Amino acid dipepetide frequency for Streptococcus pantholopis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.805AlaAla: 8.805 ± 0.158
0.53AlaCys: 0.53 ± 0.029
5.57AlaAsp: 5.57 ± 0.116
6.139AlaGlu: 6.139 ± 0.12
3.765AlaPhe: 3.765 ± 0.093
6.111AlaGly: 6.111 ± 0.123
1.358AlaHis: 1.358 ± 0.054
5.467AlaIle: 5.467 ± 0.105
5.15AlaLys: 5.15 ± 0.097
8.458AlaLeu: 8.458 ± 0.141
1.902AlaMet: 1.902 ± 0.055
3.073AlaAsn: 3.073 ± 0.089
2.284AlaPro: 2.284 ± 0.067
3.524AlaGln: 3.524 ± 0.077
3.011AlaArg: 3.011 ± 0.072
4.789AlaSer: 4.789 ± 0.096
3.639AlaThr: 3.639 ± 0.125
7.099AlaVal: 7.099 ± 0.109
0.656AlaTrp: 0.656 ± 0.036
3.254AlaTyr: 3.254 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.335CysAla: 0.335 ± 0.024
0.061CysCys: 0.061 ± 0.009
0.295CysAsp: 0.295 ± 0.024
0.236CysGlu: 0.236 ± 0.022
0.334CysPhe: 0.334 ± 0.026
0.533CysGly: 0.533 ± 0.032
0.161CysHis: 0.161 ± 0.018
0.317CysIle: 0.317 ± 0.022
0.184CysLys: 0.184 ± 0.018
0.686CysLeu: 0.686 ± 0.038
0.125CysMet: 0.125 ± 0.015
0.204CysAsn: 0.204 ± 0.019
0.222CysPro: 0.222 ± 0.021
0.309CysGln: 0.309 ± 0.025
0.319CysArg: 0.319 ± 0.025
0.413CysSer: 0.413 ± 0.026
0.261CysThr: 0.261 ± 0.019
0.334CysVal: 0.334 ± 0.027
0.065CysTrp: 0.065 ± 0.011
0.199CysTyr: 0.199 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.71AspAla: 3.71 ± 0.09
0.354AspCys: 0.354 ± 0.028
3.126AspAsp: 3.126 ± 0.097
3.705AspGlu: 3.705 ± 0.087
3.544AspPhe: 3.544 ± 0.08
3.891AspGly: 3.891 ± 0.096
0.895AspHis: 0.895 ± 0.039
4.496AspIle: 4.496 ± 0.085
3.891AspLys: 3.891 ± 0.09
6.131AspLeu: 6.131 ± 0.096
1.418AspMet: 1.418 ± 0.045
2.525AspAsn: 2.525 ± 0.075
1.657AspPro: 1.657 ± 0.078
1.8AspGln: 1.8 ± 0.055
2.273AspArg: 2.273 ± 0.059
3.953AspSer: 3.953 ± 0.084
2.827AspThr: 2.827 ± 0.074
3.49AspVal: 3.49 ± 0.074
0.649AspTrp: 0.649 ± 0.036
3.309AspTyr: 3.309 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
5.96GluAla: 5.96 ± 0.112
0.256GluCys: 0.256 ± 0.021
3.486GluAsp: 3.486 ± 0.075
5.649GluGlu: 5.649 ± 0.115
2.23GluPhe: 2.23 ± 0.066
3.448GluGly: 3.448 ± 0.075
1.305GluHis: 1.305 ± 0.05
4.985GluIle: 4.985 ± 0.11
5.477GluLys: 5.477 ± 0.119
7.007GluLeu: 7.007 ± 0.135
1.677GluMet: 1.677 ± 0.055
3.544GluAsn: 3.544 ± 0.085
1.66GluPro: 1.66 ± 0.06
2.84GluGln: 2.84 ± 0.068
3.211GluArg: 3.211 ± 0.092
3.227GluSer: 3.227 ± 0.076
3.893GluThr: 3.893 ± 0.095
3.845GluVal: 3.845 ± 0.087
0.535GluTrp: 0.535 ± 0.027
1.69GluTyr: 1.69 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.92PheAla: 3.92 ± 0.093
0.327PheCys: 0.327 ± 0.023
2.867PheAsp: 2.867 ± 0.074
2.608PheGlu: 2.608 ± 0.073
2.266PhePhe: 2.266 ± 0.073
3.101PheGly: 3.101 ± 0.08
0.76PheHis: 0.76 ± 0.036
3.397PheIle: 3.397 ± 0.085
2.485PheLys: 2.485 ± 0.063
4.766PheLeu: 4.766 ± 0.124
1.048PheMet: 1.048 ± 0.046
1.997PheAsn: 1.997 ± 0.059
1.546PhePro: 1.546 ± 0.053
1.514PheGln: 1.514 ± 0.054
1.607PheArg: 1.607 ± 0.051
3.672PheSer: 3.672 ± 0.091
2.683PheThr: 2.683 ± 0.083
2.968PheVal: 2.968 ± 0.088
0.438PheTrp: 0.438 ± 0.029
1.828PheTyr: 1.828 ± 0.066
0.0PheXaa: 0.0 ± 0.0
Gly
4.708GlyAla: 4.708 ± 0.106
0.427GlyCys: 0.427 ± 0.029
3.41GlyAsp: 3.41 ± 0.085
3.647GlyGlu: 3.647 ± 0.089
3.317GlyPhe: 3.317 ± 0.081
4.409GlyGly: 4.409 ± 0.119
1.267GlyHis: 1.267 ± 0.05
5.201GlyIle: 5.201 ± 0.117
4.034GlyLys: 4.034 ± 0.082
7.084GlyLeu: 7.084 ± 0.124
1.72GlyMet: 1.72 ± 0.052
2.498GlyAsn: 2.498 ± 0.059
1.484GlyPro: 1.484 ± 0.049
3.101GlyGln: 3.101 ± 0.08
3.216GlyArg: 3.216 ± 0.079
4.24GlySer: 4.24 ± 0.093
3.885GlyThr: 3.885 ± 0.141
4.525GlyVal: 4.525 ± 0.094
0.637GlyTrp: 0.637 ± 0.038
2.714GlyTyr: 2.714 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.175HisAla: 1.175 ± 0.045
0.131HisCys: 0.131 ± 0.014
0.94HisAsp: 0.94 ± 0.038
0.868HisGlu: 0.868 ± 0.036
1.21HisPhe: 1.21 ± 0.048
1.2HisGly: 1.2 ± 0.045
0.538HisHis: 0.538 ± 0.032
1.396HisIle: 1.396 ± 0.05
0.891HisLys: 0.891 ± 0.041
2.163HisLeu: 2.163 ± 0.064
0.374HisMet: 0.374 ± 0.027
0.727HisAsn: 0.727 ± 0.038
0.858HisPro: 0.858 ± 0.038
0.928HisGln: 0.928 ± 0.041
0.845HisArg: 0.845 ± 0.035
1.154HisSer: 1.154 ± 0.041
0.911HisThr: 0.911 ± 0.042
1.028HisVal: 1.028 ± 0.046
0.206HisTrp: 0.206 ± 0.018
0.979HisTyr: 0.979 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
6.481IleAla: 6.481 ± 0.111
0.528IleCys: 0.528 ± 0.033
4.328IleAsp: 4.328 ± 0.097
4.65IleGlu: 4.65 ± 0.104
3.289IlePhe: 3.289 ± 0.088
4.871IleGly: 4.871 ± 0.096
1.23IleHis: 1.23 ± 0.049
5.216IleIle: 5.216 ± 0.112
4.499IleLys: 4.499 ± 0.093
6.748IleLeu: 6.748 ± 0.122
1.59IleMet: 1.59 ± 0.055
3.048IleAsn: 3.048 ± 0.078
2.671IlePro: 2.671 ± 0.073
2.377IleGln: 2.377 ± 0.074
2.887IleArg: 2.887 ± 0.071
4.926IleSer: 4.926 ± 0.105
3.88IleThr: 3.88 ± 0.075
4.675IleVal: 4.675 ± 0.104
0.666IleTrp: 0.666 ± 0.035
2.563IleTyr: 2.563 ± 0.083
0.0IleXaa: 0.0 ± 0.0
Lys
5.317LysAla: 5.317 ± 0.117
0.171LysCys: 0.171 ± 0.018
3.714LysAsp: 3.714 ± 0.088
5.543LysGlu: 5.543 ± 0.111
1.785LysPhe: 1.785 ± 0.061
3.755LysGly: 3.755 ± 0.082
1.076LysHis: 1.076 ± 0.041
4.615LysIle: 4.615 ± 0.11
5.111LysLys: 5.111 ± 0.127
5.493LysLeu: 5.493 ± 0.113
1.735LysMet: 1.735 ± 0.051
3.35LysAsn: 3.35 ± 0.083
1.871LysPro: 1.871 ± 0.059
2.747LysGln: 2.747 ± 0.065
3.191LysArg: 3.191 ± 0.081
3.579LysSer: 3.579 ± 0.082
4.076LysThr: 4.076 ± 0.084
3.851LysVal: 3.851 ± 0.082
0.554LysTrp: 0.554 ± 0.032
2.098LysTyr: 2.098 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
9.971LeuAla: 9.971 ± 0.14
0.566LeuCys: 0.566 ± 0.033
5.596LeuAsp: 5.596 ± 0.089
6.468LeuGlu: 6.468 ± 0.132
4.514LeuPhe: 4.514 ± 0.109
6.357LeuGly: 6.357 ± 0.114
1.66LeuHis: 1.66 ± 0.063
7.11LeuIle: 7.11 ± 0.149
6.431LeuLys: 6.431 ± 0.103
11.398LeuLeu: 11.398 ± 0.242
2.341LeuMet: 2.341 ± 0.068
4.174LeuAsn: 4.174 ± 0.099
4.414LeuPro: 4.414 ± 0.091
3.979LeuGln: 3.979 ± 0.086
3.747LeuArg: 3.747 ± 0.083
8.056LeuSer: 8.056 ± 0.142
6.601LeuThr: 6.601 ± 0.109
6.323LeuVal: 6.323 ± 0.118
0.709LeuTrp: 0.709 ± 0.04
3.333LeuTyr: 3.333 ± 0.094
0.0LeuXaa: 0.0 ± 0.0
Met
2.354MetAla: 2.354 ± 0.059
0.115MetCys: 0.115 ± 0.014
1.238MetAsp: 1.238 ± 0.046
1.287MetGlu: 1.287 ± 0.049
0.779MetPhe: 0.779 ± 0.045
1.584MetGly: 1.584 ± 0.052
0.37MetHis: 0.37 ± 0.023
1.745MetIle: 1.745 ± 0.056
1.635MetLys: 1.635 ± 0.054
2.274MetLeu: 2.274 ± 0.065
0.594MetMet: 0.594 ± 0.034
1.029MetAsn: 1.029 ± 0.048
0.827MetPro: 0.827 ± 0.034
0.953MetGln: 0.953 ± 0.039
0.943MetArg: 0.943 ± 0.041
1.482MetSer: 1.482 ± 0.052
1.924MetThr: 1.924 ± 0.056
1.541MetVal: 1.541 ± 0.051
0.171MetTrp: 0.171 ± 0.018
0.571MetTyr: 0.571 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.904AsnAla: 2.904 ± 0.085
0.262AsnCys: 0.262 ± 0.024
2.205AsnAsp: 2.205 ± 0.066
2.223AsnGlu: 2.223 ± 0.065
1.816AsnPhe: 1.816 ± 0.05
3.063AsnGly: 3.063 ± 0.088
0.986AsnHis: 0.986 ± 0.049
3.167AsnIle: 3.167 ± 0.084
2.631AsnLys: 2.631 ± 0.078
4.343AsnLeu: 4.343 ± 0.087
1.102AsnMet: 1.102 ± 0.045
1.849AsnAsn: 1.849 ± 0.071
2.088AsnPro: 2.088 ± 0.061
2.087AsnGln: 2.087 ± 0.062
2.07AsnArg: 2.07 ± 0.059
2.542AsnSer: 2.542 ± 0.072
2.135AsnThr: 2.135 ± 0.065
2.495AsnVal: 2.495 ± 0.066
0.513AsnTrp: 0.513 ± 0.03
1.926AsnTyr: 1.926 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
2.84ProAla: 2.84 ± 0.082
0.139ProCys: 0.139 ± 0.016
2.326ProAsp: 2.326 ± 0.069
2.746ProGlu: 2.746 ± 0.087
1.68ProPhe: 1.68 ± 0.055
1.761ProGly: 1.761 ± 0.061
0.686ProHis: 0.686 ± 0.033
2.263ProIle: 2.263 ± 0.072
1.964ProLys: 1.964 ± 0.068
3.446ProLeu: 3.446 ± 0.086
0.656ProMet: 0.656 ± 0.032
1.423ProAsn: 1.423 ± 0.049
0.619ProPro: 0.619 ± 0.035
1.431ProGln: 1.431 ± 0.05
1.046ProArg: 1.046 ± 0.043
2.16ProSer: 2.16 ± 0.072
1.765ProThr: 1.765 ± 0.082
2.57ProVal: 2.57 ± 0.075
0.299ProTrp: 0.299 ± 0.021
1.38ProTyr: 1.38 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.145GlnAla: 4.145 ± 0.102
0.139GlnCys: 0.139 ± 0.017
2.108GlnAsp: 2.108 ± 0.061
3.274GlnGlu: 3.274 ± 0.09
1.703GlnPhe: 1.703 ± 0.058
2.492GlnGly: 2.492 ± 0.061
0.707GlnHis: 0.707 ± 0.032
2.938GlnIle: 2.938 ± 0.07
3.207GlnLys: 3.207 ± 0.084
4.202GlnLeu: 4.202 ± 0.086
1.006GlnMet: 1.006 ± 0.042
1.853GlnAsn: 1.853 ± 0.06
1.398GlnPro: 1.398 ± 0.052
1.826GlnGln: 1.826 ± 0.069
1.572GlnArg: 1.572 ± 0.05
2.515GlnSer: 2.515 ± 0.078
2.716GlnThr: 2.716 ± 0.076
2.734GlnVal: 2.734 ± 0.067
0.32GlnTrp: 0.32 ± 0.024
1.394GlnTyr: 1.394 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.733ArgAla: 2.733 ± 0.064
0.184ArgCys: 0.184 ± 0.017
2.221ArgAsp: 2.221 ± 0.068
2.786ArgGlu: 2.786 ± 0.078
2.123ArgPhe: 2.123 ± 0.067
2.151ArgGly: 2.151 ± 0.06
0.96ArgHis: 0.96 ± 0.037
3.048ArgIle: 3.048 ± 0.07
2.791ArgLys: 2.791 ± 0.075
4.862ArgLeu: 4.862 ± 0.11
1.086ArgMet: 1.086 ± 0.04
1.577ArgAsn: 1.577 ± 0.058
1.386ArgPro: 1.386 ± 0.056
2.47ArgGln: 2.47 ± 0.067
2.429ArgArg: 2.429 ± 0.078
2.397ArgSer: 2.397 ± 0.072
2.044ArgThr: 2.044 ± 0.06
2.557ArgVal: 2.557 ± 0.072
0.342ArgTrp: 0.342 ± 0.024
1.708ArgTyr: 1.708 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
5.048SerAla: 5.048 ± 0.105
0.35SerCys: 0.35 ± 0.026
3.964SerAsp: 3.964 ± 0.09
3.86SerGlu: 3.86 ± 0.082
3.166SerPhe: 3.166 ± 0.084
5.199SerGly: 5.199 ± 0.107
1.313SerHis: 1.313 ± 0.045
3.871SerIle: 3.871 ± 0.09
3.765SerLys: 3.765 ± 0.095
6.909SerLeu: 6.909 ± 0.135
1.408SerMet: 1.408 ± 0.05
2.548SerAsn: 2.548 ± 0.077
2.05SerPro: 2.05 ± 0.05
3.423SerGln: 3.423 ± 0.089
2.847SerArg: 2.847 ± 0.071
4.635SerSer: 4.635 ± 0.127
2.885SerThr: 2.885 ± 0.097
4.268SerVal: 4.268 ± 0.095
0.647SerTrp: 0.647 ± 0.035
2.734SerTyr: 2.734 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
5.495ThrAla: 5.495 ± 0.125
0.295ThrCys: 0.295 ± 0.026
3.661ThrAsp: 3.661 ± 0.08
3.558ThrGlu: 3.558 ± 0.086
2.525ThrPhe: 2.525 ± 0.076
4.212ThrGly: 4.212 ± 0.129
0.958ThrHis: 0.958 ± 0.041
4.11ThrIle: 4.11 ± 0.091
3.065ThrLys: 3.065 ± 0.075
5.072ThrLeu: 5.072 ± 0.097
1.132ThrMet: 1.132 ± 0.046
2.103ThrAsn: 2.103 ± 0.059
2.062ThrPro: 2.062 ± 0.127
1.883ThrGln: 1.883 ± 0.076
1.785ThrArg: 1.785 ± 0.06
3.388ThrSer: 3.388 ± 0.096
3.005ThrThr: 3.005 ± 0.157
5.158ThrVal: 5.158 ± 0.119
0.445ThrTrp: 0.445 ± 0.029
2.253ThrTyr: 2.253 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
5.414ValAla: 5.414 ± 0.103
0.465ValCys: 0.465 ± 0.029
3.666ValAsp: 3.666 ± 0.081
3.964ValGlu: 3.964 ± 0.096
3.224ValPhe: 3.224 ± 0.077
4.207ValGly: 4.207 ± 0.118
1.116ValHis: 1.116 ± 0.047
4.799ValIle: 4.799 ± 0.098
4.145ValLys: 4.145 ± 0.088
7.011ValLeu: 7.011 ± 0.109
1.552ValMet: 1.552 ± 0.057
2.84ValAsn: 2.84 ± 0.085
2.439ValPro: 2.439 ± 0.094
2.261ValGln: 2.261 ± 0.06
2.706ValArg: 2.706 ± 0.071
4.721ValSer: 4.721 ± 0.08
4.388ValThr: 4.388 ± 0.136
4.144ValVal: 4.144 ± 0.112
0.589ValTrp: 0.589 ± 0.038
2.528ValTyr: 2.528 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.549TrpAla: 0.549 ± 0.025
0.065TrpCys: 0.065 ± 0.01
0.428TrpAsp: 0.428 ± 0.028
0.569TrpGlu: 0.569 ± 0.027
0.435TrpPhe: 0.435 ± 0.029
0.674TrpGly: 0.674 ± 0.037
0.224TrpHis: 0.224 ± 0.018
0.559TrpIle: 0.559 ± 0.031
0.387TrpLys: 0.387 ± 0.028
1.22TrpLeu: 1.22 ± 0.05
0.186TrpMet: 0.186 ± 0.016
0.413TrpAsn: 0.413 ± 0.026
0.224TrpPro: 0.224 ± 0.021
0.576TrpGln: 0.576 ± 0.037
0.365TrpArg: 0.365 ± 0.028
0.579TrpSer: 0.579 ± 0.034
0.51TrpThr: 0.51 ± 0.034
0.478TrpVal: 0.478 ± 0.029
0.111TrpTrp: 0.111 ± 0.014
0.34TrpTyr: 0.34 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.719TyrAla: 2.719 ± 0.073
0.227TyrCys: 0.227 ± 0.02
2.493TyrAsp: 2.493 ± 0.073
2.145TyrGlu: 2.145 ± 0.055
2.093TyrPhe: 2.093 ± 0.067
2.505TyrGly: 2.505 ± 0.077
0.955TyrHis: 0.955 ± 0.04
2.42TyrIle: 2.42 ± 0.07
1.889TyrLys: 1.889 ± 0.061
4.474TyrLeu: 4.474 ± 0.098
0.764TyrMet: 0.764 ± 0.038
1.632TyrAsn: 1.632 ± 0.06
1.438TyrPro: 1.438 ± 0.053
2.221TyrGln: 2.221 ± 0.067
1.786TyrArg: 1.786 ± 0.063
2.464TyrSer: 2.464 ± 0.07
2.138TyrThr: 2.138 ± 0.077
2.097TyrVal: 2.097 ± 0.057
0.342TyrTrp: 0.342 ± 0.025
1.846TyrTyr: 1.846 ± 0.079
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1974 proteins (602372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski