Amino acid dipepetide frequency for Marinirhabdus gelatinilytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.581AlaAla: 4.581 ± 0.073	0.561AlaCys: 0.561 ± 0.025	3.199AlaAsp: 3.199 ± 0.068	4.684AlaGlu: 4.684 ± 0.074	3.321AlaPhe: 3.321 ± 0.064	4.466AlaGly: 4.466 ± 0.094	1.208AlaHis: 1.208 ± 0.036	5.342AlaIle: 5.342 ± 0.091	4.694AlaLys: 4.694 ± 0.09	6.537AlaLeu: 6.537 ± 0.092	1.727AlaMet: 1.727 ± 0.047	3.594AlaAsn: 3.594 ± 0.07	2.178AlaPro: 2.178 ± 0.046	2.964AlaGln: 2.964 ± 0.063	2.24AlaArg: 2.24 ± 0.048	4.298AlaSer: 4.298 ± 0.075	4.435AlaThr: 4.435 ± 0.081	4.476AlaVal: 4.476 ± 0.075	0.623AlaTrp: 0.623 ± 0.026	2.45AlaTyr: 2.45 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.476CysAla: 0.476 ± 0.023	0.111CysCys: 0.111 ± 0.011	0.464CysAsp: 0.464 ± 0.032	0.484CysGlu: 0.484 ± 0.022	0.396CysPhe: 0.396 ± 0.023	0.612CysGly: 0.612 ± 0.028	0.212CysHis: 0.212 ± 0.035	0.578CysIle: 0.578 ± 0.025	0.448CysLys: 0.448 ± 0.024	0.613CysLeu: 0.613 ± 0.025	0.145CysMet: 0.145 ± 0.011	0.405CysAsn: 0.405 ± 0.021	0.344CysPro: 0.344 ± 0.023	0.208CysGln: 0.208 ± 0.014	0.197CysArg: 0.197 ± 0.014	0.506CysSer: 0.506 ± 0.028	0.482CysThr: 0.482 ± 0.022	0.435CysVal: 0.435 ± 0.021	0.056CysTrp: 0.056 ± 0.007	0.273CysTyr: 0.273 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.055AspAla: 4.055 ± 0.077	0.463AspCys: 0.463 ± 0.03	3.07AspAsp: 3.07 ± 0.109	3.742AspGlu: 3.742 ± 0.078	3.511AspPhe: 3.511 ± 0.064	4.399AspGly: 4.399 ± 0.169	0.879AspHis: 0.879 ± 0.034	4.252AspIle: 4.252 ± 0.071	3.472AspLys: 3.472 ± 0.063	4.76AspLeu: 4.76 ± 0.083	1.116AspMet: 1.116 ± 0.036	2.959AspAsn: 2.959 ± 0.088	2.146AspPro: 2.146 ± 0.083	1.439AspGln: 1.439 ± 0.038	1.965AspArg: 1.965 ± 0.048	3.065AspSer: 3.065 ± 0.068	3.464AspThr: 3.464 ± 0.069	3.787AspVal: 3.787 ± 0.066	0.745AspTrp: 0.745 ± 0.03	2.594AspTyr: 2.594 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.963GluAla: 4.963 ± 0.093	0.358GluCys: 0.358 ± 0.019	4.145GluAsp: 4.145 ± 0.07	5.508GluGlu: 5.508 ± 0.104	2.846GluPhe: 2.846 ± 0.054	4.206GluGly: 4.206 ± 0.064	1.216GluHis: 1.216 ± 0.043	5.654GluIle: 5.654 ± 0.075	6.052GluLys: 6.052 ± 0.11	5.855GluLeu: 5.855 ± 0.082	1.692GluMet: 1.692 ± 0.035	4.849GluAsn: 4.849 ± 0.078	1.694GluPro: 1.694 ± 0.041	2.414GluGln: 2.414 ± 0.06	2.858GluArg: 2.858 ± 0.064	3.031GluSer: 3.031 ± 0.055	4.655GluThr: 4.655 ± 0.07	4.492GluVal: 4.492 ± 0.073	0.569GluTrp: 0.569 ± 0.025	2.415GluTyr: 2.415 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.13PheAla: 3.13 ± 0.063	0.407PheCys: 0.407 ± 0.023	3.061PheAsp: 3.061 ± 0.063	3.597PheGlu: 3.597 ± 0.057	2.82PhePhe: 2.82 ± 0.071	3.743PheGly: 3.743 ± 0.064	0.828PheHis: 0.828 ± 0.035	3.483PheIle: 3.483 ± 0.07	3.451PheLys: 3.451 ± 0.068	4.627PheLeu: 4.627 ± 0.079	1.101PheMet: 1.101 ± 0.033	3.004PheAsn: 3.004 ± 0.053	1.847PhePro: 1.847 ± 0.04	1.721PheGln: 1.721 ± 0.047	1.693PheArg: 1.693 ± 0.042	4.036PheSer: 4.036 ± 0.07	3.274PheThr: 3.274 ± 0.059	3.292PheVal: 3.292 ± 0.063	0.562PheTrp: 0.562 ± 0.026	2.08PheTyr: 2.08 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.565GlyAla: 4.565 ± 0.081	0.576GlyCys: 0.576 ± 0.03	3.916GlyAsp: 3.916 ± 0.097	3.967GlyGlu: 3.967 ± 0.067	3.689GlyPhe: 3.689 ± 0.065	4.941GlyGly: 4.941 ± 0.105	1.126GlyHis: 1.126 ± 0.033	5.227GlyIle: 5.227 ± 0.088	4.597GlyLys: 4.597 ± 0.068	5.816GlyLeu: 5.816 ± 0.078	1.705GlyMet: 1.705 ± 0.048	4.064GlyAsn: 4.064 ± 0.089	1.462GlyPro: 1.462 ± 0.043	1.991GlyGln: 1.991 ± 0.053	2.14GlyArg: 2.14 ± 0.048	4.033GlySer: 4.033 ± 0.067	4.666GlyThr: 4.666 ± 0.099	4.617GlyVal: 4.617 ± 0.084	0.765GlyTrp: 0.765 ± 0.026	2.846GlyTyr: 2.846 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.948HisAla: 0.948 ± 0.032	0.189HisCys: 0.189 ± 0.015	0.827HisAsp: 0.827 ± 0.031	0.928HisGlu: 0.928 ± 0.034	1.175HisPhe: 1.175 ± 0.036	1.07HisGly: 1.07 ± 0.032	0.493HisHis: 0.493 ± 0.022	1.415HisIle: 1.415 ± 0.041	1.239HisLys: 1.239 ± 0.038	1.743HisLeu: 1.743 ± 0.042	0.304HisMet: 0.304 ± 0.02	0.963HisAsn: 0.963 ± 0.031	0.97HisPro: 0.97 ± 0.038	0.658HisGln: 0.658 ± 0.028	0.706HisArg: 0.706 ± 0.025	0.993HisSer: 0.993 ± 0.03	1.082HisThr: 1.082 ± 0.032	0.876HisVal: 0.876 ± 0.032	0.224HisTrp: 0.224 ± 0.016	0.835HisTyr: 0.835 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.761IleAla: 5.761 ± 0.077	0.592IleCys: 0.592 ± 0.026	4.451IleAsp: 4.451 ± 0.07	5.208IleGlu: 5.208 ± 0.08	3.45IlePhe: 3.45 ± 0.084	4.778IleGly: 4.778 ± 0.091	1.24IleHis: 1.24 ± 0.032	4.994IleIle: 4.994 ± 0.09	4.594IleLys: 4.594 ± 0.082	6.623IleLeu: 6.623 ± 0.104	1.188IleMet: 1.188 ± 0.034	3.731IleAsn: 3.731 ± 0.063	3.21IlePro: 3.21 ± 0.058	2.506IleGln: 2.506 ± 0.057	2.345IleArg: 2.345 ± 0.054	5.224IleSer: 5.224 ± 0.084	4.717IleThr: 4.717 ± 0.073	4.871IleVal: 4.871 ± 0.081	0.633IleTrp: 0.633 ± 0.027	2.459IleTyr: 2.459 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.81LysAla: 