Amino acid dipepetide frequency for Salisediminibacterium haloalkalitolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.09AlaAla: 9.09 ± 0.139	0.668AlaCys: 0.668 ± 0.029	5.681AlaAsp: 5.681 ± 0.092	7.892AlaGlu: 7.892 ± 0.111	3.671AlaPhe: 3.671 ± 0.081	7.06AlaGly: 7.06 ± 0.097	1.49AlaHis: 1.49 ± 0.043	4.888AlaIle: 4.888 ± 0.082	4.262AlaLys: 4.262 ± 0.082	7.836AlaLeu: 7.836 ± 0.121	2.423AlaMet: 2.423 ± 0.061	2.881AlaAsn: 2.881 ± 0.065	2.525AlaPro: 2.525 ± 0.052	2.41AlaGln: 2.41 ± 0.06	3.247AlaArg: 3.247 ± 0.061	4.753AlaSer: 4.753 ± 0.081	3.153AlaThr: 3.153 ± 0.068	7.562AlaVal: 7.562 ± 0.108	0.764AlaTrp: 0.764 ± 0.034	2.562AlaTyr: 2.562 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.47CysAla: 0.47 ± 0.023	0.09CysCys: 0.09 ± 0.012	0.349CysAsp: 0.349 ± 0.023	0.437CysGlu: 0.437 ± 0.024	0.222CysPhe: 0.222 ± 0.017	0.657CysGly: 0.657 ± 0.03	0.156CysHis: 0.156 ± 0.014	0.322CysIle: 0.322 ± 0.02	0.227CysLys: 0.227 ± 0.017	0.547CysLeu: 0.547 ± 0.029	0.147CysMet: 0.147 ± 0.013	0.209CysAsn: 0.209 ± 0.015	0.401CysPro: 0.401 ± 0.023	0.201CysGln: 0.201 ± 0.013	0.398CysArg: 0.398 ± 0.022	0.435CysSer: 0.435 ± 0.022	0.349CysThr: 0.349 ± 0.02	0.353CysVal: 0.353 ± 0.019	0.051CysTrp: 0.051 ± 0.008	0.21CysTyr: 0.21 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.592AspAla: 4.592 ± 0.082	0.341AspCys: 0.341 ± 0.021	3.866AspAsp: 3.866 ± 0.086	6.244AspGlu: 6.244 ± 0.111	2.418AspPhe: 2.418 ± 0.058	4.466AspGly: 4.466 ± 0.094	1.494AspHis: 1.494 ± 0.039	3.906AspIle: 3.906 ± 0.076	2.546AspLys: 2.546 ± 0.056	5.316AspLeu: 5.316 ± 0.093	1.675AspMet: 1.675 ± 0.045	1.967AspAsn: 1.967 ± 0.057	2.621AspPro: 2.621 ± 0.058	2.334AspGln: 2.334 ± 0.054	3.003AspArg: 3.003 ± 0.071	2.754AspSer: 2.754 ± 0.06	2.877AspThr: 2.877 ± 0.066	4.678AspVal: 4.678 ± 0.083	0.736AspTrp: 0.736 ± 0.031	2.353AspTyr: 2.353 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	7.28GluAla: 7.28 ± 0.11	0.315GluCys: 0.315 ± 0.02	5.162GluAsp: 5.162 ± 0.123	8.556GluGlu: 8.556 ± 0.159	2.33GluPhe: 2.33 ± 0.056	4.678GluGly: 4.678 ± 0.079	1.862GluHis: 1.862 ± 0.043	5.161GluIle: 5.161 ± 0.089	5.735GluLys: 5.735 ± 0.102	7.546GluLeu: 7.546 ± 0.106	2.702GluMet: 2.702 ± 0.052	3.899GluAsn: 3.899 ± 0.091	2.631GluPro: 2.631 ± 0.066	3.927GluGln: 3.927 ± 0.085	4.609GluArg: 4.609 ± 0.085	3.893GluSer: 3.893 ± 0.069	5.336GluThr: 5.336 ± 0.08	4.946GluVal: 4.946 ± 0.092	0.917GluTrp: 0.917 ± 0.037	2.05GluTyr: 2.05 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.656PheAla: 3.656 ± 0.073	0.269PheCys: 0.269 ± 0.018	2.654PheAsp: 2.654 ± 0.052	2.783PheGlu: 2.783 ± 0.058	2.291PhePhe: 2.291 ± 0.058	3.357PheGly: 3.357 ± 0.073	1.041PheHis: 1.041 ± 0.037	3.275PheIle: 3.275 ± 0.078	1.568PheLys: 1.568 ± 0.044	3.975PheLeu: 3.975 ± 0.089	1.2PheMet: 1.2 ± 0.04	1.511PheAsn: 1.511 ± 0.046	1.702PhePro: 1.702 ± 0.05	1.651PheGln: 1.651 ± 0.05	1.785PheArg: 1.785 ± 0.048	2.992PheSer: 2.992 ± 0.062	2.617PheThr: 2.617 ± 0.052	2.841PheVal: 2.841 ± 0.068	0.478PheTrp: 0.478 ± 0.024	1.577PheTyr: 1.577 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	5.966GlyAla: 5.966 ± 0.087	0.554GlyCys: 0.554 ± 0.028	3.856GlyAsp: 3.856 ± 0.087	5.616GlyGlu: 5.616 ± 0.087	3.425GlyPhe: 3.425 ± 0.065	5.415GlyGly: 5.415 ± 0.101	1.464GlyHis: 1.464 ± 0.041	5.337GlyIle: 5.337 ± 0.09	4.111GlyLys: 4.111 ± 0.079	6.584GlyLeu: 6.584 ± 0.097	2.36GlyMet: 2.36 ± 0.057	2.416GlyAsn: 2.416 ± 0.062	2.025GlyPro: 2.025 ± 0.054	2.185GlyGln: 2.185 ± 0.053	3.248GlyArg: 3.248 ± 0.069	4.116GlySer: 4.116 ± 0.062	4.187GlyThr: 4.187 ± 0.066	5.379GlyVal: 5.379 ± 0.077	0.793GlyTrp: 0.793 ± 0.032	2.686GlyTyr: 2.686 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.668HisAla: 1.668 ± 0.045	0.201HisCys: 0.201 ± 0.017	1.251HisAsp: 1.251 ± 0.044	1.715HisGlu: 1.715 ± 0.042	1.009HisPhe: 1.009 ± 0.036	1.604HisGly: 1.604 ± 0.047	0.687HisHis: 0.687 ± 0.032	1.416HisIle: 1.416 ± 0.041	0.829HisLys: 0.829 ± 0.037	2.22HisLeu: 2.22 ± 0.051	0.569HisMet: 0.569 ± 0.028	0.73HisAsn: 0.73 ± 0.027	1.239HisPro: 1.239 ± 0.043	0.841HisGln: 0.841 ± 0.031	1.126HisArg: 1.126 ± 0.031	1.12HisSer: 1.12 ± 0.04	1.09HisThr: 1.09 ± 0.038	1.662HisVal: 1.662 ± 0.05	0.255HisTrp: 0.255 ± 0.016	0.821HisTyr: 0.821 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.953IleAla: 5.953 ± 0.085	0.468IleCys: 0.468 ± 0.023	4.682IleAsp: 4.682 ± 0.076	5.411IleGlu: 5.411 ± 0.081	2.739IlePhe: 2.739 ± 0.073	5.368IleGly: 5.368 ± 0.096	1.522IleHis: 1.522 ± 0.046	4.164IleIle: 4.164 ± 0.087	2.61IleLys: 2.61 ± 0.056	5.397IleLeu: 5.397 ± 0.094	1.581IleMet: 1.581 ± 0.05	2.512IleAsn: 2.512 ± 0.055	2.954IlePro: 2.954 ± 0.065	2.276IleGln: 2.276 ± 0.047	3.149IleArg: 3.149 ± 0.065	4.159IleSer: 4.159 ± 0.067	3.747IleThr: 3.747 ± 0.073	4.705IleVal: 4.705 ± 0.083	0.519IleTrp: 0.519 ± 0.029	2.072IleTyr: 2.072 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.136LysAla: 4.136 ± 0.087	0.245LysCys: 0.245 ± 0.019	2.906LysAsp: 2.906 ± 0.053	4.935LysGlu: 4.935 ± 0.089	1.328LysPhe: 1.328 ± 0.039	3.203LysGly: 3.203 ± 0.071	1.212LysHis: 1.212 ± 0.039	2.977LysIle: 2.977 ± 0.071	4.036LysLys: 4.036 ± 0.092	4.264LysLeu: 4.264 ± 0.084	1.751LysMet: 1.751 ± 0.047	2.329LysAsn: 2.329 ± 0.058	1.947LysPro: 1.947 ± 0.046	2.666LysGln: 2.666 ± 0.062	3.104LysArg: 3.104 ± 0.066	2.682LysSer: 2.682 ± 0.055	3.374LysThr: 3.374 ± 0.062	3.084LysVal: 3.084 ± 0.069	0.532LysTrp: 0.532 ± 0.026	1.403LysTyr: 1.403 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	8.145LeuAla: 8.145 ± 0.104	0.458LeuCys: 0.458 ± 0.027	5.239LeuAsp: 5.239 ± 0.091	6.553LeuGlu: 6.553 ± 0.089	4.446LeuPhe: 4.446 ± 0.096	6.013LeuGly: 6.013 ± 0.085	2.028LeuHis: 2.028 ± 0.05	6.417LeuIle: 6.417 ± 0.105	4.925LeuLys: 4.925 ± 0.083	8.976LeuLeu: 8.976 ± 0.131	2.534LeuMet: 2.534 ± 0.051	3.979LeuAsn: 3.979 ± 0.071	3.943LeuPro: 3.943 ± 0.08	3.591LeuGln: 3.591 ± 0.076	3.933LeuArg: 3.933 ± 0.065	6.034LeuSer: 6.034 ± 0.088	6.251LeuThr: 6.251 ± 0.09	5.427LeuVal: 5.427 ± 0.09	0.726LeuTrp: 0.726 ± 0.027	2.946LeuTyr: 2.946 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.382MetAla: 2.382 ± 0.053	0.132MetCys: 0.132 ± 0.013	1.527MetAsp: 1.527 ± 0.046	1.826MetGlu: 1.826 ± 0.047	1.183MetPhe: 1.183 ± 0.041	1.602MetGly: 1.602 ± 0.051	0.565MetHis: 0.565 ± 0.023	2.381MetIle: 2.381 ± 0.063	2.194MetLys: 2.194 ± 0.05	2.663MetLeu: 2.663 ± 0.058	0.966MetMet: 0.966 ± 0.036	1.762MetAsn: 1.762 ± 0.047	1.136MetPro: 1.136 ± 0.04	1.178MetGln: 1.178 ± 0.043	1.221MetArg: 1.221 ± 0.043	1.806MetSer: 1.806 ± 0.046	2.224MetThr: 2.224 ± 0.057	1.535MetVal: 1.535 ± 0.04	0.188MetTrp: 0.188 ± 0.015	0.828MetTyr: 0.828 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	2.913AsnAla: 2.913 ± 0.061	0.211AsnCys: 0.211 ± 0.014	2.605AsnAsp: 2.605 ± 0.067	3.942AsnGlu: 3.942 ± 0.091	1.248AsnPhe: 1.248 ± 0.036	3.086AsnGly: 3.086 ± 0.059	0.868AsnHis: 0.868 ± 0.038	2.606AsnIle: 2.606 ± 0.058	1.857AsnLys: 1.857 ± 0.052	3.045AsnLeu: 3.045 ± 0.061	1.13AsnMet: 1.13 ± 0.035	1.86AsnAsn: 1.86 ± 0.09	1.822AsnPro: 1.822 ± 0.05	1.624AsnGln: 1.624 ± 0.042	2.074AsnArg: 2.074 ± 0.055	1.792AsnSer: 1.792 ± 0.057	1.905AsnThr: 1.905 ± 0.053	2.935AsnVal: 2.935 ± 0.059	0.423AsnTrp: 0.423 ± 0.024	1.196AsnTyr: 1.196 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.327ProAla: 3.327 ± 0.072	0.224ProCys: 0.224 ± 0.017	2.716ProAsp: 2.716 ± 0.068	3.74ProGlu: 3.74 ± 0.072	1.959ProPhe: 1.959 ± 0.051	2.806ProGly: 2.806 ± 0.058	0.863ProHis: 0.863 ± 0.03	2.147ProIle: 2.147 ± 0.048	1.724ProLys: 1.724 ± 0.049	3.754ProLeu: 3.754 ± 0.065	0.883ProMet: 0.883 ± 0.034	1.301ProAsn: 1.301 ± 0.04	1.207ProPro: 1.207 ± 0.043	1.237ProGln: 1.237 ± 0.041	1.315ProArg: 1.315 ± 0.037	2.185ProSer: 2.185 ± 0.055	1.583ProThr: 1.583 ± 0.042	3.383ProVal: 3.383 ± 0.053	0.394ProTrp: 0.394 ± 0.024	1.408ProTyr: 1.408 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.434GlnAla: 3.434 ± 0.067	0.178GlnCys: 0.178 ± 0.016	1.748GlnAsp: 1.748 ± 0.044	2.993GlnGlu: 2.993 ± 0.063	1.508GlnPhe: 1.508 ± 0.044	2.273GlnGly: 2.273 ± 0.05	0.811GlnHis: 0.811 ± 0.033	2.27GlnIle: 2.27 ± 0.058	2.065GlnLys: 2.065 ± 0.053	4.038GlnLeu: 4.038 ± 0.073	1.235GlnMet: 1.235 ± 0.038	1.401GlnAsn: 1.401 ± 0.044	1.302GlnPro: 1.302 ± 0.035	1.793GlnGln: 1.793 ± 0.065	1.778GlnArg: 1.778 ± 0.054	2.19GlnSer: 2.19 ± 0.05	2.467GlnThr: 2.467 ± 0.058	2.201GlnVal: 2.201 ± 0.052	0.444GlnTrp: 0.444 ± 0.025	1.081GlnTyr: 1.081 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.185ArgAla: 3.185 ± 0.064	0.26ArgCys: 0.26 ± 0.017	2.546ArgAsp: 2.546 ± 0.057	3.898ArgGlu: 3.898 ± 0.076	2.253ArgPhe: 2.253 ± 0.057	2.949ArgGly: 2.949 ± 0.057	1.03ArgHis: 1.03 ± 0.037	3.153ArgIle: 3.153 ± 0.06	2.776ArgLys: 2.776 ± 0.057	4.603ArgLeu: 4.603 ± 0.075	1.525ArgMet: 1.525 ± 0.043	1.727ArgAsn: 1.727 ± 0.046	1.695ArgPro: 1.695 ± 0.043	1.816ArgGln: 1.816 ± 0.053	2.571ArgArg: 2.571 ± 0.061	2.845ArgSer: 2.845 ± 0.063	2.625ArgThr: 2.625 ± 0.058	2.892ArgVal: 2.892 ± 0.063	0.49ArgTrp: 0.49 ± 0.024	1.739ArgTyr: 1.739 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.958SerAla: 4.958 ± 0.084	0.388SerCys: 0.388 ± 0.022	3.112SerAsp: 3.112 ± 0.063	4.462SerGlu: 4.462 ± 0.083	3.136SerPhe: 3.136 ± 0.062	5.146SerGly: 5.146 ± 0.081	1.163SerHis: 1.163 ± 0.042	3.518SerIle: 3.518 ± 0.07	2.485SerLys: 2.485 ± 0.053	5.614SerLeu: 5.614 ± 0.09	1.771SerMet: 1.771 ± 0.051	1.898SerAsn: 1.898 ± 0.052	2.147SerPro: 2.147 ± 0.047	1.835SerGln: 1.835 ± 0.046	2.585SerArg: 2.585 ± 0.055	3.901SerSer: 3.901 ± 0.098	2.562SerThr: 2.562 ± 0.051	4.412SerVal: 4.412 ± 0.076	0.658SerTrp: 0.658 ± 0.031	2.025SerTyr: 2.025 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.706ThrAla: 5.706 ± 0.097	0.341ThrCys: 0.341 ± 0.02	3.542ThrAsp: 3.542 ± 0.069	4.333ThrGlu: 4.333 ± 0.075	2.502ThrPhe: 2.502 ± 0.06	4.861ThrGly: 4.861 ± 0.069	1.101ThrHis: 1.101 ± 0.035	3.739ThrIle: 3.739 ± 0.068	2.537ThrLys: 2.537 ± 0.056	5.032ThrLeu: 5.032 ± 0.081	1.532ThrMet: 1.532 ± 0.049	2.116ThrAsn: 2.116 ± 0.046	2.203ThrPro: 2.203 ± 0.057	1.274ThrGln: 1.274 ± 0.039	1.93ThrArg: 1.93 ± 0.055	2.956ThrSer: 2.956 ± 0.062	2.534ThrThr: 2.534 ± 0.062	5.069ThrVal: 5.069 ± 0.088	0.538ThrTrp: 0.538 ± 0.024	1.91ThrTyr: 1.91 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.945ValAla: 4.945 ± 0.078	0.568ValCys: 0.568 ± 0.026	4.034ValAsp: 4.034 ± 0.088	4.768ValGlu: 4.768 ± 0.092	3.348ValPhe: 3.348 ± 0.068	4.159ValGly: 4.159 ± 0.083	1.604ValHis: 1.604 ± 0.044	5.503ValIle: 5.503 ± 0.09	3.742ValLys: 3.742 ± 0.077	6.877ValLeu: 6.877 ± 0.096	2.19ValMet: 2.19 ± 0.055	3.016ValAsn: 3.016 ± 0.071	2.927ValPro: 2.927 ± 0.059	2.444ValGln: 2.444 ± 0.056	3.248ValArg: 3.248 ± 0.074	4.685ValSer: 4.685 ± 0.069	4.57ValThr: 4.57 ± 0.082	4.743ValVal: 4.743 ± 0.094	0.636ValTrp: 0.636 ± 0.029	2.567ValTyr: 2.567 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.643TrpAla: 0.643 ± 0.03	0.054TrpCys: 0.054 ± 0.008	0.507TrpAsp: 0.507 ± 0.029	0.705TrpGlu: 0.705 ± 0.034	0.539TrpPhe: 0.539 ± 0.024	0.638TrpGly: 0.638 ± 0.026	0.253TrpHis: 0.253 ± 0.017	0.782TrpIle: 0.782 ± 0.037	0.486TrpLys: 0.486 ± 0.025	1.231TrpLeu: 1.231 ± 0.034	0.35TrpMet: 0.35 ± 0.018	0.432TrpAsn: 0.432 ± 0.022	0.338TrpPro: 0.338 ± 0.024	0.482TrpGln: 0.482 ± 0.026	0.462TrpArg: 0.462 ± 0.027	0.56TrpSer: 0.56 ± 0.022	0.517TrpThr: 0.517 ± 0.023	0.58TrpVal: 0.58 ± 0.025	0.113TrpTrp: 0.113 ± 0.013	0.331TrpTyr: 0.331 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.369TyrAla: 2.369 ± 0.05	0.266TyrCys: 0.266 ± 0.016	2.205TyrAsp: 2.205 ± 0.065	2.725TyrGlu: 2.725 ± 0.062	1.668TyrPhe: 1.668 ± 0.047	2.385TyrGly: 2.385 ± 0.052	0.84TyrHis: 0.84 ± 0.036	2.023TyrIle: 2.023 ± 0.047	1.396TyrLys: 1.396 ± 0.049	3.046TyrLeu: 3.046 ± 0.066	0.773TyrMet: 0.773 ± 0.029	1.199TyrAsn: 1.199 ± 0.042	1.391TyrPro: 1.391 ± 0.043	1.448TyrGln: 1.448 ± 0.045	1.794TyrArg: 1.794 ± 0.055	1.919TyrSer: 1.919 ± 0.052	1.788TyrThr: 1.788 ± 0.049	2.184TyrVal: 2.184 ± 0.048	0.345TyrTrp: 0.345 ± 0.021	1.307TyrTyr: 1.307 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2769 proteins (857196 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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