Amino acid dipepetide frequency for Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.028AlaAla: 4.028 ± 0.156
1.021AlaCys: 1.021 ± 0.063
2.591AlaAsp: 2.591 ± 0.104
2.794AlaGlu: 2.794 ± 0.105
2.21AlaPhe: 2.21 ± 0.115
3.209AlaGly: 3.209 ± 0.125
1.205AlaHis: 1.205 ± 0.061
5.326AlaIle: 5.326 ± 0.155
3.77AlaLys: 3.77 ± 0.125
5.484AlaLeu: 5.484 ± 0.13
1.44AlaMet: 1.44 ± 0.073
2.645AlaAsn: 2.645 ± 0.111
1.315AlaPro: 1.315 ± 0.072
1.811AlaGln: 1.811 ± 0.08
2.149AlaArg: 2.149 ± 0.081
4.06AlaSer: 4.06 ± 0.153
2.497AlaThr: 2.497 ± 0.09
3.973AlaVal: 3.973 ± 0.144
0.316AlaTrp: 0.316 ± 0.038
1.859AlaTyr: 1.859 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.896CysAla: 0.896 ± 0.065
0.403CysCys: 0.403 ± 0.045
0.983CysAsp: 0.983 ± 0.062
0.738CysGlu: 0.738 ± 0.056
0.799CysPhe: 0.799 ± 0.053
1.086CysGly: 1.086 ± 0.066
0.396CysHis: 0.396 ± 0.041
1.65CysIle: 1.65 ± 0.08
1.021CysLys: 1.021 ± 0.058
1.369CysLeu: 1.369 ± 0.077
0.335CysMet: 0.335 ± 0.027
1.199CysAsn: 1.199 ± 0.063
0.432CysPro: 0.432 ± 0.04
0.464CysGln: 0.464 ± 0.041
0.635CysArg: 0.635 ± 0.046
1.324CysSer: 1.324 ± 0.066
0.87CysThr: 0.87 ± 0.048
1.17CysVal: 1.17 ± 0.07
0.106CysTrp: 0.106 ± 0.02
0.818CysTyr: 0.818 ± 0.053
0.0CysXaa: 0.0 ± 0.0
Asp
2.71AspAla: 2.71 ± 0.106
0.715AspCys: 0.715 ± 0.052
3.109AspAsp: 3.109 ± 0.184
2.929AspGlu: 2.929 ± 0.145
2.787AspPhe: 2.787 ± 0.11
2.742AspGly: 2.742 ± 0.112
0.934AspHis: 0.934 ± 0.052
6.193AspIle: 6.193 ± 0.163
4.118AspLys: 4.118 ± 0.128
4.707AspLeu: 4.707 ± 0.127
1.253AspMet: 1.253 ± 0.075
3.831AspAsn: 3.831 ± 0.138
1.54AspPro: 1.54 ± 0.076
1.795AspGln: 1.795 ± 0.11
1.592AspArg: 1.592 ± 0.072
3.883AspSer: 3.883 ± 0.185
2.919AspThr: 2.919 ± 0.152
4.06AspVal: 4.06 ± 0.198
0.374AspTrp: 0.374 ± 0.039
2.149AspTyr: 2.149 ± 0.102
0.0AspXaa: 0.0 ± 0.0
Glu
2.922GluAla: 2.922 ± 0.112
0.831GluCys: 0.831 ± 0.054
3.209GluAsp: 3.209 ± 0.152
4.179GluGlu: 4.179 ± 0.172
2.368GluPhe: 2.368 ± 0.088
2.707GluGly: 2.707 ± 0.167
1.424GluHis: 1.424 ± 0.096
5.255GluIle: 5.255 ± 0.154
4.308GluLys: 4.308 ± 0.157
5.117GluLeu: 5.117 ± 0.156
1.408GluMet: 1.408 ± 0.072
3.557GluAsn: 3.557 ± 0.112
1.205GluPro: 1.205 ± 0.074
1.982GluGln: 1.982 ± 0.107
2.011GluArg: 2.011 ± 0.088
3.918GluSer: 3.918 ± 0.162
2.075GluThr: 2.075 ± 0.08
3.866GluVal: 3.866 ± 0.111
0.319GluTrp: 0.319 ± 0.035
2.281GluTyr: 2.281 ± 0.091
0.0GluXaa: 0.0 ± 0.0
Phe
2.484PheAla: 2.484 ± 0.097
0.947PheCys: 0.947 ± 0.058
2.384PheAsp: 2.384 ± 0.101
1.791PheGlu: 1.791 ± 0.076
2.594PhePhe: 2.594 ± 0.125
2.655PheGly: 2.655 ± 0.111
0.967PheHis: 0.967 ± 0.056
4.717PheIle: 4.717 ± 0.164
2.413PheLys: 2.413 ± 0.095
4.369PheLeu: 4.369 ± 0.155
1.102PheMet: 1.102 ± 0.055
3.061PheAsn: 3.061 ± 0.113
1.543PhePro: 1.543 ± 0.085
1.157PheGln: 1.157 ± 0.057
1.282PheArg: 1.282 ± 0.063
4.256PheSer: 4.256 ± 0.145
2.52PheThr: 2.52 ± 0.096
2.881PheVal: 2.881 ± 0.118
0.351PheTrp: 0.351 ± 0.043
1.94PheTyr: 1.94 ± 0.103
0.0PheXaa: 0.0 ± 0.0
Gly
3.035GlyAla: 3.035 ± 0.128
0.98GlyCys: 0.98 ± 0.058
2.884GlyAsp: 2.884 ± 0.167
2.777GlyGlu: 2.777 ± 0.103
2.349GlyPhe: 2.349 ± 0.1
3.686GlyGly: 3.686 ± 0.161
1.141GlyHis: 1.141 ± 0.054
5.764GlyIle: 5.764 ± 0.153
4.301GlyLys: 4.301 ± 0.139
4.769GlyLeu: 4.769 ± 0.139
1.498GlyMet: 1.498 ± 0.07
3.29GlyAsn: 3.29 ± 0.119
1.273GlyPro: 1.273 ± 0.069
1.714GlyGln: 1.714 ± 0.086
2.049GlyArg: 2.049 ± 0.095
3.947GlySer: 3.947 ± 0.113
2.623GlyThr: 2.623 ± 0.099
4.082GlyVal: 4.082 ± 0.142
0.454GlyTrp: 0.454 ± 0.04
2.394GlyTyr: 2.394 ± 0.096
0.0GlyXaa: 0.0 ± 0.0
His
1.263HisAla: 1.263 ± 0.065
0.361HisCys: 0.361 ± 0.036
1.286HisAsp: 1.286 ± 0.082
1.066HisGlu: 1.066 ± 0.083
0.98HisPhe: 0.98 ± 0.047
1.311HisGly: 1.311 ± 0.065
0.493HisHis: 0.493 ± 0.044
2.094HisIle: 2.094 ± 0.086
1.553HisLys: 1.553 ± 0.067
1.962HisLeu: 1.962 ± 0.083
0.528HisMet: 0.528 ± 0.047
1.875HisAsn: 1.875 ± 0.089
0.818HisPro: 0.818 ± 0.056
0.693HisGln: 0.693 ± 0.05
0.757HisArg: 0.757 ± 0.056
1.453HisSer: 1.453 ± 0.069
1.099HisThr: 1.099 ± 0.058
1.482HisVal: 1.482 ± 0.075
0.177HisTrp: 0.177 ± 0.023
0.989HisTyr: 0.989 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
5.97IleAla: 5.97 ± 0.176
1.701IleCys: 1.701 ± 0.071
5.352IleAsp: 5.352 ± 0.171
5.645IleGlu: 5.645 ± 0.128
4.189IlePhe: 4.189 ± 0.13
5.361IleGly: 5.361 ± 0.158
1.866IleHis: 1.866 ± 0.094
9.096IleIle: 9.096 ± 0.239
7.217IleLys: 7.217 ± 0.184
9.093IleLeu: 9.093 ± 0.246
2.304IleMet: 2.304 ± 0.112
6.219IleAsn: 6.219 ± 0.175
3.586IlePro: 3.586 ± 0.121
2.819IleGln: 2.819 ± 0.098
3.39IleArg: 3.39 ± 0.104
8.616IleSer: 8.616 ± 0.198
5.184IleThr: 5.184 ± 0.162
6.27IleVal: 6.27 ± 0.173
0.48IleTrp: 0.48 ± 0.046
3.109IleTyr: 3.109 ± 0.12
0.0IleXaa: 0.0 ± 0.0
Lys
3.412LysAla: 3.412 ± 0.118
0.973LysCys: 0.973 ± 0.063
3.908LysAsp: 3.908 ± 0.137
4.55LysGlu: 4.55 ± 0.161
3.235LysPhe: 3.235 ± 0.111
3.08LysGly: 3.08 ± 0.105
1.714LysHis: 1.714 ± 0.07
7.314LysIle: 7.314 ± 0.201
6.103LysLys: 6.103 ± 0.182
7.192LysLeu: 7.192 ± 0.195
1.824LysMet: 1.824 ± 0.081
5.065LysAsn: 5.065 ± 0.145
1.83LysPro: 1.83 ± 0.081
2.562LysGln: 2.562 ± 0.094
2.481LysArg: 2.481 ± 0.104
5.233LysSer: 5.233 ± 0.134
3.125LysThr: 3.125 ± 0.106
5.184LysVal: 5.184 ± 0.136
0.422LysTrp: 0.422 ± 0.039
3.129LysTyr: 3.129 ± 0.107
0.0LysXaa: 0.0 ± 0.0
Leu
4.759LeuAla: 4.759 ± 0.135
1.878LeuCys: 1.878 ± 0.077
4.956LeuAsp: 4.956 ± 0.148
5.01LeuGlu: 5.01 ± 0.146
4.247LeuPhe: 4.247 ± 0.161
5.097LeuGly: 5.097 ± 0.132
2.449LeuHis: 2.449 ± 0.111
8.045LeuIle: 8.045 ± 0.2
6.673LeuLys: 6.673 ± 0.174
10.488LeuLeu: 10.488 ± 0.262
2.359LeuMet: 2.359 ± 0.101
5.548LeuAsn: 5.548 ± 0.138
3.68LeuPro: 3.68 ± 0.109
3.477LeuGln: 3.477 ± 0.146
3.651LeuArg: 3.651 ± 0.113
9.086LeuSer: 9.086 ± 0.204
4.221LeuThr: 4.221 ± 0.148
5.39LeuVal: 5.39 ± 0.15
0.696LeuTrp: 0.696 ± 0.051
3.799LeuTyr: 3.799 ± 0.11
0.0LeuXaa: 0.0 ± 0.0
Met
1.25MetAla: 1.25 ± 0.071
0.467MetCys: 0.467 ± 0.039
0.986MetAsp: 0.986 ± 0.06
1.047MetGlu: 1.047 ± 0.064
1.25MetPhe: 1.25 ± 0.069
1.263MetGly: 1.263 ± 0.066
0.68MetHis: 0.68 ± 0.042
2.091MetIle: 2.091 ± 0.094
1.695MetLys: 1.695 ± 0.074
3.171MetLeu: 3.171 ± 0.119
0.686MetMet: 0.686 ± 0.047
1.369MetAsn: 1.369 ± 0.071
0.851MetPro: 0.851 ± 0.047
0.918MetGln: 0.918 ± 0.054
0.925MetArg: 0.925 ± 0.053
2.252MetSer: 2.252 ± 0.092
1.031MetThr: 1.031 ± 0.064
1.508MetVal: 1.508 ± 0.068
0.151MetTrp: 0.151 ± 0.023
0.983MetTyr: 0.983 ± 0.059
0.0MetXaa: 0.0 ± 0.0
Asn
3.27AsnAla: 3.27 ± 0.116
0.886AsnCys: 0.886 ± 0.06
3.245AsnAsp: 3.245 ± 0.095
2.887AsnGlu: 2.887 ± 0.104
3.167AsnPhe: 3.167 ± 0.112
2.819AsnGly: 2.819 ± 0.104
1.253AsnHis: 1.253 ± 0.072
7.678AsnIle: 7.678 ± 0.188
4.962AsnLys: 4.962 ± 0.176
5.871AsnLeu: 5.871 ± 0.15
1.556AsnMet: 1.556 ± 0.076
5.455AsnAsn: 5.455 ± 0.202
2.175AsnPro: 2.175 ± 0.086
2.007AsnGln: 2.007 ± 0.096
2.091AsnArg: 2.091 ± 0.079
4.685AsnSer: 4.685 ± 0.127
3.712AsnThr: 3.712 ± 0.145
4.479AsnVal: 4.479 ± 0.134
0.371AsnTrp: 0.371 ± 0.041
2.42AsnTyr: 2.42 ± 0.109
0.0AsnXaa: 0.0 ± 0.0
Pro
1.402ProAla: 1.402 ± 0.075
0.396ProCys: 0.396 ± 0.038
1.675ProAsp: 1.675 ± 0.076
2.11ProGlu: 2.11 ± 0.097
1.36ProPhe: 1.36 ± 0.082
1.83ProGly: 1.83 ± 0.073
0.712ProHis: 0.712 ± 0.052
2.942ProIle: 2.942 ± 0.104
2.02ProLys: 2.02 ± 0.076
2.739ProLeu: 2.739 ± 0.1
0.599ProMet: 0.599 ± 0.049
1.737ProAsn: 1.737 ± 0.091
0.77ProPro: 0.77 ± 0.057
0.967ProGln: 0.967 ± 0.062
0.951ProArg: 0.951 ± 0.059
2.359ProSer: 2.359 ± 0.09
1.63ProThr: 1.63 ± 0.081
2.342ProVal: 2.342 ± 0.092
0.277ProTrp: 0.277 ± 0.029
1.392ProTyr: 1.392 ± 0.076
0.0ProXaa: 0.0 ± 0.0
Gln
1.779GlnAla: 1.779 ± 0.078
0.57GlnCys: 0.57 ± 0.042
2.388GlnAsp: 2.388 ± 0.136
2.6GlnGlu: 2.6 ± 0.107
1.263GlnPhe: 1.263 ± 0.065
1.74GlnGly: 1.74 ± 0.093
1.05GlnHis: 1.05 ± 0.054
2.51GlnIle: 2.51 ± 0.118
2.394GlnLys: 2.394 ± 0.094
2.997GlnLeu: 2.997 ± 0.105
0.789GlnMet: 0.789 ± 0.051
2.156GlnAsn: 2.156 ± 0.098
0.777GlnPro: 0.777 ± 0.065
1.498GlnGln: 1.498 ± 0.128
1.17GlnArg: 1.17 ± 0.071
2.381GlnSer: 2.381 ± 0.117
1.041GlnThr: 1.041 ± 0.061
2.42GlnVal: 2.42 ± 0.096
0.203GlnTrp: 0.203 ± 0.023
1.55GlnTyr: 1.55 ± 0.074
0.0GlnXaa: 0.0 ± 0.0
Arg
1.817ArgAla: 1.817 ± 0.084
0.532ArgCys: 0.532 ± 0.036
1.917ArgAsp: 1.917 ± 0.088
2.11ArgGlu: 2.11 ± 0.106
1.746ArgPhe: 1.746 ± 0.091
1.872ArgGly: 1.872 ± 0.083
0.719ArgHis: 0.719 ± 0.052
3.364ArgIle: 3.364 ± 0.114
2.781ArgLys: 2.781 ± 0.1
3.367ArgLeu: 3.367 ± 0.116
0.973ArgMet: 0.973 ± 0.061
2.249ArgAsn: 2.249 ± 0.099
0.925ArgPro: 0.925 ± 0.055
1.121ArgGln: 1.121 ± 0.069
1.559ArgArg: 1.559 ± 0.096
2.581ArgSer: 2.581 ± 0.109
1.44ArgThr: 1.44 ± 0.073
2.407ArgVal: 2.407 ± 0.113
0.216ArgTrp: 0.216 ± 0.028
1.621ArgTyr: 1.621 ± 0.077
0.0ArgXaa: 0.0 ± 0.0
Ser
4.111SerAla: 4.111 ± 0.132
1.35SerCys: 1.35 ± 0.078
4.511SerAsp: 4.511 ± 0.17
4.26SerGlu: 4.26 ± 0.165
3.373SerPhe: 3.373 ± 0.11
5.043SerGly: 5.043 ± 0.17
1.663SerHis: 1.663 ± 0.08
8.203SerIle: 8.203 ± 0.191
5.13SerLys: 5.13 ± 0.152
7.266SerLeu: 7.266 ± 0.153
2.001SerMet: 2.001 ± 0.088
5.191SerAsn: 5.191 ± 0.16
2.201SerPro: 2.201 ± 0.088
2.713SerGln: 2.713 ± 0.139
2.816SerArg: 2.816 ± 0.138
6.985SerSer: 6.985 ± 0.289
4.134SerThr: 4.134 ± 0.155
5.677SerVal: 5.677 ± 0.171
0.509SerTrp: 0.509 ± 0.043
3.257SerTyr: 3.257 ± 0.112
0.0SerXaa: 0.0 ± 0.0
Thr
2.574ThrAla: 2.574 ± 0.081
0.67ThrCys: 0.67 ± 0.054
2.494ThrAsp: 2.494 ± 0.102
2.555ThrGlu: 2.555 ± 0.122
2.094ThrPhe: 2.094 ± 0.065
2.939ThrGly: 2.939 ± 0.108
1.063ThrHis: 1.063 ± 0.058
4.388ThrIle: 4.388 ± 0.169
3.238ThrLys: 3.238 ± 0.12
4.881ThrLeu: 4.881 ± 0.134
1.057ThrMet: 1.057 ± 0.066
3.022ThrAsn: 3.022 ± 0.114
1.772ThrPro: 1.772 ± 0.103
1.849ThrGln: 1.849 ± 0.106
1.614ThrArg: 1.614 ± 0.085
4.069ThrSer: 4.069 ± 0.153
2.958ThrThr: 2.958 ± 0.129
3.415ThrVal: 3.415 ± 0.102
0.316ThrTrp: 0.316 ± 0.037
1.682ThrTyr: 1.682 ± 0.089
0.0ThrXaa: 0.0 ± 0.0
Val
3.779ValAla: 3.779 ± 0.121
1.16ValCys: 1.16 ± 0.058
3.754ValAsp: 3.754 ± 0.142
3.676ValGlu: 3.676 ± 0.165
3.212ValPhe: 3.212 ± 0.121
3.957ValGly: 3.957 ± 0.128
1.318ValHis: 1.318 ± 0.063
6.509ValIle: 6.509 ± 0.179
5.223ValLys: 5.223 ± 0.178
6.724ValLeu: 6.724 ± 0.179
1.791ValMet: 1.791 ± 0.076
4.144ValAsn: 4.144 ± 0.136
2.21ValPro: 2.21 ± 0.088
1.994ValGln: 1.994 ± 0.083
2.452ValArg: 2.452 ± 0.086
5.651ValSer: 5.651 ± 0.193
3.386ValThr: 3.386 ± 0.128
5.21ValVal: 5.21 ± 0.16
0.4ValTrp: 0.4 ± 0.039
2.21ValTyr: 2.21 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.274TrpAla: 0.274 ± 0.031
0.119TrpCys: 0.119 ± 0.021
0.354TrpAsp: 0.354 ± 0.037
0.303TrpGlu: 0.303 ± 0.033
0.367TrpPhe: 0.367 ± 0.039
0.354TrpGly: 0.354 ± 0.041
0.177TrpHis: 0.177 ± 0.02
0.59TrpIle: 0.59 ± 0.055
0.506TrpLys: 0.506 ± 0.044
0.731TrpLeu: 0.731 ± 0.053
0.155TrpMet: 0.155 ± 0.02
0.438TrpAsn: 0.438 ± 0.038
0.206TrpPro: 0.206 ± 0.028
0.303TrpGln: 0.303 ± 0.034
0.245TrpArg: 0.245 ± 0.032
0.403TrpSer: 0.403 ± 0.04
0.226TrpThr: 0.226 ± 0.026
0.374TrpVal: 0.374 ± 0.036
0.071TrpTrp: 0.071 ± 0.015
0.329TrpTyr: 0.329 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.965TyrAla: 1.965 ± 0.083
0.731TyrCys: 0.731 ± 0.047
2.355TyrAsp: 2.355 ± 0.103
1.917TyrGlu: 1.917 ± 0.095
1.824TyrPhe: 1.824 ± 0.088
2.259TyrGly: 2.259 ± 0.095
1.018TyrHis: 1.018 ± 0.058
3.738TyrIle: 3.738 ± 0.143
2.91TyrLys: 2.91 ± 0.107
3.212TyrLeu: 3.212 ± 0.111
0.912TyrMet: 0.912 ± 0.052
2.939TyrAsn: 2.939 ± 0.116
1.102TyrPro: 1.102 ± 0.068
1.431TyrGln: 1.431 ± 0.075
1.498TyrArg: 1.498 ± 0.067
3.251TyrSer: 3.251 ± 0.116
1.962TyrThr: 1.962 ± 0.087
2.571TyrVal: 2.571 ± 0.1
0.316TyrTrp: 0.316 ± 0.033
1.737TyrTyr: 1.737 ± 0.081
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1100 proteins (310362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski