Amino acid dipepetide frequency for Microbacterium esteraromaticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.738AlaAla: 19.738 ± 0.195	0.672AlaCys: 0.672 ± 0.03	8.749AlaAsp: 8.749 ± 0.092	8.569AlaGlu: 8.569 ± 0.102	3.775AlaPhe: 3.775 ± 0.069	11.365AlaGly: 11.365 ± 0.134	2.634AlaHis: 2.634 ± 0.055	6.12AlaIle: 6.12 ± 0.086	2.922AlaLys: 2.922 ± 0.067	13.661AlaLeu: 13.661 ± 0.127	2.848AlaMet: 2.848 ± 0.048	2.298AlaAsn: 2.298 ± 0.052	6.221AlaPro: 6.221 ± 0.115	4.188AlaGln: 4.188 ± 0.074	8.821AlaArg: 8.821 ± 0.11	7.671AlaSer: 7.671 ± 0.085	7.169AlaThr: 7.169 ± 0.09	11.124AlaVal: 11.124 ± 0.123	1.871AlaTrp: 1.871 ± 0.044	2.34AlaTyr: 2.34 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.686CysAla: 0.686 ± 0.029	0.046CysCys: 0.046 ± 0.006	0.322CysAsp: 0.322 ± 0.022	0.269CysGlu: 0.269 ± 0.018	0.185CysPhe: 0.185 ± 0.013	0.55CysGly: 0.55 ± 0.028	0.114CysHis: 0.114 ± 0.013	0.215CysIle: 0.215 ± 0.013	0.073CysLys: 0.073 ± 0.01	0.45CysLeu: 0.45 ± 0.02	0.078CysMet: 0.078 ± 0.009	0.113CysAsn: 0.113 ± 0.01	0.267CysPro: 0.267 ± 0.018	0.132CysGln: 0.132 ± 0.013	0.362CysArg: 0.362 ± 0.021	0.311CysSer: 0.311 ± 0.018	0.331CysThr: 0.331 ± 0.017	0.425CysVal: 0.425 ± 0.023	0.075CysTrp: 0.075 ± 0.009	0.092CysTyr: 0.092 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.847AspAla: 9.847 ± 0.109	0.241AspCys: 0.241 ± 0.015	4.522AspAsp: 4.522 ± 0.083	4.616AspGlu: 4.616 ± 0.073	1.699AspPhe: 1.699 ± 0.04	6.047AspGly: 6.047 ± 0.084	1.239AspHis: 1.239 ± 0.032	2.614AspIle: 2.614 ± 0.046	1.181AspLys: 1.181 ± 0.039	6.091AspLeu: 6.091 ± 0.08	0.993AspMet: 0.993 ± 0.032	1.01AspAsn: 1.01 ± 0.036	3.997AspPro: 3.997 ± 0.073	1.747AspGln: 1.747 ± 0.041	4.399AspArg: 4.399 ± 0.085	2.963AspSer: 2.963 ± 0.053	3.003AspThr: 3.003 ± 0.051	5.32AspVal: 5.32 ± 0.071	0.97AspTrp: 0.97 ± 0.032	1.247AspTyr: 1.247 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.892GluAla: 6.892 ± 0.092	0.273GluCys: 0.273 ± 0.015	2.887GluAsp: 2.887 ± 0.067	2.972GluGlu: 2.972 ± 0.066	1.757GluPhe: 1.757 ± 0.042	3.943GluGly: 3.943 ± 0.052	1.706GluHis: 1.706 ± 0.045	3.007GluIle: 3.007 ± 0.061	1.664GluLys: 1.664 ± 0.047	6.471GluLeu: 6.471 ± 0.078	1.033GluMet: 1.033 ± 0.031	1.419GluAsn: 1.419 ± 0.039	2.873GluPro: 2.873 ± 0.061	2.579GluGln: 2.579 ± 0.067	5.217GluArg: 5.217 ± 0.095	3.204GluSer: 3.204 ± 0.058	3.187GluThr: 3.187 ± 0.061	4.464GluVal: 4.464 ± 0.078	0.905GluTrp: 0.905 ± 0.031	1.26GluTyr: 1.26 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.173PheAla: 4.173 ± 0.071	0.174PheCys: 0.174 ± 0.014	2.414PheAsp: 2.414 ± 0.049	1.806PheGlu: 1.806 ± 0.045	1.046PhePhe: 1.046 ± 0.037	3.29PheGly: 3.29 ± 0.059	0.566PheHis: 0.566 ± 0.025	1.305PheIle: 1.305 ± 0.038	0.492PheLys: 0.492 ± 0.024	2.801PheLeu: 2.801 ± 0.063	0.495PheMet: 0.495 ± 0.026	0.684PheAsn: 0.684 ± 0.027	1.318PhePro: 1.318 ± 0.035	0.792PheGln: 0.792 ± 0.028	1.793PheArg: 1.793 ± 0.044	1.685PheSer: 1.685 ± 0.041	2.237PheThr: 2.237 ± 0.047	2.653PheVal: 2.653 ± 0.058	0.43PheTrp: 0.43 ± 0.023	0.58PheTyr: 0.58 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.298GlyAla: 10.298 ± 0.12	0.523GlyCys: 0.523 ± 0.023	5.053GlyAsp: 5.053 ± 0.077	5.002GlyGlu: 5.002 ± 0.068	3.039GlyPhe: 3.039 ± 0.052	7.116GlyGly: 7.116 ± 0.114	1.732GlyHis: 1.732 ± 0.044	5.122GlyIle: 5.122 ± 0.085	2.262GlyLys: 2.262 ± 0.059	8.196GlyLeu: 8.196 ± 0.107	2.155GlyMet: 2.155 ± 0.052	1.735GlyAsn: 1.735 ± 0.052	3.392GlyPro: 3.392 ± 0.065	2.489GlyGln: 2.489 ± 0.049	5.822GlyArg: 5.822 ± 0.08	5.164GlySer: 5.164 ± 0.079	5.259GlyThr: 5.259 ± 0.075	7.427GlyVal: 7.427 ± 0.084	1.601GlyTrp: 1.601 ± 0.043	2.191GlyTyr: 2.191 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.596HisAla: 2.596 ± 0.053	0.115HisCys: 0.115 ± 0.012	1.48HisAsp: 1.48 ± 0.038	1.246HisGlu: 1.246 ± 0.034	0.558HisPhe: 0.558 ± 0.026	2.019HisGly: 2.019 ± 0.045	0.592HisHis: 0.592 ± 0.028	0.818HisIle: 0.818 ± 0.031	0.325HisLys: 0.325 ± 0.018	2.09HisLeu: 2.09 ± 0.048	0.34HisMet: 0.34 ± 0.019	0.385HisAsn: 0.385 ± 0.021	1.601HisPro: 1.601 ± 0.037	0.547HisGln: 0.547 ± 0.023	1.67HisArg: 1.67 ± 0.047	1.119HisSer: 1.119 ± 0.032	1.111HisThr: 1.111 ± 0.035	1.688HisVal: 1.688 ± 0.041	0.27HisTrp: 0.27 ± 0.014	0.42HisTyr: 0.42 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.621IleAla: 7.621 ± 0.092	0.26IleCys: 0.26 ± 0.019	3.795IleAsp: 3.795 ± 0.061	3.227IleGlu: 3.227 ± 0.061	1.316IlePhe: 1.316 ± 0.045	4.955IleGly: 4.955 ± 0.08	0.772IleHis: 0.772 ± 0.032	2.406IleIle: 2.406 ± 0.058	0.851IleLys: 0.851 ± 0.035	3.94IleLeu: 3.94 ± 0.066	0.763IleMet: 0.763 ± 0.027	0.955IleAsn: 0.955 ± 0.031	2.503IlePro: 2.503 ± 0.054	1.017IleGln: 1.017 ± 0.035	3.104IleArg: 3.104 ± 0.056	2.777IleSer: 2.777 ± 0.053	3.128IleThr: 3.128 ± 0.067	4.877IleVal: 4.877 ± 0.088	0.592IleTrp: 0.592 ± 0.026	0.786IleTyr: 0.786 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.664LysAla: 2.664 ± 0.069	0.087LysCys: 0.087 ± 0.01	1.271LysAsp: 1.271 ± 0.038	1.066LysGlu: 1.066 ± 0.035	0.521LysPhe: 0.521 ± 0.027	1.622LysGly: 1.622 ± 0.05	0.533LysHis: 0.533 ± 0.025	1.096LysIle: 1.096 ± 0.038	0.918LysLys: 0.918 ± 0.041	1.99LysLeu: 1.99 ± 0.048	0.459LysMet: 0.459 ± 0.022	0.566LysAsn: 0.566 ± 0.028	1.239LysPro: 1.239 ± 0.047	0.827LysGln: 0.827 ± 0.029	1.684LysArg: 1.684 ± 0.046	1.287LysSer: 1.287 ± 0.039	1.478LysThr: 1.478 ± 0.042	1.752LysVal: 1.752 ± 0.051	0.291LysTrp: 0.291 ± 0.017	0.487LysTyr: 0.487 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.746LeuAla: 13.746 ± 0.126	0.508LeuCys: 0.508 ± 0.022	6.527LeuAsp: 6.527 ± 0.095	4.972LeuGlu: 4.972 ± 0.083	2.921LeuPhe: 2.921 ± 0.063	8.512LeuGly: 8.512 ± 0.091	2.043LeuHis: 2.043 ± 0.05	5.118LeuIle: 5.118 ± 0.085	1.883LeuLys: 1.883 ± 0.049	10.018LeuLeu: 10.018 ± 0.139	1.753LeuMet: 1.753 ± 0.048	1.97LeuAsn: 1.97 ± 0.047	5.228LeuPro: 5.228 ± 0.071	2.694LeuGln: 2.694 ± 0.048	7.675LeuArg: 7.675 ± 0.085	5.986LeuSer: 5.986 ± 0.08	6.443LeuThr: 6.443 ± 0.084	8.425LeuVal: 8.425 ± 0.114	1.292LeuTrp: 1.292 ± 0.041	1.61LeuTyr: 1.61 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.264MetAla: 2.264 ± 0.05	0.097MetCys: 0.097 ± 0.009	0.855MetAsp: 0.855 ± 0.029	0.691MetGlu: 0.691 ± 0.023	0.592MetPhe: 0.592 ± 0.024	1.345MetGly: 1.345 ± 0.038	0.408MetHis: 0.408 ± 0.018	1.041MetIle: 1.041 ± 0.033	0.497MetLys: 0.497 ± 0.025	2.473MetLeu: 2.473 ± 0.046	0.469MetMet: 0.469 ± 0.023	0.535MetAsn: 0.535 ± 0.022	1.279MetPro: 1.279 ± 0.039	0.659MetGln: 0.659 ± 0.024	1.577MetArg: 1.577 ± 0.041	1.534MetSer: 1.534 ± 0.035	1.833MetThr: 1.833 ± 0.044	1.437MetVal: 1.437 ± 0.042	0.254MetTrp: 0.254 ± 0.018	0.297MetTyr: 0.297 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.544AsnAla: 2.544 ± 0.049	0.101AsnCys: 0.101 ± 0.01	1.287AsnAsp: 1.287 ± 0.038	1.037AsnGlu: 1.037 ± 0.033	0.59AsnPhe: 0.59 ± 0.026	1.92AsnGly: 1.92 ± 0.045	0.385AsnHis: 0.385 ± 0.018	0.929AsnIle: 0.929 ± 0.027	0.422AsnLys: 0.422 ± 0.022	1.914AsnLeu: 1.914 ± 0.046	0.349AsnMet: 0.349 ± 0.019	0.488AsnAsn: 0.488 ± 0.024	1.592AsnPro: 1.592 ± 0.041	0.594AsnGln: 0.594 ± 0.024	1.39AsnArg: 1.39 ± 0.041	1.103AsnSer: 1.103 ± 0.036	1.221AsnThr: 1.221 ± 0.04	1.614AsnVal: 1.614 ± 0.043	0.32AsnTrp: 0.32 ± 0.017	0.462AsnTyr: 0.462 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.816ProAla: 6.816 ± 0.114	0.187ProCys: 0.187 ± 0.015	3.867ProAsp: 3.867 ± 0.067	3.722ProGlu: 3.722 ± 0.058	1.663ProPhe: 1.663 ± 0.043	4.539ProGly: 4.539 ± 0.071	1.13ProHis: 1.13 ± 0.033	2.255ProIle: 2.255 ± 0.047	1.132ProLys: 1.132 ± 0.039	4.701ProLeu: 4.701 ± 0.075	0.984ProMet: 0.984 ± 0.035	1.022ProAsn: 1.022 ± 0.033	2.216ProPro: 2.216 ± 0.063	1.623ProGln: 1.623 ± 0.042	3.27ProArg: 3.27 ± 0.064	2.974ProSer: 2.974 ± 0.054	3.288ProThr: 3.288 ± 0.062	4.533ProVal: 4.533 ± 0.085	0.796ProTrp: 0.796 ± 0.029	0.968ProTyr: 0.968 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.703GlnAla: 3.703 ± 0.07	0.131GlnCys: 0.131 ± 0.012	1.421GlnAsp: 1.421 ± 0.039	1.451GlnGlu: 1.451 ± 0.045	0.874GlnPhe: 0.874 ± 0.032	2.155GlnGly: 2.155 ± 0.046	0.835GlnHis: 0.835 ± 0.034	1.658GlnIle: 1.658 ± 0.039	0.84GlnLys: 0.84 ± 0.029	3.333GlnLeu: 3.333 ± 0.07	0.624GlnMet: 0.624 ± 0.025	0.706GlnAsn: 0.706 ± 0.027	1.611GlnPro: 1.611 ± 0.04	1.399GlnGln: 1.399 ± 0.037	2.698GlnArg: 2.698 ± 0.065	1.621GlnSer: 1.621 ± 0.041	1.698GlnThr: 1.698 ± 0.044	2.48GlnVal: 2.48 ± 0.05	0.512GlnTrp: 0.512 ± 0.023	0.618GlnTyr: 0.618 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.836ArgAla: 8.836 ± 0.115	0.384ArgCys: 0.384 ± 0.023	4.33ArgAsp: 4.33 ± 0.076	4.37ArgGlu: 4.37 ± 0.074	2.433ArgPhe: 2.433 ± 0.049	5.365ArgGly: 5.365 ± 0.086	1.61ArgHis: 1.61 ± 0.038	3.82ArgIle: 3.82 ± 0.066	1.541ArgLys: 1.541 ± 0.043	7.068ArgLeu: 7.068 ± 0.09	2.035ArgMet: 2.035 ± 0.046	1.434ArgAsn: 1.434 ± 0.047	3.424ArgPro: 3.424 ± 0.061	2.25ArgGln: 2.25 ± 0.046	6.424ArgArg: 6.424 ± 0.096	4.288ArgSer: 4.288 ± 0.073	4.443ArgThr: 4.443 ± 0.071	5.798ArgVal: 5.798 ± 0.083	1.148ArgTrp: 1.148 ± 0.031	1.507ArgTyr: 1.507 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.642SerAla: 7.642 ± 0.101	0.277SerCys: 0.277 ± 0.019	3.478SerAsp: 3.478 ± 0.06	3.058SerGlu: 3.058 ± 0.06	1.978SerPhe: 1.978 ± 0.044	5.813SerGly: 5.813 ± 0.079	1.068SerHis: 1.068 ± 0.036	2.857SerIle: 2.857 ± 0.057	1.264SerLys: 1.264 ± 0.04	5.25SerLeu: 5.25 ± 0.07	1.282SerMet: 1.282 ± 0.034	1.158SerAsn: 1.158 ± 0.032	2.88SerPro: 2.88 ± 0.056	1.568SerGln: 1.568 ± 0.04	3.917SerArg: 3.917 ± 0.068	3.606SerSer: 3.606 ± 0.081	3.772SerThr: 3.772 ± 0.066	4.725SerVal: 4.725 ± 0.078	0.94SerTrp: 0.94 ± 0.03	1.133SerTyr: 1.133 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	8.056ThrAla: 8.056 ± 0.102	0.299ThrCys: 0.299 ± 0.017	3.807ThrAsp: 3.807 ± 0.061	3.186ThrGlu: 3.186 ± 0.066	1.784ThrPhe: 1.784 ± 0.047	5.693ThrGly: 5.693 ± 0.075	1.169ThrHis: 1.169 ± 0.032	3.139ThrIle: 3.139 ± 0.054	1.257ThrLys: 1.257 ± 0.038	5.887ThrLeu: 5.887 ± 0.08	1.143ThrMet: 1.143 ± 0.038	1.192ThrAsn: 1.192 ± 0.039	3.866ThrPro: 3.866 ± 0.074	1.651ThrGln: 1.651 ± 0.038	3.878ThrArg: 3.878 ± 0.067	3.414ThrSer: 3.414 ± 0.059	3.839ThrThr: 3.839 ± 0.074	5.602ThrVal: 5.602 ± 0.086	0.903ThrTrp: 0.903 ± 0.03	1.174ThrTyr: 1.174 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.592ValAla: 10.592 ± 0.117	0.506ValCys: 0.506 ± 0.024	5.529ValAsp: 5.529 ± 0.08	4.618ValGlu: 4.618 ± 0.07	2.763ValPhe: 2.763 ± 0.056	6.506ValGly: 6.506 ± 0.096	1.82ValHis: 1.82 ± 0.043	4.688ValIle: 4.688 ± 0.069	1.643ValLys: 1.643 ± 0.048	9.298ValLeu: 9.298 ± 0.103	1.608ValMet: 1.608 ± 0.046	1.717ValAsn: 1.717 ± 0.043	4.46ValPro: 4.46 ± 0.069	2.423ValGln: 2.423 ± 0.058	5.95ValArg: 5.95 ± 0.08	4.938ValSer: 4.938 ± 0.073	5.541ValThr: 5.541 ± 0.079	7.78ValVal: 7.78 ± 0.106	1.093ValTrp: 1.093 ± 0.036	1.373ValTyr: 1.373 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.667TrpAla: 1.667 ± 0.049	0.102TrpCys: 0.102 ± 0.01	0.796TrpAsp: 0.796 ± 0.029	0.738TrpGlu: 0.738 ± 0.03	0.567TrpPhe: 0.567 ± 0.026	1.044TrpGly: 1.044 ± 0.04	0.355TrpHis: 0.355 ± 0.021	0.678TrpIle: 0.678 ± 0.029	0.323TrpLys: 0.323 ± 0.019	1.686TrpLeu: 1.686 ± 0.045	0.419TrpMet: 0.419 ± 0.021	0.442TrpAsn: 0.442 ± 0.023	0.704TrpPro: 0.704 ± 0.03	0.614TrpGln: 0.614 ± 0.023	1.249TrpArg: 1.249 ± 0.036	0.905TrpSer: 0.905 ± 0.033	0.866TrpThr: 0.866 ± 0.031	1.184TrpVal: 1.184 ± 0.035	0.377TrpTrp: 0.377 ± 0.021	0.243TrpTyr: 0.243 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.373TyrAla: 2.373 ± 0.049	0.113TyrCys: 0.113 ± 0.01	1.359TyrAsp: 1.359 ± 0.037	1.096TyrGlu: 1.096 ± 0.036	0.671TyrPhe: 0.671 ± 0.024	1.78TyrGly: 1.78 ± 0.041	0.282TyrHis: 0.282 ± 0.016	0.759TyrIle: 0.759 ± 0.031	0.345TyrLys: 0.345 ± 0.02	2.005TyrLeu: 2.005 ± 0.046	0.303TyrMet: 0.303 ± 0.018	0.437TyrAsn: 0.437 ± 0.021	1.018TyrPro: 1.018 ± 0.032	0.575TyrGln: 0.575 ± 0.027	1.608TyrArg: 1.608 ± 0.038	1.116TyrSer: 1.116 ± 0.036	1.093TyrThr: 1.093 ± 0.033	1.537TyrVal: 1.537 ± 0.042	0.32TyrTrp: 0.32 ± 0.019	0.427TyrTyr: 0.427 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3202 proteins (1007737 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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