Amino acid dipepetide frequency for Aspergillus carbonarius (strain ITEM 5010)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.527AlaAla: 8.527 ± 0.057	1.164AlaCys: 1.164 ± 0.018	4.149AlaAsp: 4.149 ± 0.03	4.801AlaGlu: 4.801 ± 0.036	3.26AlaPhe: 3.26 ± 0.029	5.799AlaGly: 5.799 ± 0.033	1.84AlaHis: 1.84 ± 0.022	4.434AlaIle: 4.434 ± 0.034	3.5AlaLys: 3.5 ± 0.033	8.096AlaLeu: 8.096 ± 0.048	2.04AlaMet: 2.04 ± 0.024	2.778AlaAsn: 2.778 ± 0.025	4.405AlaPro: 4.405 ± 0.032	3.27AlaGln: 3.27 ± 0.032	4.951AlaArg: 4.951 ± 0.036	7.082AlaSer: 7.082 ± 0.04	5.233AlaThr: 5.233 ± 0.035	5.603AlaVal: 5.603 ± 0.047	1.254AlaTrp: 1.254 ± 0.02	2.308AlaTyr: 2.308 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.997CysAla: 0.997 ± 0.015	0.26CysCys: 0.26 ± 0.007	0.711CysAsp: 0.711 ± 0.012	0.634CysGlu: 0.634 ± 0.011	0.57CysPhe: 0.57 ± 0.011	0.973CysGly: 0.973 ± 0.018	0.375CysHis: 0.375 ± 0.009	0.759CysIle: 0.759 ± 0.014	0.456CysLys: 0.456 ± 0.01	1.448CysLeu: 1.448 ± 0.018	0.294CysMet: 0.294 ± 0.008	0.445CysAsn: 0.445 ± 0.01	0.679CysPro: 0.679 ± 0.013	0.483CysGln: 0.483 ± 0.011	0.864CysArg: 0.864 ± 0.015	1.006CysSer: 1.006 ± 0.016	0.743CysThr: 0.743 ± 0.013	0.867CysVal: 0.867 ± 0.015	0.225CysTrp: 0.225 ± 0.007	0.387CysTyr: 0.387 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.601AspAla: 4.601 ± 0.034	0.653AspCys: 0.653 ± 0.013	3.797AspAsp: 3.797 ± 0.04	4.067AspGlu: 4.067 ± 0.033	2.174AspPhe: 2.174 ± 0.021	3.983AspGly: 3.983 ± 0.037	1.31AspHis: 1.31 ± 0.016	3.132AspIle: 3.132 ± 0.025	2.071AspLys: 2.071 ± 0.023	5.293AspLeu: 5.293 ± 0.035	1.244AspMet: 1.244 ± 0.019	1.791AspAsn: 1.791 ± 0.022	3.469AspPro: 3.469 ± 0.028	1.934AspGln: 1.934 ± 0.019	3.147AspArg: 3.147 ± 0.029	3.931AspSer: 3.931 ± 0.03	2.975AspThr: 2.975 ± 0.026	3.66AspVal: 3.66 ± 0.029	0.929AspTrp: 0.929 ± 0.014	1.702AspTyr: 1.702 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.033GluAla: 5.033 ± 0.037	0.649GluCys: 0.649 ± 0.013	3.878GluAsp: 3.878 ± 0.034	5.033GluGlu: 5.033 ± 0.046	1.977GluPhe: 1.977 ± 0.02	3.792GluGly: 3.792 ± 0.031	1.383GluHis: 1.383 ± 0.018	3.018GluIle: 3.018 ± 0.027	3.252GluLys: 3.252 ± 0.03	5.091GluLeu: 5.091 ± 0.031	1.475GluMet: 1.475 ± 0.017	2.132GluAsn: 2.132 ± 0.019	2.637GluPro: 2.637 ± 0.024	2.378GluGln: 2.378 ± 0.025	3.797GluArg: 3.797 ± 0.032	4.16GluSer: 4.16 ± 0.031	3.463GluThr: 3.463 ± 0.025	3.592GluVal: 3.592 ± 0.03	0.921GluTrp: 0.921 ± 