Amino acid dipepetide frequency for Proteus mirabilis (strain HI4320)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.329AlaAla: 6.329 ± 0.113	0.922AlaCys: 0.922 ± 0.033	4.284AlaAsp: 4.284 ± 0.062	4.766AlaGlu: 4.766 ± 0.093	3.275AlaPhe: 3.275 ± 0.052	5.802AlaGly: 5.802 ± 0.092	1.493AlaHis: 1.493 ± 0.037	6.446AlaIle: 6.446 ± 0.086	4.696AlaLys: 4.696 ± 0.067	9.501AlaLeu: 9.501 ± 0.115	2.389AlaMet: 2.389 ± 0.053	3.478AlaAsn: 3.478 ± 0.064	2.87AlaPro: 2.87 ± 0.049	4.163AlaGln: 4.163 ± 0.067	3.599AlaArg: 3.599 ± 0.069	4.729AlaSer: 4.729 ± 0.072	4.372AlaThr: 4.372 ± 0.064	5.104AlaVal: 5.104 ± 0.067	0.959AlaTrp: 0.959 ± 0.033	2.305AlaTyr: 2.305 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.852CysAla: 0.852 ± 0.028	0.193CysCys: 0.193 ± 0.014	0.611CysAsp: 0.611 ± 0.023	0.592CysGlu: 0.592 ± 0.023	0.477CysPhe: 0.477 ± 0.022	0.939CysGly: 0.939 ± 0.033	0.347CysHis: 0.347 ± 0.019	0.652CysIle: 0.652 ± 0.025	0.388CysLys: 0.388 ± 0.019	1.012CysLeu: 1.012 ± 0.036	0.224CysMet: 0.224 ± 0.015	0.378CysAsn: 0.378 ± 0.016	0.478CysPro: 0.478 ± 0.024	0.575CysGln: 0.575 ± 0.021	0.516CysArg: 0.516 ± 0.023	0.663CysSer: 0.663 ± 0.027	0.508CysThr: 0.508 ± 0.023	0.699CysVal: 0.699 ± 0.025	0.173CysTrp: 0.173 ± 0.012	0.402CysTyr: 0.402 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.031AspAla: 4.031 ± 0.065	0.531AspCys: 0.531 ± 0.021	2.814AspAsp: 2.814 ± 0.059	3.68AspGlu: 3.68 ± 0.063	2.274AspPhe: 2.274 ± 0.046	3.291AspGly: 3.291 ± 0.056	0.902AspHis: 0.902 ± 0.028	4.423AspIle: 4.423 ± 0.071	3.601AspLys: 3.601 ± 0.066	4.614AspLeu: 4.614 ± 0.067	1.315AspMet: 1.315 ± 0.04	3.023AspAsn: 3.023 ± 0.06	2.052AspPro: 2.052 ± 0.044	1.419AspGln: 1.419 ± 0.033	2.067AspArg: 2.067 ± 0.042	2.934AspSer: 2.934 ± 0.053	2.469AspThr: 2.469 ± 0.046	3.364AspVal: 3.364 ± 0.052	0.725AspTrp: 0.725 ± 0.026	2.096AspTyr: 2.096 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.452GluAla: 4.452 ± 0.082	0.519GluCys: 0.519 ± 0.022	2.555GluAsp: 2.555 ± 0.05	3.537GluGlu: 3.537 ± 0.074	1.974GluPhe: 1.974 ± 0.044	3.537GluGly: 3.537 ± 0.062	1.419GluHis: 1.419 ± 0.039	4.227GluIle: 4.227 ± 0.06	4.499GluLys: 4.499 ± 0.071	6.084GluLeu: 6.084 ± 0.082	1.74GluMet: 1.74 ± 0.045	3.184GluAsn: 3.184 ± 0.055	1.894GluPro: 1.894 ± 0.044	3.66GluGln: 3.66 ± 0.06	3.18GluArg: 3.18 ± 0.064	2.986GluSer: 2.986 ± 0.049	3.135GluThr: 3.135 ± 0.051	3.613GluVal: 3.613 ± 0.073	0.75GluTrp: 0.75 ± 0.027	1.851GluTyr: 1.851 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.244PheAla: 3.244 ± 0.061	0.524PheCys: 0.524 ± 0.021	2.471PheAsp: 2.471 ± 0.049	2.019PheGlu: 2.019 ± 0.037	1.987PhePhe: 1.987 ± 0.052	2.869PheGly: 2.869 ± 0.058	0.82PheHis: 0.82 ± 0.031	3.378PheIle: 3.378 ± 0.071	1.891PheLys: 1.891 ± 0.038	3.598PheLeu: 3.598 ± 0.066	1.084PheMet: 1.084 ± 0.031	2.22PheAsn: 2.22 ± 0.042	1.511PhePro: 1.511 ± 0.036	1.219PheGln: 1.219 ± 0.032	1.598PheArg: 1.598 ± 0.04	3.595PheSer: 3.595 ± 0.066	2.441PheThr: 2.441 ± 0.045	2.434PheVal: 2.434 ± 0.048	0.558PheTrp: 0.558 ± 0.021	1.491PheTyr: 1.491 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.103GlyAla: 5.103 ± 0.089	0.899GlyCys: 0.899 ± 0.035	3.381GlyAsp: 3.381 ± 0.06	4.033GlyGlu: 4.033 ± 0.064	3.055GlyPhe: 3.055 ± 0.052	4.663GlyGly: 4.663 ± 0.094	1.525GlyHis: 1.525 ± 0.043	5.313GlyIle: 5.313 ± 0.07	4.178GlyLys: 4.178 ± 0.067	6.593GlyLeu: 6.593 ± 0.095	1.991GlyMet: 1.991 ± 0.04	2.857GlyAsn: 2.857 ± 0.072	1.554GlyPro: 1.554 ± 0.037	2.642GlyGln: 2.642 ± 0.05	3.094GlyArg: 3.094 ± 0.053	3.829GlySer: 3.829 ± 0.061	3.342GlyThr: 3.342 ± 0.06	4.803GlyVal: 4.803 ± 0.068	0.994GlyTrp: 0.994 ± 0.031	2.622GlyTyr: 2.622 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.574HisAla: 1.574 ± 0.036	0.34HisCys: 0.34 ± 0.017	1.042HisAsp: 1.042 ± 0.038	1.08HisGlu: 1.08 ± 0.034	1.156HisPhe: 1.156 ± 0.032	1.376HisGly: 1.376 ± 0.04	0.812HisHis: 0.812 ± 0.031	1.568HisIle: 1.568 ± 0.039	0.985HisLys: 0.985 ± 0.03	2.192HisLeu: 2.192 ± 0.043	0.431HisMet: 0.431 ± 0.019	0.932HisAsn: 0.932 ± 0.032	1.147HisPro: 1.147 ± 0.035	1.298HisGln: 1.298 ± 0.034	1.059HisArg: 1.059 ± 0.031	1.378HisSer: 1.378 ± 0.032	1.073HisThr: 1.073 ± 0.029	1.204HisVal: 1.204 ± 0.033	0.379HisTrp: 0.379 ± 0.019	1.043HisTyr: 1.043 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.727IleAla: 6.727 ± 0.103	0.78IleCys: 0.78 ± 0.027	4.333IleAsp: 4.333 ± 0.054	4.727IleGlu: 4.727 ± 0.061	2.751IlePhe: 2.751 ± 0.061	5.023IleGly: 5.023 ± 0.083	1.39IleHis: 1.39 ± 0.04	5.287IleIle: 5.287 ± 0.091	4.031IleLys: 4.031 ± 0.07	6.242IleLeu: 6.242 ± 0.087	1.572IleMet: 1.572 ± 0.04	4.185IleAsn: 4.185 ± 0.08	3.199IlePro: 3.199 ± 0.058	2.448IleGln: 2.448 ± 0.045	3.149IleArg: 3.149 ± 0.057	5.242IleSer: 5.242 ± 0.077	4.546IleThr: 4.546 ± 0.074	4.324IleVal: 4.324 ± 0.075	0.757IleTrp: 0.757 ± 0.026	2.272IleTyr: 2.272 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.655LysAla: 4.655 ± 0.08	0.364LysCys: 0.364 ± 0.019	2.764LysAsp: 2.764 ± 0.059	3.913LysGlu: 3.913 ± 0.06	1.453LysPhe: 1.453 ± 0.038	3.585LysGly: 3.585 ± 0.061	1.101LysHis: 1.101 ± 0.033	3.844LysIle: 3.844 ± 0.067	3.782LysLys: 3.782 ± 0.082	5.509LysLeu: 5.509 ± 0.08	1.639LysMet: 1.639 ± 0.04	3.016LysAsn: 3.016 ± 0.059	2.325LysPro: 2.325 ± 0.055	3.083LysGln: 3.083 ± 0.058	2.752LysArg: 2.752 ± 0.047	3.146LysSer: 3.146 ± 0.056	3.241LysThr: 3.241 ± 0.056	3.56LysVal: 3.56 ± 0.066	0.599LysTrp: 0.599 ± 0.023	1.629LysTyr: 1.629 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	9.525LeuAla: 9.525 ± 0.11	1.191LeuCys: 1.191 ± 0.036	5.218LeuAsp: 5.218 ± 0.072	5.343LeuGlu: 5.343 ± 0.075	4.526LeuPhe: 4.526 ± 0.077	6.596LeuGly: 6.596 ± 0.083	1.982LeuHis: 1.982 ± 0.041	7.087LeuIle: 7.087 ± 0.097	5.502LeuLys: 5.502 ± 0.074	11.061LeuLeu: 11.061 ± 0.146	2.648LeuMet: 2.648 ± 0.051	4.83LeuAsn: 4.83 ± 0.067	5.149LeuPro: 5.149 ± 0.071	3.801LeuGln: 3.801 ± 0.068	4.838LeuArg: 4.838 ± 0.06	8.096LeuSer: 8.096 ± 0.084	6.464LeuThr: 6.464 ± 0.094	6.17LeuVal: 6.17 ± 0.087	1.166LeuTrp: 1.166 ± 0.034	2.987LeuTyr: 2.987 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.457MetAla: 2.457 ± 0.051	0.199MetCys: 0.199 ± 0.014	1.216MetAsp: 1.216 ± 0.029	1.236MetGlu: 1.236 ± 0.03	0.822MetPhe: 0.822 ± 0.029	1.8MetGly: 1.8 ± 0.048	0.434MetHis: 0.434 ± 0.018	1.7MetIle: 1.7 ± 0.041	1.609MetLys: 1.609 ± 0.036	2.729MetLeu: 2.729 ± 0.056	0.81MetMet: 0.81 ± 0.03	1.239MetAsn: 1.239 ± 0.037	1.183MetPro: 1.183 ± 0.036	1.043MetGln: 1.043 ± 0.026	1.244MetArg: 1.244 ± 0.033	1.902MetSer: 1.902 ± 0.042	1.68MetThr: 1.68 ± 0.039	1.71MetVal: 1.71 ± 0.046	0.235MetTrp: 0.235 ± 0.015	0.58MetTyr: 0.58 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.638AsnAla: 3.638 ± 0.064	0.422AsnCys: 0.422 ± 0.021	2.492AsnAsp: 2.492 ± 0.05	2.792AsnGlu: 2.792 ± 0.061	1.596AsnPhe: 1.596 ± 0.044	3.061AsnGly: 3.061 ± 0.061	1.083AsnHis: 1.083 ± 0.032	3.823AsnIle: 3.823 ± 0.082	3.126AsnLys: 3.126 ± 0.064	4.082AsnLeu: 4.082 ± 0.069	1.14AsnMet: 1.14 ± 0.03	2.855AsnAsn: 2.855 ± 0.072	2.047AsnPro: 2.047 ± 0.04	2.288AsnGln: 2.288 ± 0.042	2.06AsnArg: 2.06 ± 0.047	2.95AsnSer: 2.95 ± 0.057	2.655AsnThr: 2.655 ± 0.057	2.656AsnVal: 2.656 ± 0.052	0.591AsnTrp: 0.591 ± 0.021	1.699AsnTyr: 1.699 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.329ProAla: 3.329 ± 0.06	0.357ProCys: 0.357 ± 0.018	2.43ProAsp: 2.43 ± 0.049	3.139ProGlu: 3.139 ± 0.053	1.834ProPhe: 1.834 ± 0.043	2.196ProGly: 2.196 ± 0.055	0.933ProHis: 0.933 ± 0.031	2.933ProIle: 2.933 ± 0.049	2.0ProLys: 2.0 ± 0.048	4.392ProLeu: 4.392 ± 0.064	0.979ProMet: 0.979 ± 0.029	1.769ProAsn: 1.769 ± 0.042	1.326ProPro: 1.326 ± 0.04	1.808ProGln: 1.808 ± 0.042	1.458ProArg: 1.458 ± 0.036	2.372ProSer: 2.372 ± 0.042	2.308ProThr: 2.308 ± 0.046	3.052ProVal: 3.052 ± 0.059	0.523ProTrp: 0.523 ± 0.023	1.436ProTyr: 1.436 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.207GlnAla: 4.207 ± 0.08	0.461GlnCys: 0.461 ± 0.023	1.904GlnAsp: 1.904 ± 0.049	2.528GlnGlu: 2.528 ± 0.051	1.797GlnPhe: 1.797 ± 0.04	3.058GlnGly: 3.058 ± 0.053	1.198GlnHis: 1.198 ± 0.039	2.828GlnIle: 2.828 ± 0.052	2.439GlnLys: 2.439 ± 0.051	5.354GlnLeu: 5.354 ± 0.074	1.083GlnMet: 1.083 ± 0.029	1.723GlnAsn: 1.723 ± 0.046	1.884GlnPro: 1.884 ± 0.041	3.534GlnGln: 3.534 ± 0.079	2.68GlnArg: 2.68 ± 0.049	2.729GlnSer: 2.729 ± 0.054	2.241GlnThr: 2.241 ± 0.043	2.876GlnVal: 2.876 ± 0.05	0.78GlnTrp: 0.78 ± 0.028	1.569GlnTyr: 1.569 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.214ArgAla: 3.214 ± 0.061	0.484ArgCys: 0.484 ± 0.02	2.323ArgAsp: 2.323 ± 0.049	2.978ArgGlu: 2.978 ± 0.057	2.383ArgPhe: 2.383 ± 0.045	2.624ArgGly: 2.624 ± 0.053	1.279ArgHis: 1.279 ± 0.033	3.34ArgIle: 3.34 ± 0.052	2.561ArgLys: 2.561 ± 0.043	5.197ArgLeu: 5.197 ± 0.077	1.195ArgMet: 1.195 ± 0.032	1.991ArgAsn: 1.991 ± 0.041	1.744ArgPro: 1.744 ± 0.039	2.651ArgGln: 2.651 ± 0.054	2.604ArgArg: 2.604 ± 0.059	2.391ArgSer: 2.391 ± 0.043	2.086ArgThr: 2.086 ± 0.048	2.936ArgVal: 2.936 ± 0.051	0.687ArgTrp: 0.687 ± 0.026	2.155ArgTyr: 2.155 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.163SerAla: 5.163 ± 0.08	0.656SerCys: 0.656 ± 0.025	3.289SerAsp: 3.289 ± 0.062	3.545SerGlu: 3.545 ± 0.062	2.68SerPhe: 2.68 ± 0.053	4.763SerGly: 4.763 ± 0.069	1.612SerHis: 1.612 ± 0.039	4.347SerIle: 4.347 ± 0.063	2.877SerLys: 2.877 ± 0.054	7.308SerLeu: 7.308 ± 0.087	1.569SerMet: 1.569 ± 0.037	2.401SerAsn: 2.401 ± 0.05	2.675SerPro: 2.675 ± 0.045	3.165SerGln: 3.165 ± 0.059	3.02SerArg: 3.02 ± 0.059	4.105SerSer: 4.105 ± 0.075	3.318SerThr: 3.318 ± 0.054	4.093SerVal: 4.093 ± 0.069	0.905SerTrp: 0.905 ± 0.028	2.12SerTyr: 2.12 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.355ThrAla: 4.355 ± 0.064	0.511ThrCys: 0.511 ± 0.022	2.752ThrAsp: 2.752 ± 0.049	3.17ThrGlu: 3.17 ± 0.053	2.202ThrPhe: 2.202 ± 0.037	3.983ThrGly: 3.983 ± 0.064	1.323ThrHis: 1.323 ± 0.036	3.872ThrIle: 3.872 ± 0.053	2.389ThrLys: 2.389 ± 0.051	6.89ThrLeu: 6.89 ± 0.08	1.09ThrMet: 1.09 ± 0.032	2.121ThrAsn: 2.121 ± 0.047	3.079ThrPro: 3.079 ± 0.054	2.802ThrGln: 2.802 ± 0.056	2.403ThrArg: 2.403 ± 0.05	3.168ThrSer: 3.168 ± 0.049	3.123ThrThr: 3.123 ± 0.058	3.574ThrVal: 3.574 ± 0.059	0.605ThrTrp: 0.605 ± 0.024	1.581ThrTyr: 1.581 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.513ValAla: 5.513 ± 0.07	0.712ValCys: 0.712 ± 0.024	3.488ValAsp: 3.488 ± 0.056	3.639ValGlu: 3.639 ± 0.066	2.499ValPhe: 2.499 ± 0.049	4.244ValGly: 4.244 ± 0.074	1.076ValHis: 1.076 ± 0.026	5.008ValIle: 5.008 ± 0.069	3.376ValLys: 3.376 ± 0.057	6.205ValLeu: 6.205 ± 0.094	1.892ValMet: 1.892 ± 0.041	2.913ValAsn: 2.913 ± 0.052	2.473ValPro: 2.473 ± 0.047	1.952ValGln: 1.952 ± 0.039	2.731ValArg: 2.731 ± 0.051	4.444ValSer: 4.444 ± 0.065	3.903ValThr: 3.903 ± 0.068	4.445ValVal: 4.445 ± 0.078	0.704ValTrp: 0.704 ± 0.024	1.791ValTyr: 1.791 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.785TrpAla: 0.785 ± 0.027	0.166TrpCys: 0.166 ± 0.011	0.598TrpAsp: 0.598 ± 0.024	0.607TrpGlu: 0.607 ± 0.026	0.578TrpPhe: 0.578 ± 0.024	0.796TrpGly: 0.796 ± 0.029	0.389TrpHis: 0.389 ± 0.019	0.8TrpIle: 0.8 ± 0.028	0.614TrpLys: 0.614 ± 0.022	1.874TrpLeu: 1.874 ± 0.05	0.357TrpMet: 0.357 ± 0.017	0.474TrpAsn: 0.474 ± 0.022	0.432TrpPro: 0.432 ± 0.022	1.024TrpGln: 1.024 ± 0.03	0.777TrpArg: 0.777 ± 0.028	0.728TrpSer: 0.728 ± 0.027	0.438TrpThr: 0.438 ± 0.019	0.749TrpVal: 0.749 ± 0.025	0.182TrpTrp: 0.182 ± 0.015	0.391TrpTyr: 0.391 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.328TyrAla: 2.328 ± 0.05	0.448TyrCys: 0.448 ± 0.02	1.662TyrAsp: 1.662 ± 0.044	1.469TyrGlu: 1.469 ± 0.038	1.632TyrPhe: 1.632 ± 0.039	2.262TyrGly: 2.262 ± 0.056	0.952TyrHis: 0.952 ± 0.031	2.107TyrIle: 2.107 ± 0.042	1.419TyrLys: 1.419 ± 0.036	3.744TyrLeu: 3.744 ± 0.065	0.68TyrMet: 0.68 ± 0.024	1.466TyrAsn: 1.466 ± 0.044	1.553TyrPro: 1.553 ± 0.04	2.301TyrGln: 2.301 ± 0.057	1.998TyrArg: 1.998 ± 0.041	2.224TyrSer: 2.224 ± 0.044	1.651TyrThr: 1.651 ± 0.044	1.64TyrVal: 1.64 ± 0.034	0.485TyrTrp: 0.485 ± 0.024	1.255TyrTyr: 1.255 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3661 proteins (1149705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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