4.81 ± 0.092	0.294LysCys: 0.294 ± 0.014	4.192LysAsp: 4.192 ± 0.079	6.078LysGlu: 6.078 ± 0.106	2.749LysPhe: 2.749 ± 0.059	4.37LysGly: 4.37 ± 0.061	1.292LysHis: 1.292 ± 0.044	5.308LysIle: 5.308 ± 0.085	6.846LysLys: 6.846 ± 0.11	6.225LysLeu: 6.225 ± 0.101	1.912LysMet: 1.912 ± 0.047	4.744LysAsn: 4.744 ± 0.08	2.283LysPro: 2.283 ± 0.051	2.739LysGln: 2.739 ± 0.064	3.001LysArg: 3.001 ± 0.063	3.717LysSer: 3.717 ± 0.077	4.381LysThr: 4.381 ± 0.07	4.306LysVal: 4.306 ± 0.072	0.626LysTrp: 0.626 ± 0.022	2.556LysTyr: 2.556 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.162LeuAla: 6.162 ± 0.088	0.708LeuCys: 0.708 ± 0.028	5.174LeuAsp: 5.174 ± 0.081	6.272LeuGlu: 6.272 ± 0.092	4.807LeuPhe: 4.807 ± 0.085	5.997LeuGly: 5.997 ± 0.086	1.652LeuHis: 1.652 ± 0.046	5.83LeuIle: 5.83 ± 0.102	7.172LeuLys: 7.172 ± 0.108	9.25LeuLeu: 9.25 ± 0.119	1.892LeuMet: 1.892 ± 0.049	4.84LeuAsn: 4.84 ± 0.072	3.534LeuPro: 3.534 ± 0.067	4.039LeuGln: 4.039 ± 0.073	3.515LeuArg: 3.515 ± 0.063	6.23LeuSer: 6.23 ± 0.078	5.06LeuThr: 5.06 ± 0.074	5.947LeuVal: 5.947 ± 0.097	0.882LeuTrp: 0.882 ± 0.031	3.297LeuTyr: 3.297 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.774MetAla: 1.774 ± 0.049	0.124MetCys: 0.124 ± 0.011	1.256MetAsp: 1.256 ± 0.036	1.565MetGlu: 1.565 ± 0.045	0.766MetPhe: 0.766 ± 0.029	1.565MetGly: 1.565 ± 0.044	0.394MetHis: 0.394 ± 0.02	1.24MetIle: 1.24 ± 0.038	2.17MetLys: 2.17 ± 0.047	2.062MetLeu: 2.062 ± 0.052	0.546MetMet: 0.546 ± 0.027	1.139MetAsn: 1.139 ± 0.038	0.824MetPro: 0.824 ± 0.026	0.881MetGln: 0.881 ± 0.027	0.89MetArg: 0.89 ± 0.029	1.224MetSer: 1.224 ± 0.034	1.05MetThr: 1.05 ± 0.035	1.498MetVal: 1.498 ± 0.045	0.158MetTrp: 0.158 ± 0.013	0.79MetTyr: 0.79 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.821AsnAla: 3.821 ± 0.067	0.434AsnCys: 0.434 ± 0.024	3.195AsnAsp: 3.195 ± 0.094	3.562AsnGlu: 3.562 ± 0.068	3.04AsnPhe: 3.04 ± 0.068	4.136AsnGly: 4.136 ± 0.104	0.964AsnHis: 0.964 ± 0.032	4.313AsnIle: 4.313 ± 0.073	3.667AsnLys: 3.667 ± 0.068	5.023AsnLeu: 5.023 ± 0.08	1.209AsnMet: 1.209 ± 0.034	3.827AsnAsn: 3.827 ± 0.099	2.872AsnPro: 2.872 ± 0.06	1.936AsnGln: 1.936 ± 0.053	2.239AsnArg: 2.239 ± 0.054	3.368AsnSer: 3.368 ± 0.069	3.792AsnThr: 3.792 ± 0.079	3.503AsnVal: 3.503 ± 0.066	0.685AsnTrp: 0.685 ± 0.031	2.497AsnTyr: 2.497 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.137ProAla: 2.137 ± 0.055	0.231ProCys: 0.231 ± 0.017	2.089ProAsp: 2.089 ± 0.06	2.973ProGlu: 2.973 ± 0.052	1.946ProPhe: 1.946 ± 0.044	2.083ProGly: 2.083 ± 0.054	0.631ProHis: 0.631 ± 0.025	2.624ProIle: 2.624 ± 0.049	2.65ProLys: 2.65 ± 0.057	3.117ProLeu: 3.117 ± 0.065	0.739ProMet: 0.739 ± 0.029	2.408ProAsn: 2.408 ± 0.065	1.048ProPro: 1.048 ± 0.044	1.329ProGln: 1.329 ± 0.045	1.052ProArg: 1.052 ± 0.035	2.322ProSer: 2.322 ± 0.043	2.228ProThr: 2.228 ± 0.055	2.402ProVal: 2.402 ± 0.052	0.345ProTrp: 0.345 ± 0.018	1.454ProTyr: 1.454 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.205GlnAla: 2.205 ± 0.046	0.207GlnCys: 0.207 ± 0.014	2.004GlnAsp: 2.004 ± 0.05	2.592GlnGlu: 2.592 ± 0.052	1.825GlnPhe: 1.825 ± 0.044	2.109GlnGly: 2.109 ± 0.045	0.764GlnHis: 0.764 ± 0.029	2.348GlnIle: 2.348 ± 0.05	2.969GlnLys: 2.969 ± 0.065	3.848GlnLeu: 3.848 ± 0.071	0.934GlnMet: 0.934 ± 0.031	2.093GlnAsn: 2.093 ± 0.049	1.318GlnPro: 1.318 ± 0.04	1.92GlnGln: 1.92 ± 0.052	1.474GlnArg: 1.474 ± 0.04	1.712GlnSer: 1.712 ± 0.053	2.01GlnThr: 2.01 ± 0.049	2.159GlnVal: 2.159 ± 0.042	0.406GlnTrp: 0.406 ± 0.022	1.434GlnTyr: 1.434 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.27ArgAla: 2.27 ± 0.048	0.212ArgCys: 0.212 ± 0.014	2.039ArgAsp: 2.039 ± 0.045	2.435ArgGlu: 2.435 ± 0.054	2.032ArgPhe: 2.032 ± 0.051	2.116ArgGly: 2.116 ± 0.052	0.613ArgHis: 0.613 ± 0.026	2.728ArgIle: 2.728 ± 0.055	2.94ArgLys: 2.94 ± 0.061	3.379ArgLeu: 3.379 ± 0.06	0.928ArgMet: 0.928 ± 0.032	2.229ArgAsn: 2.229 ± 0.049	1.125ArgPro: 1.125 ± 0.036	1.218ArgGln: 1.218 ± 0.039	1.459ArgArg: 1.459 ± 0.044	1.956ArgSer: 1.956 ± 0.046	2.028ArgThr: 2.028 ± 0.046	2.266ArgVal: 2.266 ± 0.043	0.427ArgTrp: 0.427 ± 0.021	1.699ArgTyr: 1.699 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.655SerAla: 3.655 ± 0.08	0.612SerCys: 0.612 ± 0.025	3.082SerAsp: 3.082 ± 0.072	4.326SerGlu: 4.326 ± 0.073	3.528SerPhe: 3.528 ± 0.061	4.479SerGly: 4.479 ± 0.087	0.975SerHis: 0.975 ± 0.037	4.595SerIle: 4.595 ± 0.068	4.158SerLys: 4.158 ± 0.076	5.724SerLeu: 5.724 ± 0.088	1.208SerMet: 1.208 ± 0.036	3.458SerAsn: 3.458 ± 0.076	2.118SerPro: 2.118 ± 0.047	2.148SerGln: 2.148 ± 0.051	2.16SerArg: 2.16 ± 0.045	3.657SerSer: 3.657 ± 0.077	3.504SerThr: 3.504 ± 0.063	4.054SerVal: 4.054 ± 0.077	0.653SerTrp: 0.653 ± 0.026	2.496SerTyr: 2.496 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.333ThrAla: 4.333 ± 0.079	0.388ThrCys: 0.388 ± 0.025	3.172ThrAsp: 3.172 ± 0.081	4.196ThrGlu: 4.196 ± 0.07	3.353ThrPhe: 3.353 ± 0.058	4.283ThrGly: 4.283 ± 0.084	1.081ThrHis: 1.081 ± 0.032	5.067ThrIle: 5.067 ± 0.074	3.749ThrLys: 3.749 ± 0.058	5.877ThrLeu: 5.877 ± 0.081	1.165ThrMet: 1.165 ± 0.037	3.371ThrAsn: 3.371 ± 0.075	2.649ThrPro: 2.649 ± 0.064	2.277ThrGln: 2.277 ± 0.056	1.795ThrArg: 1.795 ± 0.043	3.804ThrSer: 3.804 ± 0.067	4.242ThrThr: 4.242 ± 0.088	4.487ThrVal: 4.487 ± 0.089	0.658ThrTrp: 0.658 ± 0.034	2.501ThrTyr: 2.501 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.863ValAla: 4.863 ± 0.088	0.556ValCys: 0.556 ± 0.027	3.681ValAsp: 3.681 ± 0.071	4.238ValGlu: 4.238 ± 0.073	3.477ValPhe: 3.477 ± 0.072	4.136ValGly: 4.136 ± 0.068	1.108ValHis: 1.108 ± 0.034	4.272ValIle: 4.272 ± 0.073	3.956ValLys: 3.956 ± 0.062	6.497ValLeu: 6.497 ± 0.095	1.454ValMet: 1.454 ± 0.041	3.338ValAsn: 3.338 ± 0.061	2.448ValPro: 2.448 ± 0.052	2.167ValGln: 2.167 ± 0.05	2.226ValArg: 2.226 ± 0.047	4.584ValSer: 4.584 ± 0.07	4.335ValThr: 4.335 ± 0.084	4.756ValVal: 4.756 ± 0.08	0.679ValTrp: 0.679 ± 0.027	2.502ValTyr: 2.502 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.632TrpAla: 0.632 ± 0.028	0.099TrpCys: 0.099 ± 0.01	0.625TrpAsp: 0.625 ± 0.028	0.694TrpGlu: 0.694 ± 0.029	0.563TrpPhe: 0.563 ± 0.022	0.632TrpGly: 0.632 ± 0.028	0.225TrpHis: 0.225 ± 0.013	0.655TrpIle: 0.655 ± 0.028	0.758TrpLys: 0.758 ± 0.029	1.036TrpLeu: 1.036 ± 0.033	0.289TrpMet: 0.289 ± 0.018	0.622TrpAsn: 0.622 ± 0.029	0.267TrpPro: 0.267 ± 0.019	0.434TrpGln: 0.434 ± 0.024	0.431TrpArg: 0.431 ± 0.019	0.527TrpSer: 0.527 ± 0.023	0.535TrpThr: 0.535 ± 0.028	0.678TrpVal: 0.678 ± 0.025	0.147TrpTrp: 0.147 ± 0.014	0.453TrpTyr: 0.453 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.436TyrAla: 2.436 ± 0.058	0.321TyrCys: 0.321 ± 0.019	2.24TyrAsp: 2.24 ± 0.047	2.423TyrGlu: 2.423 ± 0.05	2.464TyrPhe: 2.464 ± 0.053	2.591TyrGly: 2.591 ± 0.054	0.739TyrHis: 0.739 ± 0.029	2.652TyrIle: 2.652 ± 0.05	2.847TyrLys: 2.847 ± 0.059	3.648TyrLeu: 3.648 ± 0.059	0.661TyrMet: 0.661 ± 0.026	2.445TyrAsn: 2.445 ± 0.056	1.467TyrPro: 1.467 ± 0.033	1.341TyrGln: 1.341 ± 0.041	1.713TyrArg: 1.713 ± 0.045	2.304TyrSer: 2.304 ± 0.053	2.508TyrThr: 2.508 ± 0.059	2.37TyrVal: 2.37 ± 0.051	0.459TyrTrp: 0.459 ± 0.024	1.781TyrTyr: 1.781 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3022 proteins (992534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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