Amino acid dipepetide frequency for Planctomycetes bacterium Pan189

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.342AlaAla: 12.342 ± 0.14	0.99AlaCys: 0.99 ± 0.029	6.606AlaAsp: 6.606 ± 0.084	7.881AlaGlu: 7.881 ± 0.098	3.499AlaPhe: 3.499 ± 0.054	8.276AlaGly: 8.276 ± 0.151	1.557AlaHis: 1.557 ± 0.034	5.805AlaIle: 5.805 ± 0.08	3.744AlaLys: 3.744 ± 0.06	8.341AlaLeu: 8.341 ± 0.091	2.338AlaMet: 2.338 ± 0.046	2.71AlaAsn: 2.71 ± 0.057	3.759AlaPro: 3.759 ± 0.055	2.64AlaGln: 2.64 ± 0.046	5.788AlaArg: 5.788 ± 0.066	5.917AlaSer: 5.917 ± 0.094	5.717AlaThr: 5.717 ± 0.095	7.801AlaVal: 7.801 ± 0.089	1.166AlaTrp: 1.166 ± 0.031	2.01AlaTyr: 2.01 ± 0.035	0.002AlaXaa: 0.002 ± 0.001
Cys	0.77CysAla: 0.77 ± 0.025	0.22CysCys: 0.22 ± 0.015	0.753CysAsp: 0.753 ± 0.025	0.686CysGlu: 0.686 ± 0.021	0.42CysPhe: 0.42 ± 0.016	1.176CysGly: 1.176 ± 0.035	0.383CysHis: 0.383 ± 0.019	0.407CysIle: 0.407 ± 0.016	0.283CysLys: 0.283 ± 0.013	1.037CysLeu: 1.037 ± 0.027	0.148CysMet: 0.148 ± 0.01	0.265CysAsn: 0.265 ± 0.014	0.596CysPro: 0.596 ± 0.023	0.283CysGln: 0.283 ± 0.014	0.921CysArg: 0.921 ± 0.028	0.624CysSer: 0.624 ± 0.021	0.44CysThr: 0.44 ± 0.016	0.823CysVal: 0.823 ± 0.023	0.149CysTrp: 0.149 ± 0.011	0.293CysTyr: 0.293 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.298AspAla: 6.298 ± 0.089	0.586AspCys: 0.586 ± 0.021	4.447AspAsp: 4.447 ± 0.07	5.14AspGlu: 5.14 ± 0.059	2.642AspPhe: 2.642 ± 0.044	5.793AspGly: 5.793 ± 0.11	1.354AspHis: 1.354 ± 0.035	2.804AspIle: 2.804 ± 0.052	1.605AspLys: 1.605 ± 0.039	6.141AspLeu: 6.141 ± 0.068	0.986AspMet: 0.986 ± 0.032	1.425AspAsn: 1.425 ± 0.035	3.8AspPro: 3.8 ± 0.051	2.159AspGln: 2.159 ± 0.041	5.323AspArg: 5.323 ± 0.068	3.792AspSer: 3.792 ± 0.061	2.516AspThr: 2.516 ± 0.05	4.773AspVal: 4.773 ± 0.075	1.049AspTrp: 1.049 ± 0.026	1.538AspTyr: 1.538 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.632GluAla: 6.632 ± 0.076	0.533GluCys: 0.533 ± 0.021	3.378GluAsp: 3.378 ± 0.047	4.391GluGlu: 4.391 ± 0.075	2.84GluPhe: 2.84 ± 0.041	4.153GluGly: 4.153 ± 0.053	1.443GluHis: 1.443 ± 0.035	3.932GluIle: 3.932 ± 0.047	2.613GluLys: 2.613 ± 0.059	7.244GluLeu: 7.244 ± 0.082	1.599GluMet: 1.599 ± 0.035	1.98GluAsn: 1.98 ± 0.03	3.458GluPro: 3.458 ± 0.057	3.192GluGln: 3.192 ± 0.053	5.179GluArg: 5.179 ± 0.07	4.691GluSer: 4.691 ± 0.066	3.963GluThr: 3.963 ± 0.052	4.898GluVal: 4.898 ± 0.063	0.86GluTrp: 0.86 ± 0.025	1.581GluTyr: 1.581 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.102PheAla: 4.102 ± 0.058	0.516PheCys: 0.516 ± 0.02	3.153PheAsp: 3.153 ± 0.049	2.912PheGlu: 2.912 ± 0.053	1.51PhePhe: 1.51 ± 0.034	3.749PheGly: 3.749 ± 0.064	0.759PheHis: 0.759 ± 0.023	1.536PheIle: 1.536 ± 0.038	1.07PheLys: 1.07 ± 0.033	3.628PheLeu: 3.628 ± 0.062	0.582PheMet: 0.582 ± 0.022	1.149PheAsn: 1.149 ± 0.029	1.749PhePro: 1.749 ± 0.03	1.158PheGln: 1.158 ± 0.032	2.823PheArg: 2.823 ± 0.05	2.353PheSer: 2.353 ± 0.041	1.844PheThr: 1.844 ± 0.038	3.021PheVal: 3.021 ± 0.054	0.502PheTrp: 0.502 ± 0.02	0.944PheTyr: 0.944 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	6.069GlyAla: 6.069 ± 0.137	1.014GlyCys: 1.014 ± 0.03	5.003GlyAsp: 5.003 ± 0.085	5.386GlyGlu: 5.386 ± 0.067	3.283GlyPhe: 3.283 ± 0.045	6.977GlyGly: 6.977 ± 0.193	1.71GlyHis: 1.71 ± 0.037	4.071GlyIle: 4.071 ± 0.064	3.161GlyLys: 3.161 ± 0.064	7.273GlyLeu: 7.273 ± 0.075	1.752GlyMet: 1.752 ± 0.045	2.387GlyAsn: 2.387 ± 0.064	3.534GlyPro: 3.534 ± 0.059	2.61GlyGln: 2.61 ± 0.046	6.062GlyArg: 6.062 ± 0.075	5.269GlySer: 5.269 ± 0.117	4.619GlyThr: 4.619 ± 0.123	5.574GlyVal: 5.574 ± 0.075	1.269GlyTrp: 1.269 ± 0.034	2.152GlyTyr: 2.152 ± 0.048	0.001GlyXaa: 0.001 ± 0.001
His	1.811HisAla: 1.811 ± 0.048	0.293HisCys: 0.293 ± 0.013	1.288HisAsp: 1.288 ± 0.032	1.271HisGlu: 1.271 ± 0.037	0.928HisPhe: 0.928 ± 0.028	1.704HisGly: 1.704 ± 0.036	0.593HisHis: 0.593 ± 0.025	0.774HisIle: 0.774 ± 0.024	0.53HisLys: 0.53 ± 0.02	2.036HisLeu: 2.036 ± 0.042	0.318HisMet: 0.318 ± 0.016	0.569HisAsn: 0.569 ± 0.021	1.33HisPro: 1.33 ± 0.032	0.682HisGln: 0.682 ± 0.021	1.647HisArg: 1.647 ± 0.037	1.209HisSer: 1.209 ± 0.03	0.841HisThr: 0.841 ± 0.028	1.47HisVal: 1.47 ± 0.031	0.387HisTrp: 0.387 ± 0.015	0.573HisTyr: 0.573 ± 0.021	0.001HisXaa: 0.001 ± 0.001
Ile	6.24IleAla: 6.24 ± 0.073	0.632IleCys: 0.632 ± 0.022	4.318IleAsp: 4.318 ± 0.056	4.221IleGlu: 4.221 ± 0.06	1.66IlePhe: 1.66 ± 0.038	4.498IleGly: 4.498 ± 0.075	0.91IleHis: 0.91 ± 0.027	1.91IleIle: 1.91 ± 0.042	1.536IleLys: 1.536 ± 0.041	4.167IleLeu: 4.167 ± 0.056	0.637IleMet: 0.637 ± 0.022	1.493IleAsn: 1.493 ± 0.04	2.526IlePro: 2.526 ± 0.047	1.24IleGln: 1.24 ± 0.031	3.617IleArg: 3.617 ± 0.049	3.143IleSer: 3.143 ± 0.065	2.502IleThr: 2.502 ± 0.061	4.104IleVal: 4.104 ± 0.054	0.555IleTrp: 0.555 ± 0.019	1.191IleTyr: 1.191 ± 0.027	0.001IleXaa: 0.001 ± 0.001
Lys	3.298LysAla: 3.298 ± 0.061	0.274LysCys: 0.274 ± 0.014	1.753LysAsp: 1.753 ± 0.039	2.047LysGlu: 2.047 ± 0.043	1.34LysPhe: 1.34 ± 0.034	2.168LysGly: 2.168 ± 0.054	0.758LysHis: 0.758 ± 0.025	1.798LysIle: 1.798 ± 0.036	1.772LysLys: 1.772 ± 0.048	3.651LysLeu: 3.651 ± 0.056	0.784LysMet: 0.784 ± 0.024	1.197LysAsn: 1.197 ± 0.028	2.148LysPro: 2.148 ± 0.047	1.508LysGln: 1.508 ± 0.035	2.572LysArg: 2.572 ± 0.048	2.7LysSer: 2.7 ± 0.051	2.113LysThr: 2.113 ± 0.043	2.36LysVal: 2.36 ± 0.053	0.513LysTrp: 0.513 ± 0.02	0.891LysTyr: 0.891 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	10.146LeuAla: 10.146 ± 0.092	1.123LeuCys: 1.123 ± 0.028	5.916LeuAsp: 5.916 ± 0.066	5.682LeuGlu: 5.682 ± 0.063	3.646LeuPhe: 3.646 ± 0.062	7.08LeuGly: 7.08 ± 0.077	1.78LeuHis: 1.78 ± 0.037	5.247LeuIle: 5.247 ± 0.077	4.075LeuLys: 4.075 ± 0.065	9.474LeuLeu: 9.474 ± 0.123	1.87LeuMet: 1.87 ± 0.038	2.952LeuAsn: 2.952 ± 0.045	5.3LeuPro: 5.3 ± 0.08	2.863LeuGln: 2.863 ± 0.044	6.89LeuArg: 6.89 ± 0.084	6.55LeuSer: 6.55 ± 0.07	5.715LeuThr: 5.715 ± 0.078	6.456LeuVal: 6.456 ± 0.077	1.185LeuTrp: 1.185 ± 0.038	1.997LeuTyr: 1.997 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	1.894MetAla: 1.894 ± 0.043	0.19MetCys: 0.19 ± 0.014	0.801MetAsp: 0.801 ± 0.023	0.938MetGlu: 0.938 ± 0.03	0.672MetPhe: 0.672 ± 0.023	1.185MetGly: 1.185 ± 0.032	0.409MetHis: 0.409 ± 0.018	1.119MetIle: 1.119 ± 0.027	0.954MetLys: 0.954 ± 0.027	2.152MetLeu: 2.152 ± 0.045	0.41MetMet: 0.41 ± 0.017	0.721MetAsn: 0.721 ± 0.022	1.315MetPro: 1.315 ± 0.035	0.726MetGln: 0.726 ± 0.026	1.436MetArg: 1.436 ± 0.03	1.622MetSer: 1.622 ± 0.038	1.401MetThr: 1.401 ± 0.029	1.17MetVal: 1.17 ± 0.029	0.212MetTrp: 0.212 ± 0.011	0.349MetTyr: 0.349 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.839AsnAla: 2.839 ± 0.058	0.337AsnCys: 0.337 ± 0.018	1.925AsnAsp: 1.925 ± 0.054	1.843AsnGlu: 1.843 ± 0.039	1.161AsnPhe: 1.161 ± 0.032	2.533AsnGly: 2.533 ± 0.06	0.592AsnHis: 0.592 ± 0.017	1.271AsnIle: 1.271 ± 0.03	0.769AsnLys: 0.769 ± 0.022	2.719AsnLeu: 2.719 ± 0.045	0.521AsnMet: 0.521 ± 0.02	0.882AsnAsn: 0.882 ± 0.036	1.903AsnPro: 1.903 ± 0.038	0.945AsnGln: 0.945 ± 0.025	2.306AsnArg: 2.306 ± 0.039	1.915AsnSer: 1.915 ± 0.042	1.401AsnThr: 1.401 ± 0.049	2.226AsnVal: 2.226 ± 0.041	0.49AsnTrp: 0.49 ± 0.02	0.81AsnTyr: 0.81 ± 0.028	0.001AsnXaa: 0.001 ± 0.001
Pro	5.06ProAla: 5.06 ± 0.068	0.359ProCys: 0.359 ± 0.019	3.894ProAsp: 3.894 ± 0.059	4.255ProGlu: 4.255 ± 0.054	1.934ProPhe: 1.934 ± 0.034	3.847ProGly: 3.847 ± 0.058	1.15ProHis: 1.15 ± 0.03	2.658ProIle: 2.658 ± 0.04	2.028ProLys: 2.028 ± 0.05	4.625ProLeu: 4.625 ± 0.061	0.945ProMet: 0.945 ± 0.025	1.704ProAsn: 1.704 ± 0.037	3.061ProPro: 3.061 ± 0.073	1.895ProGln: 1.895 ± 0.039	2.932ProArg: 2.932 ± 0.047	3.219ProSer: 3.219 ± 0.054	3.089ProThr: 3.089 ± 0.047	3.907ProVal: 3.907 ± 0.054	0.659ProTrp: 0.659 ± 0.022	1.172ProTyr: 1.172 ± 0.029	0.001ProXaa: 0.001 ± 0.001
Gln	3.211GlnAla: 3.211 ± 0.051	0.323GlnCys: 0.323 ± 0.014	1.464GlnAsp: 1.464 ± 0.03	1.718GlnGlu: 1.718 ± 0.035	1.559GlnPhe: 1.559 ± 0.031	1.878GlnGly: 1.878 ± 0.039	0.706GlnHis: 0.706 ± 0.022	1.976GlnIle: 1.976 ± 0.04	1.242GlnLys: 1.242 ± 0.032	3.486GlnLeu: 3.486 ± 0.053	0.761GlnMet: 0.761 ± 0.025	1.046GlnAsn: 1.046 ± 0.029	1.901GlnPro: 1.901 ± 0.042	1.565GlnGln: 1.565 ± 0.038	2.521GlnArg: 2.521 ± 0.04	2.372GlnSer: 2.372 ± 0.043	1.906GlnThr: 1.906 ± 0.038	2.309GlnVal: 2.309 ± 0.039	0.524GlnTrp: 0.524 ± 0.018	0.837GlnTyr: 0.837 ± 0.025	0.001GlnXaa: 0.001 ± 0.001
Arg	5.444ArgAla: 5.444 ± 0.059	0.776ArgCys: 0.776 ± 0.029	4.343ArgAsp: 4.343 ± 0.053	4.862ArgGlu: 4.862 ± 0.073	3.168ArgPhe: 3.168 ± 0.051	4.76ArgGly: 4.76 ± 0.067	1.6ArgHis: 1.6 ± 0.036	3.875ArgIle: 3.875 ± 0.051	2.726ArgLys: 2.726 ± 0.052	7.723ArgLeu: 7.723 ± 0.085	1.663ArgMet: 1.663 ± 0.04	2.218ArgAsn: 2.218 ± 0.047	3.794ArgPro: 3.794 ± 0.059	2.722ArgGln: 2.722 ± 0.045	6.175ArgArg: 6.175 ± 0.085	4.793ArgSer: 4.793 ± 0.058	3.815ArgThr: 3.815 ± 0.053	4.831ArgVal: 4.831 ± 0.062	1.113ArgTrp: 1.113 ± 0.026	1.889ArgTyr: 1.889 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.182SerAla: 6.182 ± 0.09	0.62SerCys: 0.62 ± 0.024	4.472SerAsp: 4.472 ± 0.074	4.35SerGlu: 4.35 ± 0.066	2.326SerPhe: 2.326 ± 0.039	5.938SerGly: 5.938 ± 0.114	1.263SerHis: 1.263 ± 0.032	3.338SerIle: 3.338 ± 0.057	2.235SerLys: 2.235 ± 0.046	6.098SerLeu: 6.098 ± 0.07	1.258SerMet: 1.258 ± 0.028	2.021SerAsn: 2.021 ± 0.042	3.527SerPro: 3.527 ± 0.05	2.076SerGln: 2.076 ± 0.045	4.497SerArg: 4.497 ± 0.053	4.252SerSer: 4.252 ± 0.073	3.527SerThr: 3.527 ± 0.066	4.519SerVal: 4.519 ± 0.062	0.762SerTrp: 0.762 ± 0.023	1.379SerTyr: 1.379 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.78ThrAla: 5.78 ± 0.095	0.541ThrCys: 0.541 ± 0.019	3.506ThrAsp: 3.506 ± 0.063	3.349ThrGlu: 3.349 ± 0.047	2.146ThrPhe: 2.146 ± 0.039	4.871ThrGly: 4.871 ± 0.121	1.024ThrHis: 1.024 ± 0.028	3.119ThrIle: 3.119 ± 0.082	1.745ThrLys: 1.745 ± 0.039	5.383ThrLeu: 5.383 ± 0.075	0.981ThrMet: 0.981 ± 0.027	1.547ThrAsn: 1.547 ± 0.044	3.194ThrPro: 3.194 ± 0.047	1.607ThrGln: 1.607 ± 0.035	3.182ThrArg: 3.182 ± 0.05	3.378ThrSer: 3.378 ± 0.064	3.006ThrThr: 3.006 ± 0.082	4.388ThrVal: 4.388 ± 0.083	0.654ThrTrp: 0.654 ± 0.025	1.299ThrTyr: 1.299 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.675ValAla: 7.675 ± 0.073	0.853ValCys: 0.853 ± 0.031	4.836ValAsp: 4.836 ± 0.064	5.277ValGlu: 5.277 ± 0.058	2.697ValPhe: 2.697 ± 0.044	5.633ValGly: 5.633 ± 0.062	1.314ValHis: 1.314 ± 0.032	3.912ValIle: 3.912 ± 0.056	2.336ValLys: 2.336 ± 0.05	6.942ValLeu: 6.942 ± 0.085	1.424ValMet: 1.424 ± 0.035	1.959ValAsn: 1.959 ± 0.054	3.713ValPro: 3.713 ± 0.057	1.921ValGln: 1.921 ± 0.041	5.237ValArg: 5.237 ± 0.061	4.536ValSer: 4.536 ± 0.071	4.479ValThr: 4.479 ± 0.087	5.703ValVal: 5.703 ± 0.072	0.925ValTrp: 0.925 ± 0.027	1.534ValTyr: 1.534 ± 0.032	0.001ValXaa: 0.001 ± 0.001
Trp	1.044TrpAla: 1.044 ± 0.029	0.165TrpCys: 0.165 ± 0.009	0.753TrpAsp: 0.753 ± 0.025	0.766TrpGlu: 0.766 ± 0.022	0.516TrpPhe: 0.516 ± 0.021	0.907TrpGly: 0.907 ± 0.028	0.372TrpHis: 0.372 ± 0.018	0.728TrpIle: 0.728 ± 0.024	0.602TrpLys: 0.602 ± 0.022	1.465TrpLeu: 1.465 ± 0.037	0.352TrpMet: 0.352 ± 0.015	0.531TrpAsn: 0.531 ± 0.019	0.663TrpPro: 0.663 ± 0.023	0.586TrpGln: 0.586 ± 0.025	0.99TrpArg: 0.99 ± 0.031	0.968TrpSer: 0.968 ± 0.027	0.787TrpThr: 0.787 ± 0.025	0.856TrpVal: 0.856 ± 0.026	0.253TrpTrp: 0.253 ± 0.014	0.364TrpTyr: 0.364 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.049TyrAla: 2.049 ± 0.038	0.333TyrCys: 0.333 ± 0.018	1.563TyrAsp: 1.563 ± 0.034	1.587TyrGlu: 1.587 ± 0.037	1.11TyrPhe: 1.11 ± 0.03	2.048TyrGly: 2.048 ± 0.037	0.576TyrHis: 0.576 ± 0.019	0.822TyrIle: 0.822 ± 0.027	0.616TyrLys: 0.616 ± 0.021	2.36TyrLeu: 2.36 ± 0.042	0.346TyrMet: 0.346 ± 0.018	0.632TyrAsn: 0.632 ± 0.024	1.122TyrPro: 1.122 ± 0.031	0.927TyrGln: 0.927 ± 0.024	2.192TyrArg: 2.192 ± 0.043	1.336TyrSer: 1.336 ± 0.035	1.021TyrThr: 1.021 ± 0.032	1.719TyrVal: 1.719 ± 0.036	0.443TyrTrp: 0.443 ± 0.018	0.733TyrTyr: 0.733 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4295 proteins (1510845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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