Amino acid dipepetide frequency for Mycobacterium phage Panamaxus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.389AlaAla: 11.389 ± 1.146
0.582AlaCys: 0.582 ± 0.186
5.889AlaAsp: 5.889 ± 0.765
7.248AlaGlu: 7.248 ± 0.787
3.041AlaPhe: 3.041 ± 0.62
7.442AlaGly: 7.442 ± 0.828
1.941AlaHis: 1.941 ± 0.406
4.336AlaIle: 4.336 ± 0.507
4.983AlaLys: 4.983 ± 0.553
8.283AlaLeu: 8.283 ± 0.677
2.33AlaMet: 2.33 ± 0.321
2.588AlaAsn: 2.588 ± 0.473
5.501AlaPro: 5.501 ± 0.812
4.077AlaGln: 4.077 ± 0.563
5.695AlaArg: 5.695 ± 0.591
4.336AlaSer: 4.336 ± 0.545
5.371AlaThr: 5.371 ± 0.555
7.83AlaVal: 7.83 ± 0.788
2.33AlaTrp: 2.33 ± 0.384
2.653AlaTyr: 2.653 ± 0.505
0.0AlaXaa: 0.0 ± 0.0
Cys
0.777CysAla: 0.777 ± 0.213
0.129CysCys: 0.129 ± 0.123
0.647CysAsp: 0.647 ± 0.225
0.777CysGlu: 0.777 ± 0.193
0.129CysPhe: 0.129 ± 0.087
0.971CysGly: 0.971 ± 0.25
0.065CysHis: 0.065 ± 0.063
0.259CysIle: 0.259 ± 0.111
0.518CysLys: 0.518 ± 0.168
0.647CysLeu: 0.647 ± 0.219
0.388CysMet: 0.388 ± 0.16
0.453CysAsn: 0.453 ± 0.138
0.324CysPro: 0.324 ± 0.153
0.259CysGln: 0.259 ± 0.117
0.582CysArg: 0.582 ± 0.18
0.259CysSer: 0.259 ± 0.118
0.388CysThr: 0.388 ± 0.176
0.453CysVal: 0.453 ± 0.154
0.065CysTrp: 0.065 ± 0.06
0.388CysTyr: 0.388 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
6.536AspAla: 6.536 ± 0.683
0.582AspCys: 0.582 ± 0.181
4.336AspAsp: 4.336 ± 0.566
4.336AspGlu: 4.336 ± 0.674
2.459AspPhe: 2.459 ± 0.396
6.212AspGly: 6.212 ± 0.687
1.23AspHis: 1.23 ± 0.308
3.041AspIle: 3.041 ± 0.454
2.33AspLys: 2.33 ± 0.401
5.436AspLeu: 5.436 ± 0.597
1.359AspMet: 1.359 ± 0.271
1.747AspAsn: 1.747 ± 0.336
4.789AspPro: 4.789 ± 0.528
1.877AspGln: 1.877 ± 0.277
3.494AspArg: 3.494 ± 0.545
3.689AspSer: 3.689 ± 0.476
3.753AspThr: 3.753 ± 0.464
4.142AspVal: 4.142 ± 0.358
1.553AspTrp: 1.553 ± 0.336
2.783AspTyr: 2.783 ± 0.367
0.0AspXaa: 0.0 ± 0.0
Glu
7.701GluAla: 7.701 ± 0.715
0.647GluCys: 0.647 ± 0.235
4.918GluAsp: 4.918 ± 0.617
5.112GluGlu: 5.112 ± 0.583
2.524GluPhe: 2.524 ± 0.422
5.565GluGly: 5.565 ± 0.601
1.165GluHis: 1.165 ± 0.265
3.171GluIle: 3.171 ± 0.469
2.33GluLys: 2.33 ± 0.36
6.277GluLeu: 6.277 ± 0.619
1.488GluMet: 1.488 ± 0.328
1.941GluAsn: 1.941 ± 0.366
3.171GluPro: 3.171 ± 0.513
2.912GluGln: 2.912 ± 0.498
5.048GluArg: 5.048 ± 0.832
3.559GluSer: 3.559 ± 0.463
3.43GluThr: 3.43 ± 0.435
4.918GluVal: 4.918 ± 0.56
1.23GluTrp: 1.23 ± 0.227
2.33GluTyr: 2.33 ± 0.476
0.0GluXaa: 0.0 ± 0.0
Phe
3.559PheAla: 3.559 ± 0.527
0.259PheCys: 0.259 ± 0.148
2.847PheAsp: 2.847 ± 0.483
2.588PheGlu: 2.588 ± 0.421
0.906PhePhe: 0.906 ± 0.23
3.3PheGly: 3.3 ± 0.596
0.518PheHis: 0.518 ± 0.164
1.23PheIle: 1.23 ± 0.23
1.1PheLys: 1.1 ± 0.289
3.041PheLeu: 3.041 ± 0.509
0.841PheMet: 0.841 ± 0.224
1.683PheAsn: 1.683 ± 0.339
1.812PhePro: 1.812 ± 0.335
1.035PheGln: 1.035 ± 0.228
2.006PheArg: 2.006 ± 0.331
1.747PheSer: 1.747 ± 0.291
1.747PheThr: 1.747 ± 0.345
2.524PheVal: 2.524 ± 0.346
0.388PheTrp: 0.388 ± 0.178
0.777PheTyr: 0.777 ± 0.203
0.0PheXaa: 0.0 ± 0.0
Gly
6.989GlyAla: 6.989 ± 0.893
1.035GlyCys: 1.035 ± 0.287
6.083GlyAsp: 6.083 ± 0.738
4.724GlyGlu: 4.724 ± 0.534
3.494GlyPhe: 3.494 ± 0.581
8.218GlyGly: 8.218 ± 1.515
1.941GlyHis: 1.941 ± 0.445
4.012GlyIle: 4.012 ± 0.565
3.559GlyLys: 3.559 ± 0.448
6.665GlyLeu: 6.665 ± 0.769
2.071GlyMet: 2.071 ± 0.374
3.171GlyAsn: 3.171 ± 0.636
6.536GlyPro: 6.536 ± 2.681
3.3GlyGln: 3.3 ± 0.524
5.436GlyArg: 5.436 ± 0.762
3.883GlySer: 3.883 ± 0.631
5.306GlyThr: 5.306 ± 0.639
5.954GlyVal: 5.954 ± 0.629
1.424GlyTrp: 1.424 ± 0.285
3.236GlyTyr: 3.236 ± 0.52
0.0GlyXaa: 0.0 ± 0.0
His
1.165HisAla: 1.165 ± 0.238
0.129HisCys: 0.129 ± 0.074
1.424HisAsp: 1.424 ± 0.279
1.1HisGlu: 1.1 ± 0.261
0.906HisPhe: 0.906 ± 0.224
2.265HisGly: 2.265 ± 0.493
0.582HisHis: 0.582 ± 0.185
1.553HisIle: 1.553 ± 0.307
0.841HisLys: 0.841 ± 0.242
1.23HisLeu: 1.23 ± 0.328
0.388HisMet: 0.388 ± 0.153
0.777HisAsn: 0.777 ± 0.199
1.294HisPro: 1.294 ± 0.304
0.971HisGln: 0.971 ± 0.237
1.747HisArg: 1.747 ± 0.364
0.582HisSer: 0.582 ± 0.222
0.841HisThr: 0.841 ± 0.229
0.841HisVal: 0.841 ± 0.229
0.324HisTrp: 0.324 ± 0.171
0.777HisTyr: 0.777 ± 0.225
0.0HisXaa: 0.0 ± 0.0
Ile
5.242IleAla: 5.242 ± 0.692
0.324IleCys: 0.324 ± 0.126
3.559IleAsp: 3.559 ± 0.439
4.077IleGlu: 4.077 ± 0.498
1.23IlePhe: 1.23 ± 0.302
4.4IleGly: 4.4 ± 0.493
1.23IleHis: 1.23 ± 0.306
1.747IleIle: 1.747 ± 0.347
1.553IleLys: 1.553 ± 0.267
2.847IleLeu: 2.847 ± 0.328
0.971IleMet: 0.971 ± 0.261
1.359IleAsn: 1.359 ± 0.334
3.43IlePro: 3.43 ± 0.439
1.424IleGln: 1.424 ± 0.352
3.494IleArg: 3.494 ± 0.422
2.265IleSer: 2.265 ± 0.55
3.43IleThr: 3.43 ± 0.424
3.43IleVal: 3.43 ± 0.503
0.777IleTrp: 0.777 ± 0.208
0.647IleTyr: 0.647 ± 0.185
0.0IleXaa: 0.0 ± 0.0
Lys
4.142LysAla: 4.142 ± 0.514
0.065LysCys: 0.065 ± 0.058
2.459LysAsp: 2.459 ± 0.428
2.912LysGlu: 2.912 ± 0.54
1.165LysPhe: 1.165 ± 0.255
4.336LysGly: 4.336 ± 0.559
0.971LysHis: 0.971 ± 0.261
1.941LysIle: 1.941 ± 0.411
2.071LysLys: 2.071 ± 0.41
3.236LysLeu: 3.236 ± 0.372
1.23LysMet: 1.23 ± 0.285
1.035LysAsn: 1.035 ± 0.21
2.394LysPro: 2.394 ± 0.485
1.683LysGln: 1.683 ± 0.268
2.912LysArg: 2.912 ± 0.488
2.2LysSer: 2.2 ± 0.398
2.524LysThr: 2.524 ± 0.479
2.783LysVal: 2.783 ± 0.466
0.841LysTrp: 0.841 ± 0.237
0.971LysTyr: 0.971 ± 0.221
0.0LysXaa: 0.0 ± 0.0
Leu
7.83LeuAla: 7.83 ± 0.705
0.712LeuCys: 0.712 ± 0.222
5.759LeuAsp: 5.759 ± 0.581
6.407LeuGlu: 6.407 ± 0.527
2.006LeuPhe: 2.006 ± 0.278
6.083LeuGly: 6.083 ± 0.784
1.812LeuHis: 1.812 ± 0.406
4.271LeuIle: 4.271 ± 0.49
3.559LeuLys: 3.559 ± 0.466
5.759LeuLeu: 5.759 ± 0.67
2.2LeuMet: 2.2 ± 0.406
2.653LeuAsn: 2.653 ± 0.431
4.077LeuPro: 4.077 ± 0.425
2.265LeuGln: 2.265 ± 0.506
6.407LeuArg: 6.407 ± 0.602
4.142LeuSer: 4.142 ± 0.401
5.501LeuThr: 5.501 ± 0.564
5.306LeuVal: 5.306 ± 0.551
1.165LeuTrp: 1.165 ± 0.309
2.524LeuTyr: 2.524 ± 0.456
0.0LeuXaa: 0.0 ± 0.0
Met
3.171MetAla: 3.171 ± 0.594
0.065MetCys: 0.065 ± 0.068
2.006MetAsp: 2.006 ± 0.382
1.035MetGlu: 1.035 ± 0.227
0.647MetPhe: 0.647 ± 0.202
1.683MetGly: 1.683 ± 0.376
0.129MetHis: 0.129 ± 0.082
1.359MetIle: 1.359 ± 0.324
1.488MetLys: 1.488 ± 0.261
1.294MetLeu: 1.294 ± 0.277
0.324MetMet: 0.324 ± 0.144
1.035MetAsn: 1.035 ± 0.271
1.424MetPro: 1.424 ± 0.318
0.777MetGln: 0.777 ± 0.297
1.683MetArg: 1.683 ± 0.357
1.747MetSer: 1.747 ± 0.233
2.071MetThr: 2.071 ± 0.335
1.23MetVal: 1.23 ± 0.297
0.324MetTrp: 0.324 ± 0.124
0.712MetTyr: 0.712 ± 0.207
0.0MetXaa: 0.0 ± 0.0
Asn
3.171AsnAla: 3.171 ± 0.446
0.324AsnCys: 0.324 ± 0.133
1.941AsnAsp: 1.941 ± 0.3
1.618AsnGlu: 1.618 ± 0.244
1.424AsnPhe: 1.424 ± 0.322
3.494AsnGly: 3.494 ± 0.643
0.841AsnHis: 0.841 ± 0.224
2.006AsnIle: 2.006 ± 0.398
0.712AsnLys: 0.712 ± 0.185
2.718AsnLeu: 2.718 ± 0.341
0.647AsnMet: 0.647 ± 0.173
1.165AsnAsn: 1.165 ± 0.247
2.653AsnPro: 2.653 ± 0.463
1.165AsnGln: 1.165 ± 0.343
2.265AsnArg: 2.265 ± 0.345
1.294AsnSer: 1.294 ± 0.246
1.812AsnThr: 1.812 ± 0.287
2.653AsnVal: 2.653 ± 0.462
0.647AsnTrp: 0.647 ± 0.176
0.777AsnTyr: 0.777 ± 0.22
0.0AsnXaa: 0.0 ± 0.0
Pro
5.565ProAla: 5.565 ± 0.509
0.388ProCys: 0.388 ± 0.178
3.236ProAsp: 3.236 ± 0.478
4.465ProGlu: 4.465 ± 0.598
1.618ProPhe: 1.618 ± 0.261
4.918ProGly: 4.918 ± 0.77
0.906ProHis: 0.906 ± 0.182
2.136ProIle: 2.136 ± 0.345
2.524ProLys: 2.524 ± 0.537
4.077ProLeu: 4.077 ± 0.644
1.23ProMet: 1.23 ± 0.289
2.524ProAsn: 2.524 ± 0.452
2.912ProPro: 2.912 ± 0.677
3.689ProGln: 3.689 ± 1.426
3.43ProArg: 3.43 ± 0.643
2.459ProSer: 2.459 ± 0.334
4.142ProThr: 4.142 ± 0.563
4.206ProVal: 4.206 ± 0.575
1.035ProTrp: 1.035 ± 0.34
1.553ProTyr: 1.553 ± 0.264
0.0ProXaa: 0.0 ± 0.0
Gln
3.43GlnAla: 3.43 ± 0.439
0.129GlnCys: 0.129 ± 0.076
1.618GlnAsp: 1.618 ± 0.344
2.394GlnGlu: 2.394 ± 0.428
1.294GlnPhe: 1.294 ± 0.382
4.918GlnGly: 4.918 ± 2.018
0.647GlnHis: 0.647 ± 0.201
1.941GlnIle: 1.941 ± 0.394
1.165GlnLys: 1.165 ± 0.273
3.883GlnLeu: 3.883 ± 0.65
1.165GlnMet: 1.165 ± 0.393
0.841GlnAsn: 0.841 ± 0.267
1.812GlnPro: 1.812 ± 0.294
2.394GlnGln: 2.394 ± 0.521
3.236GlnArg: 3.236 ± 0.512
2.006GlnSer: 2.006 ± 0.432
1.683GlnThr: 1.683 ± 0.438
2.718GlnVal: 2.718 ± 0.418
0.777GlnTrp: 0.777 ± 0.217
0.841GlnTyr: 0.841 ± 0.181
0.0GlnXaa: 0.0 ± 0.0
Arg
6.212ArgAla: 6.212 ± 0.696
0.906ArgCys: 0.906 ± 0.324
3.624ArgAsp: 3.624 ± 0.54
4.853ArgGlu: 4.853 ± 0.684
2.459ArgPhe: 2.459 ± 0.361
4.206ArgGly: 4.206 ± 0.58
1.488ArgHis: 1.488 ± 0.303
3.883ArgIle: 3.883 ± 0.489
3.689ArgLys: 3.689 ± 0.496
5.63ArgLeu: 5.63 ± 0.789
2.2ArgMet: 2.2 ± 0.333
2.459ArgAsn: 2.459 ± 0.321
2.459ArgPro: 2.459 ± 0.362
2.33ArgGln: 2.33 ± 0.371
5.112ArgArg: 5.112 ± 0.672
3.3ArgSer: 3.3 ± 0.581
2.524ArgThr: 2.524 ± 0.359
5.501ArgVal: 5.501 ± 0.417
1.747ArgTrp: 1.747 ± 0.376
2.071ArgTyr: 2.071 ± 0.388
0.0ArgXaa: 0.0 ± 0.0
Ser
3.883SerAla: 3.883 ± 0.573
0.194SerCys: 0.194 ± 0.108
2.977SerAsp: 2.977 ± 0.405
3.559SerGlu: 3.559 ± 0.451
2.653SerPhe: 2.653 ± 0.405
4.918SerGly: 4.918 ± 0.692
1.1SerHis: 1.1 ± 0.252
2.136SerIle: 2.136 ± 0.306
2.394SerLys: 2.394 ± 0.466
4.4SerLeu: 4.4 ± 0.671
1.553SerMet: 1.553 ± 0.279
1.424SerAsn: 1.424 ± 0.319
2.524SerPro: 2.524 ± 0.361
1.812SerGln: 1.812 ± 0.495
2.912SerArg: 2.912 ± 0.491
2.071SerSer: 2.071 ± 0.397
2.783SerThr: 2.783 ± 0.432
3.494SerVal: 3.494 ± 0.429
1.1SerTrp: 1.1 ± 0.256
1.359SerTyr: 1.359 ± 0.354
0.0SerXaa: 0.0 ± 0.0
Thr
5.889ThrAla: 5.889 ± 0.605
0.712ThrCys: 0.712 ± 0.248
3.106ThrAsp: 3.106 ± 0.548
3.753ThrGlu: 3.753 ± 0.432
2.265ThrPhe: 2.265 ± 0.353
5.565ThrGly: 5.565 ± 0.73
0.906ThrHis: 0.906 ± 0.277
2.33ThrIle: 2.33 ± 0.493
2.006ThrLys: 2.006 ± 0.413
5.695ThrLeu: 5.695 ± 0.663
0.906ThrMet: 0.906 ± 0.239
1.812ThrAsn: 1.812 ± 0.359
3.624ThrPro: 3.624 ± 0.484
2.588ThrGln: 2.588 ± 0.498
3.559ThrArg: 3.559 ± 0.594
2.394ThrSer: 2.394 ± 0.364
3.3ThrThr: 3.3 ± 0.443
3.947ThrVal: 3.947 ± 0.464
1.553ThrTrp: 1.553 ± 0.35
1.941ThrTyr: 1.941 ± 0.321
0.0ThrXaa: 0.0 ± 0.0
Val
6.342ValAla: 6.342 ± 0.643
0.518ValCys: 0.518 ± 0.179
5.501ValAsp: 5.501 ± 0.547
5.177ValGlu: 5.177 ± 0.597
2.394ValPhe: 2.394 ± 0.493
4.983ValGly: 4.983 ± 0.605
1.294ValHis: 1.294 ± 0.289
3.624ValIle: 3.624 ± 0.523
3.559ValLys: 3.559 ± 0.498
5.242ValLeu: 5.242 ± 0.476
1.1ValMet: 1.1 ± 0.275
2.588ValAsn: 2.588 ± 0.469
4.206ValPro: 4.206 ± 0.625
2.394ValGln: 2.394 ± 0.424
4.465ValArg: 4.465 ± 0.483
4.918ValSer: 4.918 ± 0.502
4.077ValThr: 4.077 ± 0.551
5.565ValVal: 5.565 ± 0.552
1.488ValTrp: 1.488 ± 0.332
1.941ValTyr: 1.941 ± 0.377
0.0ValXaa: 0.0 ± 0.0
Trp
1.877TrpAla: 1.877 ± 0.438
0.453TrpCys: 0.453 ± 0.191
1.553TrpAsp: 1.553 ± 0.348
1.165TrpGlu: 1.165 ± 0.277
0.712TrpPhe: 0.712 ± 0.234
1.424TrpGly: 1.424 ± 0.269
0.453TrpHis: 0.453 ± 0.184
1.294TrpIle: 1.294 ± 0.289
0.518TrpLys: 0.518 ± 0.155
1.424TrpLeu: 1.424 ± 0.29
0.777TrpMet: 0.777 ± 0.18
0.777TrpAsn: 0.777 ± 0.259
0.777TrpPro: 0.777 ± 0.218
0.971TrpGln: 0.971 ± 0.266
0.906TrpArg: 0.906 ± 0.202
1.23TrpSer: 1.23 ± 0.294
1.1TrpThr: 1.1 ± 0.295
1.618TrpVal: 1.618 ± 0.28
0.518TrpTrp: 0.518 ± 0.163
0.324TrpTyr: 0.324 ± 0.112
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.977TyrAla: 2.977 ± 0.544
0.324TyrCys: 0.324 ± 0.141
2.2TyrAsp: 2.2 ± 0.476
2.2TyrGlu: 2.2 ± 0.419
0.582TyrPhe: 0.582 ± 0.161
2.136TyrGly: 2.136 ± 0.418
0.518TyrHis: 0.518 ± 0.19
1.165TyrIle: 1.165 ± 0.306
0.971TyrLys: 0.971 ± 0.261
2.653TyrLeu: 2.653 ± 0.393
0.971TyrMet: 0.971 ± 0.318
1.294TyrAsn: 1.294 ± 0.274
1.294TyrPro: 1.294 ± 0.243
0.971TyrGln: 0.971 ± 0.237
2.265TyrArg: 2.265 ± 0.397
1.165TyrSer: 1.165 ± 0.25
2.071TyrThr: 2.071 ± 0.359
2.265TyrVal: 2.265 ± 0.524
0.582TyrTrp: 0.582 ± 0.193
1.1TyrTyr: 1.1 ± 0.339
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (15454 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski