Amino acid dipepetide frequency for Sulfitobacter geojensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.007AlaAla: 16.007 ± 0.18	1.095AlaCys: 1.095 ± 0.029	7.156AlaAsp: 7.156 ± 0.067	7.383AlaGlu: 7.383 ± 0.082	4.373AlaPhe: 4.373 ± 0.068	10.43AlaGly: 10.43 ± 0.096	2.348AlaHis: 2.348 ± 0.046	5.905AlaIle: 5.905 ± 0.066	4.572AlaLys: 4.572 ± 0.06	13.194AlaLeu: 13.194 ± 0.119	3.94AlaMet: 3.94 ± 0.061	2.955AlaAsn: 2.955 ± 0.056	5.53AlaPro: 5.53 ± 0.079	5.257AlaGln: 5.257 ± 0.076	7.549AlaArg: 7.549 ± 0.091	5.695AlaSer: 5.695 ± 0.068	6.068AlaThr: 6.068 ± 0.068	8.335AlaVal: 8.335 ± 0.083	1.368AlaTrp: 1.368 ± 0.037	2.501AlaTyr: 2.501 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.124CysAla: 1.124 ± 0.028	0.105CysCys: 0.105 ± 0.01	0.654CysAsp: 0.654 ± 0.021	0.435CysGlu: 0.435 ± 0.021	0.354CysPhe: 0.354 ± 0.017	0.936CysGly: 0.936 ± 0.031	0.273CysHis: 0.273 ± 0.018	0.438CysIle: 0.438 ± 0.019	0.269CysLys: 0.269 ± 0.016	0.828CysLeu: 0.828 ± 0.026	0.186CysMet: 0.186 ± 0.012	0.247CysAsn: 0.247 ± 0.014	0.484CysPro: 0.484 ± 0.021	0.229CysGln: 0.229 ± 0.014	0.449CysArg: 0.449 ± 0.024	0.449CysSer: 0.449 ± 0.018	0.48CysThr: 0.48 ± 0.019	0.642CysVal: 0.642 ± 0.025	0.112CysTrp: 0.112 ± 0.01	0.215CysTyr: 0.215 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.004AspAla: 8.004 ± 0.086	0.517AspCys: 0.517 ± 0.021	3.625AspAsp: 3.625 ± 0.073	3.433AspGlu: 3.433 ± 0.05	2.354AspPhe: 2.354 ± 0.045	5.639AspGly: 5.639 ± 0.082	1.393AspHis: 1.393 ± 0.035	3.419AspIle: 3.419 ± 0.066	1.99AspLys: 1.99 ± 0.04	6.384AspLeu: 6.384 ± 0.079	1.898AspMet: 1.898 ± 0.041	1.462AspAsn: 1.462 ± 0.04	3.51AspPro: 3.51 ± 0.059	2.028AspGln: 2.028 ± 0.038	3.745AspArg: 3.745 ± 0.061	2.228AspSer: 2.228 ± 0.047	3.317AspThr: 3.317 ± 0.064	4.892AspVal: 4.892 ± 0.062	1.081AspTrp: 1.081 ± 0.025	1.444AspTyr: 1.444 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.138GluAla: 7.138 ± 0.084	0.359GluCys: 0.359 ± 0.018	3.149GluAsp: 3.149 ± 0.057	3.259GluGlu: 3.259 ± 0.062	1.841GluPhe: 1.841 ± 0.042	4.533GluGly: 4.533 ± 0.063	1.12GluHis: 1.12 ± 0.031	3.627GluIle: 3.627 ± 0.06	2.274GluLys: 2.274 ± 0.049	4.876GluLeu: 4.876 ± 0.065	1.908GluMet: 1.908 ± 0.039	2.028GluAsn: 2.028 ± 0.037	2.209GluPro: 2.209 ± 0.058	2.117GluGln: 2.117 ± 0.047	3.789GluArg: 3.789 ± 0.058	2.068GluSer: 2.068 ± 0.041	3.878GluThr: 3.878 ± 0.063	4.35GluVal: 4.35 ± 0.063	0.694GluTrp: 0.694 ± 0.026	1.119GluTyr: 1.119 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.633PheAla: 4.633 ± 0.073	0.445PheCys: 0.445 ± 0.018	3.084PheAsp: 3.084 ± 0.052	2.399PheGlu: 2.399 ± 0.05	1.488PhePhe: 1.488 ± 0.041	3.796PheGly: 3.796 ± 0.053	0.721PheHis: 0.721 ± 0.024	1.784PheIle: 1.784 ± 0.04	1.186PheLys: 1.186 ± 0.038	3.327PheLeu: 3.327 ± 0.062	0.95PheMet: 0.95 ± 0.03	1.156PheAsn: 1.156 ± 0.028	1.466PhePro: 1.466 ± 0.035	1.115PheGln: 1.115 ± 0.031	1.924PheArg: 1.924 ± 0.044	2.236PheSer: 2.236 ± 0.048	2.171PheThr: 2.171 ± 0.043	2.752PheVal: 2.752 ± 0.051	0.569PheTrp: 0.569 ± 0.022	0.937PheTyr: 0.937 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.471GlyAla: 9.471 ± 0.112	0.856GlyCys: 0.856 ± 0.025	4.845GlyAsp: 4.845 ± 0.076	4.423GlyGlu: 4.423 ± 0.061	3.821GlyPhe: 3.821 ± 0.055	7.307GlyGly: 7.307 ± 0.113	1.889GlyHis: 1.889 ± 0.04	4.578GlyIle: 4.578 ± 0.059	3.528GlyLys: 3.528 ± 0.056	8.701GlyLeu: 8.701 ± 0.085	2.695GlyMet: 2.695 ± 0.049	2.354GlyAsn: 2.354 ± 0.059	3.406GlyPro: 3.406 ± 0.053	3.243GlyGln: 3.243 ± 0.051	5.041GlyArg: 5.041 ± 0.073	4.286GlySer: 4.286 ± 0.068	4.767GlyThr: 4.767 ± 0.078	6.511GlyVal: 6.511 ± 0.084	1.415GlyTrp: 1.415 ± 0.034	2.245GlyTyr: 2.245 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.377HisAla: 2.377 ± 0.049	0.252HisCys: 0.252 ± 0.016	1.26HisAsp: 1.26 ± 0.029	0.996HisGlu: 0.996 ± 0.032	0.831HisPhe: 0.831 ± 0.029	1.747HisGly: 1.747 ± 0.032	0.543HisHis: 0.543 ± 0.024	1.073HisIle: 1.073 ± 0.029	0.62HisLys: 0.62 ± 0.023	2.146HisLeu: 2.146 ± 0.043	0.587HisMet: 0.587 ± 0.023	0.51HisAsn: 0.51 ± 0.021	1.318HisPro: 1.318 ± 0.034	0.631HisGln: 0.631 ± 0.023	1.177HisArg: 1.177 ± 0.031	0.974HisSer: 0.974 ± 0.029	0.936HisThr: 0.936 ± 0.031	1.506HisVal: 1.506 ± 0.033	0.303HisTrp: 0.303 ± 0.015	0.55HisTyr: 0.55 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.116IleAla: 7.116 ± 0.092	0.641IleCys: 0.641 ± 0.02	3.619IleAsp: 3.619 ± 0.051	3.605IleGlu: 3.605 ± 0.056	1.823IlePhe: 1.823 ± 0.043	4.922IleGly: 4.922 ± 0.063	0.906IleHis: 0.906 ± 0.03	2.517IleIle: 2.517 ± 0.048	1.904IleLys: 1.904 ± 0.037	4.716IleLeu: 4.716 ± 0.074	1.203IleMet: 1.203 ± 0.031	1.662IleAsn: 1.662 ± 0.039	2.302IlePro: 2.302 ± 0.05	1.287IleGln: 1.287 ± 0.029	2.865IleArg: 2.865 ± 0.052	3.187IleSer: 3.187 ± 0.053	3.287IleThr: 3.287 ± 0.047	3.857IleVal: 3.857 ± 0.063	0.776IleTrp: 0.776 ± 0.027	1.197IleTyr: 1.197 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.364LysAla: 4.364 ± 0.06	0.202LysCys: 0.202 ± 0.011	2.109LysAsp: 2.109 ± 0.044	1.761LysGlu: 1.761 ± 0.04	1.115LysPhe: 1.115 ± 0.027	3.153LysGly: 3.153 ± 0.057	0.757LysHis: 0.757 ± 0.024	1.878LysIle: 1.878 ± 0.044	1.432LysLys: 1.432 ± 0.045	3.373LysLeu: 3.373 ± 0.051	1.083LysMet: 1.083 ± 0.031	0.97LysAsn: 0.97 ± 0.028	2.017LysPro: 2.017 ± 0.046	1.14LysGln: 1.14 ± 0.031	2.4LysArg: 2.4 ± 0.052	2.18LysSer: 2.18 ± 0.042	2.279LysThr: 2.279 ± 0.042	2.551LysVal: 2.551 ± 0.047	0.427LysTrp: 0.427 ± 0.018	0.752LysTyr: 0.752 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.167LeuAla: 12.167 ± 0.118	0.941LeuCys: 0.941 ± 0.029	6.053LeuAsp: 6.053 ± 0.075	5.23LeuGlu: 5.23 ± 0.068	3.543LeuPhe: 3.543 ± 0.062	8.191LeuGly: 8.191 ± 0.092	1.866LeuHis: 1.866 ± 0.042	5.434LeuIle: 5.434 ± 0.08	3.423LeuLys: 3.423 ± 0.06	8.427LeuLeu: 8.427 ± 0.106	2.824LeuMet: 2.824 ± 0.047	2.979LeuAsn: 2.979 ± 0.049	5.151LeuPro: 5.151 ± 0.075	2.972LeuGln: 2.972 ± 0.046	6.583LeuArg: 6.583 ± 0.085	6.673LeuSer: 6.673 ± 0.079	5.977LeuThr: 5.977 ± 0.067	6.55LeuVal: 6.55 ± 0.083	1.187LeuTrp: 1.187 ± 0.035	1.898LeuTyr: 1.898 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.612MetAla: 3.612 ± 0.048	0.213MetCys: 0.213 ± 0.012	1.567MetAsp: 1.567 ± 0.032	1.375MetGlu: 1.375 ± 0.034	0.928MetPhe: 0.928 ± 0.026	2.472MetGly: 2.472 ± 0.043	0.504MetHis: 0.504 ± 0.02	1.716MetIle: 1.716 ± 0.033	1.21MetLys: 1.21 ± 0.031	2.76MetLeu: 2.76 ± 0.041	0.874MetMet: 0.874 ± 0.026	0.963MetAsn: 0.963 ± 0.025	1.591MetPro: 1.591 ± 0.033	1.116MetGln: 1.116 ± 0.026	1.96MetArg: 1.96 ± 0.04	1.949MetSer: 1.949 ± 0.039	2.12MetThr: 2.12 ± 0.04	1.897MetVal: 1.897 ± 0.035	0.265MetTrp: 0.265 ± 0.016	0.425MetTyr: 0.425 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.619AsnAla: 3.619 ± 0.053	0.294AsnCys: 0.294 ± 0.015	1.7AsnAsp: 1.7 ± 0.056	1.314AsnGlu: 1.314 ± 0.034	1.036AsnPhe: 1.036 ± 0.028	2.571AsnGly: 2.571 ± 0.049	0.557AsnHis: 0.557 ± 0.02	1.567AsnIle: 1.567 ± 0.037	0.864AsnLys: 0.864 ± 0.024	2.716AsnLeu: 2.716 ± 0.054	0.824AsnMet: 0.824 ± 0.025	0.841AsnAsn: 0.841 ± 0.028	1.891AsnPro: 1.891 ± 0.042	0.765AsnGln: 0.765 ± 0.029	1.772AsnArg: 1.772 ± 0.04	1.288AsnSer: 1.288 ± 0.035	1.587AsnThr: 1.587 ± 0.034	2.062AsnVal: 2.062 ± 0.042	0.487AsnTrp: 0.487 ± 0.02	0.725AsnTyr: 0.725 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.629ProAla: 5.629 ± 0.074	0.341ProCys: 0.341 ± 0.017	4.035ProAsp: 4.035 ± 0.069	3.583ProGlu: 3.583 ± 0.064	1.99ProPhe: 1.99 ± 0.039	3.255ProGly: 3.255 ± 0.052	1.037ProHis: 1.037 ± 0.032	2.173ProIle: 2.173 ± 0.043	1.889ProLys: 1.889 ± 0.046	4.531ProLeu: 4.531 ± 0.066	1.335ProMet: 1.335 ± 0.033	1.43ProAsn: 1.43 ± 0.032	2.111ProPro: 2.111 ± 0.048	1.854ProGln: 1.854 ± 0.04	2.439ProArg: 2.439 ± 0.053	2.512ProSer: 2.512 ± 0.05	2.459ProThr: 2.459 ± 0.049	4.123ProVal: 4.123 ± 0.062	0.603ProTrp: 0.603 ± 0.021	1.119ProTyr: 1.119 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.331GlnAla: 4.331 ± 0.072	0.209GlnCys: 0.209 ± 0.013	1.993GlnAsp: 1.993 ± 0.037	1.731GlnGlu: 1.731 ± 0.039	1.185GlnPhe: 1.185 ± 0.028	2.804GlnGly: 2.804 ± 0.048	0.682GlnHis: 0.682 ± 0.024	2.215GlnIle: 2.215 ± 0.047	1.215GlnLys: 1.215 ± 0.032	3.066GlnLeu: 3.066 ± 0.058	1.242GlnMet: 1.242 ± 0.032	1.098GlnAsn: 1.098 ± 0.031	1.55GlnPro: 1.55 ± 0.034	1.262GlnGln: 1.262 ± 0.029	2.205GlnArg: 2.205 ± 0.042	2.076GlnSer: 2.076 ± 0.046	2.193GlnThr: 2.193 ± 0.045	2.523GlnVal: 2.523 ± 0.05	0.404GlnTrp: 0.404 ± 0.017	0.636GlnTyr: 0.636 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.33ArgAla: 7.33 ± 0.087	0.445ArgCys: 0.445 ± 0.02	4.028ArgAsp: 4.028 ± 0.072	3.332ArgGlu: 3.332 ± 0.054	2.532ArgPhe: 2.532 ± 0.048	4.122ArgGly: 4.122 ± 0.067	1.333ArgHis: 1.333 ± 0.033	3.484ArgIle: 3.484 ± 0.056	2.447ArgLys: 2.447 ± 0.047	6.323ArgLeu: 6.323 ± 0.078	1.905ArgMet: 1.905 ± 0.043	1.768ArgAsn: 1.768 ± 0.037	2.75ArgPro: 2.75 ± 0.048	2.183ArgGln: 2.183 ± 0.043	4.0ArgArg: 4.0 ± 0.069	3.09ArgSer: 3.09 ± 0.05	2.861ArgThr: 2.861 ± 0.054	4.23ArgVal: 4.23 ± 0.061	0.819ArgTrp: 0.819 ± 0.027	1.433ArgTyr: 1.433 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.863SerAla: 5.863 ± 0.078	0.468SerCys: 0.468 ± 0.019	3.546SerAsp: 3.546 ± 0.06	2.866SerGlu: 2.866 ± 0.046	2.414SerPhe: 2.414 ± 0.047	5.447SerGly: 5.447 ± 0.079	1.112SerHis: 1.112 ± 0.028	2.67SerIle: 2.67 ± 0.05	1.832SerLys: 1.832 ± 0.04	5.031SerLeu: 5.031 ± 0.062	1.48SerMet: 1.48 ± 0.034	1.578SerAsn: 1.578 ± 0.038	2.383SerPro: 2.383 ± 0.047	1.737SerGln: 1.737 ± 0.045	2.979SerArg: 2.979 ± 0.048	2.638SerSer: 2.638 ± 0.058	2.772SerThr: 2.772 ± 0.049	3.922SerVal: 3.922 ± 0.048	0.662SerTrp: 0.662 ± 0.024	1.305SerTyr: 1.305 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.521ThrAla: 6.521 ± 0.067	0.521ThrCys: 0.521 ± 0.023	3.334ThrAsp: 3.334 ± 0.056	2.876ThrGlu: 2.876 ± 0.048	2.018ThrPhe: 2.018 ± 0.045	5.515ThrGly: 5.515 ± 0.072	1.149ThrHis: 1.149 ± 0.031	2.82ThrIle: 2.82 ± 0.052	1.765ThrLys: 1.765 ± 0.038	6.368ThrLeu: 6.368 ± 0.073	1.432ThrMet: 1.432 ± 0.035	1.415ThrAsn: 1.415 ± 0.033	3.641ThrPro: 3.641 ± 0.063	1.985ThrGln: 1.985 ± 0.039	3.301ThrArg: 3.301 ± 0.054	3.012ThrSer: 3.012 ± 0.051	2.966ThrThr: 2.966 ± 0.055	4.181ThrVal: 4.181 ± 0.066	0.683ThrTrp: 0.683 ± 0.023	1.334ThrTyr: 1.334 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.506ValAla: 8.506 ± 0.1	0.647ValCys: 0.647 ± 0.024	4.24ValAsp: 4.24 ± 0.066	4.458ValGlu: 4.458 ± 0.052	2.943ValPhe: 2.943 ± 0.056	5.405ValGly: 5.405 ± 0.072	1.306ValHis: 1.306 ± 0.03	4.394ValIle: 4.394 ± 0.067	2.422ValLys: 2.422 ± 0.049	7.521ValLeu: 7.521 ± 0.082	2.259ValMet: 2.259 ± 0.045	2.024ValAsn: 2.024 ± 0.04	3.424ValPro: 3.424 ± 0.051	2.393ValGln: 2.393 ± 0.048	3.857ValArg: 3.857 ± 0.062	4.31ValSer: 4.31 ± 0.06	4.827ValThr: 4.827 ± 0.075	5.623ValVal: 5.623 ± 0.073	0.898ValTrp: 0.898 ± 0.028	1.502ValTyr: 1.502 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.274TrpAla: 1.274 ± 0.032	0.126TrpCys: 0.126 ± 0.009	0.775TrpAsp: 0.775 ± 0.027	0.647TrpGlu: 0.647 ± 0.025	0.591TrpPhe: 0.591 ± 0.022	1.015TrpGly: 1.015 ± 0.032	0.321TrpHis: 0.321 ± 0.016	0.708TrpIle: 0.708 ± 0.023	0.445TrpLys: 0.445 ± 0.021	1.502TrpLeu: 1.502 ± 0.036	0.406TrpMet: 0.406 ± 0.017	0.419TrpAsn: 0.419 ± 0.02	0.653TrpPro: 0.653 ± 0.022	0.615TrpGln: 0.615 ± 0.02	0.967TrpArg: 0.967 ± 0.026	0.747TrpSer: 0.747 ± 0.027	0.719TrpThr: 0.719 ± 0.023	0.919TrpVal: 0.919 ± 0.029	0.211TrpTrp: 0.211 ± 0.013	0.255TrpTyr: 0.255 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.576TyrAla: 2.576 ± 0.046	0.231TyrCys: 0.231 ± 0.015	1.59TyrAsp: 1.59 ± 0.037	1.231TyrGlu: 1.231 ± 0.035	0.96TyrPhe: 0.96 ± 0.025	2.123TyrGly: 2.123 ± 0.041	0.519TyrHis: 0.519 ± 0.02	0.994TyrIle: 0.994 ± 0.027	0.655TyrLys: 0.655 ± 0.024	2.278TyrLeu: 2.278 ± 0.044	0.488TyrMet: 0.488 ± 0.017	0.622TyrAsn: 0.622 ± 0.022	1.062TyrPro: 1.062 ± 0.029	0.692TyrGln: 0.692 ± 0.025	1.41TyrArg: 1.41 ± 0.031	1.108TyrSer: 1.108 ± 0.036	1.171TyrThr: 1.171 ± 0.03	1.531TyrVal: 1.531 ± 0.036	0.352TyrTrp: 0.352 ± 0.018	0.579TyrTyr: 0.579 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3982 proteins (1277318 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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