Amino acid dipepetide frequency for Collinsella sp. AK_207A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.52AlaAla: 16.52 ± 0.293
1.963AlaCys: 1.963 ± 0.066
7.367AlaAsp: 7.367 ± 0.133
7.669AlaGlu: 7.669 ± 0.135
3.904AlaPhe: 3.904 ± 0.088
10.883AlaGly: 10.883 ± 0.144
2.238AlaHis: 2.238 ± 0.061
5.534AlaIle: 5.534 ± 0.106
4.265AlaLys: 4.265 ± 0.115
11.84AlaLeu: 11.84 ± 0.177
3.083AlaMet: 3.083 ± 0.073
2.851AlaAsn: 2.851 ± 0.081
4.955AlaPro: 4.955 ± 0.12
3.599AlaGln: 3.599 ± 0.075
8.08AlaArg: 8.08 ± 0.156
6.793AlaSer: 6.793 ± 0.116
5.721AlaThr: 5.721 ± 0.112
9.013AlaVal: 9.013 ± 0.15
1.379AlaTrp: 1.379 ± 0.057
3.025AlaTyr: 3.025 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
1.641CysAla: 1.641 ± 0.064
0.243CysCys: 0.243 ± 0.019
0.915CysAsp: 0.915 ± 0.044
0.874CysGlu: 0.874 ± 0.038
0.521CysPhe: 0.521 ± 0.028
1.531CysGly: 1.531 ± 0.054
0.321CysHis: 0.321 ± 0.025
0.658CysIle: 0.658 ± 0.04
0.375CysLys: 0.375 ± 0.024
1.172CysLeu: 1.172 ± 0.049
0.333CysMet: 0.333 ± 0.023
0.344CysAsn: 0.344 ± 0.026
0.733CysPro: 0.733 ± 0.04
0.4CysGln: 0.4 ± 0.027
0.849CysArg: 0.849 ± 0.037
0.746CysSer: 0.746 ± 0.04
0.774CysThr: 0.774 ± 0.04
1.089CysVal: 1.089 ± 0.042
0.133CysTrp: 0.133 ± 0.014
0.331CysTyr: 0.331 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
8.784AspAla: 8.784 ± 0.13
0.748AspCys: 0.748 ± 0.039
3.907AspAsp: 3.907 ± 0.097
5.001AspGlu: 5.001 ± 0.105
2.327AspPhe: 2.327 ± 0.07
5.411AspGly: 5.411 ± 0.121
1.099AspHis: 1.099 ± 0.042
3.074AspIle: 3.074 ± 0.078
1.861AspLys: 1.861 ± 0.062
5.522AspLeu: 5.522 ± 0.092
1.438AspMet: 1.438 ± 0.048
1.441AspAsn: 1.441 ± 0.048
3.16AspPro: 3.16 ± 0.076
1.551AspGln: 1.551 ± 0.055
3.456AspArg: 3.456 ± 0.078
2.72AspSer: 2.72 ± 0.072
3.115AspThr: 3.115 ± 0.074
5.076AspVal: 5.076 ± 0.093
0.718AspTrp: 0.718 ± 0.038
1.91AspTyr: 1.91 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
7.128GluAla: 7.128 ± 0.127
0.631GluCys: 0.631 ± 0.035
3.83GluAsp: 3.83 ± 0.083
4.216GluGlu: 4.216 ± 0.1
2.056GluPhe: 2.056 ± 0.05
5.132GluGly: 5.132 ± 0.097
1.677GluHis: 1.677 ± 0.057
2.751GluIle: 2.751 ± 0.067
2.523GluLys: 2.523 ± 0.074
7.026GluLeu: 7.026 ± 0.121
1.725GluMet: 1.725 ± 0.053
2.035GluAsn: 2.035 ± 0.059
2.568GluPro: 2.568 ± 0.067
2.397GluGln: 2.397 ± 0.066
5.622GluArg: 5.622 ± 0.124
2.91GluSer: 2.91 ± 0.069
2.956GluThr: 2.956 ± 0.058
4.822GluVal: 4.822 ± 0.108
0.523GluTrp: 0.523 ± 0.028
1.517GluTyr: 1.517 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.924PheAla: 3.924 ± 0.089
0.633PheCys: 0.633 ± 0.032
2.678PheAsp: 2.678 ± 0.082
2.253PheGlu: 2.253 ± 0.068
1.353PhePhe: 1.353 ± 0.053
3.32PheGly: 3.32 ± 0.076
0.699PheHis: 0.699 ± 0.033
1.64PheIle: 1.64 ± 0.054
1.238PheLys: 1.238 ± 0.047
3.032PheLeu: 3.032 ± 0.078
0.953PheMet: 0.953 ± 0.036
1.067PheAsn: 1.067 ± 0.044
1.343PhePro: 1.343 ± 0.052
0.951PheGln: 0.951 ± 0.041
1.687PheArg: 1.687 ± 0.054
2.443PheSer: 2.443 ± 0.066
2.228PheThr: 2.228 ± 0.072
2.764PheVal: 2.764 ± 0.071
0.39PheTrp: 0.39 ± 0.027
1.003PheTyr: 1.003 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
9.043GlyAla: 9.043 ± 0.147
1.42GlyCys: 1.42 ± 0.056
4.842GlyAsp: 4.842 ± 0.089
5.262GlyGlu: 5.262 ± 0.095
3.274GlyPhe: 3.274 ± 0.074
6.821GlyGly: 6.821 ± 0.133
1.672GlyHis: 1.672 ± 0.061
4.909GlyIle: 4.909 ± 0.105
3.768GlyLys: 3.768 ± 0.078
7.551GlyLeu: 7.551 ± 0.116
2.435GlyMet: 2.435 ± 0.073
2.437GlyAsn: 2.437 ± 0.074
2.382GlyPro: 2.382 ± 0.062
2.194GlyGln: 2.194 ± 0.069
5.194GlyArg: 5.194 ± 0.11
5.336GlySer: 5.336 ± 0.124
5.185GlyThr: 5.185 ± 0.108
6.959GlyVal: 6.959 ± 0.122
1.0GlyTrp: 1.0 ± 0.044
2.643GlyTyr: 2.643 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
2.22HisAla: 2.22 ± 0.059
0.241HisCys: 0.241 ± 0.021
1.313HisAsp: 1.313 ± 0.049
1.39HisGlu: 1.39 ± 0.053
0.662HisPhe: 0.662 ± 0.033
1.85HisGly: 1.85 ± 0.063
0.428HisHis: 0.428 ± 0.029
0.951HisIle: 0.951 ± 0.038
0.513HisLys: 0.513 ± 0.028
1.694HisLeu: 1.694 ± 0.055
0.462HisMet: 0.462 ± 0.027
0.474HisAsn: 0.474 ± 0.028
1.131HisPro: 1.131 ± 0.048
0.461HisGln: 0.461 ± 0.026
1.181HisArg: 1.181 ± 0.047
0.769HisSer: 0.769 ± 0.032
0.931HisThr: 0.931 ± 0.038
1.745HisVal: 1.745 ± 0.048
0.166HisTrp: 0.166 ± 0.016
0.536HisTyr: 0.536 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.28IleAla: 6.28 ± 0.121
0.817IleCys: 0.817 ± 0.04
3.632IleAsp: 3.632 ± 0.082
3.281IleGlu: 3.281 ± 0.077
1.607IlePhe: 1.607 ± 0.052
3.817IleGly: 3.817 ± 0.096
0.862IleHis: 0.862 ± 0.041
2.397IleIle: 2.397 ± 0.071
1.769IleLys: 1.769 ± 0.056
3.738IleLeu: 3.738 ± 0.087
1.222IleMet: 1.222 ± 0.049
1.443IleAsn: 1.443 ± 0.057
2.34IlePro: 2.34 ± 0.06
1.338IleGln: 1.338 ± 0.047
2.548IleArg: 2.548 ± 0.069
3.001IleSer: 3.001 ± 0.063
2.715IleThr: 2.715 ± 0.072
4.15IleVal: 4.15 ± 0.095
0.484IleTrp: 0.484 ± 0.03
1.167IleTyr: 1.167 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
3.829LysAla: 3.829 ± 0.103
0.287LysCys: 0.287 ± 0.021
2.135LysAsp: 2.135 ± 0.057
1.889LysGlu: 1.889 ± 0.068
0.899LysPhe: 0.899 ± 0.033
2.742LysGly: 2.742 ± 0.068
0.636LysHis: 0.636 ± 0.034
1.886LysIle: 1.886 ± 0.059
2.135LysLys: 2.135 ± 0.083
3.647LysLeu: 3.647 ± 0.077
0.979LysMet: 0.979 ± 0.044
1.345LysAsn: 1.345 ± 0.054
1.871LysPro: 1.871 ± 0.065
1.218LysGln: 1.218 ± 0.055
2.576LysArg: 2.576 ± 0.069
1.925LysSer: 1.925 ± 0.068
2.387LysThr: 2.387 ± 0.087
2.892LysVal: 2.892 ± 0.079
0.267LysTrp: 0.267 ± 0.02
1.007LysTyr: 1.007 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
12.319LeuAla: 12.319 ± 0.186
1.151LeuCys: 1.151 ± 0.044
6.329LeuAsp: 6.329 ± 0.107
5.572LeuGlu: 5.572 ± 0.128
3.363LeuPhe: 3.363 ± 0.095
7.746LeuGly: 7.746 ± 0.117
1.563LeuHis: 1.563 ± 0.055
4.181LeuIle: 4.181 ± 0.104
3.263LeuLys: 3.263 ± 0.069
8.438LeuLeu: 8.438 ± 0.151
2.563LeuMet: 2.563 ± 0.074
2.456LeuAsn: 2.456 ± 0.07
4.422LeuPro: 4.422 ± 0.087
2.202LeuGln: 2.202 ± 0.06
5.314LeuArg: 5.314 ± 0.101
6.155LeuSer: 6.155 ± 0.117
5.234LeuThr: 5.234 ± 0.095
7.836LeuVal: 7.836 ± 0.128
0.746LeuTrp: 0.746 ± 0.041
2.255LeuTyr: 2.255 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
3.176MetAla: 3.176 ± 0.079
0.313MetCys: 0.313 ± 0.022
1.577MetAsp: 1.577 ± 0.05
1.445MetGlu: 1.445 ± 0.053
0.746MetPhe: 0.746 ± 0.038
2.307MetGly: 2.307 ± 0.076
0.467MetHis: 0.467 ± 0.027
1.108MetIle: 1.108 ± 0.043
1.018MetLys: 1.018 ± 0.039
2.461MetLeu: 2.461 ± 0.061
0.684MetMet: 0.684 ± 0.038
0.931MetAsn: 0.931 ± 0.041
1.43MetPro: 1.43 ± 0.049
0.776MetGln: 0.776 ± 0.038
1.771MetArg: 1.771 ± 0.057
1.659MetSer: 1.659 ± 0.051
1.472MetThr: 1.472 ± 0.046
1.902MetVal: 1.902 ± 0.053
0.195MetTrp: 0.195 ± 0.014
0.539MetTyr: 0.539 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.197AsnAla: 3.197 ± 0.079
0.338AsnCys: 0.338 ± 0.024
1.62AsnAsp: 1.62 ± 0.057
1.648AsnGlu: 1.648 ± 0.06
0.826AsnPhe: 0.826 ± 0.037
2.605AsnGly: 2.605 ± 0.096
0.507AsnHis: 0.507 ± 0.029
1.44AsnIle: 1.44 ± 0.05
1.085AsnLys: 1.085 ± 0.048
2.728AsnLeu: 2.728 ± 0.059
0.723AsnMet: 0.723 ± 0.033
0.807AsnAsn: 0.807 ± 0.049
1.833AsnPro: 1.833 ± 0.06
0.784AsnGln: 0.784 ± 0.036
1.595AsnArg: 1.595 ± 0.052
1.389AsnSer: 1.389 ± 0.061
1.428AsnThr: 1.428 ± 0.056
2.428AsnVal: 2.428 ± 0.061
0.29AsnTrp: 0.29 ± 0.026
0.782AsnTyr: 0.782 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
5.747ProAla: 5.747 ± 0.126
0.577ProCys: 0.577 ± 0.032
2.914ProAsp: 2.914 ± 0.075
3.617ProGlu: 3.617 ± 0.092
1.704ProPhe: 1.704 ± 0.05
3.67ProGly: 3.67 ± 0.082
0.869ProHis: 0.869 ± 0.04
1.838ProIle: 1.838 ± 0.06
1.605ProLys: 1.605 ± 0.057
3.796ProLeu: 3.796 ± 0.085
0.967ProMet: 0.967 ± 0.041
1.174ProAsn: 1.174 ± 0.046
1.051ProPro: 1.051 ± 0.044
1.364ProGln: 1.364 ± 0.057
2.548ProArg: 2.548 ± 0.075
2.546ProSer: 2.546 ± 0.071
2.31ProThr: 2.31 ± 0.059
3.993ProVal: 3.993 ± 0.092
0.533ProTrp: 0.533 ± 0.032
1.195ProTyr: 1.195 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
3.425GlnAla: 3.425 ± 0.082
0.259GlnCys: 0.259 ± 0.02
1.446GlnAsp: 1.446 ± 0.051
1.679GlnGlu: 1.679 ± 0.057
0.91GlnPhe: 0.91 ± 0.036
2.364GlnGly: 2.364 ± 0.062
0.497GlnHis: 0.497 ± 0.028
1.554GlnIle: 1.554 ± 0.048
1.118GlnLys: 1.118 ± 0.051
2.883GlnLeu: 2.883 ± 0.08
0.884GlnMet: 0.884 ± 0.038
0.899GlnAsn: 0.899 ± 0.036
1.238GlnPro: 1.238 ± 0.047
1.156GlnGln: 1.156 ± 0.055
2.028GlnArg: 2.028 ± 0.071
1.336GlnSer: 1.336 ± 0.058
1.563GlnThr: 1.563 ± 0.054
2.581GlnVal: 2.581 ± 0.066
0.264GlnTrp: 0.264 ± 0.023
0.643GlnTyr: 0.643 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
7.551ArgAla: 7.551 ± 0.132
0.853ArgCys: 0.853 ± 0.041
3.653ArgAsp: 3.653 ± 0.078
4.727ArgGlu: 4.727 ± 0.099
2.364ArgPhe: 2.364 ± 0.072
4.711ArgGly: 4.711 ± 0.114
1.315ArgHis: 1.315 ± 0.05
3.256ArgIle: 3.256 ± 0.086
1.856ArgLys: 1.856 ± 0.064
5.719ArgLeu: 5.719 ± 0.115
1.854ArgMet: 1.854 ± 0.058
1.59ArgAsn: 1.59 ± 0.049
2.601ArgPro: 2.601 ± 0.072
1.886ArgGln: 1.886 ± 0.065
5.153ArgArg: 5.153 ± 0.123
3.37ArgSer: 3.37 ± 0.084
3.235ArgThr: 3.235 ± 0.075
5.198ArgVal: 5.198 ± 0.111
0.658ArgTrp: 0.658 ± 0.035
1.9ArgTyr: 1.9 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
6.506SerAla: 6.506 ± 0.117
0.807SerCys: 0.807 ± 0.038
3.294SerAsp: 3.294 ± 0.073
3.242SerGlu: 3.242 ± 0.073
2.517SerPhe: 2.517 ± 0.064
5.273SerGly: 5.273 ± 0.106
1.049SerHis: 1.049 ± 0.041
2.85SerIle: 2.85 ± 0.076
2.122SerLys: 2.122 ± 0.07
5.181SerLeu: 5.181 ± 0.109
1.531SerMet: 1.531 ± 0.045
1.577SerAsn: 1.577 ± 0.058
2.256SerPro: 2.256 ± 0.053
1.625SerGln: 1.625 ± 0.051
3.26SerArg: 3.26 ± 0.077
3.712SerSer: 3.712 ± 0.114
3.24SerThr: 3.24 ± 0.082
4.712SerVal: 4.712 ± 0.094
0.667SerTrp: 0.667 ± 0.033
1.925SerTyr: 1.925 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
5.834ThrAla: 5.834 ± 0.122
0.841ThrCys: 0.841 ± 0.04
3.197ThrAsp: 3.197 ± 0.09
2.817ThrGlu: 2.817 ± 0.075
2.174ThrPhe: 2.174 ± 0.066
5.08ThrGly: 5.08 ± 0.106
0.94ThrHis: 0.94 ± 0.036
2.892ThrIle: 2.892 ± 0.077
1.909ThrLys: 1.909 ± 0.065
5.024ThrLeu: 5.024 ± 0.101
1.246ThrMet: 1.246 ± 0.042
1.423ThrAsn: 1.423 ± 0.049
2.938ThrPro: 2.938 ± 0.073
1.369ThrGln: 1.369 ± 0.053
2.881ThrArg: 2.881 ± 0.072
3.265ThrSer: 3.265 ± 0.082
3.055ThrThr: 3.055 ± 0.085
5.204ThrVal: 5.204 ± 0.113
0.608ThrTrp: 0.608 ± 0.029
1.717ThrTyr: 1.717 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
9.654ValAla: 9.654 ± 0.143
1.348ValCys: 1.348 ± 0.054
5.235ValAsp: 5.235 ± 0.11
5.155ValGlu: 5.155 ± 0.094
2.956ValPhe: 2.956 ± 0.071
5.936ValGly: 5.936 ± 0.118
1.454ValHis: 1.454 ± 0.046
4.078ValIle: 4.078 ± 0.103
2.838ValLys: 2.838 ± 0.087
7.851ValLeu: 7.851 ± 0.137
2.002ValMet: 2.002 ± 0.064
2.489ValAsn: 2.489 ± 0.07
4.129ValPro: 4.129 ± 0.077
2.091ValGln: 2.091 ± 0.053
5.127ValArg: 5.127 ± 0.103
5.296ValSer: 5.296 ± 0.116
4.742ValThr: 4.742 ± 0.103
7.082ValVal: 7.082 ± 0.12
0.669ValTrp: 0.669 ± 0.033
2.104ValTyr: 2.104 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.921TrpAla: 0.921 ± 0.039
0.162TrpCys: 0.162 ± 0.016
0.613TrpAsp: 0.613 ± 0.033
0.6TrpGlu: 0.6 ± 0.031
0.431TrpPhe: 0.431 ± 0.027
0.849TrpGly: 0.849 ± 0.036
0.246TrpHis: 0.246 ± 0.022
0.453TrpIle: 0.453 ± 0.025
0.431TrpLys: 0.431 ± 0.028
0.989TrpLeu: 0.989 ± 0.046
0.334TrpMet: 0.334 ± 0.024
0.398TrpAsn: 0.398 ± 0.026
0.384TrpPro: 0.384 ± 0.024
0.38TrpGln: 0.38 ± 0.024
0.676TrpArg: 0.676 ± 0.032
0.579TrpSer: 0.579 ± 0.029
0.53TrpThr: 0.53 ± 0.034
0.702TrpVal: 0.702 ± 0.036
0.134TrpTrp: 0.134 ± 0.016
0.294TrpTyr: 0.294 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.983TyrAla: 2.983 ± 0.075
0.354TyrCys: 0.354 ± 0.025
1.822TyrAsp: 1.822 ± 0.055
1.712TyrGlu: 1.712 ± 0.053
1.003TyrPhe: 1.003 ± 0.043
2.281TyrGly: 2.281 ± 0.065
0.579TyrHis: 0.579 ± 0.031
1.158TyrIle: 1.158 ± 0.045
0.856TyrLys: 0.856 ± 0.038
2.815TyrLeu: 2.815 ± 0.073
0.559TyrMet: 0.559 ± 0.034
0.872TyrAsn: 0.872 ± 0.045
1.254TyrPro: 1.254 ± 0.042
0.985TyrGln: 0.985 ± 0.046
1.902TyrArg: 1.902 ± 0.058
1.397TyrSer: 1.397 ± 0.051
1.592TyrThr: 1.592 ± 0.058
2.087TyrVal: 2.087 ± 0.056
0.282TyrTrp: 0.282 ± 0.02
0.826TyrTyr: 0.826 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1796 proteins (609878 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski