Amino acid dipepetide frequency for Serinibacter arcticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.251AlaAla: 22.251 ± 0.223	0.783AlaCys: 0.783 ± 0.031	9.057AlaAsp: 9.057 ± 0.117	7.83AlaGlu: 7.83 ± 0.107	3.614AlaPhe: 3.614 ± 0.079	13.604AlaGly: 13.604 ± 0.163	2.599AlaHis: 2.599 ± 0.05	4.661AlaIle: 4.661 ± 0.086	1.715AlaLys: 1.715 ± 0.055	14.608AlaLeu: 14.608 ± 0.169	2.65AlaMet: 2.65 ± 0.046	1.883AlaAsn: 1.883 ± 0.044	8.078AlaPro: 8.078 ± 0.136	3.923AlaGln: 3.923 ± 0.065	10.445AlaArg: 10.445 ± 0.128	7.616AlaSer: 7.616 ± 0.088	9.273AlaThr: 9.273 ± 0.12	13.929AlaVal: 13.929 ± 0.156	2.225AlaTrp: 2.225 ± 0.05	2.245AlaTyr: 2.245 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.641CysAla: 0.641 ± 0.03	0.043CysCys: 0.043 ± 0.006	0.3CysAsp: 0.3 ± 0.018	0.254CysGlu: 0.254 ± 0.017	0.12CysPhe: 0.12 ± 0.011	0.6CysGly: 0.6 ± 0.031	0.112CysHis: 0.112 ± 0.01	0.158CysIle: 0.158 ± 0.013	0.038CysLys: 0.038 ± 0.005	0.443CysLeu: 0.443 ± 0.023	0.054CysMet: 0.054 ± 0.008	0.075CysAsn: 0.075 ± 0.009	0.304CysPro: 0.304 ± 0.02	0.104CysGln: 0.104 ± 0.01	0.336CysArg: 0.336 ± 0.017	0.32CysSer: 0.32 ± 0.016	0.348CysThr: 0.348 ± 0.024	0.422CysVal: 0.422 ± 0.02	0.083CysTrp: 0.083 ± 0.007	0.084CysTyr: 0.084 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.602AspAla: 9.602 ± 0.115	0.226AspCys: 0.226 ± 0.015	4.606AspAsp: 4.606 ± 0.087	3.733AspGlu: 3.733 ± 0.068	1.342AspPhe: 1.342 ± 0.041	7.684AspGly: 7.684 ± 0.108	1.247AspHis: 1.247 ± 0.04	1.548AspIle: 1.548 ± 0.041	0.601AspLys: 0.601 ± 0.029	7.354AspLeu: 7.354 ± 0.093	0.678AspMet: 0.678 ± 0.027	0.781AspAsn: 0.781 ± 0.032	4.71AspPro: 4.71 ± 0.076	1.334AspGln: 1.334 ± 0.035	4.309AspArg: 4.309 ± 0.078	2.427AspSer: 2.427 ± 0.059	2.807AspThr: 2.807 ± 0.061	7.416AspVal: 7.416 ± 0.094	0.861AspTrp: 0.861 ± 0.033	1.092AspTyr: 1.092 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.324GluAla: 7.324 ± 0.114	0.236GluCys: 0.236 ± 0.014	2.953GluAsp: 2.953 ± 0.055	2.811GluGlu: 2.811 ± 0.063	1.274GluPhe: 1.274 ± 0.039	4.205GluGly: 4.205 ± 0.065	1.559GluHis: 1.559 ± 0.045	2.687GluIle: 2.687 ± 0.054	0.896GluLys: 0.896 ± 0.034	6.056GluLeu: 6.056 ± 0.078	0.824GluMet: 0.824 ± 0.028	1.106GluAsn: 1.106 ± 0.04	3.174GluPro: 3.174 ± 0.068	2.072GluGln: 2.072 ± 0.05	5.208GluArg: 5.208 ± 0.086	2.548GluSer: 2.548 ± 0.059	3.006GluThr: 3.006 ± 0.056	5.407GluVal: 5.407 ± 0.084	0.658GluTrp: 0.658 ± 0.024	0.832GluTyr: 0.832 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.558PheAla: 3.558 ± 0.063	0.142PheCys: 0.142 ± 0.013	1.919PheAsp: 1.919 ± 0.051	1.361PheGlu: 1.361 ± 0.041	0.814PhePhe: 0.814 ± 0.033	2.719PheGly: 2.719 ± 0.055	0.49PheHis: 0.49 ± 0.023	0.699PheIle: 0.699 ± 0.025	0.286PheLys: 0.286 ± 0.018	2.461PheLeu: 2.461 ± 0.051	0.333PheMet: 0.333 ± 0.019	0.47PheAsn: 0.47 ± 0.023	1.201PhePro: 1.201 ± 0.034	0.614PheGln: 0.614 ± 0.026	1.506PheArg: 1.506 ± 0.042	1.536PheSer: 1.536 ± 0.039	2.022PheThr: 2.022 ± 0.078	2.393PheVal: 2.393 ± 0.056	0.386PheTrp: 0.386 ± 0.021	0.556PheTyr: 0.556 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	12.339GlyAla: 12.339 ± 0.154	0.517GlyCys: 0.517 ± 0.024	5.677GlyAsp: 5.677 ± 0.079	5.662GlyGlu: 5.662 ± 0.079	2.655GlyPhe: 2.655 ± 0.052	9.351GlyGly: 9.351 ± 0.149	1.914GlyHis: 1.914 ± 0.042	3.532GlyIle: 3.532 ± 0.066	1.56GlyLys: 1.56 ± 0.039	9.226GlyLeu: 9.226 ± 0.122	1.731GlyMet: 1.731 ± 0.045	1.564GlyAsn: 1.564 ± 0.056	4.652GlyPro: 4.652 ± 0.086	2.471GlyGln: 2.471 ± 0.061	7.101GlyArg: 7.101 ± 0.094	6.116GlySer: 6.116 ± 0.09	6.658GlyThr: 6.658 ± 0.106	9.088GlyVal: 9.088 ± 0.107	1.795GlyTrp: 1.795 ± 0.05	2.058GlyTyr: 2.058 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.666HisAla: 2.666 ± 0.061	0.1HisCys: 0.1 ± 0.01	1.423HisAsp: 1.423 ± 0.035	1.173HisGlu: 1.173 ± 0.034	0.379HisPhe: 0.379 ± 0.02	1.981HisGly: 1.981 ± 0.049	0.628HisHis: 0.628 ± 0.03	0.446HisIle: 0.446 ± 0.019	0.2HisLys: 0.2 ± 0.015	2.373HisLeu: 2.373 ± 0.056	0.22HisMet: 0.22 ± 0.013	0.27HisAsn: 0.27 ± 0.016	1.493HisPro: 1.493 ± 0.039	0.481HisGln: 0.481 ± 0.023	1.698HisArg: 1.698 ± 0.038	0.758HisSer: 0.758 ± 0.027	1.012HisThr: 1.012 ± 0.032	1.971HisVal: 1.971 ± 0.048	0.25HisTrp: 0.25 ± 0.015	0.346HisTyr: 0.346 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.449IleAla: 5.449 ± 0.078	0.187IleCys: 0.187 ± 0.014	2.758IleAsp: 2.758 ± 0.053	2.057IleGlu: 2.057 ± 0.048	0.82IlePhe: 0.82 ± 0.033	3.673IleGly: 3.673 ± 0.079	0.567IleHis: 0.567 ± 0.024	0.983IleIle: 0.983 ± 0.039	0.493IleLys: 0.493 ± 0.021	2.735IleLeu: 2.735 ± 0.06	0.435IleMet: 0.435 ± 0.022	0.656IleAsn: 0.656 ± 0.029	1.719IlePro: 1.719 ± 0.039	0.649IleGln: 0.649 ± 0.025	1.859IleArg: 1.859 ± 0.044	1.893IleSer: 1.893 ± 0.048	2.317IleThr: 2.317 ± 0.057	3.453IleVal: 3.453 ± 0.066	0.369IleTrp: 0.369 ± 0.019	0.591IleTyr: 0.591 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	1.651LysAla: 1.651 ± 0.052	0.048LysCys: 0.048 ± 0.007	0.786LysAsp: 0.786 ± 0.033	0.7LysGlu: 0.7 ± 0.029	0.278LysPhe: 0.278 ± 0.017	1.016LysGly: 1.016 ± 0.041	0.279LysHis: 0.279 ± 0.017	0.604LysIle: 0.604 ± 0.027	0.386LysLys: 0.386 ± 0.022	1.117LysLeu: 1.117 ± 0.042	0.224LysMet: 0.224 ± 0.016	0.29LysAsn: 0.29 ± 0.018	0.768LysPro: 0.768 ± 0.028	0.398LysGln: 0.398 ± 0.023	0.913LysArg: 0.913 ± 0.032	0.663LysSer: 0.663 ± 0.028	0.774LysThr: 0.774 ± 0.033	1.278LysVal: 1.278 ± 0.041	0.119LysTrp: 0.119 ± 0.011	0.236LysTyr: 0.236 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.777LeuAla: 16.777 ± 0.166	0.442LeuCys: 0.442 ± 0.02	6.957LeuAsp: 6.957 ± 0.091	5.393LeuGlu: 5.393 ± 0.082	2.116LeuPhe: 2.116 ± 0.054	9.746LeuGly: 9.746 ± 0.119	1.829LeuHis: 1.829 ± 0.046	2.922LeuIle: 2.922 ± 0.072	1.089LeuLys: 1.089 ± 0.038	10.543LeuLeu: 10.543 ± 0.134	1.435LeuMet: 1.435 ± 0.04	1.439LeuAsn: 1.439 ± 0.037	5.876LeuPro: 5.876 ± 0.086	2.182LeuGln: 2.182 ± 0.047	7.796LeuArg: 7.796 ± 0.108	4.723LeuSer: 4.723 ± 0.074	7.207LeuThr: 7.207 ± 0.092	10.7LeuVal: 10.7 ± 0.139	1.144LeuTrp: 1.144 ± 0.037	1.398LeuTyr: 1.398 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.132MetAla: 2.132 ± 0.042	0.076MetCys: 0.076 ± 0.009	0.731MetAsp: 0.731 ± 0.026	0.547MetGlu: 0.547 ± 0.026	0.446MetPhe: 0.446 ± 0.02	1.194MetGly: 1.194 ± 0.035	0.264MetHis: 0.264 ± 0.017	0.644MetIle: 0.644 ± 0.028	0.254MetLys: 0.254 ± 0.015	1.639MetLeu: 1.639 ± 0.046	0.234MetMet: 0.234 ± 0.016	0.325MetAsn: 0.325 ± 0.019	0.924MetPro: 0.924 ± 0.027	0.373MetGln: 0.373 ± 0.021	1.25MetArg: 1.25 ± 0.036	1.313MetSer: 1.313 ± 0.036	1.7MetThr: 1.7 ± 0.044	1.247MetVal: 1.247 ± 0.039	0.173MetTrp: 0.173 ± 0.013	0.21MetTyr: 0.21 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.136AsnAla: 2.136 ± 0.055	0.078AsnCys: 0.078 ± 0.008	1.02AsnAsp: 1.02 ± 0.038	0.792AsnGlu: 0.792 ± 0.029	0.448AsnPhe: 0.448 ± 0.026	1.623AsnGly: 1.623 ± 0.056	0.346AsnHis: 0.346 ± 0.019	0.573AsnIle: 0.573 ± 0.024	0.203AsnLys: 0.203 ± 0.015	1.62AsnLeu: 1.62 ± 0.042	0.229AsnMet: 0.229 ± 0.015	0.339AsnAsn: 0.339 ± 0.019	1.261AsnPro: 1.261 ± 0.036	0.476AsnGln: 0.476 ± 0.023	1.048AsnArg: 1.048 ± 0.039	0.683AsnSer: 0.683 ± 0.028	0.865AsnThr: 0.865 ± 0.042	1.499AsnVal: 1.499 ± 0.041	0.194AsnTrp: 0.194 ± 0.014	0.389AsnTyr: 0.389 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.599ProAla: 8.599 ± 0.123	0.198ProCys: 0.198 ± 0.013	4.384ProAsp: 4.384 ± 0.076	3.911ProGlu: 3.911 ± 0.065	1.608ProPhe: 1.608 ± 0.043	6.14ProGly: 6.14 ± 0.084	1.194ProHis: 1.194 ± 0.038	1.645ProIle: 1.645 ± 0.042	0.578ProLys: 0.578 ± 0.027	5.07ProLeu: 5.07 ± 0.075	0.831ProMet: 0.831 ± 0.032	0.793ProAsn: 0.793 ± 0.03	3.129ProPro: 3.129 ± 0.088	1.545ProGln: 1.545 ± 0.045	3.914ProArg: 3.914 ± 0.075	3.616ProSer: 3.616 ± 0.065	4.186ProThr: 4.186 ± 0.088	5.636ProVal: 5.636 ± 0.109	0.929ProTrp: 0.929 ± 0.029	1.013ProTyr: 1.013 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.348GlnAla: 3.348 ± 0.064	0.112GlnCys: 0.112 ± 0.01	1.4GlnAsp: 1.4 ± 0.035	1.328GlnGlu: 1.328 ± 0.034	0.709GlnPhe: 0.709 ± 0.03	2.24GlnGly: 2.24 ± 0.058	0.591GlnHis: 0.591 ± 0.022	1.18GlnIle: 1.18 ± 0.032	0.35GlnLys: 0.35 ± 0.019	2.777GlnLeu: 2.777 ± 0.053	0.416GlnMet: 0.416 ± 0.02	0.426GlnAsn: 0.426 ± 0.026	1.556GlnPro: 1.556 ± 0.047	1.103GlnGln: 1.103 ± 0.045	2.224GlnArg: 2.224 ± 0.051	1.027GlnSer: 1.027 ± 0.035	1.298GlnThr: 1.298 ± 0.036	2.682GlnVal: 2.682 ± 0.055	0.391GlnTrp: 0.391 ± 0.018	0.463GlnTyr: 0.463 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.735ArgAla: 9.735 ± 0.126	0.341ArgCys: 0.341 ± 0.021	4.599ArgAsp: 4.599 ± 0.075	4.539ArgGlu: 4.539 ± 0.071	1.915ArgPhe: 1.915 ± 0.048	6.121ArgGly: 6.121 ± 0.084	1.608ArgHis: 1.608 ± 0.041	2.809ArgIle: 2.809 ± 0.058	0.921ArgLys: 0.921 ± 0.035	7.513ArgLeu: 7.513 ± 0.104	1.44ArgMet: 1.44 ± 0.042	1.044ArgAsn: 1.044 ± 0.035	4.3ArgPro: 4.3 ± 0.07	1.823ArgGln: 1.823 ± 0.04	7.683ArgArg: 7.683 ± 0.119	4.417ArgSer: 4.417 ± 0.067	5.22ArgThr: 5.22 ± 0.071	6.326ArgVal: 6.326 ± 0.089	1.338ArgTrp: 1.338 ± 0.036	1.482ArgTyr: 1.482 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	7.004SerAla: 7.004 ± 0.088	0.277SerCys: 0.277 ± 0.016	3.3SerAsp: 3.3 ± 0.059	2.562SerGlu: 2.562 ± 0.057	1.64SerPhe: 1.64 ± 0.04	5.908SerGly: 5.908 ± 0.091	0.983SerHis: 0.983 ± 0.032	1.966SerIle: 1.966 ± 0.048	0.642SerLys: 0.642 ± 0.024	5.048SerLeu: 5.048 ± 0.077	1.09SerMet: 1.09 ± 0.034	0.954SerAsn: 0.954 ± 0.036	3.453SerPro: 3.453 ± 0.069	1.359SerGln: 1.359 ± 0.035	3.801SerArg: 3.801 ± 0.06	3.625SerSer: 3.625 ± 0.08	3.973SerThr: 3.973 ± 0.072	4.46SerVal: 4.46 ± 0.074	0.942SerTrp: 0.942 ± 0.029	1.191SerTyr: 1.191 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	9.091ThrAla: 9.091 ± 0.108	0.333ThrCys: 0.333 ± 0.019	4.064ThrAsp: 4.064 ± 0.081	2.919ThrGlu: 2.919 ± 0.062	2.092ThrPhe: 2.092 ± 0.057	6.591ThrGly: 6.591 ± 0.101	1.219ThrHis: 1.219 ± 0.035	2.428ThrIle: 2.428 ± 0.058	0.791ThrLys: 0.791 ± 0.031	6.506ThrLeu: 6.506 ± 0.081	0.954ThrMet: 0.954 ± 0.032	1.096ThrAsn: 1.096 ± 0.051	4.761ThrPro: 4.761 ± 0.12	1.595ThrGln: 1.595 ± 0.042	4.124ThrArg: 4.124 ± 0.072	4.283ThrSer: 4.283 ± 0.078	5.297ThrThr: 5.297 ± 0.12	6.235ThrVal: 6.235 ± 0.113	1.125ThrTrp: 1.125 ± 0.034	1.479ThrTyr: 1.479 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	14.751ValAla: 14.751 ± 0.158	0.48ValCys: 0.48 ± 0.022	6.275ValAsp: 6.275 ± 0.082	5.54ValGlu: 5.54 ± 0.086	2.143ValPhe: 2.143 ± 0.046	8.429ValGly: 8.429 ± 0.105	1.826ValHis: 1.826 ± 0.048	3.15ValIle: 3.15 ± 0.064	1.12ValLys: 1.12 ± 0.035	11.001ValLeu: 11.001 ± 0.144	1.434ValMet: 1.434 ± 0.036	1.581ValAsn: 1.581 ± 0.044	5.843ValPro: 5.843 ± 0.078	2.151ValGln: 2.151 ± 0.042	7.085ValArg: 7.085 ± 0.099	4.688ValSer: 4.688 ± 0.064	7.023ValThr: 7.023 ± 0.149	12.267ValVal: 12.267 ± 0.179	1.139ValTrp: 1.139 ± 0.034	1.332ValTyr: 1.332 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.623TrpAla: 1.623 ± 0.045	0.107TrpCys: 0.107 ± 0.011	0.91TrpAsp: 0.91 ± 0.031	0.752TrpGlu: 0.752 ± 0.029	0.518TrpPhe: 0.518 ± 0.023	1.062TrpGly: 1.062 ± 0.034	0.316TrpHis: 0.316 ± 0.018	0.624TrpIle: 0.624 ± 0.026	0.179TrpLys: 0.179 ± 0.014	1.72TrpLeu: 1.72 ± 0.045	0.27TrpMet: 0.27 ± 0.015	0.373TrpAsn: 0.373 ± 0.02	0.72TrpPro: 0.72 ± 0.028	0.465TrpGln: 0.465 ± 0.022	1.361TrpArg: 1.361 ± 0.036	0.948TrpSer: 0.948 ± 0.032	0.944TrpThr: 0.944 ± 0.03	1.233TrpVal: 1.233 ± 0.041	0.401TrpTrp: 0.401 ± 0.022	0.274TrpTyr: 0.274 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.308TyrAla: 2.308 ± 0.053	0.115TyrCys: 0.115 ± 0.01	1.239TyrAsp: 1.239 ± 0.04	0.974TyrGlu: 0.974 ± 0.031	0.535TyrPhe: 0.535 ± 0.024	1.778TyrGly: 1.778 ± 0.048	0.293TyrHis: 0.293 ± 0.02	0.4TyrIle: 0.4 ± 0.021	0.228TyrLys: 0.228 ± 0.016	1.908TyrLeu: 1.908 ± 0.041	0.195TyrMet: 0.195 ± 0.014	0.356TyrAsn: 0.356 ± 0.024	0.996TyrPro: 0.996 ± 0.036	0.504TyrGln: 0.504 ± 0.033	1.515TyrArg: 1.515 ± 0.045	0.977TyrSer: 0.977 ± 0.033	1.055TyrThr: 1.055 ± 0.038	1.617TyrVal: 1.617 ± 0.043	0.277TyrTrp: 0.277 ± 0.019	0.37TyrTyr: 0.37 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2999 proteins (1041505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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