1.012TrpSer: 1.012 ± 0.015	0.728TrpThr: 0.728 ± 0.013	0.71TrpVal: 0.71 ± 0.012	0.203TrpTrp: 0.203 ± 0.006	0.411TrpTyr: 0.411 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.955TyrAla: 1.955 ± 0.019	0.685TyrCys: 0.685 ± 0.012	1.835TyrAsp: 1.835 ± 0.018	1.836TyrGlu: 1.836 ± 0.02	1.599TyrPhe: 1.599 ± 0.019	1.91TyrGly: 1.91 ± 0.018	0.853TyrHis: 0.853 ± 0.012	2.153TyrIle: 2.153 ± 0.021	1.983TyrLys: 1.983 ± 0.02	3.287TyrLeu: 3.287 ± 0.024	0.926TyrMet: 0.926 ± 0.013	1.767TyrAsn: 1.767 ± 0.019	1.504TyrPro: 1.504 ± 0.02	1.432TyrGln: 1.432 ± 0.017	1.704TyrArg: 1.704 ± 0.017	2.617TyrSer: 2.617 ± 0.023	2.068TyrThr: 2.068 ± 0.015	1.898TyrVal: 1.898 ± 0.018	0.464TyrTrp: 0.464 ± 0.01	1.344TyrTyr: 1.344 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 16155 proteins (5761222 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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