Amino acid dipepetide frequency for Acinetobacter marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.351AlaAla: 6.351 ± 0.145
0.95AlaCys: 0.95 ± 0.036
5.26AlaAsp: 5.26 ± 0.088
6.07AlaGlu: 6.07 ± 0.091
3.401AlaPhe: 3.401 ± 0.057
6.006AlaGly: 6.006 ± 0.102
2.035AlaHis: 2.035 ± 0.054
5.998AlaIle: 5.998 ± 0.096
5.395AlaLys: 5.395 ± 0.09
9.926AlaLeu: 9.926 ± 0.124
2.762AlaMet: 2.762 ± 0.061
3.597AlaAsn: 3.597 ± 0.066
3.221AlaPro: 3.221 ± 0.069
5.708AlaGln: 5.708 ± 0.095
3.565AlaArg: 3.565 ± 0.078
5.284AlaSer: 5.284 ± 0.071
5.155AlaThr: 5.155 ± 0.095
6.08AlaVal: 6.08 ± 0.096
1.201AlaTrp: 1.201 ± 0.04
2.627AlaTyr: 2.627 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.879CysAla: 0.879 ± 0.037
0.121CysCys: 0.121 ± 0.013
0.511CysAsp: 0.511 ± 0.024
0.537CysGlu: 0.537 ± 0.024
0.436CysPhe: 0.436 ± 0.023
0.762CysGly: 0.762 ± 0.032
0.307CysHis: 0.307 ± 0.02
0.627CysIle: 0.627 ± 0.027
0.352CysLys: 0.352 ± 0.023
0.986CysLeu: 0.986 ± 0.033
0.254CysMet: 0.254 ± 0.015
0.336CysAsn: 0.336 ± 0.019
0.384CysPro: 0.384 ± 0.02
0.489CysGln: 0.489 ± 0.027
0.444CysArg: 0.444 ± 0.022
0.585CysSer: 0.585 ± 0.031
0.463CysThr: 0.463 ± 0.023
0.69CysVal: 0.69 ± 0.031
0.103CysTrp: 0.103 ± 0.011
0.306CysTyr: 0.306 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.466AspAla: 5.466 ± 0.1
0.492AspCys: 0.492 ± 0.026
3.203AspAsp: 3.203 ± 0.075
3.6AspGlu: 3.6 ± 0.074
2.525AspPhe: 2.525 ± 0.062
3.571AspGly: 3.571 ± 0.081
1.426AspHis: 1.426 ± 0.046
3.594AspIle: 3.594 ± 0.06
2.328AspLys: 2.328 ± 0.053
5.768AspLeu: 5.768 ± 0.086
1.38AspMet: 1.38 ± 0.043
2.065AspAsn: 2.065 ± 0.056
2.113AspPro: 2.113 ± 0.053
3.663AspGln: 3.663 ± 0.069
2.712AspArg: 2.712 ± 0.067
2.902AspSer: 2.902 ± 0.062
2.718AspThr: 2.718 ± 0.066
4.033AspVal: 4.033 ± 0.078
0.853AspTrp: 0.853 ± 0.035
2.166AspTyr: 2.166 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.848GluAla: 4.848 ± 0.089
0.385GluCys: 0.385 ± 0.02
2.823GluAsp: 2.823 ± 0.064
2.751GluGlu: 2.751 ± 0.062
2.174GluPhe: 2.174 ± 0.053
2.924GluGly: 2.924 ± 0.067
1.67GluHis: 1.67 ± 0.047
3.941GluIle: 3.941 ± 0.077
3.62GluLys: 3.62 ± 0.071
5.808GluLeu: 5.808 ± 0.096
1.571GluMet: 1.571 ± 0.041
2.777GluAsn: 2.777 ± 0.063
1.66GluPro: 1.66 ± 0.053
4.541GluGln: 4.541 ± 0.086
3.051GluArg: 3.051 ± 0.076
3.129GluSer: 3.129 ± 0.064
2.707GluThr: 2.707 ± 0.057
3.678GluVal: 3.678 ± 0.076
0.705GluTrp: 0.705 ± 0.028
1.723GluTyr: 1.723 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
4.097PheAla: 4.097 ± 0.072
0.455PheCys: 0.455 ± 0.021
2.869PheAsp: 2.869 ± 0.06
2.598PheGlu: 2.598 ± 0.061
1.796PhePhe: 1.796 ± 0.057
3.132PheGly: 3.132 ± 0.072
0.924PheHis: 0.924 ± 0.032
2.65PheIle: 2.65 ± 0.068
2.106PheLys: 2.106 ± 0.051
3.658PheLeu: 3.658 ± 0.077
1.006PheMet: 1.006 ± 0.034
1.882PheAsn: 1.882 ± 0.05
1.364PhePro: 1.364 ± 0.035
1.866PheGln: 1.866 ± 0.055
1.498PheArg: 1.498 ± 0.041
2.96PheSer: 2.96 ± 0.062
1.905PheThr: 1.905 ± 0.053
2.55PheVal: 2.55 ± 0.059
0.585PheTrp: 0.585 ± 0.032
1.504PheTyr: 1.504 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.291GlyAla: 5.291 ± 0.105
0.785GlyCys: 0.785 ± 0.032
3.211GlyAsp: 3.211 ± 0.067
3.828GlyGlu: 3.828 ± 0.064
3.129GlyPhe: 3.129 ± 0.07
4.512GlyGly: 4.512 ± 0.103
1.523GlyHis: 1.523 ± 0.045
4.346GlyIle: 4.346 ± 0.072
3.566GlyLys: 3.566 ± 0.065
6.707GlyLeu: 6.707 ± 0.111
1.901GlyMet: 1.901 ± 0.052
2.412GlyAsn: 2.412 ± 0.061
1.148GlyPro: 1.148 ± 0.041
3.371GlyGln: 3.371 ± 0.063
2.848GlyArg: 2.848 ± 0.07
3.627GlySer: 3.627 ± 0.081
3.476GlyThr: 3.476 ± 0.078
4.951GlyVal: 4.951 ± 0.101
0.911GlyTrp: 0.911 ± 0.034
2.353GlyTyr: 2.353 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.29HisAla: 2.29 ± 0.058
0.295HisCys: 0.295 ± 0.022
1.425HisAsp: 1.425 ± 0.044
1.183HisGlu: 1.183 ± 0.037
1.224HisPhe: 1.224 ± 0.045
1.722HisGly: 1.722 ± 0.038
0.874HisHis: 0.874 ± 0.038
1.648HisIle: 1.648 ± 0.045
0.845HisLys: 0.845 ± 0.031
2.627HisLeu: 2.627 ± 0.063
0.54HisMet: 0.54 ± 0.024
0.854HisAsn: 0.854 ± 0.036
1.356HisPro: 1.356 ± 0.04
1.628HisGln: 1.628 ± 0.047
1.184HisArg: 1.184 ± 0.035
1.429HisSer: 1.429 ± 0.045
1.139HisThr: 1.139 ± 0.042
1.525HisVal: 1.525 ± 0.045
0.392HisTrp: 0.392 ± 0.021
1.029HisTyr: 1.029 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.655IleAla: 6.655 ± 0.095
0.696IleCys: 0.696 ± 0.029
4.425IleAsp: 4.425 ± 0.075
4.404IleGlu: 4.404 ± 0.075
2.553IlePhe: 2.553 ± 0.069
4.554IleGly: 4.554 ± 0.095
1.513IleHis: 1.513 ± 0.046
3.852IleIle: 3.852 ± 0.083
3.026IleLys: 3.026 ± 0.061
5.972IleLeu: 5.972 ± 0.103
1.409IleMet: 1.409 ± 0.04
2.755IleAsn: 2.755 ± 0.061
2.649IlePro: 2.649 ± 0.058
3.348IleGln: 3.348 ± 0.07
3.017IleArg: 3.017 ± 0.067
4.164IleSer: 4.164 ± 0.069
3.385IleThr: 3.385 ± 0.063
4.207IleVal: 4.207 ± 0.08
0.691IleTrp: 0.691 ± 0.033
2.051IleTyr: 2.051 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.83LysAla: 4.83 ± 0.093
