Amino acid dipepetide frequency for Plasmodium cynomolgi (strain B)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.055AlaAla: 3.055 ± 0.062	0.706AlaCys: 0.706 ± 0.016	2.664AlaAsp: 2.664 ± 0.045	3.264AlaGlu: 3.264 ± 0.052	1.527AlaPhe: 1.527 ± 0.026	2.516AlaGly: 2.516 ± 0.046	1.395AlaHis: 1.395 ± 0.026	2.273AlaIle: 2.273 ± 0.03	3.925AlaLys: 3.925 ± 0.047	3.373AlaLeu: 3.373 ± 0.036	0.79AlaMet: 0.79 ± 0.018	3.623AlaAsn: 3.623 ± 0.051	1.808AlaPro: 1.808 ± 0.031	1.747AlaGln: 1.747 ± 0.03	1.619AlaArg: 1.619 ± 0.027	3.7AlaSer: 3.7 ± 0.043	2.315AlaThr: 2.315 ± 0.035	2.237AlaVal: 2.237 ± 0.033	0.227AlaTrp: 0.227 ± 0.009	1.607AlaTyr: 1.607 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	1.009CysAla: 1.009 ± 0.019	0.385CysCys: 0.385 ± 0.011	1.081CysAsp: 1.081 ± 0.02	1.268CysGlu: 1.268 ± 0.023	0.87CysPhe: 0.87 ± 0.019	0.972CysGly: 0.972 ± 0.018	0.411CysHis: 0.411 ± 0.013	1.308CysIle: 1.308 ± 0.023	1.516CysLys: 1.516 ± 0.021	1.7CysLeu: 1.7 ± 0.025	0.387CysMet: 0.387 ± 0.012	1.3CysAsn: 1.3 ± 0.022	0.642CysPro: 0.642 ± 0.018	0.456CysGln: 0.456 ± 0.011	0.792CysArg: 0.792 ± 0.018	1.746CysSer: 1.746 ± 0.029	1.03CysThr: 1.03 ± 0.019	1.183CysVal: 1.183 ± 0.021	0.095CysTrp: 0.095 ± 0.005	0.771CysTyr: 0.771 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.075AspAla: 3.075 ± 0.041	0.774AspCys: 0.774 ± 0.017	4.437AspAsp: 4.437 ± 0.076	5.553AspGlu: 5.553 ± 0.069	2.198AspPhe: 2.198 ± 0.027	3.513AspGly: 3.513 ± 0.046	1.432AspHis: 1.432 ± 0.026	3.962AspIle: 3.962 ± 0.047	4.485AspLys: 4.485 ± 0.044	4.313AspLeu: 4.313 ± 0.039	1.385AspMet: 1.385 ± 0.024	3.741AspAsn: 3.741 ± 0.048	1.78AspPro: 1.78 ± 0.028	1.686AspGln: 1.686 ± 0.026	2.288AspArg: 2.288 ± 0.041	4.107AspSer: 4.107 ± 0.042	2.531AspThr: 2.531 ± 0.03	3.549AspVal: 3.549 ± 0.034	0.299AspTrp: 0.299 ± 0.012	2.294AspTyr: 2.294 ± 0.032	0.001AspXaa: 0.001 ± 0.0
Glu	3.896GluAla: 3.896 ± 0.06	1.194GluCys: 1.194 ± 0.021	4.759GluAsp: 4.759 ± 0.057	9.743GluGlu: 9.743 ± 0.127	2.099GluPhe: 2.099 ± 0.027	4.913GluGly: 4.913 ± 0.059	1.698GluHis: 1.698 ± 0.025	4.263GluIle: 4.263 ± 0.05	8.941GluLys: 8.941 ± 0.084	5.201GluLeu: 5.201 ± 0.059	1.72GluMet: 1.72 ± 0.03	5.922GluAsn: 5.922 ± 0.059	1.629GluPro: 1.629 ± 0.034	2.902GluGln: 2.902 ± 0.043	3.941GluArg: 3.941 ± 0.044	4.57GluSer: 4.57 ± 0.042	2.824GluThr: 2.824 ± 0.032	3.716GluVal: 3.716 ± 0.044	0.512GluTrp: 0.512 ± 0.016	2.601GluTyr: 2.601 ± 0.036	0.001GluXaa: 0.001 ± 0.0
Phe	1.509PheAla: 1.509 ± 0.024	1.01PheCys: 1.01 ± 0.019	2.42PheAsp: 2.42 ± 0.027	2.476PheGlu: 2.476 ± 0.031	3.223PhePhe: 3.223 ± 0.044	1.639PheGly: 1.639 ± 0.03	1.113PheHis: 1.113 ± 0.02	2.971PheIle: 2.971 ± 0.039	3.084PheLys: 3.084 ± 0.038	5.009PheLeu: 5.009 ± 0.062	0.84PheMet: 0.84 ± 0.018	2.997PheAsn: 2.997 ± 0.035	1.347PhePro: 1.347 ± 0.022	1.201PheGln: 1.201 ± 0.019	1.501PheArg: 1.501 ± 0.024	3.546PheSer: 3.546 ± 0.041	1.779PheThr: 1.779 ± 0.025	2.45PheVal: 2.45 ± 0.033	0.266PheTrp: 0.266 ± 0.01	2.421PheTyr: 2.421 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	3.409GlyAla: 3.409 ± 0.054	0.834GlyCys: 0.834 ± 0.018	3.962GlyAsp: 3.962 ± 0.056	5.904GlyGlu: 5.904 ± 0.076	1.431GlyPhe: 1.431 ± 0.026	6.962GlyGly: 6.962 ± 0.12	1.319GlyHis: 1.319 ± 0.026	2.771GlyIle: 2.771 ± 0.034	5.04GlyLys: 5.04 ± 0.048	2.848GlyLeu: 2.848 ± 0.041	1.197GlyMet: 1.197 ± 0.023	4.218GlyAsn: 4.218 ± 0.073	1.267GlyPro: 1.267 ± 0.025	1.596GlyGln: 1.596 ± 0.03	3.108GlyArg: 3.108 ± 0.053	5.569GlySer: 5.569 ± 0.084	2.975GlyThr: 2.975 ± 0.039	3.318GlyVal: 3.318 ± 0.051	0.276GlyTrp: 0.276 ± 0.011	1.653GlyTyr: 1.653 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	1.163HisAla: 1.163 ± 0.024	0.447HisCys: 0.447 ± 0.013	1.259HisAsp: 1.259 ± 0.023	1.5HisGlu: 1.5 ± 0.023	1.49HisPhe: 1.49 ± 0.027	1.382HisGly: 1.382 ± 0.03	0.848HisHis: 0.848 ± 0.022	1.782HisIle: 1.782 ± 0.028	1.846HisLys: 1.846 ± 0.026	2.62HisLeu: 2.62 ± 0.034	0.747HisMet: 0.747 ± 0.018	1.77HisAsn: 1.77 ± 0.026	1.15HisPro: 1.15 ± 0.023	0.804HisGln: 0.804 ± 0.016	1.205HisArg: 1.205 ± 0.024	2.175HisSer: 2.175 ± 0.028	1.318HisThr: 1.318 ± 0.021	1.694HisVal: 1.694 ± 0.024	0.15HisTrp: 0.15 ± 0.006	1.038HisTyr: 1.038 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	2.099IleAla: 2.099 ± 0.03	1.555IleCys: 1.555 ± 0.028	3.357IleAsp: 3.357 ± 0.042	3.806IleGlu: 3.806 ± 0.046	3.556IlePhe: 3.556 ± 0.046	2.595IleGly: 2.595 ± 0.038	1.686IleHis: 1.686 ± 0.023	4.56IleIle: 4.56 ± 0.062	5.969IleLys: 5.969 ± 0.059	6.106IleLeu: 6.106 ± 0.067	1.172IleMet: 1.172 ± 0.02	5.221IleAsn: 5.221 ± 0.048	2.145IlePro: 2.145 ± 0.031	1.936IleGln: 1.936 ± 0.028	2.393IleArg: 2.393 ± 0.033	4.778IleSer: 4.778 ± 0.046	2.721IleThr: 2.721 ± 0.033	2.904IleVal: 2.904 ± 0.036	0.441IleTrp: 0.441 ± 0.013	3.295IleTyr: 3.295 ± 0.04	0.001IleXaa: 0.001 ± 0.001
Lys	3.215LysAla: 3.215 ± 0.049	1.787LysCys: 1.787 ± 0.028	4.623LysAsp: 4.623 ± 0.052	8.007LysGlu: 8.007 ± 0.081	2.977LysPhe: 2.977 ± 0.038	5.438LysGly: 5.438 ± 0.061	2.011LysHis: 2.011 ± 0.028	6.356LysIle: 6.356 ± 0.064	13.167LysLys: 13.167 ± 0.129	6.804LysLeu: 6.804 ± 0.061	2.307LysMet: 2.307 ± 0.029	8.86LysAsn: 8.86 ± 0.083	1.73LysPro: 1.73 ± 0.026	2.782LysGln: 2.782 ± 0.034	5.074LysArg: 5.074 ± 0.059	5.725LysSer: 5.725 ± 0.055	3.672LysThr: 3.672 ± 0.031	3.933LysVal: 3.933 ± 0.036	0.784LysTrp: 0.784 ± 0.022	4.39LysTyr: 4.39 ± 0.039	0.002LysXaa: 0.002 ± 0.001
Leu	2.939LeuAla: 2.939 ± 0.033	1.941LeuCys: 1.941 ± 0.027	3.814LeuAsp: 3.814 ± 0.04	4.565LeuGlu: 4.565 ± 0.046	4.607LeuPhe: 4.607 ± 0.06	3.399LeuGly: 3.399 ± 0.037	2.489LeuHis: 2.489 ± 0.03	5.091LeuIle: 5.091 ± 0.051	7.878LeuLys: 7.878 ± 0.068	8.304LeuLeu: 8.304 ± 0.083	1.602LeuMet: 1.602 ± 0.023	6.641LeuAsn: 6.641 ± 0.06	2.76LeuPro: 2.76 ± 0.039	2.848LeuGln: 2.848 ± 0.035	3.809LeuArg: 3.809 ± 0.043	6.841LeuSer: 6.841 ± 0.055	3.602LeuThr: 3.602 ± 0.038	3.509LeuVal: 3.509 ± 0.038	0.546LeuTrp: 0.546 ± 0.013	4.101LeuTyr: 4.101 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	0.855MetAla: 0.855 ± 0.019	0.448MetCys: 0.448 ± 0.013	1.273MetAsp: 1.273 ± 0.022	1.742MetGlu: 1.742 ± 0.024	0.723MetPhe: 0.723 ± 0.015	1.274MetGly: 1.274 ± 0.026	0.673MetHis: 0.673 ± 0.015	1.086MetIle: 1.086 ± 0.021	2.264MetLys: 2.264 ± 0.026	1.672MetLeu: 1.672 ± 0.023	0.52MetMet: 0.52 ± 0.014	2.24MetAsn: 2.24 ± 0.042	0.589MetPro: 0.589 ± 0.017	0.773MetGln: 0.773 ± 0.019	0.98MetArg: 0.98 ± 0.018	1.68MetSer: 1.68 ± 0.027	0.825MetThr: 0.825 ± 0.017	0.892MetVal: 0.892 ± 0.018	0.142MetTrp: 0.142 ± 0.006	0.928MetTyr: 0.928 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.584AsnAla: 3.584 ± 0.05	1.519AsnCys: 1.519 ± 0.022	4.652AsnAsp: 4.652 ± 0.052	6.317AsnGlu: 6.317 ± 0.057	3.77AsnPhe: 3.77 ± 0.044	4.826AsnGly: 4.826 ± 0.075	1.814AsnHis: 1.814 ± 0.025	5.73AsnIle: 5.73 ± 0.064	6.599AsnLys: 6.599 ± 0.06	6.373AsnLeu: 6.373 ± 0.051	1.924AsnMet: 1.924 ± 0.032	6.46AsnAsn: 6.46 ± 0.105	2.285AsnPro: 2.285 ± 0.038	2.272AsnGln: 2.272 ± 0.029	3.282AsnArg: 3.282 ± 0.037	6.302AsnSer: 6.302 ± 0.073	3.283AsnThr: 3.283 ± 0.041	4.85AsnVal: 4.85 ± 0.045	0.461AsnTrp: 0.461 ± 0.013	3.893AsnTyr: 3.893 ± 0.045	0.001AsnXaa: 0.001 ± 0.001
Pro	1.229ProAla: 1.229 ± 0.027	0.582ProCys: 0.582 ± 0.015	1.261ProAsp: 1.261 ± 0.022	1.639ProGlu: 1.639 ± 0.029	1.601ProPhe: 1.601 ± 0.03	1.48ProGly: 1.48 ± 0.028	1.06ProHis: 1.06 ± 0.022	1.732ProIle: 1.732 ± 0.025	2.148ProLys: 2.148 ± 0.028	2.801ProLeu: 2.801 ± 0.036	0.629ProMet: 0.629 ± 0.018	2.57ProAsn: 2.57 ± 0.043	2.148ProPro: 2.148 ± 0.039	1.244ProGln: 1.244 ± 0.022	1.328ProArg: 1.328 ± 0.021	3.088ProSer: 3.088 ± 0.037	1.657ProThr: 1.657 ± 0.028	1.513ProVal: 1.513 ± 0.024	0.202ProTrp: 0.202 ± 0.008	1.257ProTyr: 1.257 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	1.265GlnAla: 1.265 ± 0.021	0.481GlnCys: 0.481 ± 0.014	1.35GlnAsp: 1.35 ± 0.024	2.239GlnGlu: 2.239 ± 0.031	1.137GlnPhe: 1.137 ± 0.023	1.936GlnGly: 1.936 ± 0.031	0.863GlnHis: 0.863 ± 0.019	2.088GlnIle: 2.088 ± 0.026	3.262GlnLys: 3.262 ± 0.045	2.627GlnLeu: 2.627 ± 0.03	0.991GlnMet: 0.991 ± 0.019	2.977GlnAsn: 2.977 ± 0.036	0.993GlnPro: 0.993 ± 0.026	1.388GlnGln: 1.388 ± 0.037	1.684GlnArg: 1.684 ± 0.031	2.258GlnSer: 2.258 ± 0.033	1.481GlnThr: 1.481 ± 0.024	1.653GlnVal: 1.653 ± 0.026	0.248GlnTrp: 0.248 ± 0.011	1.057GlnTyr: 1.057 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	1.768ArgAla: 1.768 ± 0.028	0.799ArgCys: 0.799 ± 0.016	2.734ArgAsp: 2.734 ± 0.043	3.726ArgGlu: 3.726 ± 0.049	1.328ArgPhe: 1.328 ± 0.02	3.591ArgGly: 3.591 ± 0.055	1.093ArgHis: 1.093 ± 0.023	2.495ArgIle: 2.495 ± 0.034	4.993ArgLys: 4.993 ± 0.06	2.686ArgLeu: 2.686 ± 0.036	0.928ArgMet: 0.928 ± 0.02	3.741ArgAsn: 3.741 ± 0.038	0.93ArgPro: 0.93 ± 0.02	1.283ArgGln: 1.283 ± 0.022	3.433ArgArg: 3.433 ± 0.061	4.004ArgSer: 4.004 ± 0.056	2.031ArgThr: 2.031 ± 0.026	2.197ArgVal: 2.197 ± 0.03	0.275ArgTrp: 0.275 ± 0.009	1.57ArgTyr: 1.57 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	3.919SerAla: 3.919 ± 0.047	1.514SerCys: 1.514 ± 0.022	4.611SerAsp: 4.611 ± 0.05	5.125SerGlu: 5.125 ± 0.046	3.595SerPhe: 3.595 ± 0.038	5.603SerGly: 5.603 ± 0.085	2.148SerHis: 2.148 ± 0.03	4.628SerIle: 4.628 ± 0.043	5.95SerLys: 5.95 ± 0.052	6.195SerLeu: 6.195 ± 0.049	1.53SerMet: 1.53 ± 0.024	6.231SerAsn: 6.231 ± 0.074	2.784SerPro: 2.784 ± 0.041	2.319SerGln: 2.319 ± 0.03	3.389SerArg: 3.389 ± 0.044	8.395SerSer: 8.395 ± 0.1	3.999SerThr: 3.999 ± 0.037	4.12SerVal: 4.12 ± 0.037	0.425SerTrp: 0.425 ± 0.012	3.339SerTyr: 3.339 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	2.083ThrAla: 2.083 ± 0.037	0.937ThrCys: 0.937 ± 0.018	2.515ThrAsp: 2.515 ± 0.035	2.801ThrGlu: 2.801 ± 0.039	2.025ThrPhe: 2.025 ± 0.028	2.252ThrGly: 2.252 ± 0.029	1.511ThrHis: 1.511 ± 0.026	2.551ThrIle: 2.551 ± 0.033	3.708ThrLys: 3.708 ± 0.039	3.713ThrLeu: 3.713 ± 0.038	0.798ThrMet: 0.798 ± 0.016	3.882ThrAsn: 3.882 ± 0.045	2.075ThrPro: 2.075 ± 0.03	1.644ThrGln: 1.644 ± 0.026	1.67ThrArg: 1.67 ± 0.026	3.815ThrSer: 3.815 ± 0.04	2.405ThrThr: 2.405 ± 0.036	2.204ThrVal: 2.204 ± 0.028	0.32ThrTrp: 0.32 ± 0.01	2.062ThrTyr: 2.062 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	2.276ValAla: 2.276 ± 0.032	1.068ValCys: 1.068 ± 0.021	3.317ValAsp: 3.317 ± 0.043	4.005ValGlu: 4.005 ± 0.051	1.966ValPhe: 1.966 ± 0.027	3.074ValGly: 3.074 ± 0.046	1.628ValHis: 1.628 ± 0.025	2.97ValIle: 2.97 ± 0.036	4.721ValLys: 4.721 ± 0.043	4.291ValLeu: 4.291 ± 0.051	0.962ValMet: 0.962 ± 0.017	3.957ValAsn: 3.957 ± 0.04	1.782ValPro: 1.782 ± 0.033	1.817ValGln: 1.817 ± 0.025	2.193ValArg: 2.193 ± 0.032	4.009ValSer: 4.009 ± 0.039	2.387ValThr: 2.387 ± 0.027	2.727ValVal: 2.727 ± 0.033	0.286ValTrp: 0.286 ± 0.01	2.172ValTyr: 2.172 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	0.238TrpAla: 0.238 ± 0.008	0.136TrpCys: 0.136 ± 0.006	0.373TrpAsp: 0.373 ± 0.011	0.434TrpGlu: 0.434 ± 0.014	0.246TrpPhe: 0.246 ± 0.01	0.464TrpGly: 0.464 ± 0.013	0.129TrpHis: 0.129 ± 0.006	0.444TrpIle: 0.444 ± 0.014	0.695TrpLys: 0.695 ± 0.018	0.542TrpLeu: 0.542 ± 0.015	0.152TrpMet: 0.152 ± 0.007	0.503TrpAsn: 0.503 ± 0.014	0.145TrpPro: 0.145 ± 0.008	0.143TrpGln: 0.143 ± 0.006	0.335TrpArg: 0.335 ± 0.011	0.465TrpSer: 0.465 ± 0.013	0.261TrpThr: 0.261 ± 0.009	0.368TrpVal: 0.368 ± 0.01	0.054TrpTrp: 0.054 ± 0.004	0.191TrpTyr: 0.191 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.784TyrAla: 1.784 ± 0.026	0.805TyrCys: 0.805 ± 0.017	2.942TyrAsp: 2.942 ± 0.035	2.932TyrGlu: 2.932 ± 0.035	2.432TyrPhe: 2.432 ± 0.037	1.825TyrGly: 1.825 ± 0.031	1.068TyrHis: 1.068 ± 0.018	3.233TyrIle: 3.233 ± 0.043	3.452TyrLys: 3.452 ± 0.041	4.11TyrLeu: 4.11 ± 0.047	0.996TyrMet: 0.996 ± 0.019	3.344TyrAsn: 3.344 ± 0.041	1.18TyrPro: 1.18 ± 0.024	1.134TyrGln: 1.134 ± 0.019	1.581TyrArg: 1.581 ± 0.023	3.049TyrSer: 3.049 ± 0.032	1.876TyrThr: 1.876 ± 0.023	2.591TyrVal: 2.591 ± 0.033	0.308TyrTrp: 0.308 ± 0.01	2.232TyrTyr: 2.232 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.056XaaXaa: 0.056 ± 0.028

Statistics based on 5713 proteins (3284714 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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