Amino acid dipepetide frequency for Anaerobium acetethylicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.726AlaAla: 7.726 ± 0.119	1.077AlaCys: 1.077 ± 0.028	4.743AlaAsp: 4.743 ± 0.078	5.84AlaGlu: 5.84 ± 0.086	3.172AlaPhe: 3.172 ± 0.055	6.679AlaGly: 6.679 ± 0.084	0.981AlaHis: 0.981 ± 0.029	5.509AlaIle: 5.509 ± 0.075	4.682AlaLys: 4.682 ± 0.069	6.609AlaLeu: 6.609 ± 0.082	2.343AlaMet: 2.343 ± 0.037	2.697AlaAsn: 2.697 ± 0.049	1.93AlaPro: 1.93 ± 0.046	1.883AlaGln: 1.883 ± 0.037	2.733AlaArg: 2.733 ± 0.045	4.298AlaSer: 4.298 ± 0.072	3.402AlaThr: 3.402 ± 0.06	6.378AlaVal: 6.378 ± 0.083	0.577AlaTrp: 0.577 ± 0.02	2.9AlaTyr: 2.9 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.837CysAla: 0.837 ± 0.027	0.24CysCys: 0.24 ± 0.015	0.795CysAsp: 0.795 ± 0.022	0.834CysGlu: 0.834 ± 0.024	0.567CysPhe: 0.567 ± 0.022	1.39CysGly: 1.39 ± 0.038	0.279CysHis: 0.279 ± 0.016	1.073CysIle: 1.073 ± 0.029	0.688CysLys: 0.688 ± 0.02	0.994CysLeu: 0.994 ± 0.029	0.427CysMet: 0.427 ± 0.016	0.6CysAsn: 0.6 ± 0.022	0.599CysPro: 0.599 ± 0.023	0.336CysGln: 0.336 ± 0.015	0.742CysArg: 0.742 ± 0.026	0.893CysSer: 0.893 ± 0.027	0.705CysThr: 0.705 ± 0.021	0.818CysVal: 0.818 ± 0.024	0.112CysTrp: 0.112 ± 0.009	0.496CysTyr: 0.496 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.212AspAla: 4.212 ± 0.067	0.728AspCys: 0.728 ± 0.026	2.757AspAsp: 2.757 ± 0.044	4.583AspGlu: 4.583 ± 0.061	2.707AspPhe: 2.707 ± 0.043	4.351AspGly: 4.351 ± 0.075	0.809AspHis: 0.809 ± 0.028	4.873AspIle: 4.873 ± 0.069	3.506AspLys: 3.506 ± 0.046	4.492AspLeu: 4.492 ± 0.064	1.819AspMet: 1.819 ± 0.038	2.27AspAsn: 2.27 ± 0.049	1.709AspPro: 1.709 ± 0.044	1.382AspGln: 1.382 ± 0.034	2.573AspArg: 2.573 ± 0.045	3.441AspSer: 3.441 ± 0.058	2.817AspThr: 2.817 ± 0.053	3.654AspVal: 3.654 ± 0.056	0.6AspTrp: 0.6 ± 0.024	2.812AspTyr: 2.812 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.942GluAla: 5.942 ± 0.086	0.766GluCys: 0.766 ± 0.027	4.203GluAsp: 4.203 ± 0.067	6.997GluGlu: 6.997 ± 0.095	3.083GluPhe: 3.083 ± 0.054	4.585GluGly: 4.585 ± 0.058	1.256GluHis: 1.256 ± 0.031	6.253GluIle: 6.253 ± 0.082	6.743GluLys: 6.743 ± 0.087	6.86GluLeu: 6.86 ± 0.074	2.459GluMet: 2.459 ± 0.045	4.231GluAsn: 4.231 ± 0.057	1.828GluPro: 1.828 ± 0.045	2.434GluGln: 2.434 ± 0.048	3.019GluArg: 3.019 ± 0.051	3.795GluSer: 3.795 ± 0.054	3.932GluThr: 3.932 ± 0.062	4.415GluVal: 4.415 ± 0.058	0.716GluTrp: 0.716 ± 0.029	3.246GluTyr: 3.246 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.023PheAla: 3.023 ± 0.057	0.674PheCys: 0.674 ± 0.021	2.575PheAsp: 2.575 ± 0.045	3.1PheGlu: 3.1 ± 0.056	1.844PhePhe: 1.844 ± 0.048	3.324PheGly: 3.324 ± 0.053	0.763PheHis: 0.763 ± 0.027	3.08PheIle: 3.08 ± 0.055	2.33PheLys: 2.33 ± 0.047	3.759PheLeu: 3.759 ± 0.063	1.364PheMet: 1.364 ± 0.032	1.762PheAsn: 1.762 ± 0.039	1.299PhePro: 1.299 ± 0.031	1.244PheGln: 1.244 ± 0.028	1.846PheArg: 1.846 ± 0.042	3.007PheSer: 3.007 ± 0.054	2.287PheThr: 2.287 ± 0.049	2.929PheVal: 2.929 ± 0.047	0.439PheTrp: 0.439 ± 0.019	1.742PheTyr: 1.742 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.027GlyAla: 5.027 ± 0.08	1.206GlyCys: 1.206 ± 0.035	3.486GlyAsp: 3.486 ± 0.043	4.684GlyGlu: 4.684 ± 0.067	3.432GlyPhe: 3.432 ± 0.054	5.005GlyGly: 5.005 ± 0.073	1.255GlyHis: 1.255 ± 0.032	6.952GlyIle: 6.952 ± 0.077	5.335GlyLys: 5.335 ± 0.076	5.985GlyLeu: 5.985 ± 0.07	2.524GlyMet: 2.524 ± 0.045	3.453GlyAsn: 3.453 ± 0.061	1.36GlyPro: 1.36 ± 0.033	1.948GlyGln: 1.948 ± 0.052	3.239GlyArg: 3.239 ± 0.054	4.456GlySer: 4.456 ± 0.07	4.451GlyThr: 4.451 ± 0.075	4.738GlyVal: 4.738 ± 0.07	0.664GlyTrp: 0.664 ± 0.024	3.347GlyTyr: 3.347 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.145HisAla: 1.145 ± 0.029	0.263HisCys: 0.263 ± 0.014	0.836HisAsp: 0.836 ± 0.025	1.108HisGlu: 1.108 ± 0.029	0.828HisPhe: 0.828 ± 0.026	1.23HisGly: 1.23 ± 0.03	0.344HisHis: 0.344 ± 0.017	1.307HisIle: 1.307 ± 0.035	0.949HisLys: 0.949 ± 0.027	1.374HisLeu: 1.374 ± 0.036	0.514HisMet: 0.514 ± 0.02	0.703HisAsn: 0.703 ± 0.024	0.788HisPro: 0.788 ± 0.028	0.476HisGln: 0.476 ± 0.02	0.663HisArg: 0.663 ± 0.023	0.935HisSer: 0.935 ± 0.028	0.829HisThr: 0.829 ± 0.023	1.003HisVal: 1.003 ± 0.028	0.153HisTrp: 0.153 ± 0.012	0.782HisTyr: 0.782 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.135IleAla: 6.135 ± 0.08	1.218IleCys: 1.218 ± 0.031	4.394IleAsp: 4.394 ± 0.058	5.601IleGlu: 5.601 ± 0.074	3.143IlePhe: 3.143 ± 0.065	5.533IleGly: 5.533 ± 0.077	1.285IleHis: 1.285 ± 0.034	5.999IleIle: 5.999 ± 0.074	4.747IleLys: 4.747 ± 0.062	7.143IleLeu: 7.143 ± 0.083	2.311IleMet: 2.311 ± 0.042	3.625IleAsn: 3.625 ± 0.061	3.184IlePro: 3.184 ± 0.057	2.31IleGln: 2.31 ± 0.046	3.794IleArg: 3.794 ± 0.058	5.507IleSer: 5.507 ± 0.068	4.354IleThr: 4.354 ± 0.061	5.085IleVal: 5.085 ± 0.068	0.61IleTrp: 0.61 ± 0.021	2.905IleTyr: 2.905 ± 0.046	0.001IleXaa: 0.001 ± 0.001
Lys	5.311LysAla: 5.311 ± 0.063	0.705LysCys: 0.705 ± 0.026	3.87LysAsp: 3.87 ± 0.057	6.375LysGlu: 6.375 ± 0.085	2.01LysPhe: 2.01 ± 0.041	4.343LysGly: 4.343 ± 0.063	1.062LysHis: 1.062 ± 0.03	5.254LysIle: 5.254 ± 0.062	5.911LysLys: 5.911 ± 0.075	5.323LysLeu: 5.323 ± 0.08	2.251LysMet: 2.251 ± 0.042	3.756LysAsn: 3.756 ± 0.062	1.939LysPro: 1.939 ± 0.042	2.069LysGln: 2.069 ± 0.042	2.84LysArg: 2.84 ± 0.051	3.666LysSer: 3.666 ± 0.054	3.834LysThr: 3.834 ± 0.055	4.316LysVal: 4.316 ± 0.062	0.593LysTrp: 0.593 ± 0.022	2.906LysTyr: 2.906 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	6.685LeuAla: 6.685 ± 0.073	1.245LeuCys: 1.245 ± 0.036	4.73LeuAsp: 4.73 ± 0.065	6.366LeuGlu: 6.366 ± 0.075	3.73LeuPhe: 3.73 ± 0.069	5.923LeuGly: 5.923 ± 0.076	1.402LeuHis: 1.402 ± 0.036	6.289LeuIle: 6.289 ± 0.083	6.144LeuLys: 6.144 ± 0.066	7.728LeuLeu: 7.728 ± 0.089	2.579LeuMet: 2.579 ± 0.049	4.067LeuAsn: 4.067 ± 0.063	3.216LeuPro: 3.216 ± 0.052	2.625LeuGln: 2.625 ± 0.045	3.389LeuArg: 3.389 ± 0.061	6.135LeuSer: 6.135 ± 0.077	4.634LeuThr: 4.634 ± 0.062	5.475LeuVal: 5.475 ± 0.067	0.697LeuTrp: 0.697 ± 0.024	3.311LeuTyr: 3.311 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.458MetAla: 2.458 ± 0.048	0.299MetCys: 0.299 ± 0.015	1.945MetAsp: 1.945 ± 0.036	2.532MetGlu: 2.532 ± 0.05	1.14MetPhe: 1.14 ± 0.029	2.189MetGly: 2.189 ± 0.043	0.487MetHis: 0.487 ± 0.019	2.371MetIle: 2.371 ± 0.048	2.735MetLys: 2.735 ± 0.044	2.752MetLeu: 2.752 ± 0.056	0.995MetMet: 0.995 ± 0.025	1.719MetAsn: 1.719 ± 0.032	1.224MetPro: 1.224 ± 0.035	0.984MetGln: 0.984 ± 0.028	1.111MetArg: 1.111 ± 0.028	1.827MetSer: 1.827 ± 0.038	1.703MetThr: 1.703 ± 0.04	2.007MetVal: 2.007 ± 0.04	0.195MetTrp: 0.195 ± 0.013	0.902MetTyr: 0.902 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.298AsnAla: 3.298 ± 0.06	0.64AsnCys: 0.64 ± 0.023	2.229AsnAsp: 2.229 ± 0.042	3.147AsnGlu: 3.147 ± 0.053	1.806AsnPhe: 1.806 ± 0.037	3.739AsnGly: 3.739 ± 0.059	0.786AsnHis: 0.786 ± 0.023	3.777AsnIle: 3.777 ± 0.059	2.823AsnLys: 2.823 ± 0.042	3.899AsnLeu: 3.899 ± 0.063	1.531AsnMet: 1.531 ± 0.034	2.088AsnAsn: 2.088 ± 0.043	2.185AsnPro: 2.185 ± 0.04	1.519AsnGln: 1.519 ± 0.035	2.283AsnArg: 2.283 ± 0.046	2.74AsnSer: 2.74 ± 0.044	2.488AsnThr: 2.488 ± 0.05	2.965AsnVal: 2.965 ± 0.045	0.472AsnTrp: 0.472 ± 0.02	2.035AsnTyr: 2.035 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.543ProAla: 2.543 ± 0.051	0.432ProCys: 0.432 ± 0.019	2.256ProAsp: 2.256 ± 0.042	3.16ProGlu: 3.16 ± 0.055	1.593ProPhe: 1.593 ± 0.041	2.334ProGly: 2.334 ± 0.039	0.582ProHis: 0.582 ± 0.02	2.036ProIle: 2.036 ± 0.04	1.797ProLys: 1.797 ± 0.032	2.551ProLeu: 2.551 ± 0.046	0.887ProMet: 0.887 ± 0.025	1.293ProAsn: 1.293 ± 0.03	0.736ProPro: 0.736 ± 0.025	0.881ProGln: 0.881 ± 0.027	0.963ProArg: 0.963 ± 0.032	1.706ProSer: 1.706 ± 0.037	1.492ProThr: 1.492 ± 0.037	3.024ProVal: 3.024 ± 0.055	0.326ProTrp: 0.326 ± 0.016	1.415ProTyr: 1.415 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.247GlnAla: 2.247 ± 0.039	0.287GlnCys: 0.287 ± 0.016	1.519GlnAsp: 1.519 ± 0.035	2.265GlnGlu: 2.265 ± 0.04	1.115GlnPhe: 1.115 ± 0.03	1.832GlnGly: 1.832 ± 0.045	0.418GlnHis: 0.418 ± 0.017	2.422GlnIle: 2.422 ± 0.045	2.353GlnLys: 2.353 ± 0.039	2.53GlnLeu: 2.53 ± 0.048	1.045GlnMet: 1.045 ± 0.03	1.58GlnAsn: 1.58 ± 0.037	0.794GlnPro: 0.794 ± 0.025	0.981GlnGln: 0.981 ± 0.03	1.092GlnArg: 1.092 ± 0.035	1.551GlnSer: 1.551 ± 0.035	1.518GlnThr: 1.518 ± 0.038	1.814GlnVal: 1.814 ± 0.033	0.278GlnTrp: 0.278 ± 0.014	1.304GlnTyr: 1.304 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.419ArgAla: 2.419 ± 0.04	0.522ArgCys: 0.522 ± 0.02	2.173ArgAsp: 2.173 ± 0.036	3.711ArgGlu: 3.711 ± 0.062	1.855ArgPhe: 1.855 ± 0.037	2.394ArgGly: 2.394 ± 0.042	0.739ArgHis: 0.739 ± 0.025	3.643ArgIle: 3.643 ± 0.052	3.459ArgLys: 3.459 ± 0.061	3.686ArgLeu: 3.686 ± 0.056	1.527ArgMet: 1.527 ± 0.036	2.342ArgAsn: 2.342 ± 0.042	1.264ArgPro: 1.264 ± 0.037	1.411ArgGln: 1.411 ± 0.035	1.877ArgArg: 1.877 ± 0.041	2.112ArgSer: 2.112 ± 0.041	2.293ArgThr: 2.293 ± 0.041	2.406ArgVal: 2.406 ± 0.043	0.349ArgTrp: 0.349 ± 0.016	1.915ArgTyr: 1.915 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.401SerAla: 4.401 ± 0.064	0.793SerCys: 0.793 ± 0.026	3.495SerAsp: 3.495 ± 0.062	4.255SerGlu: 4.255 ± 0.058	2.818SerPhe: 2.818 ± 0.048	5.209SerGly: 5.209 ± 0.082	0.998SerHis: 0.998 ± 0.029	4.794SerIle: 4.794 ± 0.067	3.506SerLys: 3.506 ± 0.06	5.336SerLeu: 5.336 ± 0.07	1.922SerMet: 1.922 ± 0.036	2.554SerAsn: 2.554 ± 0.051	1.837SerPro: 1.837 ± 0.039	1.7SerGln: 1.7 ± 0.036	2.84SerArg: 2.84 ± 0.046	3.813SerSer: 3.813 ± 0.073	2.951SerThr: 2.951 ± 0.053	4.231SerVal: 4.231 ± 0.061	0.582SerTrp: 0.582 ± 0.021	2.655SerTyr: 2.655 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.556ThrAla: 4.556 ± 0.093	0.573ThrCys: 0.573 ± 0.022	3.289ThrAsp: 3.289 ± 0.065	3.92ThrGlu: 3.92 ± 0.057	2.108ThrPhe: 2.108 ± 0.045	4.786ThrGly: 4.786 ± 0.074	0.776ThrHis: 0.776 ± 0.025	4.123ThrIle: 4.123 ± 0.056	2.977ThrLys: 2.977 ± 0.053	4.387ThrLeu: 4.387 ± 0.059	1.472ThrMet: 1.472 ± 0.036	2.164ThrAsn: 2.164 ± 0.039	2.073ThrPro: 2.073 ± 0.045	1.314ThrGln: 1.314 ± 0.031	1.903ThrArg: 1.903 ± 0.037	3.0ThrSer: 3.0 ± 0.057	2.864ThrThr: 2.864 ± 0.059	4.253ThrVal: 4.253 ± 0.068	0.462ThrTrp: 0.462 ± 0.02	2.109ThrTyr: 2.109 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.833ValAla: 4.833 ± 0.062	1.021ValCys: 1.021 ± 0.031	3.693ValAsp: 3.693 ± 0.061	4.611ValGlu: 4.611 ± 0.062	3.113ValPhe: 3.113 ± 0.058	4.077ValGly: 4.077 ± 0.061	1.029ValHis: 1.029 ± 0.03	5.365ValIle: 5.365 ± 0.067	4.562ValLys: 4.562 ± 0.057	6.494ValLeu: 6.494 ± 0.079	2.115ValMet: 2.115 ± 0.043	3.015ValAsn: 3.015 ± 0.047	2.413ValPro: 2.413 ± 0.05	1.766ValGln: 1.766 ± 0.035	2.786ValArg: 2.786 ± 0.049	4.702ValSer: 4.702 ± 0.075	3.912ValThr: 3.912 ± 0.075	4.574ValVal: 4.574 ± 0.072	0.574ValTrp: 0.574 ± 0.019	2.615ValTyr: 2.615 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.548TrpAla: 0.548 ± 0.021	0.146TrpCys: 0.146 ± 0.01	0.539TrpAsp: 0.539 ± 0.02	0.653TrpGlu: 0.653 ± 0.027	0.374TrpPhe: 0.374 ± 0.017	0.655TrpGly: 0.655 ± 0.024	0.177TrpHis: 0.177 ± 0.013	0.694TrpIle: 0.694 ± 0.022	0.65TrpLys: 0.65 ± 0.023	0.771TrpLeu: 0.771 ± 0.024	0.306TrpMet: 0.306 ± 0.015	0.564TrpAsn: 0.564 ± 0.019	0.226TrpPro: 0.226 ± 0.014	0.319TrpGln: 0.319 ± 0.015	0.32TrpArg: 0.32 ± 0.016	0.522TrpSer: 0.522 ± 0.023	0.471TrpThr: 0.471 ± 0.024	0.496TrpVal: 0.496 ± 0.02	0.133TrpTrp: 0.133 ± 0.013	0.363TrpTyr: 0.363 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.814TyrAla: 2.814 ± 0.054	0.586TyrCys: 0.586 ± 0.022	2.567TyrAsp: 2.567 ± 0.056	3.024TyrGlu: 3.024 ± 0.053	1.954TyrPhe: 1.954 ± 0.035	2.968TyrGly: 2.968 ± 0.045	0.803TyrHis: 0.803 ± 0.027	3.067TyrIle: 3.067 ± 0.053	2.435TyrLys: 2.435 ± 0.044	3.696TyrLeu: 3.696 ± 0.058	1.184TyrMet: 1.184 ± 0.028	1.969TyrAsn: 1.969 ± 0.043	1.407TyrPro: 1.407 ± 0.029	1.362TyrGln: 1.362 ± 0.034	2.081TyrArg: 2.081 ± 0.044	2.585TyrSer: 2.585 ± 0.051	2.173TyrThr: 2.173 ± 0.045	2.691TyrVal: 2.691 ± 0.043	0.395TyrTrp: 0.395 ± 0.017	1.966TyrTyr: 1.966 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4003 proteins (1325591 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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