0.299LysCys: 0.299 ± 0.019
2.795LysAsp: 2.795 ± 0.06
2.445LysGlu: 2.445 ± 0.064
1.701LysPhe: 1.701 ± 0.047
2.718LysGly: 2.718 ± 0.067
1.294LysHis: 1.294 ± 0.039
3.53LysIle: 3.53 ± 0.066
3.041LysLys: 3.041 ± 0.073
4.896LysLeu: 4.896 ± 0.064
1.381LysMet: 1.381 ± 0.043
2.527LysAsn: 2.527 ± 0.059
2.134LysPro: 2.134 ± 0.052
3.275LysGln: 3.275 ± 0.064
2.505LysArg: 2.505 ± 0.056
3.223LysSer: 3.223 ± 0.069
3.021LysThr: 3.021 ± 0.059
3.477LysVal: 3.477 ± 0.066
0.525LysTrp: 0.525 ± 0.024
1.616LysTyr: 1.616 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
9.729LeuAla: 9.729 ± 0.118
1.065LeuCys: 1.065 ± 0.043
6.024LeuAsp: 6.024 ± 0.089
5.544LeuGlu: 5.544 ± 0.102
4.115LeuPhe: 4.115 ± 0.088
6.842LeuGly: 6.842 ± 0.109
2.331LeuHis: 2.331 ± 0.054
6.599LeuIle: 6.599 ± 0.101
5.833LeuLys: 5.833 ± 0.086
9.614LeuLeu: 9.614 ± 0.154
2.669LeuMet: 2.669 ± 0.062
4.792LeuAsn: 4.792 ± 0.081
4.541LeuPro: 4.541 ± 0.071
5.002LeuGln: 5.002 ± 0.096
4.325LeuArg: 4.325 ± 0.074
7.365LeuSer: 7.365 ± 0.092
5.494LeuThr: 5.494 ± 0.08
5.784LeuVal: 5.784 ± 0.089
1.163LeuTrp: 1.163 ± 0.041
2.638LeuTyr: 2.638 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.294MetAla: 2.294 ± 0.061
0.218MetCys: 0.218 ± 0.017
1.22MetAsp: 1.22 ± 0.039
0.898MetGlu: 0.898 ± 0.033
0.868MetPhe: 0.868 ± 0.034
1.617MetGly: 1.617 ± 0.049
0.646MetHis: 0.646 ± 0.029
1.725MetIle: 1.725 ± 0.05
1.349MetLys: 1.349 ± 0.047
2.669MetLeu: 2.669 ± 0.06
0.799MetMet: 0.799 ± 0.035
1.287MetAsn: 1.287 ± 0.044
1.224MetPro: 1.224 ± 0.037
1.777MetGln: 1.777 ± 0.049
1.258MetArg: 1.258 ± 0.04
2.021MetSer: 2.021 ± 0.06
1.634MetThr: 1.634 ± 0.049
1.657MetVal: 1.657 ± 0.039
0.225MetTrp: 0.225 ± 0.015
0.63MetTyr: 0.63 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.977AsnAla: 3.977 ± 0.076
0.388AsnCys: 0.388 ± 0.021
2.441AsnAsp: 2.441 ± 0.056
2.02AsnGlu: 2.02 ± 0.055
1.807AsnPhe: 1.807 ± 0.047
2.624AsnGly: 2.624 ± 0.065
1.14AsnHis: 1.14 ± 0.038
2.947AsnIle: 2.947 ± 0.059
1.857AsnLys: 1.857 ± 0.049
4.152AsnLeu: 4.152 ± 0.073
0.966AsnMet: 0.966 ± 0.031
1.892AsnAsn: 1.892 ± 0.061
2.233AsnPro: 2.233 ± 0.046
2.547AsnGln: 2.547 ± 0.061
1.924AsnArg: 1.924 ± 0.055
2.463AsnSer: 2.463 ± 0.059
2.557AsnThr: 2.557 ± 0.054
2.712AsnVal: 2.712 ± 0.062
0.535AsnTrp: 0.535 ± 0.026
1.513AsnTyr: 1.513 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
3.242ProAla: 3.242 ± 0.062
0.263ProCys: 0.263 ± 0.018
2.22ProAsp: 2.22 ± 0.05
3.194ProGlu: 3.194 ± 0.061
1.739ProPhe: 1.739 ± 0.046
1.336ProGly: 1.336 ± 0.045
0.922ProHis: 0.922 ± 0.036
2.578ProIle: 2.578 ± 0.057
2.307ProLys: 2.307 ± 0.056
3.755ProLeu: 3.755 ± 0.064
1.056ProMet: 1.056 ± 0.036
2.036ProAsn: 2.036 ± 0.048
1.059ProPro: 1.059 ± 0.039
1.931ProGln: 1.931 ± 0.052
1.428ProArg: 1.428 ± 0.045
2.613ProSer: 2.613 ± 0.058
2.322ProThr: 2.322 ± 0.069
2.736ProVal: 2.736 ± 0.054
0.451ProTrp: 0.451 ± 0.021
1.364ProTyr: 1.364 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
5.867GlnAla: 5.867 ± 0.096
0.516GlnCys: 0.516 ± 0.027
3.002GlnAsp: 3.002 ± 0.064
2.294GlnGlu: 2.294 ± 0.065
2.368GlnPhe: 2.368 ± 0.054
3.464GlnGly: 3.464 ± 0.068
2.039GlnHis: 2.039 ± 0.059
3.731GlnIle: 3.731 ± 0.07
2.822GlnLys: 2.822 ± 0.075
6.352GlnLeu: 6.352 ± 0.124
1.365GlnMet: 1.365 ± 0.045
2.594GlnAsn: 2.594 ± 0.055
2.306GlnPro: 2.306 ± 0.049
4.574GlnGln: 4.574 ± 0.128
2.972GlnArg: 2.972 ± 0.069
3.92GlnSer: 3.92 ± 0.081
2.872GlnThr: 2.872 ± 0.059
3.881GlnVal: 3.881 ± 0.065
0.726GlnTrp: 0.726 ± 0.029
1.905GlnTyr: 1.905 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
3.485ArgAla: 3.485 ± 0.075
0.383ArgCys: 0.383 ± 0.022
2.327ArgAsp: 2.327 ± 0.058
2.736ArgGlu: 2.736 ± 0.065
2.215ArgPhe: 2.215 ± 0.058
2.591ArgGly: 2.591 ± 0.058
1.199ArgHis: 1.199 ± 0.037
3.245ArgIle: 3.245 ± 0.063
2.153ArgLys: 2.153 ± 0.05
4.947ArgLeu: 4.947 ± 0.083
1.203ArgMet: 1.203 ± 0.035
1.752ArgAsn: 1.752 ± 0.042
1.744ArgPro: 1.744 ± 0.042
2.781ArgGln: 2.781 ± 0.058
2.247ArgArg: 2.247 ± 0.054
2.523ArgSer: 2.523 ± 0.051
2.081ArgThr: 2.081 ± 0.048
2.801ArgVal: 2.801 ± 0.067
0.626ArgTrp: 0.626 ± 0.03
1.825ArgTyr: 1.825 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.758SerAla: 5.758 ± 0.088
0.572SerCys: 0.572 ± 0.022
3.431SerAsp: 3.431 ± 0.07
3.305SerGlu: 3.305 ± 0.068
2.534SerPhe: 2.534 ± 0.059
4.171SerGly: 4.171 ± 0.086
1.567SerHis: 1.567 ± 0.05
4.075SerIle: 4.075 ± 0.076
3.265SerLys: 3.265 ± 0.066
5.978SerLeu: 5.978 ± 0.094
1.714SerMet: 1.714 ± 0.051
2.889SerAsn: 2.889 ± 0.072
2.339SerPro: 2.339 ± 0.05
3.417SerGln: 3.417 ± 0.07
2.474SerArg: 2.474 ± 0.056
4.234SerSer: 4.234 ± 0.081
3.904SerThr: 3.904 ± 0.072
3.83SerVal: 3.83 ± 0.067
0.702SerTrp: 0.702 ± 0.028
1.915SerTyr: 1.915 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
5.432ThrAla: 5.432 ± 0.089
0.465ThrCys: 0.465 ± 0.024
2.981ThrAsp: 2.981 ± 0.065
3.07ThrGlu: 3.07 ± 0.058
2.005ThrPhe: 2.005 ± 0.051
4.069ThrGly: 4.069 ± 0.09
1.29ThrHis: 1.29 ± 0.041
3.253ThrIle: 3.253 ± 0.065
2.175ThrLys: 2.175 ± 0.051
5.755ThrLeu: 5.755 ± 0.091
1.168ThrMet: 1.168 ± 0.041
1.875ThrAsn: 1.875 ± 0.063
2.785ThrPro: 2.785 ± 0.066
2.952ThrGln: 2.952 ± 0.062
2.207ThrArg: 2.207 ± 0.059
3.079ThrSer: 3.079 ± 0.063
3.312ThrThr: 3.312 ± 0.067
3.804ThrVal: 3.804 ± 0.077
0.729ThrTrp: 0.729 ± 0.031
1.485ThrTyr: 1.485 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
6.262ValAla: 6.262 ± 0.1
0.701ValCys: 0.701 ± 0.029
4.024ValAsp: 4.024 ± 0.083
4.127ValGlu: 4.127 ± 0.072
2.579ValPhe: 2.579 ± 0.06
4.359ValGly: 4.359 ± 0.078
1.314ValHis: 1.314 ± 0.045
4.436ValIle: 4.436 ± 0.067
3.323ValLys: 3.323 ± 0.063
6.721ValLeu: 6.721 ± 0.112
1.85ValMet: 1.85 ± 0.044
2.84ValAsn: 2.84 ± 0.066
2.552ValPro: 2.552 ± 0.058
3.133ValGln: 3.133 ± 0.057
2.838ValArg: 2.838 ± 0.069
3.958ValSer: 3.958 ± 0.072
3.585ValThr: 3.585 ± 0.075
4.764ValVal: 4.764 ± 0.097
0.757ValTrp: 0.757 ± 0.028
1.85ValTyr: 1.85 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.879TrpAla: 0.879 ± 0.033
0.157TrpCys: 0.157 ± 0.012
0.549TrpAsp: 0.549 ± 0.025
0.448TrpGlu: 0.448 ± 0.023
0.609TrpPhe: 0.609 ± 0.027
0.717TrpGly: 0.717 ± 0.029
0.376TrpHis: 0.376 ± 0.022
0.861TrpIle: 0.861 ± 0.034
0.556TrpLys: 0.556 ± 0.023
1.676TrpLeu: 1.676 ± 0.053
0.412TrpMet: 0.412 ± 0.023
0.457TrpAsn: 0.457 ± 0.022
0.241TrpPro: 0.241 ± 0.018
1.146TrpGln: 1.146 ± 0.038
0.644TrpArg: 0.644 ± 0.027
0.766TrpSer: 0.766 ± 0.031
0.604TrpThr: 0.604 ± 0.029
0.839TrpVal: 0.839 ± 0.03
0.193TrpTrp: 0.193 ± 0.014
0.405TrpTyr: 0.405 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.959TyrAla: 2.959 ± 0.06
0.366TyrCys: 0.366 ± 0.024
1.836TyrAsp: 1.836 ± 0.05
1.436TyrGlu: 1.436 ± 0.046
1.627TyrPhe: 1.627 ± 0.045
2.205TyrGly: 2.205 ± 0.057
0.817TyrHis: 0.817 ± 0.035
1.687TyrIle: 1.687 ± 0.043
1.316TyrLys: 1.316 ± 0.04
3.503TyrLeu: 3.503 ± 0.072
0.61TyrMet: 0.61 ± 0.028
1.078TyrAsn: 1.078 ± 0.042
1.5TyrPro: 1.5 ± 0.041
2.421TyrGln: 2.421 ± 0.063
1.722TyrArg: 1.722 ± 0.043
1.828TyrSer: 1.828 ± 0.045
1.557TyrThr: 1.557 ± 0.041
1.975TyrVal: 1.975 ± 0.06
0.462TyrTrp: 0.462 ± 0.023
1.147TyrTyr: 1.147 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2744 proteins (866506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski