Amino acid dipepetide frequency for Demequina mangrovi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.568AlaAla: 22.568 ± 0.238	0.934AlaCys: 0.934 ± 0.031	8.443AlaAsp: 8.443 ± 0.114	9.004AlaGlu: 9.004 ± 0.136	3.899AlaPhe: 3.899 ± 0.07	12.738AlaGly: 12.738 ± 0.14	2.96AlaHis: 2.96 ± 0.056	6.107AlaIle: 6.107 ± 0.103	2.64AlaLys: 2.64 ± 0.069	15.41AlaLeu: 15.41 ± 0.186	3.31AlaMet: 3.31 ± 0.065	2.105AlaAsn: 2.105 ± 0.051	6.997AlaPro: 6.997 ± 0.14	3.832AlaGln: 3.832 ± 0.079	10.508AlaArg: 10.508 ± 0.147	7.872AlaSer: 7.872 ± 0.103	8.34AlaThr: 8.34 ± 0.106	12.674AlaVal: 12.674 ± 0.142	2.326AlaTrp: 2.326 ± 0.056	2.589AlaTyr: 2.589 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.829CysAla: 0.829 ± 0.032	0.05CysCys: 0.05 ± 0.009	0.454CysAsp: 0.454 ± 0.027	0.365CysGlu: 0.365 ± 0.021	0.167CysPhe: 0.167 ± 0.013	0.679CysGly: 0.679 ± 0.029	0.126CysHis: 0.126 ± 0.012	0.213CysIle: 0.213 ± 0.016	0.091CysLys: 0.091 ± 0.011	0.478CysLeu: 0.478 ± 0.021	0.102CysMet: 0.102 ± 0.01	0.105CysAsn: 0.105 ± 0.012	0.376CysPro: 0.376 ± 0.023	0.127CysGln: 0.127 ± 0.012	0.357CysArg: 0.357 ± 0.022	0.328CysSer: 0.328 ± 0.02	0.438CysThr: 0.438 ± 0.028	0.521CysVal: 0.521 ± 0.023	0.067CysTrp: 0.067 ± 0.009	0.113CysTyr: 0.113 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	10.343AspAla: 10.343 ± 0.132	0.286AspCys: 0.286 ± 0.018	4.289AspAsp: 4.289 ± 0.126	4.779AspGlu: 4.779 ± 0.085	1.593AspPhe: 1.593 ± 0.043	6.715AspGly: 6.715 ± 0.132	1.308AspHis: 1.308 ± 0.042	2.207AspIle: 2.207 ± 0.048	0.955AspLys: 0.955 ± 0.036	6.394AspLeu: 6.394 ± 0.088	1.022AspMet: 1.022 ± 0.036	0.831AspAsn: 0.831 ± 0.032	4.152AspPro: 4.152 ± 0.091	1.398AspGln: 1.398 ± 0.04	4.126AspArg: 4.126 ± 0.075	2.446AspSer: 2.446 ± 0.054	2.933AspThr: 2.933 ± 0.065	5.94AspVal: 5.94 ± 0.086	0.907AspTrp: 0.907 ± 0.034	1.226AspTyr: 1.226 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	9.339GluAla: 9.339 ± 0.143	0.326GluCys: 0.326 ± 0.018	3.961GluAsp: 3.961 ± 0.08	3.758GluGlu: 3.758 ± 0.074	1.462GluPhe: 1.462 ± 0.048	5.058GluGly: 5.058 ± 0.089	1.588GluHis: 1.588 ± 0.048	2.886GluIle: 2.886 ± 0.057	1.257GluLys: 1.257 ± 0.04	6.136GluLeu: 6.136 ± 0.098	1.098GluMet: 1.098 ± 0.037	1.061GluAsn: 1.061 ± 0.034	3.791GluPro: 3.791 ± 0.102	1.946GluGln: 1.946 ± 0.053	5.477GluArg: 5.477 ± 0.093	3.032GluSer: 3.032 ± 0.071	3.25GluThr: 3.25 ± 0.064	5.467GluVal: 5.467 ± 0.088	0.868GluTrp: 0.868 ± 0.032	1.156GluTyr: 1.156 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.042PheAla: 4.042 ± 0.071	0.171PheCys: 0.171 ± 0.014	2.069PheAsp: 2.069 ± 0.05	1.706PheGlu: 1.706 ± 0.048	0.875PhePhe: 0.875 ± 0.039	2.975PheGly: 2.975 ± 0.062	0.56PheHis: 0.56 ± 0.025	0.964PheIle: 0.964 ± 0.038	0.43PheLys: 0.43 ± 0.025	2.473PheLeu: 2.473 ± 0.064	0.515PheMet: 0.515 ± 0.024	0.577PheAsn: 0.577 ± 0.024	1.23PhePro: 1.23 ± 0.041	0.679PheGln: 0.679 ± 0.028	1.489PheArg: 1.489 ± 0.045	1.57PheSer: 1.57 ± 0.044	1.889PheThr: 1.889 ± 0.048	2.466PheVal: 2.466 ± 0.055	0.421PheTrp: 0.421 ± 0.025	0.608PheTyr: 0.608 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	12.168GlyAla: 12.168 ± 0.141	0.713GlyCys: 0.713 ± 0.03	5.573GlyAsp: 5.573 ± 0.093	5.484GlyGlu: 5.484 ± 0.083	2.948GlyPhe: 2.948 ± 0.062	7.947GlyGly: 7.947 ± 0.118	1.822GlyHis: 1.822 ± 0.046	4.277GlyIle: 4.277 ± 0.078	1.928GlyLys: 1.928 ± 0.051	9.099GlyLeu: 9.099 ± 0.104	2.26GlyMet: 2.26 ± 0.047	1.439GlyAsn: 1.439 ± 0.043	3.969GlyPro: 3.969 ± 0.076	1.999GlyGln: 1.999 ± 0.05	6.221GlyArg: 6.221 ± 0.096	5.093GlySer: 5.093 ± 0.095	5.942GlyThr: 5.942 ± 0.096	8.16GlyVal: 8.16 ± 0.102	1.667GlyTrp: 1.667 ± 0.048	2.263GlyTyr: 2.263 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.816HisAla: 2.816 ± 0.063	0.141HisCys: 0.141 ± 0.014	1.326HisAsp: 1.326 ± 0.046	1.35HisGlu: 1.35 ± 0.04	0.51HisPhe: 0.51 ± 0.025	2.264HisGly: 2.264 ± 0.05	0.604HisHis: 0.604 ± 0.029	0.673HisIle: 0.673 ± 0.024	0.294HisLys: 0.294 ± 0.018	2.132HisLeu: 2.132 ± 0.048	0.334HisMet: 0.334 ± 0.021	0.32HisAsn: 0.32 ± 0.02	1.427HisPro: 1.427 ± 0.042	0.5HisGln: 0.5 ± 0.023	1.653HisArg: 1.653 ± 0.047	0.867HisSer: 0.867 ± 0.033	0.971HisThr: 0.971 ± 0.031	1.902HisVal: 1.902 ± 0.045	0.251HisTrp: 0.251 ± 0.017	0.387HisTyr: 0.387 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.861IleAla: 6.861 ± 0.091	0.226IleCys: 0.226 ± 0.016	3.209IleAsp: 3.209 ± 0.059	2.785IleGlu: 2.785 ± 0.056	0.993IlePhe: 0.993 ± 0.039	4.196IleGly: 4.196 ± 0.086	0.711IleHis: 0.711 ± 0.028	1.457IleIle: 1.457 ± 0.048	0.702IleLys: 0.702 ± 0.036	3.183IleLeu: 3.183 ± 0.072	0.6IleMet: 0.6 ± 0.029	0.732IleAsn: 0.732 ± 0.029	2.138IlePro: 2.138 ± 0.055	0.902IleGln: 0.902 ± 0.031	2.377IleArg: 2.377 ± 0.044	1.865IleSer: 1.865 ± 0.049	2.458IleThr: 2.458 ± 0.072	4.475IleVal: 4.475 ± 0.076	0.419IleTrp: 0.419 ± 0.022	0.658IleTyr: 0.658 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.63LysAla: 2.63 ± 0.06	0.077LysCys: 0.077 ± 0.009	1.24LysAsp: 1.24 ± 0.044	1.089LysGlu: 1.089 ± 0.038	0.389LysPhe: 0.389 ± 0.019	1.646LysGly: 1.646 ± 0.05	0.4LysHis: 0.4 ± 0.024	0.749LysIle: 0.749 ± 0.034	0.691LysLys: 0.691 ± 0.038	1.372LysLeu: 1.372 ± 0.045	0.33LysMet: 0.33 ± 0.023	0.423LysAsn: 0.423 ± 0.027	0.982LysPro: 0.982 ± 0.04	0.524LysGln: 0.524 ± 0.026	1.421LysArg: 1.421 ± 0.045	0.934LysSer: 0.934 ± 0.037	0.968LysThr: 0.968 ± 0.035	1.814LysVal: 1.814 ± 0.053	0.195LysTrp: 0.195 ± 0.014	0.367LysTyr: 0.367 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.932LeuAla: 15.932 ± 0.183	0.529LeuCys: 0.529 ± 0.022	6.927LeuAsp: 6.927 ± 0.092	6.079LeuGlu: 6.079 ± 0.083	2.39LeuPhe: 2.39 ± 0.062	9.344LeuGly: 9.344 ± 0.123	1.956LeuHis: 1.956 ± 0.052	3.563LeuIle: 3.563 ± 0.082	1.643LeuLys: 1.643 ± 0.049	9.262LeuLeu: 9.262 ± 0.131	1.867LeuMet: 1.867 ± 0.042	1.493LeuAsn: 1.493 ± 0.045	5.06LeuPro: 5.06 ± 0.074	2.085LeuGln: 2.085 ± 0.049	6.776LeuArg: 6.776 ± 0.108	5.186LeuSer: 5.186 ± 0.076	6.141LeuThr: 6.141 ± 0.093	9.471LeuVal: 9.471 ± 0.126	1.25LeuTrp: 1.25 ± 0.042	1.596LeuTyr: 1.596 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.592MetAla: 2.592 ± 0.064	0.103MetCys: 0.103 ± 0.01	0.989MetAsp: 0.989 ± 0.037	0.875MetGlu: 0.875 ± 0.036	0.524MetPhe: 0.524 ± 0.027	1.559MetGly: 1.559 ± 0.045	0.395MetHis: 0.395 ± 0.02	0.916MetIle: 0.916 ± 0.034	0.4MetLys: 0.4 ± 0.022	2.118MetLeu: 2.118 ± 0.053	0.378MetMet: 0.378 ± 0.021	0.424MetAsn: 0.424 ± 0.022	1.223MetPro: 1.223 ± 0.038	0.472MetGln: 0.472 ± 0.021	1.801MetArg: 1.801 ± 0.048	1.509MetSer: 1.509 ± 0.038	1.919MetThr: 1.919 ± 0.043	1.597MetVal: 1.597 ± 0.047	0.235MetTrp: 0.235 ± 0.016	0.298MetTyr: 0.298 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.316AsnAla: 2.316 ± 0.055	0.13AsnCys: 0.13 ± 0.025	0.985AsnAsp: 0.985 ± 0.051	0.867AsnGlu: 0.867 ± 0.033	0.467AsnPhe: 0.467 ± 0.024	1.569AsnGly: 1.569 ± 0.053	0.306AsnHis: 0.306 ± 0.019	0.703AsnIle: 0.703 ± 0.034	0.318AsnLys: 0.318 ± 0.018	1.632AsnLeu: 1.632 ± 0.042	0.289AsnMet: 0.289 ± 0.019	0.353AsnAsn: 0.353 ± 0.021	1.265AsnPro: 1.265 ± 0.04	0.426AsnGln: 0.426 ± 0.021	1.025AsnArg: 1.025 ± 0.035	0.753AsnSer: 0.753 ± 0.026	0.898AsnThr: 0.898 ± 0.035	1.541AsnVal: 1.541 ± 0.044	0.23AsnTrp: 0.23 ± 0.018	0.384AsnTyr: 0.384 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.449ProAla: 7.449 ± 0.11	0.236ProCys: 0.236 ± 0.018	3.777ProAsp: 3.777 ± 0.071	4.429ProGlu: 4.429 ± 0.094	1.545ProPhe: 1.545 ± 0.04	5.104ProGly: 5.104 ± 0.084	1.137ProHis: 1.137 ± 0.04	1.629ProIle: 1.629 ± 0.046	0.844ProLys: 0.844 ± 0.032	4.734ProLeu: 4.734 ± 0.079	0.988ProMet: 0.988 ± 0.032	0.773ProAsn: 0.773 ± 0.028	2.289ProPro: 2.289 ± 0.066	1.336ProGln: 1.336 ± 0.048	3.45ProArg: 3.45 ± 0.067	3.022ProSer: 3.022 ± 0.06	3.15ProThr: 3.15 ± 0.057	4.839ProVal: 4.839 ± 0.074	0.91ProTrp: 0.91 ± 0.034	1.063ProTyr: 1.063 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.316GlnAla: 3.316 ± 0.066	0.136GlnCys: 0.136 ± 0.013	1.246GlnAsp: 1.246 ± 0.038	1.36GlnGlu: 1.36 ± 0.041	0.665GlnPhe: 0.665 ± 0.028	1.976GlnGly: 1.976 ± 0.046	0.575GlnHis: 0.575 ± 0.022	1.208GlnIle: 1.208 ± 0.037	0.475GlnLys: 0.475 ± 0.024	2.477GlnLeu: 2.477 ± 0.062	0.549GlnMet: 0.549 ± 0.025	0.431GlnAsn: 0.431 ± 0.021	1.31GlnPro: 1.31 ± 0.039	0.913GlnGln: 0.913 ± 0.041	2.099GlnArg: 2.099 ± 0.052	1.122GlnSer: 1.122 ± 0.036	1.199GlnThr: 1.199 ± 0.038	2.343GlnVal: 2.343 ± 0.053	0.398GlnTrp: 0.398 ± 0.021	0.518GlnTyr: 0.518 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.61ArgAla: 9.61 ± 0.135	0.418ArgCys: 0.418 ± 0.022	4.49ArgAsp: 4.49 ± 0.076	4.857ArgGlu: 4.857 ± 0.087	2.069ArgPhe: 2.069 ± 0.064	5.585ArgGly: 5.585 ± 0.085	1.594ArgHis: 1.594 ± 0.046	3.492ArgIle: 3.492 ± 0.065	1.377ArgLys: 1.377 ± 0.045	7.181ArgLeu: 7.181 ± 0.105	1.811ArgMet: 1.811 ± 0.045	1.131ArgAsn: 1.131 ± 0.038	3.517ArgPro: 3.517 ± 0.074	1.74ArgGln: 1.74 ± 0.048	6.475ArgArg: 6.475 ± 0.118	3.646ArgSer: 3.646 ± 0.059	4.021ArgThr: 4.021 ± 0.071	5.84ArgVal: 5.84 ± 0.097	1.33ArgTrp: 1.33 ± 0.043	1.557ArgTyr: 1.557 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.831SerAla: 6.831 ± 0.107	0.319SerCys: 0.319 ± 0.02	2.971SerAsp: 2.971 ± 0.068	2.879SerGlu: 2.879 ± 0.061	1.678SerPhe: 1.678 ± 0.048	5.37SerGly: 5.37 ± 0.096	1.047SerHis: 1.047 ± 0.032	2.202SerIle: 2.202 ± 0.054	0.931SerLys: 0.931 ± 0.036	5.247SerLeu: 5.247 ± 0.078	1.103SerMet: 1.103 ± 0.038	0.921SerAsn: 0.921 ± 0.044	2.827SerPro: 2.827 ± 0.056	1.211SerGln: 1.211 ± 0.04	3.8SerArg: 3.8 ± 0.067	3.139SerSer: 3.139 ± 0.085	3.377SerThr: 3.377 ± 0.071	4.482SerVal: 4.482 ± 0.076	0.884SerTrp: 0.884 ± 0.036	1.14SerTyr: 1.14 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	8.022ThrAla: 8.022 ± 0.111	0.345ThrCys: 0.345 ± 0.022	3.409ThrAsp: 3.409 ± 0.067	3.282ThrGlu: 3.282 ± 0.073	1.959ThrPhe: 1.959 ± 0.048	5.805ThrGly: 5.805 ± 0.093	1.172ThrHis: 1.172 ± 0.039	2.263ThrIle: 2.263 ± 0.062	0.973ThrLys: 0.973 ± 0.035	6.149ThrLeu: 6.149 ± 0.084	1.34ThrMet: 1.34 ± 0.042	0.936ThrAsn: 0.936 ± 0.038	3.503ThrPro: 3.503 ± 0.069	1.346ThrGln: 1.346 ± 0.038	3.813ThrArg: 3.813 ± 0.074	3.23ThrSer: 3.23 ± 0.064	3.571ThrThr: 3.571 ± 0.082	6.495ThrVal: 6.495 ± 0.154	0.97ThrTrp: 0.97 ± 0.032	1.347ThrTyr: 1.347 ± 0.082	0.0ThrXaa: 0.0 ± 0.0
Val	13.255ValAla: 13.255 ± 0.153	0.557ValCys: 0.557 ± 0.023	6.29ValAsp: 6.29 ± 0.09	5.91ValGlu: 5.91 ± 0.098	2.417ValPhe: 2.417 ± 0.064	7.387ValGly: 7.387 ± 0.1	1.775ValHis: 1.775 ± 0.046	4.088ValIle: 4.088 ± 0.074	1.674ValLys: 1.674 ± 0.051	9.411ValLeu: 9.411 ± 0.12	1.787ValMet: 1.787 ± 0.046	1.638ValAsn: 1.638 ± 0.051	4.95ValPro: 4.95 ± 0.078	1.913ValGln: 1.913 ± 0.048	6.159ValArg: 6.159 ± 0.095	4.78ValSer: 4.78 ± 0.082	6.292ValThr: 6.292 ± 0.153	9.269ValVal: 9.269 ± 0.128	1.21ValTrp: 1.21 ± 0.041	1.483ValTyr: 1.483 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.781TrpAla: 1.781 ± 0.056	0.128TrpCys: 0.128 ± 0.013	0.899TrpAsp: 0.899 ± 0.036	0.852TrpGlu: 0.852 ± 0.035	0.502TrpPhe: 0.502 ± 0.025	1.165TrpGly: 1.165 ± 0.039	0.354TrpHis: 0.354 ± 0.02	0.72TrpIle: 0.72 ± 0.027	0.282TrpLys: 0.282 ± 0.019	1.585TrpLeu: 1.585 ± 0.054	0.337TrpMet: 0.337 ± 0.021	0.362TrpAsn: 0.362 ± 0.023	0.711TrpPro: 0.711 ± 0.031	0.432TrpGln: 0.432 ± 0.021	1.261TrpArg: 1.261 ± 0.043	0.908TrpSer: 0.908 ± 0.03	1.05TrpThr: 1.05 ± 0.031	1.205TrpVal: 1.205 ± 0.033	0.42TrpTrp: 0.42 ± 0.023	0.301TrpTyr: 0.301 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.555TyrAla: 2.555 ± 0.061	0.16TyrCys: 0.16 ± 0.015	1.303TyrAsp: 1.303 ± 0.044	1.208TyrGlu: 1.208 ± 0.035	0.656TyrPhe: 0.656 ± 0.029	1.891TyrGly: 1.891 ± 0.049	0.334TyrHis: 0.334 ± 0.021	0.629TyrIle: 0.629 ± 0.029	0.338TyrLys: 0.338 ± 0.019	2.073TyrLeu: 2.073 ± 0.049	0.308TyrMet: 0.308 ± 0.02	0.403TyrAsn: 0.403 ± 0.036	0.984TyrPro: 0.984 ± 0.036	0.537TyrGln: 0.537 ± 0.023	1.454TyrArg: 1.454 ± 0.039	1.058TyrSer: 1.058 ± 0.048	1.121TyrThr: 1.121 ± 0.058	1.744TyrVal: 1.744 ± 0.05	0.298TyrTrp: 0.298 ± 0.016	0.464TyrTyr: 0.464 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2745 proteins (912256 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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