0.016	1.754GluTyr: 1.754 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.119PheAla: 3.119 ± 0.027	0.619PheCys: 0.619 ± 0.011	2.266PheAsp: 2.266 ± 0.022	2.07PheGlu: 2.07 ± 0.021	1.708PhePhe: 1.708 ± 0.023	2.861PheGly: 2.861 ± 0.03	1.012PheHis: 1.012 ± 0.014	1.925PheIle: 1.925 ± 0.021	1.338PheLys: 1.338 ± 0.017	3.801PheLeu: 3.801 ± 0.036	0.8PheMet: 0.8 ± 0.013	1.398PheAsn: 1.398 ± 0.016	2.089PhePro: 2.089 ± 0.021	1.479PheGln: 1.479 ± 0.016	2.07PheArg: 2.07 ± 0.02	3.046PheSer: 3.046 ± 0.025	2.281PheThr: 2.281 ± 0.024	2.473PheVal: 2.473 ± 0.024	0.692PheTrp: 0.692 ± 0.013	1.206PheTyr: 1.206 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.206GlyAla: 5.206 ± 0.038	0.962GlyCys: 0.962 ± 0.015	3.607GlyAsp: 3.607 ± 0.031	3.686GlyGlu: 3.686 ± 0.032	2.885GlyPhe: 2.885 ± 0.028	5.424GlyGly: 5.424 ± 0.042	1.717GlyHis: 1.717 ± 0.021	3.701GlyIle: 3.701 ± 0.027	3.14GlyLys: 3.14 ± 0.025	6.533GlyLeu: 6.533 ± 0.037	1.624GlyMet: 1.624 ± 0.02	2.406GlyAsn: 2.406 ± 0.025	3.395GlyPro: 3.395 ± 0.032	2.575GlyGln: 2.575 ± 0.023	4.105GlyArg: 4.105 ± 0.033	5.635GlySer: 5.635 ± 0.036	4.03GlyThr: 4.03 ± 0.03	4.707GlyVal: 4.707 ± 0.034	1.259GlyTrp: 1.259 ± 0.015	2.28GlyTyr: 2.28 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.946HisAla: 1.946 ± 0.02	0.361HisCys: 0.361 ± 0.009	1.363HisAsp: 1.363 ± 0.016	1.328HisGlu: 1.328 ± 0.016	0.944HisPhe: 0.944 ± 0.015	1.783HisGly: 1.783 ± 0.02	0.93HisHis: 0.93 ± 0.017	1.299HisIle: 1.299 ± 0.017	0.814HisLys: 0.814 ± 0.013	2.486HisLeu: 2.486 ± 0.022	0.514HisMet: 0.514 ± 0.012	0.843HisAsn: 0.843 ± 0.012	1.866HisPro: 1.866 ± 0.022	1.008HisGln: 1.008 ± 0.016	1.651HisArg: 1.651 ± 0.018	1.852HisSer: 1.852 ± 0.023	1.367HisThr: 1.367 ± 0.018	1.488HisVal: 1.488 ± 0.014	0.388HisTrp: 0.388 ± 0.009	0.751HisTyr: 0.751 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.331IleAla: 4.331 ± 0.028	0.838IleCys: 0.838 ± 0.015	2.832IleAsp: 2.832 ± 0.024	2.753IleGlu: 2.753 ± 0.025	2.125IlePhe: 2.125 ± 0.021	3.363IleGly: 3.363 ± 0.034	1.349IleHis: 1.349 ± 0.014	2.664IleIle: 2.664 ± 0.028	1.937IleLys: 1.937 ± 0.021	4.992IleLeu: 4.992 ± 0.039	1.058IleMet: 1.058 ± 0.017	1.79IleAsn: 1.79 ± 0.02	3.285IlePro: 3.285 ± 0.027	2.02IleGln: 2.02 ± 0.02	2.907IleArg: 2.907 ± 0.025	3.91IleSer: 3.91 ± 0.033	2.971IleThr: 2.971 ± 0.027	3.288IleVal: 3.288 ± 0.028	0.78IleTrp: 0.78 ± 0.013	1.562IleTyr: 1.562 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.709LysAla: 3.709 ± 0.03	0.483LysCys: 0.483 ± 0.01	2.419LysAsp: 2.419 ± 0.024	2.918LysGlu: 2.918 ± 0.033	1.282LysPhe: 1.282 ± 0.018	2.703LysGly: 2.703 ± 0.023	1.015LysHis: 1.015 ± 0.014	2.07LysIle: 2.07 ± 0.018	2.536LysLys: 2.536 ± 0.035	3.722LysLeu: 3.722 ± 0.034	0.911LysMet: 0.911 ± 0.015	1.499LysAsn: 1.499 ± 0.018	2.395LysPro: 2.395 ± 0.026	1.651LysGln: 1.651 ± 0.021	3.037LysArg: 3.037 ± 0.029	3.049LysSer: 3.049 ± 0.031	2.435LysThr: 2.435 ± 0.023	2.644LysVal: 2.644 ± 0.026	0.619LysTrp: 0.619 ± 0.011	1.297LysTyr: 1.297 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	8.198LeuAla: 8.198 ± 0.051	1.319LeuCys: 1.319 ± 0.017	5.371LeuAsp: 5.371 ± 0.035	5.574LeuGlu: 5.574 ± 0.042	3.581LeuPhe: 3.581 ± 0.03	6.452LeuGly: 6.452 ± 0.039	2.451LeuHis: 2.451 ± 0.023	4.289LeuIle: 4.289 ± 0.034	3.847LeuLys: 3.847 ± 0.028	9.125LeuLeu: 9.125 ± 0.052	1.88LeuMet: 1.88 ± 0.02	3.191LeuAsn: 3.191 ± 0.026	5.697LeuPro: 5.697 ± 0.035	4.049LeuGln: 4.049 ± 0.034	6.043LeuArg: 6.043 ± 0.038	7.773LeuSer: 7.773 ± 0.046	5.227LeuThr: 5.227 ± 0.036	5.897LeuVal: 5.897 ± 0.043	1.311LeuTrp: 1.311 ± 0.016	2.64LeuTyr: 2.64 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.228MetAla: 2.228 ± 0.023	0.248MetCys: 0.248 ± 0.008	1.236MetAsp: 1.236 ± 0.019	1.31MetGlu: 1.31 ± 0.015	0.792MetPhe: 0.792 ± 0.014	1.542MetGly: 1.542 ± 0.021	0.515MetHis: 0.515 ± 0.01	1.069MetIle: 1.069 ± 0.013	0.944MetLys: 0.944 ± 0.015	1.923MetLeu: 1.923 ± 0.024	0.582MetMet: 0.582 ± 0.011	0.792MetAsn: 0.792 ± 0.013	1.212MetPro: 1.212 ± 0.015	0.865MetGln: 0.865 ± 0.013	1.25MetArg: 1.25 ± 0.016	1.908MetSer: 1.908 ± 0.019	1.337MetThr: 1.337 ± 0.017	1.446MetVal: 1.446 ± 0.019	0.274MetTrp: 0.274 ± 0.008	0.561MetTyr: 0.561 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.955AsnAla: 2.955 ± 0.025	0.445AsnCys: 0.445 ± 0.01	1.836AsnAsp: 1.836 ± 0.02	1.874AsnGlu: 1.874 ± 0.02	1.309AsnPhe: 1.309 ± 0.017	2.724AsnGly: 2.724 ± 0.022	0.865AsnHis: 0.865 ± 0.014	2.006AsnIle: 2.006 ± 0.02	1.338AsnLys: 1.338 ± 0.016	3.242AsnLeu: 3.242 ± 0.027	0.791AsnMet: 0.791 ± 0.012	1.334AsnAsn: 1.334 ± 0.018	2.501AsnPro: 2.501 ± 0.024	1.301AsnGln: 1.301 ± 0.017	1.912AsnArg: 1.912 ± 0.017	2.525AsnSer: 2.525 ± 0.024	2.116AsnThr: 2.116 ± 0.023	2.305AsnVal: 2.305 ± 0.018	0.564AsnTrp: 0.564 ± 0.01	1.099AsnTyr: 1.099 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.947ProAla: 4.947 ± 0.033	0.591ProCys: 0.591 ± 0.012	3.34ProAsp: 3.34 ± 0.028	3.796ProGlu: 3.796 ± 0.029	2.18ProPhe: 2.18 ± 0.023	3.951ProGly: 3.951 ± 0.029	1.406ProHis: 1.406 ± 0.018	2.627ProIle: 2.627 ± 0.024	2.297ProLys: 2.297 ± 0.022	4.922ProLeu: 4.922 ± 0.033	1.07ProMet: 1.07 ± 0.014	2.104ProAsn: 2.104 ± 0.019	4.483ProPro: 4.483 ± 0.053	2.31ProGln: 2.31 ± 0.029	3.427ProArg: 3.427 ± 0.031	5.924ProSer: 5.924 ± 0.046	4.011ProThr: 4.011 ± 0.034	3.723ProVal: 3.723 ± 0.03	0.823ProTrp: 0.823 ± 0.012	1.587ProTyr: 1.587 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.376GlnAla: 3.376 ± 0.029	0.497GlnCys: 0.497 ± 0.012	2.06GlnAsp: 2.06 ± 0.02	2.359GlnGlu: 2.359 ± 0.023	1.337GlnPhe: 1.337 ± 0.016	2.454GlnGly: 2.454 ± 0.023	1.054GlnHis: 1.054 ± 0.014	1.946GlnIle: 1.946 ± 0.019	1.803GlnLys: 1.803 ± 0.022	3.599GlnLeu: 3.599 ± 0.029	0.886GlnMet: 0.886 ± 0.014	1.434GlnAsn: 1.434 ± 0.017	2.457GlnPro: 2.457 ± 0.03	2.12GlnGln: 2.12 ± 0.034	2.631GlnArg: 2.631 ± 0.025	3.132GlnSer: 3.132 ± 0.032	2.383GlnThr: 2.383 ± 0.017	2.27GlnVal: 2.27 ± 0.023	0.624GlnTrp: 0.624 ± 0.01	1.213GlnTyr: 1.213 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.67ArgAla: 4.67 ± 0.035	0.787ArgCys: 0.787 ± 0.015	3.32ArgAsp: 3.32 ± 0.027	3.74ArgGlu: 3.74 ± 0.032	2.287ArgPhe: 2.287 ± 0.019	3.722ArgGly: 3.722 ± 0.03	1.602ArgHis: 1.602 ± 0.017	2.983ArgIle: 2.983 ± 0.022	3.157ArgLys: 3.157 ± 0.029	5.845ArgLeu: 5.845 ± 0.035	1.358ArgMet: 1.358 ± 0.018	2.174ArgAsn: 2.174 ± 0.019	3.47ArgPro: 3.47 ± 0.032	2.626ArgGln: 2.626 ± 0.026	4.96ArgArg: 4.96 ± 0.045	4.7ArgSer: 4.7 ± 0.038	3.343ArgThr: 3.343 ± 0.03	3.689ArgVal: 3.689 ± 0.028	1.017ArgTrp: 1.017 ± 0.014	1.798ArgTyr: 1.798 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.494SerAla: 6.494 ± 0.043	0.927SerCys: 0.927 ± 0.014	4.194SerAsp: 4.194 ± 0.03	4.006SerGlu: 4.006 ± 0.031	3.059SerPhe: 3.059 ± 0.026	5.472SerGly: 5.472 ± 0.036	2.054SerHis: 2.054 ± 0.023	4.052SerIle: 4.052 ± 0.031	3.217SerLys: 3.217 ± 0.029	7.654SerLeu: 7.654 ± 0.041	1.739SerMet: 1.739 ± 0.018	2.82SerAsn: 2.82 ± 0.028	5.368SerPro: 5.368 ± 0.047	3.24SerGln: 3.24 ± 0.031	4.932SerArg: 4.932 ± 0.038	8.352SerSer: 8.352 ± 0.069	5.505SerThr: 5.505 ± 0.041	4.783SerVal: 4.783 ± 0.034	1.202SerTrp: 1.202 ± 0.018	2.185SerTyr: 2.185 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.26ThrAla: 5.26 ± 0.033	0.812ThrCys: 0.812 ± 0.014	2.992ThrAsp: 2.992 ± 0.025	3.083ThrGlu: 3.083 ± 0.026	2.303ThrPhe: 2.303 ± 0.023	4.376ThrGly: 4.376 ± 0.028	1.386ThrHis: 1.386 ± 0.017	3.241ThrIle: 3.241 ± 0.024	2.271ThrLys: 2.271 ± 0.025	5.622ThrLeu: 5.622 ± 0.038	1.235ThrMet: 1.235 ± 0.016	2.048ThrAsn: 2.048 ± 0.021	4.143ThrPro: 4.143 ± 0.037	2.093ThrGln: 2.093 ± 0.02	3.14ThrArg: 3.14 ± 0.025	5.145ThrSer: 5.145 ± 0.036	4.436ThrThr: 4.436 ± 0.039	3.979ThrVal: 3.979 ± 0.035	0.909ThrTrp: 0.909 ± 0.014	1.806ThrTyr: 1.806 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.357ValAla: 5.357 ± 0.037	0.913ValCys: 0.913 ± 0.015	3.837ValAsp: 3.837 ± 0.029	3.891ValGlu: 3.891 ± 0.028	2.646ValPhe: 2.646 ± 0.025	4.282ValGly: 4.282 ± 0.032	1.49ValHis: 1.49 ± 0.018	3.165ValIle: 3.165 ± 0.026	2.66ValLys: 2.66 ± 0.026	6.085ValLeu: 6.085 ± 0.037	1.443ValMet: 1.443 ± 0.017	2.227ValAsn: 2.227 ± 0.024	3.669ValPro: 3.669 ± 0.028	2.48ValGln: 2.48 ± 0.024	3.654ValArg: 3.654 ± 0.03	4.867ValSer: 4.867 ± 0.031	3.669ValThr: 3.669 ± 0.03	4.576ValVal: 4.576 ± 0.04	0.932ValTrp: 0.932 ± 0.014	1.942ValTyr: 1.942 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.205TrpAla: 1.205 ± 0.016	0.205TrpCys: 0.205 ± 0.006	0.946TrpAsp: 0.946 ± 0.013	0.889TrpGlu: 0.889 ± 0.014	0.586TrpPhe: 0.586 ± 0.011	1.006TrpGly: 1.006 ± 0.016	0.379TrpHis: 0.379 ± 0.01	0.821TrpIle: 0.821 ± 0.013	0.8TrpLys: 0.8 ± 0.014	1.458TrpLeu: 1.458 ± 0.016	0.407TrpMet: 0.407 ± 0.008	0.67TrpAsn: 0.67 ± 0.011	0.648TrpPro: 0.648 ± 0.012	0.595TrpGln: 0.595 ± 0.01	1.011TrpArg: 1.011 ± 0.017	1.119TrpSer: 1.119 ± 0.015	1.008TrpThr: 1.008 ± 0.014	0.998TrpVal: 0.998 ± 0.014	0.307TrpTrp: 0.307 ± 0.009	0.461TrpTyr: 0.461 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.333TyrAla: 2.333 ± 0.024	0.442TyrCys: 0.442 ± 0.011	1.713TyrAsp: 1.713 ± 0.018	1.598TyrGlu: 1.598 ± 0.019	1.25TyrPhe: 1.25 ± 0.018	2.217TyrGly: 2.217 ± 0.027	0.848TyrHis: 0.848 ± 0.014	1.552TyrIle: 1.552 ± 0.017	1.018TyrLys: 1.018 ± 0.016	2.975TyrLeu: 2.975 ± 0.025	0.683TyrMet: 0.683 ± 0.012	1.166TyrAsn: 1.166 ± 0.016	1.65TyrPro: 1.65 ± 0.017	1.158TyrGln: 1.158 ± 0.017	1.759TyrArg: 1.759 ± 0.021	2.137TyrSer: 2.137 ± 0.02	1.747TyrThr: 1.747 ± 0.02	1.797TyrVal: 1.797 ± 0.02	0.492TyrTrp: 0.492 ± 0.009	1.03TyrTyr: 1.03 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11037 proteins (5099753 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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