Amino acid dipepetide frequency for Vibrio phage JA-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.126AlaAla: 5.126 ± 1.242
0.654AlaCys: 0.654 ± 0.224
3.326AlaAsp: 3.326 ± 0.377
5.508AlaGlu: 5.508 ± 0.613
2.999AlaPhe: 2.999 ± 0.375
3.872AlaGly: 3.872 ± 0.547
0.873AlaHis: 0.873 ± 0.214
4.144AlaIle: 4.144 ± 0.486
5.726AlaLys: 5.726 ± 0.875
5.671AlaLeu: 5.671 ± 0.672
2.29AlaMet: 2.29 ± 0.303
3.381AlaAsn: 3.381 ± 0.436
2.454AlaPro: 2.454 ± 0.437
2.89AlaGln: 2.89 ± 0.57
2.236AlaArg: 2.236 ± 0.394
3.926AlaSer: 3.926 ± 0.367
3.108AlaThr: 3.108 ± 0.372
4.253AlaVal: 4.253 ± 0.361
0.818AlaTrp: 0.818 ± 0.213
2.618AlaTyr: 2.618 ± 0.411
0.0AlaXaa: 0.0 ± 0.0
Cys
0.382CysAla: 0.382 ± 0.157
0.055CysCys: 0.055 ± 0.05
0.6CysAsp: 0.6 ± 0.17
0.491CysGlu: 0.491 ± 0.203
0.436CysPhe: 0.436 ± 0.15
0.436CysGly: 0.436 ± 0.165
0.273CysHis: 0.273 ± 0.121
0.927CysIle: 0.927 ± 0.306
0.654CysLys: 0.654 ± 0.227
0.818CysLeu: 0.818 ± 0.19
0.218CysMet: 0.218 ± 0.11
0.709CysAsn: 0.709 ± 0.183
0.164CysPro: 0.164 ± 0.098
0.055CysGln: 0.055 ± 0.052
0.218CysArg: 0.218 ± 0.154
0.545CysSer: 0.545 ± 0.216
0.873CysThr: 0.873 ± 0.222
0.327CysVal: 0.327 ± 0.146
0.055CysTrp: 0.055 ± 0.058
0.545CysTyr: 0.545 ± 0.166
0.0CysXaa: 0.0 ± 0.0
Asp
3.545AspAla: 3.545 ± 0.591
0.436AspCys: 0.436 ± 0.177
2.727AspAsp: 2.727 ± 0.508
4.472AspGlu: 4.472 ± 0.619
2.345AspPhe: 2.345 ± 0.382
3.272AspGly: 3.272 ± 0.539
0.709AspHis: 0.709 ± 0.205
4.799AspIle: 4.799 ± 0.475
4.799AspLys: 4.799 ± 0.682
4.908AspLeu: 4.908 ± 0.492
1.472AspMet: 1.472 ± 0.278
3.763AspAsn: 3.763 ± 0.455
1.636AspPro: 1.636 ± 0.217
0.982AspGln: 0.982 ± 0.271
2.072AspArg: 2.072 ± 0.292
3.217AspSer: 3.217 ± 0.348
3.708AspThr: 3.708 ± 0.422
3.381AspVal: 3.381 ± 0.48
0.982AspTrp: 0.982 ± 0.311
2.727AspTyr: 2.727 ± 0.365
0.0AspXaa: 0.0 ± 0.0
Glu
6.598GluAla: 6.598 ± 1.064
0.327GluCys: 0.327 ± 0.139
3.545GluAsp: 3.545 ± 0.458
6.217GluGlu: 6.217 ± 0.942
4.035GluPhe: 4.035 ± 0.597
3.545GluGly: 3.545 ± 0.398
1.254GluHis: 1.254 ± 0.28
4.199GluIle: 4.199 ± 0.522
3.872GluLys: 3.872 ± 0.57
8.125GluLeu: 8.125 ± 0.527
2.018GluMet: 2.018 ± 0.399
3.217GluAsn: 3.217 ± 0.374
2.672GluPro: 2.672 ± 0.362
3.108GluGln: 3.108 ± 0.396
2.508GluArg: 2.508 ± 0.491
4.799GluSer: 4.799 ± 0.561
3.926GluThr: 3.926 ± 0.48
4.744GluVal: 4.744 ± 0.519
0.927GluTrp: 0.927 ± 0.209
3.435GluTyr: 3.435 ± 0.336
0.0GluXaa: 0.0 ± 0.0
Phe
1.854PheAla: 1.854 ± 0.436
0.436PheCys: 0.436 ± 0.168
2.945PheAsp: 2.945 ± 0.386
1.854PheGlu: 1.854 ± 0.366
1.69PhePhe: 1.69 ± 0.273
2.454PheGly: 2.454 ± 0.398
0.763PheHis: 0.763 ± 0.237
3.49PheIle: 3.49 ± 0.439
3.435PheLys: 3.435 ± 0.389
2.018PheLeu: 2.018 ± 0.33
1.145PheMet: 1.145 ± 0.218
4.035PheAsn: 4.035 ± 0.486
1.309PhePro: 1.309 ± 0.316
1.2PheGln: 1.2 ± 0.24
1.472PheArg: 1.472 ± 0.391
2.508PheSer: 2.508 ± 0.332
3.272PheThr: 3.272 ± 0.393
2.672PheVal: 2.672 ± 0.484
0.491PheTrp: 0.491 ± 0.216
1.254PheTyr: 1.254 ± 0.27
0.0PheXaa: 0.0 ± 0.0
Gly
3.272GlyAla: 3.272 ± 0.475
0.436GlyCys: 0.436 ± 0.168
2.018GlyAsp: 2.018 ± 0.363
2.89GlyGlu: 2.89 ± 0.443
2.836GlyPhe: 2.836 ± 0.618
3.272GlyGly: 3.272 ± 0.619
1.091GlyHis: 1.091 ± 0.224
4.253GlyIle: 4.253 ± 0.528
4.635GlyLys: 4.635 ± 0.554
4.962GlyLeu: 4.962 ± 0.552
1.69GlyMet: 1.69 ± 0.407
4.417GlyAsn: 4.417 ± 0.478
0.164GlyPro: 0.164 ± 0.077
1.581GlyGln: 1.581 ± 0.246
1.909GlyArg: 1.909 ± 0.275
4.908GlySer: 4.908 ± 0.709
4.199GlyThr: 4.199 ± 0.546
3.599GlyVal: 3.599 ± 0.339
0.818GlyTrp: 0.818 ± 0.277
2.999GlyTyr: 2.999 ± 0.328
0.0GlyXaa: 0.0 ± 0.0
His
1.036HisAla: 1.036 ± 0.287
0.273HisCys: 0.273 ± 0.12
0.818HisAsp: 0.818 ± 0.193
1.254HisGlu: 1.254 ± 0.237
0.763HisPhe: 0.763 ± 0.232
0.709HisGly: 0.709 ± 0.177
0.927HisHis: 0.927 ± 0.266
1.363HisIle: 1.363 ± 0.304
1.963HisLys: 1.963 ± 0.389
1.581HisLeu: 1.581 ± 0.301
0.709HisMet: 0.709 ± 0.206
1.309HisAsn: 1.309 ± 0.244
0.654HisPro: 0.654 ± 0.214
0.273HisGln: 0.273 ± 0.137
1.091HisArg: 1.091 ± 0.202
0.982HisSer: 0.982 ± 0.26
0.654HisThr: 0.654 ± 0.187
1.309HisVal: 1.309 ± 0.322
0.218HisTrp: 0.218 ± 0.114
0.763HisTyr: 0.763 ± 0.216
0.0HisXaa: 0.0 ± 0.0
Ile
4.472IleAla: 4.472 ± 0.406
0.545IleCys: 0.545 ± 0.145
5.017IleAsp: 5.017 ± 0.437
5.071IleGlu: 5.071 ± 0.709
1.963IlePhe: 1.963 ± 0.327
3.817IleGly: 3.817 ± 0.642
1.091IleHis: 1.091 ± 0.272
3.872IleIle: 3.872 ± 0.494
6.489IleLys: 6.489 ± 0.512
4.69IleLeu: 4.69 ± 0.665
1.145IleMet: 1.145 ± 0.203
4.308IleAsn: 4.308 ± 0.58
2.945IlePro: 2.945 ± 0.376
2.781IleGln: 2.781 ± 0.417
3.435IleArg: 3.435 ± 0.396
2.945IleSer: 2.945 ± 0.414
4.199IleThr: 4.199 ± 0.494
3.654IleVal: 3.654 ± 0.405
0.654IleTrp: 0.654 ± 0.262
2.781IleTyr: 2.781 ± 0.454
0.0IleXaa: 0.0 ± 0.0
Lys
6.271LysAla: 6.271 ± 0.798
0.6LysCys: 0.6 ± 0.195
4.908LysAsp: 4.908 ± 0.511
6.108LysGlu: 6.108 ± 0.744
2.672LysPhe: 2.672 ± 0.388
3.272LysGly: 3.272 ± 0.52
1.69LysHis: 1.69 ± 0.333
3.654LysIle: 3.654 ± 0.636
3.926LysLys: 3.926 ± 0.467
8.889LysLeu: 8.889 ± 0.654
2.181LysMet: 2.181 ± 0.417
4.308LysAsn: 4.308 ± 0.538
4.035LysPro: 4.035 ± 0.572
4.199LysGln: 4.199 ± 0.429
3.272LysArg: 3.272 ± 0.522
4.09LysSer: 4.09 ± 0.636
4.69LysThr: 4.69 ± 0.482
5.562LysVal: 5.562 ± 0.499
0.654LysTrp: 0.654 ± 0.192
3.817LysTyr: 3.817 ± 0.496
0.0LysXaa: 0.0 ± 0.0
Leu
6.162LeuAla: 6.162 ± 0.63
0.654LeuCys: 0.654 ± 0.217
6.271LeuAsp: 6.271 ± 0.527
5.78LeuGlu: 5.78 ± 0.701
2.236LeuPhe: 2.236 ± 0.381
5.78LeuGly: 5.78 ± 0.479
2.018LeuHis: 2.018 ± 0.372
5.235LeuIle: 5.235 ± 0.747
7.362LeuLys: 7.362 ± 0.744
7.144LeuLeu: 7.144 ± 0.668
2.727LeuMet: 2.727 ± 0.386
4.799LeuAsn: 4.799 ± 0.546
3.981LeuPro: 3.981 ± 0.576
3.49LeuGln: 3.49 ± 0.383
3.763LeuArg: 3.763 ± 0.451
5.998LeuSer: 5.998 ± 0.549
6.108LeuThr: 6.108 ± 0.601
5.944LeuVal: 5.944 ± 0.607
0.982LeuTrp: 0.982 ± 0.215
2.672LeuTyr: 2.672 ± 0.402
0.0LeuXaa: 0.0 ± 0.0
Met
1.418MetAla: 1.418 ± 0.318
0.327MetCys: 0.327 ± 0.156
1.472MetAsp: 1.472 ± 0.213
1.963MetGlu: 1.963 ± 0.49
1.472MetPhe: 1.472 ± 0.292
1.581MetGly: 1.581 ± 0.303
0.382MetHis: 0.382 ± 0.145
1.636MetIle: 1.636 ± 0.32
2.618MetLys: 2.618 ± 0.456
2.181MetLeu: 2.181 ± 0.334
0.436MetMet: 0.436 ± 0.148
1.909MetAsn: 1.909 ± 0.381
1.036MetPro: 1.036 ± 0.238
1.309MetGln: 1.309 ± 0.225
1.091MetArg: 1.091 ± 0.26
1.472MetSer: 1.472 ± 0.326
1.2MetThr: 1.2 ± 0.307
1.581MetVal: 1.581 ± 0.291
0.109MetTrp: 0.109 ± 0.067
0.654MetTyr: 0.654 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
3.817AsnAla: 3.817 ± 0.407
0.327AsnCys: 0.327 ± 0.141
2.727AsnAsp: 2.727 ± 0.387
3.272AsnGlu: 3.272 ± 0.366
1.854AsnPhe: 1.854 ± 0.296
3.163AsnGly: 3.163 ± 0.504
1.69AsnHis: 1.69 ± 0.383
3.981AsnIle: 3.981 ± 0.453
5.508AsnLys: 5.508 ± 0.702
6.053AsnLeu: 6.053 ± 0.669
1.854AsnMet: 1.854 ± 0.263
3.981AsnAsn: 3.981 ± 0.502
4.308AsnPro: 4.308 ± 0.524
3.817AsnGln: 3.817 ± 0.477
2.399AsnArg: 2.399 ± 0.404
3.435AsnSer: 3.435 ± 0.428
4.035AsnThr: 4.035 ± 0.408
3.435AsnVal: 3.435 ± 0.337
0.927AsnTrp: 0.927 ± 0.255
2.454AsnTyr: 2.454 ± 0.433
0.0AsnXaa: 0.0 ± 0.0
Pro
2.399ProAla: 2.399 ± 0.302
0.491ProCys: 0.491 ± 0.161
1.854ProAsp: 1.854 ± 0.291
3.763ProGlu: 3.763 ± 0.489
1.309ProPhe: 1.309 ± 0.238
0.709ProGly: 0.709 ± 0.152
0.545ProHis: 0.545 ± 0.183
2.618ProIle: 2.618 ± 0.329
2.781ProLys: 2.781 ± 0.459
2.945ProLeu: 2.945 ± 0.402
0.927ProMet: 0.927 ± 0.233
2.945ProAsn: 2.945 ± 0.472
0.6ProPro: 0.6 ± 0.183
1.145ProGln: 1.145 ± 0.286
1.091ProArg: 1.091 ± 0.274
3.054ProSer: 3.054 ± 0.356
2.999ProThr: 2.999 ± 0.437
2.727ProVal: 2.727 ± 0.276
0.436ProTrp: 0.436 ± 0.161
1.254ProTyr: 1.254 ± 0.335
0.0ProXaa: 0.0 ± 0.0
Gln
3.054GlnAla: 3.054 ± 0.439
0.164GlnCys: 0.164 ± 0.099
2.236GlnAsp: 2.236 ± 0.369
3.272GlnGlu: 3.272 ± 0.5
1.363GlnPhe: 1.363 ± 0.261
2.999GlnGly: 2.999 ± 0.382
0.818GlnHis: 0.818 ± 0.21
2.29GlnIle: 2.29 ± 0.396
2.454GlnLys: 2.454 ± 0.403
4.199GlnLeu: 4.199 ± 0.427
1.418GlnMet: 1.418 ± 0.412
1.636GlnAsn: 1.636 ± 0.304
1.309GlnPro: 1.309 ± 0.383
2.127GlnGln: 2.127 ± 0.455
1.472GlnArg: 1.472 ± 0.283
1.909GlnSer: 1.909 ± 0.328
2.508GlnThr: 2.508 ± 0.458
2.89GlnVal: 2.89 ± 0.464
0.273GlnTrp: 0.273 ± 0.122
2.127GlnTyr: 2.127 ± 0.343
0.0GlnXaa: 0.0 ± 0.0
Arg
1.745ArgAla: 1.745 ± 0.275
0.545ArgCys: 0.545 ± 0.167
1.963ArgAsp: 1.963 ± 0.318
2.563ArgGlu: 2.563 ± 0.341
1.636ArgPhe: 1.636 ± 0.435
1.963ArgGly: 1.963 ± 0.293
0.6ArgHis: 0.6 ± 0.182
2.672ArgIle: 2.672 ± 0.342
3.272ArgLys: 3.272 ± 0.353
3.872ArgLeu: 3.872 ± 0.507
0.873ArgMet: 0.873 ± 0.23
2.563ArgAsn: 2.563 ± 0.349
0.873ArgPro: 0.873 ± 0.21
1.418ArgGln: 1.418 ± 0.317
1.309ArgArg: 1.309 ± 0.305
2.618ArgSer: 2.618 ± 0.388
2.945ArgThr: 2.945 ± 0.408
2.345ArgVal: 2.345 ± 0.4
0.273ArgTrp: 0.273 ± 0.197
1.854ArgTyr: 1.854 ± 0.317
0.0ArgXaa: 0.0 ± 0.0
Ser
4.035SerAla: 4.035 ± 0.5
0.436SerCys: 0.436 ± 0.17
3.926SerAsp: 3.926 ± 0.65
4.908SerGlu: 4.908 ± 0.62
3.163SerPhe: 3.163 ± 0.379
4.417SerGly: 4.417 ± 0.672
0.491SerHis: 0.491 ± 0.155
5.399SerIle: 5.399 ± 0.518
5.453SerLys: 5.453 ± 0.567
5.508SerLeu: 5.508 ± 0.598
1.581SerMet: 1.581 ± 0.246
3.872SerAsn: 3.872 ± 0.438
1.418SerPro: 1.418 ± 0.243
1.745SerGln: 1.745 ± 0.298
1.854SerArg: 1.854 ± 0.266
3.708SerSer: 3.708 ± 0.602
3.49SerThr: 3.49 ± 0.456
3.763SerVal: 3.763 ± 0.374
0.6SerTrp: 0.6 ± 0.16
2.236SerTyr: 2.236 ± 0.346
0.0SerXaa: 0.0 ± 0.0
Thr
3.981ThrAla: 3.981 ± 0.459
0.654ThrCys: 0.654 ± 0.199
3.381ThrAsp: 3.381 ± 0.47
4.253ThrGlu: 4.253 ± 0.543
2.727ThrPhe: 2.727 ± 0.382
4.526ThrGly: 4.526 ± 0.484
1.363ThrHis: 1.363 ± 0.342
3.817ThrIle: 3.817 ± 0.523
4.581ThrLys: 4.581 ± 0.531
4.69ThrLeu: 4.69 ± 0.507
1.091ThrMet: 1.091 ± 0.28
4.526ThrAsn: 4.526 ± 0.568
2.836ThrPro: 2.836 ± 0.37
3.054ThrGln: 3.054 ± 0.35
2.236ThrArg: 2.236 ± 0.358
3.272ThrSer: 3.272 ± 0.431
4.635ThrThr: 4.635 ± 0.531
4.363ThrVal: 4.363 ± 0.545
1.091ThrTrp: 1.091 ± 0.238
3.217ThrTyr: 3.217 ± 0.45
0.0ThrXaa: 0.0 ± 0.0
Val
3.763ValAla: 3.763 ± 0.428
0.6ValCys: 0.6 ± 0.234
3.708ValAsp: 3.708 ± 0.453
5.453ValGlu: 5.453 ± 0.501
2.29ValPhe: 2.29 ± 0.294
2.999ValGly: 2.999 ± 0.487
1.091ValHis: 1.091 ± 0.212
4.09ValIle: 4.09 ± 0.509
4.799ValLys: 4.799 ± 0.386
5.29ValLeu: 5.29 ± 0.621
1.254ValMet: 1.254 ± 0.278
4.09ValAsn: 4.09 ± 0.392
2.727ValPro: 2.727 ± 0.349
3.108ValGln: 3.108 ± 0.763
2.618ValArg: 2.618 ± 0.406
4.308ValSer: 4.308 ± 0.913
4.908ValThr: 4.908 ± 0.471
2.999ValVal: 2.999 ± 0.335
0.654ValTrp: 0.654 ± 0.155
2.727ValTyr: 2.727 ± 0.416
0.0ValXaa: 0.0 ± 0.0
Trp
0.709TrpAla: 0.709 ± 0.197
0.273TrpCys: 0.273 ± 0.14
0.709TrpAsp: 0.709 ± 0.234
0.927TrpGlu: 0.927 ± 0.317
0.873TrpPhe: 0.873 ± 0.217
0.6TrpGly: 0.6 ± 0.179
0.436TrpHis: 0.436 ± 0.171
0.818TrpIle: 0.818 ± 0.216
0.763TrpLys: 0.763 ± 0.186
1.036TrpLeu: 1.036 ± 0.232
0.109TrpMet: 0.109 ± 0.074
0.545TrpAsn: 0.545 ± 0.135
0.164TrpPro: 0.164 ± 0.097
0.273TrpGln: 0.273 ± 0.126
0.382TrpArg: 0.382 ± 0.143
0.654TrpSer: 0.654 ± 0.19
0.382TrpThr: 0.382 ± 0.16
1.036TrpVal: 1.036 ± 0.26
0.055TrpTrp: 0.055 ± 0.063
0.654TrpTyr: 0.654 ± 0.201
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.236TyrAla: 2.236 ± 0.323
0.545TyrCys: 0.545 ± 0.173
1.8TyrAsp: 1.8 ± 0.328
3.054TyrGlu: 3.054 ± 0.282
1.636TyrPhe: 1.636 ± 0.353
2.563TyrGly: 2.563 ± 0.364
0.545TyrHis: 0.545 ± 0.156
2.618TyrIle: 2.618 ± 0.476
3.708TyrLys: 3.708 ± 0.423
4.526TyrLeu: 4.526 ± 0.431
0.654TyrMet: 0.654 ± 0.206
2.727TyrAsn: 2.727 ± 0.376
1.309TyrPro: 1.309 ± 0.312
1.963TyrGln: 1.963 ± 0.303
1.472TyrArg: 1.472 ± 0.227
3.708TyrSer: 3.708 ± 0.588
2.454TyrThr: 2.454 ± 0.378
2.89TyrVal: 2.89 ± 0.412
0.382TyrTrp: 0.382 ± 0.162
1.8TyrTyr: 1.8 ± 0.505
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (18339 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski