Amino acid dipepetide frequency for Circovirus-like genome BBC-A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
1.905AlaCys: 1.905 ± 1.234
1.905AlaAsp: 1.905 ± 1.234
5.714AlaGlu: 5.714 ± 1.393
1.905AlaPhe: 1.905 ± 1.076
1.905AlaGly: 1.905 ± 1.234
0.0AlaHis: 0.0 ± 0.0
7.619AlaIle: 7.619 ± 1.993
0.0AlaLys: 0.0 ± 0.0
0.0AlaLeu: 0.0 ± 0.0
0.0AlaMet: 0.0 ± 0.0
3.81AlaAsn: 3.81 ± 2.469
0.0AlaPro: 0.0 ± 0.0
0.0AlaGln: 0.0 ± 0.0
1.905AlaArg: 1.905 ± 1.076
5.714AlaSer: 5.714 ± 1.393
1.905AlaThr: 1.905 ± 1.234
1.905AlaVal: 1.905 ± 1.234
0.0AlaTrp: 0.0 ± 0.0
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.905CysGlu: 1.905 ± 1.234
3.81CysPhe: 3.81 ± 0.158
1.905CysGly: 1.905 ± 1.076
1.905CysHis: 1.905 ± 1.234
0.0CysIle: 0.0 ± 0.0
1.905CysLys: 1.905 ± 1.076
1.905CysLeu: 1.905 ± 1.076
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.905CysPro: 1.905 ± 1.076
0.0CysGln: 0.0 ± 0.0
3.81CysArg: 3.81 ± 2.469
1.905CysSer: 1.905 ± 1.076
0.0CysThr: 0.0 ± 0.0
1.905CysVal: 1.905 ± 1.076
3.81CysTrp: 3.81 ± 0.158
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.81AspAla: 3.81 ± 2.469
0.0AspCys: 0.0 ± 0.0
1.905AspAsp: 1.905 ± 1.076
1.905AspGlu: 1.905 ± 1.076
7.619AspPhe: 7.619 ± 2.627
1.905AspGly: 1.905 ± 1.076
0.0AspHis: 0.0 ± 0.0
5.714AspIle: 5.714 ± 0.917
0.0AspLys: 0.0 ± 0.0
5.714AspLeu: 5.714 ± 3.703
0.0AspMet: 0.0 ± 0.0
3.81AspAsn: 3.81 ± 2.152
0.0AspPro: 0.0 ± 0.0
1.905AspGln: 1.905 ± 1.076
0.0AspArg: 0.0 ± 0.0
0.0AspSer: 0.0 ± 0.0
5.714AspThr: 5.714 ± 1.393
5.714AspVal: 5.714 ± 3.703
1.905AspTrp: 1.905 ± 1.076
5.714AspTyr: 5.714 ± 1.393
0.0AspXaa: 0.0 ± 0.0
Glu
3.81GluAla: 3.81 ± 0.158
0.0GluCys: 0.0 ± 0.0
9.524GluAsp: 9.524 ± 1.551
0.0GluGlu: 0.0 ± 0.0
5.714GluPhe: 5.714 ± 3.228
1.905GluGly: 1.905 ± 1.076
0.0GluHis: 0.0 ± 0.0
1.905GluIle: 1.905 ± 1.234
3.81GluLys: 3.81 ± 2.152
1.905GluLeu: 1.905 ± 1.234
3.81GluMet: 3.81 ± 0.158
5.714GluAsn: 5.714 ± 0.917
1.905GluPro: 1.905 ± 1.076
1.905GluGln: 1.905 ± 1.076
3.81GluArg: 3.81 ± 2.469
1.905GluSer: 1.905 ± 1.234
3.81GluThr: 3.81 ± 0.158
3.81GluVal: 3.81 ± 2.152
0.0GluTrp: 0.0 ± 0.0
5.714GluTyr: 5.714 ± 3.228
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
1.905PheCys: 1.905 ± 1.076
5.714PheAsp: 5.714 ± 1.393
3.81PheGlu: 3.81 ± 0.158
5.714PhePhe: 5.714 ± 0.917
11.429PheGly: 11.429 ± 6.455
3.81PheHis: 3.81 ± 0.158
1.905PheIle: 1.905 ± 1.076
5.714PheLys: 5.714 ± 0.917
1.905PheLeu: 1.905 ± 1.076
0.0PheMet: 0.0 ± 0.958
5.714PheAsn: 5.714 ± 3.228
0.0PhePro: 0.0 ± 0.0
0.0PheGln: 0.0 ± 0.0
1.905PheArg: 1.905 ± 1.234
5.714PheSer: 5.714 ± 0.917
3.81PheThr: 3.81 ± 0.158
1.905PheVal: 1.905 ± 1.234
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
5.714GlyAla: 5.714 ± 3.703
1.905GlyCys: 1.905 ± 1.076
0.0GlyAsp: 0.0 ± 0.0
3.81GlyGlu: 3.81 ± 2.152
0.0GlyPhe: 0.0 ± 0.0
1.905GlyGly: 1.905 ± 1.234
1.905GlyHis: 1.905 ± 1.076
5.714GlyIle: 5.714 ± 3.228
7.619GlyLys: 7.619 ± 4.303
1.905GlyLeu: 1.905 ± 1.234
0.0GlyMet: 0.0 ± 0.0
3.81GlyAsn: 3.81 ± 2.469
1.905GlyPro: 1.905 ± 1.076
0.0GlyGln: 0.0 ± 0.0
1.905GlyArg: 1.905 ± 1.076
1.905GlySer: 1.905 ± 1.076
7.619GlyThr: 7.619 ± 1.993
3.81GlyVal: 3.81 ± 2.469
0.0GlyTrp: 0.0 ± 0.0
3.81GlyTyr: 3.81 ± 2.152
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
1.905HisCys: 1.905 ± 1.234
0.0HisAsp: 0.0 ± 0.0
1.905HisGlu: 1.905 ± 1.234
3.81HisPhe: 3.81 ± 2.152
0.0HisGly: 0.0 ± 0.0
1.905HisHis: 1.905 ± 1.234
1.905HisIle: 1.905 ± 1.234
0.0HisLys: 0.0 ± 0.0
1.905HisLeu: 1.905 ± 1.076
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
3.81HisSer: 3.81 ± 2.152
3.81HisThr: 3.81 ± 2.152
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
3.81HisTyr: 3.81 ± 2.152
0.0HisXaa: 0.0 ± 0.0
Ile
3.81IleAla: 3.81 ± 0.158
0.0IleCys: 0.0 ± 0.0
3.81IleAsp: 3.81 ± 2.152
7.619IleGlu: 7.619 ± 0.317
3.81IlePhe: 3.81 ± 2.152
5.714IleGly: 5.714 ± 3.703
0.0IleHis: 0.0 ± 0.0
5.714IleIle: 5.714 ± 1.393
3.81IleLys: 3.81 ± 0.158
5.714IleLeu: 5.714 ± 0.917
0.0IleMet: 0.0 ± 0.0
9.524IleAsn: 9.524 ± 1.551
0.0IlePro: 0.0 ± 0.0
7.619IleGln: 7.619 ± 1.993
1.905IleArg: 1.905 ± 1.234
7.619IleSer: 7.619 ± 2.627
3.81IleThr: 3.81 ± 2.152
0.0IleVal: 0.0 ± 0.0
1.905IleTrp: 1.905 ± 1.076
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
1.905LysAla: 1.905 ± 1.076
1.905LysCys: 1.905 ± 1.234
1.905LysAsp: 1.905 ± 1.234
0.0LysGlu: 0.0 ± 0.0
1.905LysPhe: 1.905 ± 1.076
5.714LysGly: 5.714 ± 0.917
0.0LysHis: 0.0 ± 0.0
7.619LysIle: 7.619 ± 2.627
9.524LysLys: 9.524 ± 1.551
5.714LysLeu: 5.714 ± 0.917
1.905LysMet: 1.905 ± 0.91
13.333LysAsn: 13.333 ± 1.709
3.81LysPro: 3.81 ± 2.152
0.0LysGln: 0.0 ± 0.0
1.905LysArg: 1.905 ± 1.076
1.905LysSer: 1.905 ± 1.076
7.619LysThr: 7.619 ± 1.993
5.714LysVal: 5.714 ± 1.393
1.905LysTrp: 1.905 ± 1.234
3.81LysTyr: 3.81 ± 2.152
0.0LysXaa: 0.0 ± 0.0
Leu
0.0LeuAla: 0.0 ± 0.0
0.0LeuCys: 0.0 ± 0.0
1.905LeuAsp: 1.905 ± 1.234
5.714LeuGlu: 5.714 ± 0.917
1.905LeuPhe: 1.905 ± 1.234
3.81LeuGly: 3.81 ± 2.152
1.905LeuHis: 1.905 ± 1.076
3.81LeuIle: 3.81 ± 0.158
5.714LeuLys: 5.714 ± 3.228
5.714LeuLeu: 5.714 ± 3.703
1.905LeuMet: 1.905 ± 1.234
1.905LeuAsn: 1.905 ± 1.076
1.905LeuPro: 1.905 ± 1.234
1.905LeuGln: 1.905 ± 1.076
1.905LeuArg: 1.905 ± 1.076
5.714LeuSer: 5.714 ± 3.703
3.81LeuThr: 3.81 ± 2.469
1.905LeuVal: 1.905 ± 1.076
1.905LeuTrp: 1.905 ± 1.234
5.714LeuTyr: 5.714 ± 1.393
0.0LeuXaa: 0.0 ± 0.0
Met
1.905MetAla: 1.905 ± 1.234
1.905MetCys: 1.905 ± 1.234
1.905MetAsp: 1.905 ± 1.234
1.905MetGlu: 1.905 ± 1.076
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.905MetIle: 1.905 ± 1.076
3.81MetLys: 3.81 ± 0.158
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.905MetSer: 1.905 ± 1.234
1.905MetThr: 1.905 ± 1.076
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
5.714AsnAla: 5.714 ± 1.393
0.0AsnCys: 0.0 ± 0.0
1.905AsnAsp: 1.905 ± 1.234
3.81AsnGlu: 3.81 ± 2.469
9.524AsnPhe: 9.524 ± 1.551
1.905AsnGly: 1.905 ± 1.076
3.81AsnHis: 3.81 ± 2.152
3.81AsnIle: 3.81 ± 0.158
3.81AsnLys: 3.81 ± 2.469
1.905AsnLeu: 1.905 ± 1.076
1.905AsnMet: 1.905 ± 1.076
9.524AsnAsn: 9.524 ± 3.861
3.81AsnPro: 3.81 ± 0.158
7.619AsnGln: 7.619 ± 0.317
1.905AsnArg: 1.905 ± 1.076
3.81AsnSer: 3.81 ± 2.469
5.714AsnThr: 5.714 ± 3.703
5.714AsnVal: 5.714 ± 0.917
0.0AsnTrp: 0.0 ± 0.0
7.619AsnTyr: 7.619 ± 0.317
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.0ProCys: 0.0 ± 0.0
0.0ProAsp: 0.0 ± 0.0
0.0ProGlu: 0.0 ± 0.0
1.905ProPhe: 1.905 ± 1.076
1.905ProGly: 1.905 ± 1.076
1.905ProHis: 1.905 ± 1.076
0.0ProIle: 0.0 ± 0.0
3.81ProLys: 3.81 ± 2.152
0.0ProLeu: 0.0 ± 0.0
0.0ProMet: 0.0 ± 0.0
3.81ProAsn: 3.81 ± 0.158
1.905ProPro: 1.905 ± 1.076
0.0ProGln: 0.0 ± 0.0
3.81ProArg: 3.81 ± 2.152
0.0ProSer: 0.0 ± 0.0
1.905ProThr: 1.905 ± 1.076
1.905ProVal: 1.905 ± 1.234
0.0ProTrp: 0.0 ± 0.0
1.905ProTyr: 1.905 ± 1.234
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
1.905GlnCys: 1.905 ± 1.076
5.714GlnAsp: 5.714 ± 1.393
0.0GlnGlu: 0.0 ± 0.0
1.905GlnPhe: 1.905 ± 1.076
5.714GlnGly: 5.714 ± 3.228
0.0GlnHis: 0.0 ± 0.0
1.905GlnIle: 1.905 ± 1.234
1.905GlnLys: 1.905 ± 1.234
0.0GlnLeu: 0.0 ± 0.0
0.0GlnMet: 0.0 ± 0.0
1.905GlnAsn: 1.905 ± 1.234
0.0GlnPro: 0.0 ± 0.0
0.0GlnGln: 0.0 ± 0.0
1.905GlnArg: 1.905 ± 1.234
0.0GlnSer: 0.0 ± 0.0
3.81GlnThr: 3.81 ± 0.158
1.905GlnVal: 1.905 ± 1.234
0.0GlnTrp: 0.0 ± 0.0
1.905GlnTyr: 1.905 ± 1.076
0.0GlnXaa: 0.0 ± 0.0
Arg
1.905ArgAla: 1.905 ± 1.076
1.905ArgCys: 1.905 ± 1.076
1.905ArgAsp: 1.905 ± 1.076
5.714ArgGlu: 5.714 ± 3.228
1.905ArgPhe: 1.905 ± 1.076
1.905ArgGly: 1.905 ± 1.234
0.0ArgHis: 0.0 ± 0.0
3.81ArgIle: 3.81 ± 2.469
3.81ArgLys: 3.81 ± 2.469
3.81ArgLeu: 3.81 ± 0.158
1.905ArgMet: 1.905 ± 1.234
3.81ArgAsn: 3.81 ± 0.158
1.905ArgPro: 1.905 ± 1.076
0.0ArgGln: 0.0 ± 0.0
5.714ArgArg: 5.714 ± 0.917
9.524ArgSer: 9.524 ± 0.759
3.81ArgThr: 3.81 ± 2.152
0.0ArgVal: 0.0 ± 0.0
0.0ArgTrp: 0.0 ± 0.0
1.905ArgTyr: 1.905 ± 1.234
0.0ArgXaa: 0.0 ± 0.0
Ser
1.905SerAla: 1.905 ± 1.234
0.0SerCys: 0.0 ± 0.0
3.81SerAsp: 3.81 ± 0.158
1.905SerGlu: 1.905 ± 1.076
0.0SerPhe: 0.0 ± 0.0
3.81SerGly: 3.81 ± 2.469
3.81SerHis: 3.81 ± 0.158
5.714SerIle: 5.714 ± 1.393
1.905SerLys: 1.905 ± 1.076
3.81SerLeu: 3.81 ± 0.158
3.81SerMet: 3.81 ± 0.158
9.524SerAsn: 9.524 ± 6.171
0.0SerPro: 0.0 ± 0.0
0.0SerGln: 0.0 ± 0.0
7.619SerArg: 7.619 ± 1.993
1.905SerSer: 1.905 ± 1.234
5.714SerThr: 5.714 ± 1.393
0.0SerVal: 0.0 ± 0.0
0.0SerTrp: 0.0 ± 0.0
3.81SerTyr: 3.81 ± 2.152
0.0SerXaa: 0.0 ± 0.0
Thr
1.905ThrAla: 1.905 ± 1.234
0.0ThrCys: 0.0 ± 0.0
5.714ThrAsp: 5.714 ± 0.917
9.524ThrGlu: 9.524 ± 3.069
3.81ThrPhe: 3.81 ± 0.158
1.905ThrGly: 1.905 ± 1.234
1.905ThrHis: 1.905 ± 1.076
0.0ThrIle: 0.0 ± 0.0
15.238ThrLys: 15.238 ± 0.634
1.905ThrLeu: 1.905 ± 1.234
0.0ThrMet: 0.0 ± 0.0
5.714ThrAsn: 5.714 ± 1.393
3.81ThrPro: 3.81 ± 0.158
3.81ThrGln: 3.81 ± 2.469
3.81ThrArg: 3.81 ± 2.152
0.0ThrSer: 0.0 ± 0.0
13.333ThrThr: 13.333 ± 0.601
5.714ThrVal: 5.714 ± 3.228
0.0ThrTrp: 0.0 ± 0.0
1.905ThrTyr: 1.905 ± 1.234
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
5.714ValCys: 5.714 ± 0.917
3.81ValAsp: 3.81 ± 2.469
3.81ValGlu: 3.81 ± 2.152
1.905ValPhe: 1.905 ± 1.076
0.0ValGly: 0.0 ± 0.0
0.0ValHis: 0.0 ± 0.0
7.619ValIle: 7.619 ± 1.993
3.81ValLys: 3.81 ± 2.469
5.714ValLeu: 5.714 ± 1.393
0.0ValMet: 0.0 ± 0.0
0.0ValAsn: 0.0 ± 0.0
1.905ValPro: 1.905 ± 1.076
3.81ValGln: 3.81 ± 2.469
1.905ValArg: 1.905 ± 1.234
1.905ValSer: 1.905 ± 1.234
1.905ValThr: 1.905 ± 1.234
7.619ValVal: 7.619 ± 2.627
1.905ValTrp: 1.905 ± 1.076
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
1.905TrpAla: 1.905 ± 1.076
1.905TrpCys: 1.905 ± 1.234
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
1.905TrpHis: 1.905 ± 1.076
1.905TrpIle: 1.905 ± 1.234
0.0TrpLys: 0.0 ± 0.0
1.905TrpLeu: 1.905 ± 1.076
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.905TrpArg: 1.905 ± 1.234
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.905TrpTyr: 1.905 ± 1.076
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.905TyrAla: 1.905 ± 1.076
3.81TyrCys: 3.81 ± 2.152
1.905TyrAsp: 1.905 ± 1.076
1.905TyrGlu: 1.905 ± 1.234
5.714TyrPhe: 5.714 ± 0.917
1.905TyrGly: 1.905 ± 1.076
0.0TyrHis: 0.0 ± 0.0
3.81TyrIle: 3.81 ± 2.152
1.905TyrLys: 1.905 ± 1.234
7.619TyrLeu: 7.619 ± 0.317
0.0TyrMet: 0.0 ± 0.0
1.905TyrAsn: 1.905 ± 1.076
0.0TyrPro: 0.0 ± 0.0
1.905TyrGln: 1.905 ± 1.234
7.619TyrArg: 7.619 ± 1.993
3.81TyrSer: 3.81 ± 0.158
0.0TyrThr: 0.0 ± 0.0
3.81TyrVal: 3.81 ± 0.158
0.0TyrTrp: 0.0 ± 0.0
5.714TyrTyr: 5.714 ± 1.393
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (526 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski