Amino acid dipepetide frequency for Klebsiella phage KPV811

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.117AlaAla: 15.117 ± 2.029
0.735AlaCys: 0.735 ± 0.274
6.374AlaAsp: 6.374 ± 0.744
6.374AlaGlu: 6.374 ± 0.673
3.269AlaPhe: 3.269 ± 0.592
7.926AlaGly: 7.926 ± 1.148
1.716AlaHis: 1.716 ± 0.346
4.658AlaIle: 4.658 ± 0.761
5.393AlaLys: 5.393 ± 0.937
8.988AlaLeu: 8.988 ± 0.911
3.759AlaMet: 3.759 ± 0.463
3.023AlaAsn: 3.023 ± 0.415
5.066AlaPro: 5.066 ± 1.457
5.066AlaGln: 5.066 ± 0.865
5.311AlaArg: 5.311 ± 0.734
6.21AlaSer: 6.21 ± 0.809
4.903AlaThr: 4.903 ± 0.651
7.109AlaVal: 7.109 ± 0.872
1.144AlaTrp: 1.144 ± 0.317
4.331AlaTyr: 4.331 ± 0.569
0.0AlaXaa: 0.0 ± 0.0
Cys
0.735CysAla: 0.735 ± 0.272
0.163CysCys: 0.163 ± 0.12
0.654CysAsp: 0.654 ± 0.199
0.654CysGlu: 0.654 ± 0.257
0.409CysPhe: 0.409 ± 0.193
0.654CysGly: 0.654 ± 0.228
0.327CysHis: 0.327 ± 0.167
0.409CysIle: 0.409 ± 0.198
0.49CysLys: 0.49 ± 0.256
0.899CysLeu: 0.899 ± 0.268
0.49CysMet: 0.49 ± 0.163
0.082CysAsn: 0.082 ± 0.075
0.49CysPro: 0.49 ± 0.271
0.572CysGln: 0.572 ± 0.251
0.735CysArg: 0.735 ± 0.189
0.899CysSer: 0.899 ± 0.251
0.899CysThr: 0.899 ± 0.283
0.735CysVal: 0.735 ± 0.2
0.163CysTrp: 0.163 ± 0.117
0.572CysTyr: 0.572 ± 0.21
0.0CysXaa: 0.0 ± 0.0
Asp
8.09AspAla: 8.09 ± 0.805
1.553AspCys: 1.553 ± 0.508
3.35AspAsp: 3.35 ± 0.588
3.514AspGlu: 3.514 ± 0.504
2.288AspPhe: 2.288 ± 0.356
5.066AspGly: 5.066 ± 0.679
0.327AspHis: 0.327 ± 0.137
3.514AspIle: 3.514 ± 0.456
3.023AspLys: 3.023 ± 0.507
5.965AspLeu: 5.965 ± 0.59
2.206AspMet: 2.206 ± 0.506
2.942AspAsn: 2.942 ± 0.476
2.37AspPro: 2.37 ± 0.539
1.553AspGln: 1.553 ± 0.29
2.778AspArg: 2.778 ± 0.613
4.576AspSer: 4.576 ± 0.65
4.576AspThr: 4.576 ± 0.757
3.677AspVal: 3.677 ± 0.471
0.817AspTrp: 0.817 ± 0.181
2.778AspTyr: 2.778 ± 0.604
0.0AspXaa: 0.0 ± 0.0
Glu
6.047GluAla: 6.047 ± 0.967
0.654GluCys: 0.654 ± 0.186
3.269GluAsp: 3.269 ± 0.445
3.84GluGlu: 3.84 ± 0.904
2.125GluPhe: 2.125 ± 0.445
3.269GluGly: 3.269 ± 0.382
2.288GluHis: 2.288 ± 0.441
2.697GluIle: 2.697 ± 0.429
2.043GluLys: 2.043 ± 0.458
5.556GluLeu: 5.556 ± 0.613
2.288GluMet: 2.288 ± 0.432
1.716GluAsn: 1.716 ± 0.345
2.043GluPro: 2.043 ± 0.418
3.677GluGln: 3.677 ± 0.71
3.269GluArg: 3.269 ± 0.494
2.615GluSer: 2.615 ± 0.484
2.778GluThr: 2.778 ± 0.491
4.739GluVal: 4.739 ± 0.53
0.899GluTrp: 0.899 ± 0.209
2.86GluTyr: 2.86 ± 0.407
0.0GluXaa: 0.0 ± 0.0
Phe
2.697PheAla: 2.697 ± 0.407
0.327PheCys: 0.327 ± 0.25
2.043PheAsp: 2.043 ± 0.356
2.125PheGlu: 2.125 ± 0.291
1.144PhePhe: 1.144 ± 0.279
2.288PheGly: 2.288 ± 0.4
0.409PheHis: 0.409 ± 0.148
1.553PheIle: 1.553 ± 0.287
2.043PheLys: 2.043 ± 0.398
2.206PheLeu: 2.206 ± 0.389
0.735PheMet: 0.735 ± 0.303
1.798PheAsn: 1.798 ± 0.41
1.471PhePro: 1.471 ± 0.296
1.307PheGln: 1.307 ± 0.295
1.389PheArg: 1.389 ± 0.369
1.389PheSer: 1.389 ± 0.385
1.716PheThr: 1.716 ± 0.351
1.879PheVal: 1.879 ± 0.332
0.327PheTrp: 0.327 ± 0.151
1.226PheTyr: 1.226 ± 0.299
0.0PheXaa: 0.0 ± 0.0
Gly
5.066GlyAla: 5.066 ± 0.533
1.226GlyCys: 1.226 ± 0.361
4.331GlyAsp: 4.331 ± 0.656
3.514GlyGlu: 3.514 ± 0.596
2.86GlyPhe: 2.86 ± 0.511
4.331GlyGly: 4.331 ± 0.65
0.817GlyHis: 0.817 ± 0.276
4.249GlyIle: 4.249 ± 0.523
3.84GlyLys: 3.84 ± 0.726
5.802GlyLeu: 5.802 ± 0.689
1.798GlyMet: 1.798 ± 0.409
3.759GlyAsn: 3.759 ± 0.76
1.634GlyPro: 1.634 ± 0.295
3.187GlyGln: 3.187 ± 0.545
5.148GlyArg: 5.148 ± 0.612
5.802GlySer: 5.802 ± 0.783
5.393GlyThr: 5.393 ± 0.903
5.066GlyVal: 5.066 ± 0.636
0.735GlyTrp: 0.735 ± 0.258
3.84GlyTyr: 3.84 ± 0.778
0.0GlyXaa: 0.0 ± 0.0
His
1.226HisAla: 1.226 ± 0.369
0.245HisCys: 0.245 ± 0.165
1.553HisAsp: 1.553 ± 0.284
0.981HisGlu: 0.981 ± 0.375
0.245HisPhe: 0.245 ± 0.134
1.553HisGly: 1.553 ± 0.38
0.163HisHis: 0.163 ± 0.107
0.654HisIle: 0.654 ± 0.259
0.817HisLys: 0.817 ± 0.232
2.37HisLeu: 2.37 ± 0.448
0.327HisMet: 0.327 ± 0.142
0.981HisAsn: 0.981 ± 0.314
0.572HisPro: 0.572 ± 0.248
0.899HisGln: 0.899 ± 0.312
1.307HisArg: 1.307 ± 0.344
1.062HisSer: 1.062 ± 0.283
0.735HisThr: 0.735 ± 0.162
0.735HisVal: 0.735 ± 0.219
0.245HisTrp: 0.245 ± 0.131
0.817HisTyr: 0.817 ± 0.277
0.0HisXaa: 0.0 ± 0.0
Ile
3.432IleAla: 3.432 ± 0.529
0.245IleCys: 0.245 ± 0.124
3.105IleAsp: 3.105 ± 0.432
2.778IleGlu: 2.778 ± 0.48
0.572IlePhe: 0.572 ± 0.195
3.023IleGly: 3.023 ± 0.454
0.735IleHis: 0.735 ± 0.232
1.961IleIle: 1.961 ± 0.328
3.187IleLys: 3.187 ± 0.55
4.821IleLeu: 4.821 ± 0.661
1.307IleMet: 1.307 ± 0.239
1.879IleAsn: 1.879 ± 0.373
2.451IlePro: 2.451 ± 0.402
2.86IleGln: 2.86 ± 0.553
3.105IleArg: 3.105 ± 0.437
3.595IleSer: 3.595 ± 0.491
2.86IleThr: 2.86 ± 0.532
2.615IleVal: 2.615 ± 0.576
0.163IleTrp: 0.163 ± 0.114
1.389IleTyr: 1.389 ± 0.345
0.0IleXaa: 0.0 ± 0.0
Lys
6.7LysAla: 6.7 ± 1.021
0.327LysCys: 0.327 ± 0.159
2.206LysAsp: 2.206 ± 0.295
3.677LysGlu: 3.677 ± 0.437
1.144LysPhe: 1.144 ± 0.351
3.105LysGly: 3.105 ± 0.578
0.981LysHis: 0.981 ± 0.326
1.553LysIle: 1.553 ± 0.371
1.961LysLys: 1.961 ± 0.426
4.167LysLeu: 4.167 ± 0.603
1.307LysMet: 1.307 ± 0.308
1.307LysAsn: 1.307 ± 0.331
1.634LysPro: 1.634 ± 0.389
3.759LysGln: 3.759 ± 0.541
3.269LysArg: 3.269 ± 0.504
3.187LysSer: 3.187 ± 0.453
2.533LysThr: 2.533 ± 0.443
3.432LysVal: 3.432 ± 0.448
1.062LysTrp: 1.062 ± 0.283
1.307LysTyr: 1.307 ± 0.406
0.0LysXaa: 0.0 ± 0.0
Leu
8.253LeuAla: 8.253 ± 0.992
1.062LeuCys: 1.062 ± 0.349
7.599LeuAsp: 7.599 ± 0.545
5.475LeuGlu: 5.475 ± 0.625
2.533LeuPhe: 2.533 ± 0.375
6.946LeuGly: 6.946 ± 0.738
1.226LeuHis: 1.226 ± 0.312
4.739LeuIle: 4.739 ± 0.751
3.35LeuLys: 3.35 ± 0.482
6.537LeuLeu: 6.537 ± 0.55
1.716LeuMet: 1.716 ± 0.316
3.595LeuAsn: 3.595 ± 0.502
3.105LeuPro: 3.105 ± 0.575
4.004LeuGln: 4.004 ± 0.495
6.374LeuArg: 6.374 ± 0.657
5.556LeuSer: 5.556 ± 0.664
5.23LeuThr: 5.23 ± 0.632
5.965LeuVal: 5.965 ± 0.918
1.144LeuTrp: 1.144 ± 0.303
3.84LeuTyr: 3.84 ± 0.431
0.0LeuXaa: 0.0 ± 0.0
Met
3.023MetAla: 3.023 ± 0.481
0.163MetCys: 0.163 ± 0.097
2.615MetAsp: 2.615 ± 0.534
0.899MetGlu: 0.899 ± 0.293
1.062MetPhe: 1.062 ± 0.302
1.471MetGly: 1.471 ± 0.235
0.572MetHis: 0.572 ± 0.265
0.899MetIle: 0.899 ± 0.288
0.899MetLys: 0.899 ± 0.294
3.677MetLeu: 3.677 ± 0.496
0.654MetMet: 0.654 ± 0.265
1.226MetAsn: 1.226 ± 0.339
1.062MetPro: 1.062 ± 0.233
2.288MetGln: 2.288 ± 0.376
1.716MetArg: 1.716 ± 0.451
2.043MetSer: 2.043 ± 0.566
1.471MetThr: 1.471 ± 0.423
1.798MetVal: 1.798 ± 0.395
0.409MetTrp: 0.409 ± 0.157
1.144MetTyr: 1.144 ± 0.305
0.0MetXaa: 0.0 ± 0.0
Asn
3.187AsnAla: 3.187 ± 0.489
0.409AsnCys: 0.409 ± 0.261
1.961AsnAsp: 1.961 ± 0.392
1.798AsnGlu: 1.798 ± 0.482
1.389AsnPhe: 1.389 ± 0.25
3.35AsnGly: 3.35 ± 0.556
0.245AsnHis: 0.245 ± 0.124
2.615AsnIle: 2.615 ± 0.47
2.533AsnLys: 2.533 ± 0.378
3.759AsnLeu: 3.759 ± 0.539
0.981AsnMet: 0.981 ± 0.325
2.615AsnAsn: 2.615 ± 0.684
2.86AsnPro: 2.86 ± 0.435
1.879AsnGln: 1.879 ± 0.378
1.716AsnArg: 1.716 ± 0.315
3.35AsnSer: 3.35 ± 0.593
2.615AsnThr: 2.615 ± 0.538
3.105AsnVal: 3.105 ± 0.483
0.572AsnTrp: 0.572 ± 0.228
1.307AsnTyr: 1.307 ± 0.318
0.0AsnXaa: 0.0 ± 0.0
Pro
5.393ProAla: 5.393 ± 1.082
0.245ProCys: 0.245 ± 0.127
3.023ProAsp: 3.023 ± 0.491
3.432ProGlu: 3.432 ± 0.503
0.735ProPhe: 0.735 ± 0.208
2.615ProGly: 2.615 ± 0.499
0.409ProHis: 0.409 ± 0.157
1.471ProIle: 1.471 ± 0.35
1.961ProLys: 1.961 ± 0.399
2.942ProLeu: 2.942 ± 0.569
1.226ProMet: 1.226 ± 0.265
2.125ProAsn: 2.125 ± 0.478
0.735ProPro: 0.735 ± 0.256
1.307ProGln: 1.307 ± 0.345
1.634ProArg: 1.634 ± 0.347
2.206ProSer: 2.206 ± 0.459
2.615ProThr: 2.615 ± 0.509
3.105ProVal: 3.105 ± 0.528
0.572ProTrp: 0.572 ± 0.188
1.553ProTyr: 1.553 ± 0.43
0.0ProXaa: 0.0 ± 0.0
Gln
5.638GlnAla: 5.638 ± 0.699
0.327GlnCys: 0.327 ± 0.182
3.269GlnAsp: 3.269 ± 0.674
3.677GlnGlu: 3.677 ± 0.657
1.307GlnPhe: 1.307 ± 0.301
3.35GlnGly: 3.35 ± 0.687
1.389GlnHis: 1.389 ± 0.398
1.144GlnIle: 1.144 ± 0.429
2.288GlnLys: 2.288 ± 0.414
4.739GlnLeu: 4.739 ± 0.602
1.389GlnMet: 1.389 ± 0.369
2.206GlnAsn: 2.206 ± 0.362
1.389GlnPro: 1.389 ± 0.428
3.187GlnGln: 3.187 ± 0.888
3.105GlnArg: 3.105 ± 0.469
2.86GlnSer: 2.86 ± 0.467
1.798GlnThr: 1.798 ± 0.481
3.187GlnVal: 3.187 ± 0.574
0.735GlnTrp: 0.735 ± 0.257
2.451GlnTyr: 2.451 ± 0.53
0.0GlnXaa: 0.0 ± 0.0
Arg
6.374ArgAla: 6.374 ± 0.819
0.735ArgCys: 0.735 ± 0.331
3.514ArgAsp: 3.514 ± 0.526
3.677ArgGlu: 3.677 ± 0.409
2.451ArgPhe: 2.451 ± 0.331
3.759ArgGly: 3.759 ± 0.593
0.981ArgHis: 0.981 ± 0.237
3.023ArgIle: 3.023 ± 0.717
3.187ArgLys: 3.187 ± 0.63
5.148ArgLeu: 5.148 ± 0.556
1.961ArgMet: 1.961 ± 0.373
2.615ArgAsn: 2.615 ± 0.429
1.471ArgPro: 1.471 ± 0.378
2.288ArgGln: 2.288 ± 0.399
4.004ArgArg: 4.004 ± 0.752
2.451ArgSer: 2.451 ± 0.594
3.105ArgThr: 3.105 ± 0.409
3.35ArgVal: 3.35 ± 0.469
0.572ArgTrp: 0.572 ± 0.184
1.798ArgTyr: 1.798 ± 0.352
0.0ArgXaa: 0.0 ± 0.0
Ser
8.09SerAla: 8.09 ± 0.932
0.572SerCys: 0.572 ± 0.223
3.84SerAsp: 3.84 ± 0.53
2.86SerGlu: 2.86 ± 0.578
1.634SerPhe: 1.634 ± 0.333
6.21SerGly: 6.21 ± 0.912
0.817SerHis: 0.817 ± 0.219
3.35SerIle: 3.35 ± 0.676
3.759SerLys: 3.759 ± 0.571
4.739SerLeu: 4.739 ± 0.635
2.615SerMet: 2.615 ± 0.493
2.451SerAsn: 2.451 ± 0.395
3.023SerPro: 3.023 ± 0.431
2.206SerGln: 2.206 ± 0.668
2.37SerArg: 2.37 ± 0.392
3.023SerSer: 3.023 ± 0.729
4.412SerThr: 4.412 ± 0.469
3.677SerVal: 3.677 ± 0.491
1.471SerTrp: 1.471 ± 0.362
1.471SerTyr: 1.471 ± 0.376
0.0SerXaa: 0.0 ± 0.0
Thr
6.292ThrAla: 6.292 ± 0.929
0.572ThrCys: 0.572 ± 0.257
3.922ThrAsp: 3.922 ± 0.432
2.533ThrGlu: 2.533 ± 0.594
1.389ThrPhe: 1.389 ± 0.309
4.739ThrGly: 4.739 ± 0.673
1.226ThrHis: 1.226 ± 0.394
1.961ThrIle: 1.961 ± 0.417
3.105ThrLys: 3.105 ± 0.548
4.903ThrLeu: 4.903 ± 0.629
1.389ThrMet: 1.389 ± 0.381
2.206ThrAsn: 2.206 ± 0.57
2.942ThrPro: 2.942 ± 0.434
3.023ThrGln: 3.023 ± 0.501
2.778ThrArg: 2.778 ± 0.54
4.658ThrSer: 4.658 ± 0.583
3.187ThrThr: 3.187 ± 0.659
4.249ThrVal: 4.249 ± 0.724
0.654ThrTrp: 0.654 ± 0.202
2.043ThrTyr: 2.043 ± 0.56
0.0ThrXaa: 0.0 ± 0.0
Val
6.864ValAla: 6.864 ± 0.874
0.327ValCys: 0.327 ± 0.148
5.311ValAsp: 5.311 ± 0.598
4.004ValGlu: 4.004 ± 0.697
1.389ValPhe: 1.389 ± 0.452
5.475ValGly: 5.475 ± 0.577
2.125ValHis: 2.125 ± 0.423
2.206ValIle: 2.206 ± 0.407
2.37ValLys: 2.37 ± 0.475
6.047ValLeu: 6.047 ± 0.93
1.634ValMet: 1.634 ± 0.275
3.187ValAsn: 3.187 ± 0.588
3.35ValPro: 3.35 ± 0.534
3.595ValGln: 3.595 ± 0.63
3.922ValArg: 3.922 ± 0.446
3.432ValSer: 3.432 ± 0.658
3.35ValThr: 3.35 ± 0.622
5.393ValVal: 5.393 ± 0.529
0.654ValTrp: 0.654 ± 0.2
2.206ValTyr: 2.206 ± 0.365
0.0ValXaa: 0.0 ± 0.0
Trp
1.062TrpAla: 1.062 ± 0.256
0.327TrpCys: 0.327 ± 0.156
0.572TrpAsp: 0.572 ± 0.166
1.062TrpGlu: 1.062 ± 0.359
0.899TrpPhe: 0.899 ± 0.321
0.49TrpGly: 0.49 ± 0.218
0.245TrpHis: 0.245 ± 0.132
0.654TrpIle: 0.654 ± 0.259
0.49TrpLys: 0.49 ± 0.271
1.144TrpLeu: 1.144 ± 0.241
0.245TrpMet: 0.245 ± 0.207
0.735TrpAsn: 0.735 ± 0.217
0.327TrpPro: 0.327 ± 0.181
0.654TrpGln: 0.654 ± 0.229
0.572TrpArg: 0.572 ± 0.207
0.572TrpSer: 0.572 ± 0.207
1.389TrpThr: 1.389 ± 0.256
1.144TrpVal: 1.144 ± 0.239
0.327TrpTrp: 0.327 ± 0.21
0.49TrpTyr: 0.49 ± 0.215
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.187TyrAla: 3.187 ± 0.563
0.817TyrCys: 0.817 ± 0.307
2.451TyrAsp: 2.451 ± 0.457
1.798TyrGlu: 1.798 ± 0.523
1.226TyrPhe: 1.226 ± 0.291
2.778TyrGly: 2.778 ± 0.549
0.49TyrHis: 0.49 ± 0.186
2.778TyrIle: 2.778 ± 0.664
1.879TyrLys: 1.879 ± 0.388
3.84TyrLeu: 3.84 ± 0.534
0.981TyrMet: 0.981 ± 0.277
1.798TyrAsn: 1.798 ± 0.449
1.307TyrPro: 1.307 ± 0.239
2.125TyrGln: 2.125 ± 0.411
2.043TyrArg: 2.043 ± 0.429
3.105TyrSer: 3.105 ± 0.398
2.206TyrThr: 2.206 ± 0.575
1.879TyrVal: 1.879 ± 0.412
0.735TyrTrp: 0.735 ± 0.279
1.389TyrTyr: 1.389 ± 0.371
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (12239 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski