Amino acid dipepetide frequency for Marinitenerispora sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.746AlaAla: 25.746 ± 0.225	1.008AlaCys: 1.008 ± 0.028	9.268AlaAsp: 9.268 ± 0.096	10.409AlaGlu: 10.409 ± 0.092	3.586AlaPhe: 3.586 ± 0.059	14.439AlaGly: 14.439 ± 0.12	2.906AlaHis: 2.906 ± 0.047	3.744AlaIle: 3.744 ± 0.054	1.861AlaLys: 1.861 ± 0.041	14.799AlaLeu: 14.799 ± 0.112	2.549AlaMet: 2.549 ± 0.046	1.88AlaAsn: 1.88 ± 0.038	7.764AlaPro: 7.764 ± 0.081	3.218AlaGln: 3.218 ± 0.046	11.842AlaArg: 11.842 ± 0.101	5.458AlaSer: 5.458 ± 0.064	6.443AlaThr: 6.443 ± 0.066	13.201AlaVal: 13.201 ± 0.127	1.948AlaTrp: 1.948 ± 0.038	2.258AlaTyr: 2.258 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.075CysAla: 1.075 ± 0.029	0.106CysCys: 0.106 ± 0.01	0.459CysAsp: 0.459 ± 0.018	0.364CysGlu: 0.364 ± 0.015	0.194CysPhe: 0.194 ± 0.01	0.927CysGly: 0.927 ± 0.028	0.177CysHis: 0.177 ± 0.011	0.101CysIle: 0.101 ± 0.008	0.052CysLys: 0.052 ± 0.006	0.665CysLeu: 0.665 ± 0.022	0.111CysMet: 0.111 ± 0.009	0.115CysAsn: 0.115 ± 0.008	0.498CysPro: 0.498 ± 0.02	0.157CysGln: 0.157 ± 0.01	0.661CysArg: 0.661 ± 0.023	0.375CysSer: 0.375 ± 0.016	0.402CysThr: 0.402 ± 0.016	0.727CysVal: 0.727 ± 0.021	0.104CysTrp: 0.104 ± 0.009	0.21CysTyr: 0.21 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.937AspAla: 7.937 ± 0.084	0.369AspCys: 0.369 ± 0.017	3.717AspAsp: 3.717 ± 0.058	3.707AspGlu: 3.707 ± 0.05	1.553AspPhe: 1.553 ± 0.032	6.227AspGly: 6.227 ± 0.075	1.375AspHis: 1.375 ± 0.03	1.911AspIle: 1.911 ± 0.037	0.662AspLys: 0.662 ± 0.02	6.577AspLeu: 6.577 ± 0.077	0.875AspMet: 0.875 ± 0.023	0.838AspAsn: 0.838 ± 0.027	5.127AspPro: 5.127 ± 0.064	1.479AspGln: 1.479 ± 0.029	5.405AspArg: 5.405 ± 0.073	2.457AspSer: 2.457 ± 0.043	2.941AspThr: 2.941 ± 0.048	5.204AspVal: 5.204 ± 0.058	0.892AspTrp: 0.892 ± 0.023	1.175AspTyr: 1.175 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.433GluAla: 7.433 ± 0.078	0.361GluCys: 0.361 ± 0.016	2.809GluAsp: 2.809 ± 0.042	4.06GluGlu: 4.06 ± 0.065	1.626GluPhe: 1.626 ± 0.031	4.259GluGly: 4.259 ± 0.058	1.684GluHis: 1.684 ± 0.031	2.367GluIle: 2.367 ± 0.043	0.937GluLys: 0.937 ± 0.028	7.042GluLeu: 7.042 ± 0.072	0.954GluMet: 0.954 ± 0.025	1.0GluAsn: 1.0 ± 0.026	3.814GluPro: 3.814 ± 0.056	2.114GluGln: 2.114 ± 0.044	6.752GluArg: 6.752 ± 0.078	2.624GluSer: 2.624 ± 0.041	2.825GluThr: 2.825 ± 0.048	5.077GluVal: 5.077 ± 0.06	0.883GluTrp: 0.883 ± 0.022	1.148GluTyr: 1.148 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.826PheAla: 3.826 ± 0.053	0.244PheCys: 0.244 ± 0.011	1.901PheAsp: 1.901 ± 0.038	1.425PheGlu: 1.425 ± 0.031	0.79PhePhe: 0.79 ± 0.026	3.078PheGly: 3.078 ± 0.043	0.586PheHis: 0.586 ± 0.019	0.646PheIle: 0.646 ± 0.021	0.284PheLys: 0.284 ± 0.014	2.509PheLeu: 2.509 ± 0.043	0.397PheMet: 0.397 ± 0.015	0.485PheAsn: 0.485 ± 0.019	1.366PhePro: 1.366 ± 0.029	0.633PheGln: 0.633 ± 0.018	1.881PheArg: 1.881 ± 0.035	1.304PheSer: 1.304 ± 0.029	1.867PheThr: 1.867 ± 0.033	2.317PheVal: 2.317 ± 0.039	0.424PheTrp: 0.424 ± 0.017	0.527PheTyr: 0.527 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	12.427GlyAla: 12.427 ± 0.116	0.842GlyCys: 0.842 ± 0.024	5.357GlyAsp: 5.357 ± 0.058	5.377GlyGlu: 5.377 ± 0.063	2.764GlyPhe: 2.764 ± 0.047	9.485GlyGly: 9.485 ± 0.114	2.231GlyHis: 2.231 ± 0.041	3.32GlyIle: 3.32 ± 0.047	1.415GlyLys: 1.415 ± 0.033	9.335GlyLeu: 9.335 ± 0.088	2.075GlyMet: 2.075 ± 0.041	1.479GlyAsn: 1.479 ± 0.035	5.584GlyPro: 5.584 ± 0.066	2.423GlyGln: 2.423 ± 0.039	8.95GlyArg: 8.95 ± 0.088	4.857GlySer: 4.857 ± 0.052	5.861GlyThr: 5.861 ± 0.061	8.012GlyVal: 8.012 ± 0.077	1.666GlyTrp: 1.666 ± 0.038	2.51GlyTyr: 2.51 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.866HisAla: 2.866 ± 0.04	0.18HisCys: 0.18 ± 0.011	1.337HisAsp: 1.337 ± 0.03	1.193HisGlu: 1.193 ± 0.03	0.554HisPhe: 0.554 ± 0.021	2.381HisGly: 2.381 ± 0.04	0.658HisHis: 0.658 ± 0.023	0.604HisIle: 0.604 ± 0.022	0.235HisLys: 0.235 ± 0.013	2.3HisLeu: 2.3 ± 0.039	0.301HisMet: 0.301 ± 0.012	0.33HisAsn: 0.33 ± 0.014	1.838HisPro: 1.838 ± 0.033	0.561HisGln: 0.561 ± 0.019	2.25HisArg: 2.25 ± 0.046	0.885HisSer: 0.885 ± 0.02	1.147HisThr: 1.147 ± 0.029	1.858HisVal: 1.858 ± 0.037	0.306HisTrp: 0.306 ± 0.013	0.445HisTyr: 0.445 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.804IleAla: 4.804 ± 0.058	0.268IleCys: 0.268 ± 0.013	2.267IleAsp: 2.267 ± 0.042	2.016IleGlu: 2.016 ± 0.039	0.63IlePhe: 0.63 ± 0.025	3.427IleGly: 3.427 ± 0.053	0.545IleHis: 0.545 ± 0.019	0.977IleIle: 0.977 ± 0.03	0.445IleLys: 0.445 ± 0.017	2.322IleLeu: 2.322 ± 0.037	0.487IleMet: 0.487 ± 0.018	0.614IleAsn: 0.614 ± 0.019	1.782IlePro: 1.782 ± 0.036	0.661IleGln: 0.661 ± 0.023	2.349IleArg: 2.349 ± 0.047	1.576IleSer: 1.576 ± 0.034	2.082IleThr: 2.082 ± 0.041	2.744IleVal: 2.744 ± 0.043	0.309IleTrp: 0.309 ± 0.014	0.505IleTyr: 0.505 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.624LysAla: 1.624 ± 0.032	0.078LysCys: 0.078 ± 0.007	0.71LysAsp: 0.71 ± 0.023	0.773LysGlu: 0.773 ± 0.027	0.304LysPhe: 0.304 ± 0.013	1.054LysGly: 1.054 ± 0.03	0.298LysHis: 0.298 ± 0.013	0.54LysIle: 0.54 ± 0.021	0.395LysLys: 0.395 ± 0.02	1.329LysLeu: 1.329 ± 0.029	0.237LysMet: 0.237 ± 0.013	0.303LysAsn: 0.303 ± 0.013	0.802LysPro: 0.802 ± 0.029	0.379LysGln: 0.379 ± 0.016	1.13LysArg: 1.13 ± 0.03	0.763LysSer: 0.763 ± 0.029	0.725LysThr: 0.725 ± 0.023	1.184LysVal: 1.184 ± 0.033	0.178LysTrp: 0.178 ± 0.011	0.293LysTyr: 0.293 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.396LeuAla: 16.396 ± 0.141	0.748LeuCys: 0.748 ± 0.019	6.756LeuAsp: 6.756 ± 0.071	4.735LeuGlu: 4.735 ± 0.064	2.588LeuPhe: 2.588 ± 0.049	9.373LeuGly: 9.373 ± 0.102	2.17LeuHis: 2.17 ± 0.039	2.904LeuIle: 2.904 ± 0.049	1.196LeuLys: 1.196 ± 0.033	11.745LeuLeu: 11.745 ± 0.138	1.485LeuMet: 1.485 ± 0.034	1.465LeuAsn: 1.465 ± 0.034	6.62LeuPro: 6.62 ± 0.067	1.796LeuGln: 1.796 ± 0.036	10.01LeuArg: 10.01 ± 0.102	4.988LeuSer: 4.988 ± 0.061	6.048LeuThr: 6.048 ± 0.061	9.543LeuVal: 9.543 ± 0.095	1.302LeuTrp: 1.302 ± 0.031	1.674LeuTyr: 1.674 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.375MetAla: 2.375 ± 0.038	0.134MetCys: 0.134 ± 0.01	0.798MetAsp: 0.798 ± 0.022	0.712MetGlu: 0.712 ± 0.026	0.475MetPhe: 0.475 ± 0.016	1.325MetGly: 1.325 ± 0.03	0.306MetHis: 0.306 ± 0.014	0.552MetIle: 0.552 ± 0.02	0.27MetLys: 0.27 ± 0.013	1.734MetLeu: 1.734 ± 0.039	0.249MetMet: 0.249 ± 0.013	0.361MetAsn: 0.361 ± 0.017	1.091MetPro: 1.091 ± 0.03	0.343MetGln: 0.343 ± 0.015	1.617MetArg: 1.617 ± 0.032	1.288MetSer: 1.288 ± 0.029	1.364MetThr: 1.364 ± 0.028	1.429MetVal: 1.429 ± 0.028	0.214MetTrp: 0.214 ± 0.011	0.291MetTyr: 0.291 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	1.996AsnAla: 1.996 ± 0.037	0.141AsnCys: 0.141 ± 0.011	0.833AsnAsp: 0.833 ± 0.024	0.794AsnGlu: 0.794 ± 0.025	0.424AsnPhe: 0.424 ± 0.017	1.628AsnGly: 1.628 ± 0.036	0.316AsnHis: 0.316 ± 0.014	0.603AsnIle: 0.603 ± 0.018	0.221AsnLys: 0.221 ± 0.011	1.544AsnLeu: 1.544 ± 0.029	0.288AsnMet: 0.288 ± 0.012	0.342AsnAsn: 0.342 ± 0.019	1.247AsnPro: 1.247 ± 0.033	0.481AsnGln: 0.481 ± 0.017	1.247AsnArg: 1.247 ± 0.03	0.751AsnSer: 0.751 ± 0.024	0.889AsnThr: 0.889 ± 0.024	1.349AsnVal: 1.349 ± 0.032	0.267AsnTrp: 0.267 ± 0.014	0.36AsnTyr: 0.36 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.503ProAla: 9.503 ± 0.096	0.324ProCys: 0.324 ± 0.014	4.878ProAsp: 4.878 ± 0.066	5.012ProGlu: 5.012 ± 0.065	1.57ProPhe: 1.57 ± 0.032	7.247ProGly: 7.247 ± 0.075	1.396ProHis: 1.396 ± 0.028	1.418ProIle: 1.418 ± 0.033	0.824ProLys: 0.824 ± 0.03	5.417ProLeu: 5.417 ± 0.066	0.956ProMet: 0.956 ± 0.023	0.841ProAsn: 0.841 ± 0.021	4.208ProPro: 4.208 ± 0.069	1.478ProGln: 1.478 ± 0.033	4.871ProArg: 4.871 ± 0.067	2.91ProSer: 2.91 ± 0.042	2.929ProThr: 2.929 ± 0.044	5.505ProVal: 5.505 ± 0.061	0.973ProTrp: 0.973 ± 0.025	1.211ProTyr: 1.211 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.251GlnAla: 3.251 ± 0.049	0.163GlnCys: 0.163 ± 0.009	1.138GlnAsp: 1.138 ± 0.031	1.345GlnGlu: 1.345 ± 0.03	0.577GlnPhe: 0.577 ± 0.021	1.791GlnGly: 1.791 ± 0.036	0.551GlnHis: 0.551 ± 0.019	1.007GlnIle: 1.007 ± 0.024	0.343GlnLys: 0.343 ± 0.016	2.692GlnLeu: 2.692 ± 0.044	0.441GlnMet: 0.441 ± 0.018	0.436GlnAsn: 0.436 ± 0.017	1.548GlnPro: 1.548 ± 0.032	0.932GlnGln: 0.932 ± 0.032	2.614GlnArg: 2.614 ± 0.048	1.053GlnSer: 1.053 ± 0.026	1.179GlnThr: 1.179 ± 0.026	2.254GlnVal: 2.254 ± 0.041	0.368GlnTrp: 0.368 ± 0.017	0.464GlnTyr: 0.464 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	11.702ArgAla: 11.702 ± 0.109	0.647ArgCys: 0.647 ± 0.023	5.134ArgAsp: 5.134 ± 0.067	5.277ArgGlu: 5.277 ± 0.061	2.525ArgPhe: 2.525 ± 0.04	7.091ArgGly: 7.091 ± 0.081	2.351ArgHis: 2.351 ± 0.041	3.252ArgIle: 3.252 ± 0.045	1.134ArgLys: 1.134 ± 0.029	9.979ArgLeu: 9.979 ± 0.098	1.892ArgMet: 1.892 ± 0.035	1.337ArgAsn: 1.337 ± 0.029	6.147ArgPro: 6.147 ± 0.076	2.293ArgGln: 2.293 ± 0.038	10.128ArgArg: 10.128 ± 0.107	4.417ArgSer: 4.417 ± 0.058	5.245ArgThr: 5.245 ± 0.05	7.193ArgVal: 7.193 ± 0.07	1.516ArgTrp: 1.516 ± 0.035	1.981ArgTyr: 1.981 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.68SerAla: 6.68 ± 0.078	0.385SerCys: 0.385 ± 0.016	2.605SerAsp: 2.605 ± 0.046	2.435SerGlu: 2.435 ± 0.044	1.341SerPhe: 1.341 ± 0.027	5.909SerGly: 5.909 ± 0.071	0.905SerHis: 0.905 ± 0.024	1.389SerIle: 1.389 ± 0.03	0.625SerLys: 0.625 ± 0.021	4.155SerLeu: 4.155 ± 0.052	0.942SerMet: 0.942 ± 0.023	0.723SerAsn: 0.723 ± 0.022	3.01SerPro: 3.01 ± 0.05	1.022SerGln: 1.022 ± 0.028	3.746SerArg: 3.746 ± 0.052	2.428SerSer: 2.428 ± 0.047	2.676SerThr: 2.676 ± 0.046	3.956SerVal: 3.956 ± 0.053	0.853SerTrp: 0.853 ± 0.024	1.059SerTyr: 1.059 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	8.305ThrAla: 8.305 ± 0.083	0.379ThrCys: 0.379 ± 0.015	3.177ThrAsp: 3.177 ± 0.045	3.236ThrGlu: 3.236 ± 0.049	1.425ThrPhe: 1.425 ± 0.029	6.202ThrGly: 6.202 ± 0.07	1.038ThrHis: 1.038 ± 0.025	1.614ThrIle: 1.614 ± 0.035	0.695ThrLys: 0.695 ± 0.021	5.273ThrLeu: 5.273 ± 0.068	0.869ThrMet: 0.869 ± 0.025	0.849ThrAsn: 0.849 ± 0.026	3.609ThrPro: 3.609 ± 0.048	1.123ThrGln: 1.123 ± 0.033	4.091ThrArg: 4.091 ± 0.051	2.733ThrSer: 2.733 ± 0.049	3.02ThrThr: 3.02 ± 0.053	5.464ThrVal: 5.464 ± 0.06	0.847ThrTrp: 0.847 ± 0.024	0.931ThrTyr: 0.931 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	12.252ValAla: 12.252 ± 0.11	0.788ValCys: 0.788 ± 0.022	5.247ValAsp: 5.247 ± 0.061	5.054ValGlu: 5.054 ± 0.06	2.506ValPhe: 2.506 ± 0.04	7.065ValGly: 7.065 ± 0.083	1.945ValHis: 1.945 ± 0.035	2.849ValIle: 2.849 ± 0.045	1.061ValLys: 1.061 ± 0.029	10.09ValLeu: 10.09 ± 0.099	1.323ValMet: 1.323 ± 0.03	1.641ValAsn: 1.641 ± 0.038	5.455ValPro: 5.455 ± 0.062	1.872ValGln: 1.872 ± 0.034	8.179ValArg: 8.179 ± 0.076	4.22ValSer: 4.22 ± 0.057	5.254ValThr: 5.254 ± 0.062	8.648ValVal: 8.648 ± 0.086	1.199ValTrp: 1.199 ± 0.03	1.635ValTyr: 1.635 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.67TrpAla: 1.67 ± 0.039	0.142TrpCys: 0.142 ± 0.009	0.774TrpAsp: 0.774 ± 0.022	0.765TrpGlu: 0.765 ± 0.022	0.483TrpPhe: 0.483 ± 0.019	1.04TrpGly: 1.04 ± 0.028	0.347TrpHis: 0.347 ± 0.015	0.542TrpIle: 0.542 ± 0.02	0.211TrpLys: 0.211 ± 0.012	1.818TrpLeu: 1.818 ± 0.037	0.287TrpMet: 0.287 ± 0.011	0.35TrpAsn: 0.35 ± 0.014	0.886TrpPro: 0.886 ± 0.023	0.541TrpGln: 0.541 ± 0.021	1.646TrpArg: 1.646 ± 0.032	0.877TrpSer: 0.877 ± 0.027	0.893TrpThr: 0.893 ± 0.024	1.007TrpVal: 1.007 ± 0.026	0.39TrpTrp: 0.39 ± 0.015	0.272TrpTyr: 0.272 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.456TyrAla: 2.456 ± 0.039	0.173TyrCys: 0.173 ± 0.011	1.261TyrAsp: 1.261 ± 0.028	1.08TyrGlu: 1.08 ± 0.028	0.575TyrPhe: 0.575 ± 0.021	2.021TyrGly: 2.021 ± 0.039	0.444TyrHis: 0.444 ± 0.014	0.472TyrIle: 0.472 ± 0.019	0.235TyrLys: 0.235 ± 0.013	2.22TyrLeu: 2.22 ± 0.038	0.208TyrMet: 0.208 ± 0.011	0.332TyrAsn: 0.332 ± 0.015	1.077TyrPro: 1.077 ± 0.025	0.641TyrGln: 0.641 ± 0.023	1.874TyrArg: 1.874 ± 0.033	0.879TyrSer: 0.879 ± 0.024	1.091TyrThr: 1.091 ± 0.024	1.608TyrVal: 1.608 ± 0.034	0.303TyrTrp: 0.303 ± 0.013	0.444TyrTyr: 0.444 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5230 proteins (1586353 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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